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Questions and Answers
What is the cause of periodontal disease?
What is the main cause of periodontitis?
Which cells are involved in bone remodeling?
What is catabasis?
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What is the body's response to bacteria called?
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How many stages are there in the bone remodeling cycle?
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What is the host immune response to bacterial accumulation near the gingival margin?
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What regulates osteoclast differentiation and activation?
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What enables bacteria to colonize and damage the periodontium?
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What is the predominant cell type in established gingivitis?
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What protects bone from excessive resorption?
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Which factors can influence susceptibility to periodontal disease?
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What is the role of the RANKL/OPG balance in regulating alveolar bone resorption?
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What do gingival fibroblasts produce in response to inflammation?
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What is acute inflammation?
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What is the process of resolving acute inflammation called?
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How long does it take for established gingivitis to develop after plaque biofilm accumulation?
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What can chronic inflammation lead to?
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What is the main consequence of periodontitis?
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Which molecules play important roles in the pathogenesis of periodontal disease?
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What are some contributing factors to the failure to control bacterial infection in periodontitis?
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What is the role of MMPs in the periodontal connective tissue matrix?
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What are some additional contributing factors to periodontitis?
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What happens when there is a disruption in the MMP-TIMP balance?
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What is the main consequence of tissue destruction in periodontitis?
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What triggers the release of cytokines and prostaglandins in chronic bacterial infection?
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What is the function of Doxycycline in periodontal treatment?
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Study Notes
- Periodontal disease is a bacterial infection that causes inflammation in the periodontal tissues.
- The body's response to bacteria is called the host response.
- Virulence factors enable bacteria to colonize and damage the periodontium.
- Factors that influence susceptibility to periodontal disease include genetics, environment, and acquired factors.
- Acute inflammation is a host-protective response to microbial invasion.
- Resolution of acute inflammation is an actively regulated biologic process.
- Chronic inflammation can lead to damage to the host.
- Cytokines and prostaglandins play important roles in the pathogenesis of periodontal disease.
- MMPs facilitate the normal turnover of the periodontal connective tissue matrix.
- The balance between MMPs and TIMP is critical in maintaining the health of the connective tissue.
- MMPs regulate the turnover of extracellular matrix
- Disruption in MMP-TIMP balance leads to excessive breakdown of connective tissue matrix
- Chronic bacterial infection triggers release of cytokines and prostaglandins
- These mediators stimulate leukocytes and fibroblasts to release MMPs
- Elevated MMP levels overwhelm TIMPs, leading to collagen destruction in periodontal tissues
- Collagen provides structural framework for gingiva, periodontal ligament, and supporting alveolar bone
- Degradation of collagen leads to gingival recession, pocket formation, periodontal attachment loss, root exposure, and tooth mobility
- Doxycycline can be prescribed as an adjunct to periodontal instrumentation
- Doxycycline meds are concentrated in gingival crevicular fluid
- Periostat is a 20-mg doxycycline medication used for periodontitis.
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