Podcast
Questions and Answers
What is the cause of periodontal disease?
What is the cause of periodontal disease?
- A viral infection
- A fungal infection
- A bacterial infection (correct)
- An autoimmune disorder
What is the main cause of periodontitis?
What is the main cause of periodontitis?
- A genetic mutation
- A viral infection
- A bacterial-induced inflammation and tissue destruction (correct)
- Trauma to the periodontium
Which cells are involved in bone remodeling?
Which cells are involved in bone remodeling?
- Chondrocytes and fibroblasts
- Osteoblasts and osteoclasts (correct)
- Adipocytes and myocytes
- Neurons and astrocytes
What is catabasis?
What is catabasis?
What is the body's response to bacteria called?
What is the body's response to bacteria called?
How many stages are there in the bone remodeling cycle?
How many stages are there in the bone remodeling cycle?
What is the host immune response to bacterial accumulation near the gingival margin?
What is the host immune response to bacterial accumulation near the gingival margin?
What regulates osteoclast differentiation and activation?
What regulates osteoclast differentiation and activation?
What enables bacteria to colonize and damage the periodontium?
What enables bacteria to colonize and damage the periodontium?
What is the predominant cell type in established gingivitis?
What is the predominant cell type in established gingivitis?
What protects bone from excessive resorption?
What protects bone from excessive resorption?
Which factors can influence susceptibility to periodontal disease?
Which factors can influence susceptibility to periodontal disease?
What is the role of the RANKL/OPG balance in regulating alveolar bone resorption?
What is the role of the RANKL/OPG balance in regulating alveolar bone resorption?
What do gingival fibroblasts produce in response to inflammation?
What do gingival fibroblasts produce in response to inflammation?
What is acute inflammation?
What is acute inflammation?
What is the process of resolving acute inflammation called?
What is the process of resolving acute inflammation called?
How long does it take for established gingivitis to develop after plaque biofilm accumulation?
How long does it take for established gingivitis to develop after plaque biofilm accumulation?
What can chronic inflammation lead to?
What can chronic inflammation lead to?
What is the main consequence of periodontitis?
What is the main consequence of periodontitis?
Which molecules play important roles in the pathogenesis of periodontal disease?
Which molecules play important roles in the pathogenesis of periodontal disease?
What are some contributing factors to the failure to control bacterial infection in periodontitis?
What are some contributing factors to the failure to control bacterial infection in periodontitis?
What is the role of MMPs in the periodontal connective tissue matrix?
What is the role of MMPs in the periodontal connective tissue matrix?
What are some additional contributing factors to periodontitis?
What are some additional contributing factors to periodontitis?
What happens when there is a disruption in the MMP-TIMP balance?
What happens when there is a disruption in the MMP-TIMP balance?
What is the main consequence of tissue destruction in periodontitis?
What is the main consequence of tissue destruction in periodontitis?
What triggers the release of cytokines and prostaglandins in chronic bacterial infection?
What triggers the release of cytokines and prostaglandins in chronic bacterial infection?
What is the function of Doxycycline in periodontal treatment?
What is the function of Doxycycline in periodontal treatment?
Study Notes
- Periodontal disease is a bacterial infection that causes inflammation in the periodontal tissues.
- The body's response to bacteria is called the host response.
- Virulence factors enable bacteria to colonize and damage the periodontium.
- Factors that influence susceptibility to periodontal disease include genetics, environment, and acquired factors.
- Acute inflammation is a host-protective response to microbial invasion.
- Resolution of acute inflammation is an actively regulated biologic process.
- Chronic inflammation can lead to damage to the host.
- Cytokines and prostaglandins play important roles in the pathogenesis of periodontal disease.
- MMPs facilitate the normal turnover of the periodontal connective tissue matrix.
- The balance between MMPs and TIMP is critical in maintaining the health of the connective tissue.
- MMPs regulate the turnover of extracellular matrix
- Disruption in MMP-TIMP balance leads to excessive breakdown of connective tissue matrix
- Chronic bacterial infection triggers release of cytokines and prostaglandins
- These mediators stimulate leukocytes and fibroblasts to release MMPs
- Elevated MMP levels overwhelm TIMPs, leading to collagen destruction in periodontal tissues
- Collagen provides structural framework for gingiva, periodontal ligament, and supporting alveolar bone
- Degradation of collagen leads to gingival recession, pocket formation, periodontal attachment loss, root exposure, and tooth mobility
- Doxycycline can be prescribed as an adjunct to periodontal instrumentation
- Doxycycline meds are concentrated in gingival crevicular fluid
- Periostat is a 20-mg doxycycline medication used for periodontitis.
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