Foundation part 1
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Which one of the following best describes simple diffusion?

  • Relying on transporter or carrier proteins for movement
  • Active movement of substances using cellular ATP energy
  • Movement of substances from low concentration to high concentration
  • Passive movement of substances using kinetic energy (correct)

Which type of substances is simple diffusion applicable to?

  • Hydrophobic substances only
  • Substances that are fully permeable to the membrane (correct)
  • Substances that are partially permeable to the membrane
  • Polar substances only

What is the direction of movement in simple diffusion?

  • From highly negative charged molecule to positive charge area
  • From low concentration to high concentration
  • From positive charged molecule to highly negative charge area
  • From high concentration to low concentration (correct)

Which type of transmembrane protein is involved in facilitated diffusion?

<p>Carrier proteins or transporter (B)</p> Signup and view all the answers

What is the driving force for facilitated diffusion?

<p>Both concentration and electrochemical gradients (C)</p> Signup and view all the answers

What is the main difference between pores and gated protein channels in facilitated diffusion?

<p>Pores are always open, while gated protein channels can be opened or closed (B)</p> Signup and view all the answers

Which type of primary active transport utilizes phosphorylation?

<p>P-class pump (B)</p> Signup and view all the answers

Which ion is pumped out by the Na+-K+ ATPase?

<p>Na+ (A)</p> Signup and view all the answers

What is the main function of the Na+-K+ ATPase?

<p>Maintain cellular membrane potential (A)</p> Signup and view all the answers

Which type of transport utilizes ATP energy indirectly?

<p>Secondary active transport (C)</p> Signup and view all the answers

What is the direction of movement in counter-transporters?

<p>Opposite directions (A)</p> Signup and view all the answers

Why is osmolarity still commonly used despite osmolality being the preferred unit in physiology?

<p>Osmolarity is easier to measure (B)</p> Signup and view all the answers

Which type of solution has the same osmolality as the compared solution?

<p>Iso-osmolar solution (D)</p> Signup and view all the answers

Which direction does water move between hypo-osmolar and hyper-osmolar solutions?

<p>Water moves from hypo-osmolar to hyper-osmolar solution (C)</p> Signup and view all the answers

What happens to a cell in a hypotonic solution?

<p>Cell swelling &amp; burst (water in &gt; water out) (C)</p> Signup and view all the answers

Which of the following best describes the ΔF508 mutation in Cystic Fibrosis?

<p>A deletion of 3 DNA bases (D)</p> Signup and view all the answers

What is the known mechanism of disease in Cystic Fibrosis?

<p>Abnormal folding of CFTR protein (A)</p> Signup and view all the answers

In healthy cells, what is the function of CFTR protein?

<p>Excretion of chloride (D)</p> Signup and view all the answers

Which type of genetic disease is Cystic Fibrosis classified as?

<p>Monogenic (B)</p> Signup and view all the answers

What is the specific mutation that causes Cystic Fibrosis?

<p>ΔF508 mutation (B)</p> Signup and view all the answers

What is the known mechanism of disease in Cystic Fibrosis?

<p>Abnormal CFTR protein folding (D)</p> Signup and view all the answers

Which type of epithelial tissue is responsible for protection from the external environment and prevention of dessication?

<p>Stratified squamous epithelium (B)</p> Signup and view all the answers

Which type of epithelial tissue is responsible for absorption in the intestine?

<p>Simple columnar epithelium (A)</p> Signup and view all the answers

Which type of epithelial tissue is responsible for filtration in the lining of kidney tubules?

<p>Simple squamous epithelium (D)</p> Signup and view all the answers

Which type of junctions link epithelial cells to one another and the basal lamina?

<p>Desmosomes (C)</p> Signup and view all the answers

What is the main characteristic of epithelial cells in terms of vascularity?

<p>Avascular (A)</p> Signup and view all the answers

What is the term for the different functions associated with the apical, lateral, and basal domains of epithelial cells?

<p>Cellular polarity (C)</p> Signup and view all the answers

Which type of epithelial tissue is responsible for absorption and filtration in capillaries and alveoli?

<p>Simple squamous (C)</p> Signup and view all the answers

Which type of epithelial tissue is responsible for absorption and secretion in the digestive tract and gallbladder?

<p>Simple columnar (A)</p> Signup and view all the answers

Which type of epithelial tissue is responsible for barrier and protection in the skin, oral cavity, upper throat, and esophagus?

<p>Stratified squamous (D)</p> Signup and view all the answers

Which cytoskeletal proteins are found in microvilli?

<p>Actin filaments (C)</p> Signup and view all the answers

What is the main function of cilia in the respiratory tract?

<p>Sweep mucus up and out of the airway (B)</p> Signup and view all the answers

What is the role of keratin in the skin?

<p>Provide a protective layer (A)</p> Signup and view all the answers

Which function of epithelial tissue involves the prevention of dessication?

<p>Protection (A)</p> Signup and view all the answers

Which function of epithelial tissue involves the transfer of gases in the alveoli?

<p>Exchange (C)</p> Signup and view all the answers

Which function of epithelial tissue involves the absorption of nutrients in the intestine?

<p>Absorption (D)</p> Signup and view all the answers

Which division of the nervous system is responsible for controlling involuntary bodily functions such as heart rate and digestion?

<p>Enteric Nervous System (C)</p> Signup and view all the answers

Which division of the nervous system is responsible for transmitting sensory information from the body to the central nervous system?

<p>Peripheral Nervous System (C)</p> Signup and view all the answers

Which division of the autonomic nervous system is responsible for the 'fight or flight' response?

<p>Sympathetic (B)</p> Signup and view all the answers

Which part of the neuron is responsible for the initial generation of an action potential?

<p>Axon hillock (C)</p> Signup and view all the answers

Which type of neuron has a single process extending from the cell body?

<p>Unipolar (D)</p> Signup and view all the answers

Which type of glial cell is responsible for myelinating axons in the central nervous system (CNS)?

<p>Oligodendrocyte (C)</p> Signup and view all the answers

Which division of the nervous system is responsible for controlling involuntary bodily functions such as heart rate and digestion?

<p>Parasympathetic division (B)</p> Signup and view all the answers

What is the main function of the somatic nervous system?

<p>Controlling voluntary movements (B)</p> Signup and view all the answers

Which division of the autonomic nervous system is responsible for the 'fight or flight' response?

<p>Sympathetic division (D)</p> Signup and view all the answers

Which part of the nervous system is primarily responsible for integrating autonomic sensory information with effector commands from the hypothalamus?

<p>Brainstem (B)</p> Signup and view all the answers

Which control center is involved in homeostatic control and can modify brainstem control pathways?

<p>Hypothalamus (A)</p> Signup and view all the answers

Which control center controls emotional and motivational control centers and can influence physiological responses?

<p>Limbic system (C)</p> Signup and view all the answers

Which division of the autonomic nervous system is responsible for maintaining homeostasis and controlling the internal environment of the body?

<p>Both Parasympathetic and Sympathetic (C)</p> Signup and view all the answers

What is the primary function of the autonomic nervous system (ANS)?

<p>To maintain homeostasis and control the internal environment of the body (D)</p> Signup and view all the answers

Which outflow of the autonomic nervous system (ANS) is associated with the parasympathetic division?

<p>Cranio-sacral outflow (C)</p> Signup and view all the answers

Which type of neurons secrete ACh in the sympathetic division of the autonomic nervous system?

<p>Sympathetic cholinergic neurons (B)</p> Signup and view all the answers

Which neurotransmitters are NOT released by nonadrenergic, noncholinergic neurons?

<p>ACh and NE (A)</p> Signup and view all the answers

Which division of the autonomic nervous system is associated with the release of ACh by sympathetic post-ganglionic neurons?

<p>Both sympathetic and parasympathetic divisions (D)</p> Signup and view all the answers

Which receptor subtype is responsible for bronchoconstriction in the lungs?

<p>M3 (A)</p> Signup and view all the answers

Which receptor subtype is responsible for dilation of the vascular smooth muscle?

<p>b2 (A)</p> Signup and view all the answers

Which receptor subtype is responsible for vasoconstriction in the arteries to the skin?

<p>a1 (A)</p> Signup and view all the answers

Which receptor subtype is responsible for vasoconstriction in the arteries to the lung?

<p>b2 (C)</p> Signup and view all the answers

Which receptor subtype is responsible for dilation in the coronary arteries?

<p>b2 (C)</p> Signup and view all the answers

Which neurotransmitters are used by the autonomic nervous system to elicit different actions through specific receptor interactions?

<p>Acetylcholine, Epinephrine, and Norepinephrine (C)</p> Signup and view all the answers

Which neurotransmitters have different affinities for similar receptors?

<p>Epinephrine and Norepinephrine (D)</p> Signup and view all the answers

Which term is commonly associated with the abuse of drugs like ecstasy?

<p>Drug (B)</p> Signup and view all the answers

How is medicine defined?

<p>A modern chemical preparation that contains drugs (D)</p> Signup and view all the answers

What is pharmacology?

<p>The study of drugs and their interactions with the body through chemical reaction (B)</p> Signup and view all the answers

Which of the following best describes clinical pharmacology?

<p>The study of drug therapy in clinical practice (D)</p> Signup and view all the answers

What is the main purpose of therapeutics?

<p>To alleviate pain or injury (A)</p> Signup and view all the answers

How would you define a drug?

<p>Any substance that alters biological function through a chemical reaction (D)</p> Signup and view all the answers

Which of the following best describes pharmacokinetics?

<p>The study of drug absorption, distribution, metabolism, and excretion (A)</p> Signup and view all the answers

Where does drug absorption occur?

<p>In the interstitial fluids (B)</p> Signup and view all the answers

How is a drug eliminated from the body?

<p>Through the kidneys (A)</p> Signup and view all the answers

Which of the following best describes pharmacodynamics?

<p>The study of the effects of a drug on the body (B)</p> Signup and view all the answers

What is the main purpose of therapeutics?

<p>To compare the effectiveness and safety of one drug to another (D)</p> Signup and view all the answers

What is the therapeutic window?

<p>The range of doses at which a drug is both effective and safe (C)</p> Signup and view all the answers

Which organelle is responsible for the synthesis of proteins?

<p>Rough Endoplasmic Reticulum (RER) (C)</p> Signup and view all the answers

Which organelle is involved in the oxidation of organic molecules?

<p>Peroxisome (A)</p> Signup and view all the answers

Which organelle contains digestive enzymes that break down macromolecules?

<p>Lysosome (C)</p> Signup and view all the answers

Which statement about the plasma membrane is true?

<p>The plasma membrane is a double membrane composed of phospholipids. (A)</p> Signup and view all the answers

What is the function of proteins in the plasma membrane?

<p>Proteins play a key role in many membrane functions. (A)</p> Signup and view all the answers

What is NOT the function of the glycocalyx in the plasma membrane?

<p>The glycocalyx is responsible for the synthesis of proteins. (C)</p> Signup and view all the answers

Which of the following is NOT a function of the plasma membrane?

<p>Synthesis of ATP (D)</p> Signup and view all the answers

What is the main component of the plasma membrane?

<p>Phospholipids (C)</p> Signup and view all the answers

What is the role of cholesterol in the plasma membrane?

<p>It stiffens the region (D)</p> Signup and view all the answers

Which molecule contains genetic information and acts as a store for genetic information?

<p>DNA (C)</p> Signup and view all the answers

What provides functions key for life, such as enzymes, peptide hormones, and structural proteins?

<p>Proteins (A)</p> Signup and view all the answers

What is the role of genes in the genetic information of DNA?

<p>Encode proteins (A)</p> Signup and view all the answers

Which of the following is NOT one of the four bases found in DNA?

<p>B- Base (D)</p> Signup and view all the answers

Which part of the DNA molecule is on the outside?

<p>Phosphate backbone (B)</p> Signup and view all the answers

Which groove of the DNA double helix is easier to access for transcription factor binding?

<p>Major groove (D)</p> Signup and view all the answers

Which molecule is responsible for translating genetic information to proteins?

<p>RNA (C)</p> Signup and view all the answers

What is the main function of RNA?

<p>To translate genetic information to proteins (D)</p> Signup and view all the answers

Which of the following is NOT a function of RNA?

<p>Storage of genetic information (D)</p> Signup and view all the answers

Which base is not found in RNA?

<p>T-Thymine (A)</p> Signup and view all the answers

What type of sugar is found in RNA?

<p>Ribose (B)</p> Signup and view all the answers

What is the charge of RNA?

<p>Negative (B)</p> Signup and view all the answers

Which enzyme is responsible for unwinding the DNA molecule during replication?

<p>DNA helicase (C)</p> Signup and view all the answers

Which enzyme adds RNA primers to initiate complementary base pairing during DNA replication?

<p>DNA primase (C)</p> Signup and view all the answers

Which enzyme seals breaks in DNA strands during replication?

<p>DNA ligase (B)</p> Signup and view all the answers

Which enzyme is responsible for synthesizing DNA in the 5' to 3' direction during DNA replication?

<p>DNA polymerase (A)</p> Signup and view all the answers

What is the direction of DNA synthesis on the leading strand during DNA replication?

<p>5' to 3' (A)</p> Signup and view all the answers

Which of the following is the main function of chromosomes?

<p>To package and store DNA (B)</p> Signup and view all the answers

What is the structure of chromosomes that enables tight packaging of DNA?

<p>Nucleosomes (C)</p> Signup and view all the answers

Why is accurate distribution of DNA important during cell division?

<p>To ensure each new cell receives a complete set of genetic information (B)</p> Signup and view all the answers

Which cells have 23 pairs of chromosomes?

<p>Diploid cells (B)</p> Signup and view all the answers

What does acetylation of DNA do?

<p>Turns genes on (A)</p> Signup and view all the answers

What does methylation of DNA do?

<p>Turns genes off (C)</p> Signup and view all the answers

Which of the following mechanisms is responsible for turning off gene expression in cells?

<p>Methylation and acetylation (C)</p> Signup and view all the answers

What is the role of transcription factor proteins in gene expression?

<p>To bind to enhancer or promoter regions and stimulate gene expression (B)</p> Signup and view all the answers

Why is it important for specific cells to express only a subset of the entire genome?

<p>To maintain cell differentiation (A)</p> Signup and view all the answers

Which of the following is an example of a triose?

<p>Glyceraldehyde (B)</p> Signup and view all the answers

Which polysaccharide is primarily composed of a-1,4 glycosidic bonds?

<p>Starch amylose (D)</p> Signup and view all the answers

Which of the following is responsible for the branching in glycogen?

<p>a-1,6 glycosidic bond (B)</p> Signup and view all the answers

Which of the following is a pentose sugar?

<p>Ribose (C)</p> Signup and view all the answers

Which of the following is a hexose sugar?

<p>Fructose (D)</p> Signup and view all the answers

Which of the following is NOT a function of glycosylation of proteins?

<p>Promotes polymerisation with other mucins via disulfide bonds (A)</p> Signup and view all the answers

What is the basic structure of mucin?

<p>Protein backbone (A)</p> Signup and view all the answers

What allows the polymerisation of mucin via disulfide bonds?

<p>D-domain (D)</p> Signup and view all the answers

Which enzyme is responsible for the conversion of DNA to RNA?

<p>RNA polymerase (D)</p> Signup and view all the answers

What is the role of transfer RNA (tRNA) in the process of translation?

<p>It directs the incorporation of amino acids into protein (A)</p> Signup and view all the answers

Which cellular component carries out the translation process?

<p>Ribosomes (A)</p> Signup and view all the answers

Which enzyme is responsible for adding multiple adenine nucleotides to the end of the mRNA transcript, resulting in the poly-A tail?

<p>Polymerase A (C)</p> Signup and view all the answers

What is the function of the capping enzyme mRNA guanylyltransferase?

<p>Add a 7-methylguanylate cap to the 5' end of the mRNA (D)</p> Signup and view all the answers

Which process involves the removal of introns and joining of exons in the pre-mRNA molecule?

<p>Splicing (B)</p> Signup and view all the answers

Which enzyme is responsible for the enzymatic activities of RNA polymerases during transcription?

<p>RNA polymerase (D)</p> Signup and view all the answers

What is the role of mRNA processing mechanisms in gene expression?

<p>Producing mature mRNA (D)</p> Signup and view all the answers

Which components interact in the process of translation (protein synthesis)?

<p>Triplet codons, ribosome, and tRNA (D)</p> Signup and view all the answers

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