Perio Lecture 12
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Perio Lecture 12

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Questions and Answers

What is the cause of periodontal disease?

  • A viral infection
  • A fungal infection
  • A bacterial infection (correct)
  • An autoimmune disorder

    • What is the main cause of periodontitis?

  • A genetic mutation
  • A viral infection
  • A bacterial-induced inflammation and tissue destruction (correct)
  • Trauma to the periodontium

    • Which cells are involved in bone remodeling?

  • Chondrocytes and fibroblasts
  • Osteoblasts and osteoclasts (correct)
  • Adipocytes and myocytes
  • Neurons and astrocytes

    • What is catabasis?

    <p>The resolution of inflammation and return to homeostasis</p> Signup and view all the answers

    What is the body's response to bacteria called?

    <p>Host response</p> Signup and view all the answers

    How many stages are there in the bone remodeling cycle?

    <p>Four</p> Signup and view all the answers

    What is the host immune response to bacterial accumulation near the gingival margin?

    <p>The recruitment of PMNs to the site</p> Signup and view all the answers

    What regulates osteoclast differentiation and activation?

    <p>RANKL</p> Signup and view all the answers

    What enables bacteria to colonize and damage the periodontium?

    <p>Virulence factors</p> Signup and view all the answers

    What is the predominant cell type in established gingivitis?

    <p>Plasma cells</p> Signup and view all the answers

    What protects bone from excessive resorption?

    <p>OPG</p> Signup and view all the answers

    Which factors can influence susceptibility to periodontal disease?

    <p>Genetics, environment, and acquired factors</p> Signup and view all the answers

    What is the role of the RANKL/OPG balance in regulating alveolar bone resorption?

    <p>It is important in regulating alveolar bone resorption</p> Signup and view all the answers

    What do gingival fibroblasts produce in response to inflammation?

    <p>All of the above</p> Signup and view all the answers

    What is acute inflammation?

    <p>A host-protective response to microbial invasion</p> Signup and view all the answers

    What is the process of resolving acute inflammation called?

    <p>Actively regulated biologic process</p> Signup and view all the answers

    How long does it take for established gingivitis to develop after plaque biofilm accumulation?

    <p>21 days</p> Signup and view all the answers

    What can chronic inflammation lead to?

    <p>Collagen destruction</p> Signup and view all the answers

    What is the main consequence of periodontitis?

    <p>All of the above</p> Signup and view all the answers

    Which molecules play important roles in the pathogenesis of periodontal disease?

    <p>Cytokines and prostaglandins</p> Signup and view all the answers

    What are some contributing factors to the failure to control bacterial infection in periodontitis?

    <p>All of the above</p> Signup and view all the answers

    What is the role of MMPs in the periodontal connective tissue matrix?

    <p>They facilitate the normal turnover of the matrix</p> Signup and view all the answers

    What are some additional contributing factors to periodontitis?

    <p>All of the above</p> Signup and view all the answers

    What happens when there is a disruption in the MMP-TIMP balance?

    <p>There is excessive breakdown of the matrix</p> Signup and view all the answers

    What is the main consequence of tissue destruction in periodontitis?

    <p>All of the above</p> Signup and view all the answers

    What triggers the release of cytokines and prostaglandins in chronic bacterial infection?

    <p>Bacteria</p> Signup and view all the answers

    What is the function of Doxycycline in periodontal treatment?

    <p>To reduce inflammation</p> Signup and view all the answers

    Study Notes

    1. Periodontal disease is a bacterial infection that causes inflammation in the periodontal tissues.
    2. The body's response to bacteria is called the host response.
    3. Virulence factors enable bacteria to colonize and damage the periodontium.
    4. Factors that influence susceptibility to periodontal disease include genetics, environment, and acquired factors.
    5. Acute inflammation is a host-protective response to microbial invasion.
    6. Resolution of acute inflammation is an actively regulated biologic process.
    7. Chronic inflammation can lead to damage to the host.
    8. Cytokines and prostaglandins play important roles in the pathogenesis of periodontal disease.
    9. MMPs facilitate the normal turnover of the periodontal connective tissue matrix.
    10. The balance between MMPs and TIMP is critical in maintaining the health of the connective tissue.
    • MMPs regulate the turnover of extracellular matrix
    • Disruption in MMP-TIMP balance leads to excessive breakdown of connective tissue matrix
    • Chronic bacterial infection triggers release of cytokines and prostaglandins
    • These mediators stimulate leukocytes and fibroblasts to release MMPs
    • Elevated MMP levels overwhelm TIMPs, leading to collagen destruction in periodontal tissues
    • Collagen provides structural framework for gingiva, periodontal ligament, and supporting alveolar bone
    • Degradation of collagen leads to gingival recession, pocket formation, periodontal attachment loss, root exposure, and tooth mobility
    • Doxycycline can be prescribed as an adjunct to periodontal instrumentation
    • Doxycycline meds are concentrated in gingival crevicular fluid
    • Periostat is a 20-mg doxycycline medication used for periodontitis.

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