Cellular changes and adaptation 1

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Which of the following best describes hypoxia?

A condition caused by a reduced oxygen delivery to the tissues

What is the primary source of energy production in cells?

Oxidative phosphorylation

Which of the following is a consequence of hypoxia?

Cell swelling

What is the effect of reduced oxygen levels on oxidative phosphorylation?

<p>Impaired ATP synthesis</p> Signup and view all the answers

What is the primary cause of metabolic acidosis in hypoxia?

<p>Increased lactic acid production</p> Signup and view all the answers

Which of the following is NOT a consequence of hypoxia?

<p>Activation of protein synthesis</p> Signup and view all the answers

What is the effect of hypoxia on oxidative phosphorylation?

<p>Decreased ATP production</p> Signup and view all the answers

What is the primary cause of cellular swelling in hypoxia?

<p>Influx of Na+</p> Signup and view all the answers

Which of the following is a consequence of increased lactic acid in cells during anaerobic respiration?

<p>Clumping of nuclear chromatin</p> Signup and view all the answers

Which of the following is NOT an example of a free radical?

<p>Oxygen molecules</p> Signup and view all the answers

What happens to free radicals in normal conditions?

<p>They are removed by specialized enzymatic systems</p> Signup and view all the answers

What is the primary function of glutathione in dealing with free radicals?

<p>To remove free radicals</p> Signup and view all the answers

Which of the following is a consequence of excessive production or inadequate removal of free radicals in cells?

<p>Decreased protein synthesis</p> Signup and view all the answers

What is the effect of cell injury resulting from excessive production or inadequate removal of free radicals?

<p>Lipid peroxidation</p> Signup and view all the answers

Which of the following best describes direct-acting toxins?

<p>Toxins that act directly by combining with a critical molecular component</p> Signup and view all the answers

Which of the following is an example of latent toxins?

<p>CCl4 poisoning</p> Signup and view all the answers

What is the primary mechanism of cell injury caused by latent toxins?

<p>Conversion to reactive metabolites</p> Signup and view all the answers

Which of the following is a common result of radiation?

<p>Damage to DNA</p> Signup and view all the answers

What happens if the damage to DNA caused by radiation is too great to be repaired successfully?

<p>p53 triggers apoptosis</p> Signup and view all the answers

Which of the following is a mechanism by which cells become injured in autoimmunity and infection?

<p>All of the above</p> Signup and view all the answers

What is the process by which inflammatory cells generate ROS?

<p>Oxidative burst</p> Signup and view all the answers

Which cellular components can be damaged by ROS, resulting in cell injury?

<p>All of the above</p> Signup and view all the answers

Which type of cell death is characterized by an inflammatory response?

<p>Necrosis</p> Signup and view all the answers

Which type of cell death is energy-dependent and does not elicit an inflammatory response?

<p>Apoptosis</p> Signup and view all the answers

Which type of cell death is a normal physiological process as well as a response to injury?

<p>Apoptosis</p> Signup and view all the answers

Which of the following is a characteristic feature of necrosis?

<p>Pathologic role in cell development</p> Signup and view all the answers

Which nuclear change is characterized by the rupture of the pyknotic nuclear membrane and fragmentation of the nucleus?

<p>Karyorrhexis</p> Signup and view all the answers

Which nuclear change is characterized by the fading of the nucleus and dissolution of chromatin due to the action of DNAases and RNAases?

<p>Karyolysis</p> Signup and view all the answers

Which nuclear change is characterized by nuclear shrinkage and condensation of DNA into a shrunken basophilic mass?

<p>Pyknosis</p> Signup and view all the answers

Which of the following is NOT a characteristic feature of apoptosis?

<p>Pathologic role in cell development</p> Signup and view all the answers

Which type of cell death is characterized by adjacent inflammation?

<p>Necrosis</p> Signup and view all the answers

Which of the following is a characteristic feature of apoptosis?

<p>Fragmentation into nucleosome-sized fragments</p> Signup and view all the answers

What is the primary role of apoptosis?

<p>Physiologic means of eliminating unwanted cells</p> Signup and view all the answers

Which of the following is a characteristic feature of necrosis?

<p>Adjacent inflammation</p> Signup and view all the answers

Which of the following is a consequence of excessive production or inadequate removal of free radicals in cells?

<p>Cellular damage</p> Signup and view all the answers

What is the primary cause of infarction?

<p>Insufficient blood supply</p> Signup and view all the answers

Which of the following is a consequence of ischaemia?

<p>Inadequate blood supply</p> Signup and view all the answers

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