Podcast
Questions and Answers
What is the primary factor released in response to a hypoxic environment in the context of the text?
What is the primary factor released in response to a hypoxic environment in the context of the text?
Which signaling pathway can be inhibited to prevent pathological ocular neovascularization, as mentioned in the text?
Which signaling pathway can be inhibited to prevent pathological ocular neovascularization, as mentioned in the text?
What does gene deletion at P12 and analysis at P17 show regarding VEGF signaling in the text?
What does gene deletion at P12 and analysis at P17 show regarding VEGF signaling in the text?
What is the ideal treatment approach for proliferative retinopathy, as suggested in the text?
What is the ideal treatment approach for proliferative retinopathy, as suggested in the text?
Signup and view all the answers
Which condition leads to the release of a significant amount of VEGF, causing retinopathies like high bleeding and leaking?
Which condition leads to the release of a significant amount of VEGF, causing retinopathies like high bleeding and leaking?
Signup and view all the answers
What prevents both Slit2/Robo1&2 signaling pathways from reinforcing each other?
What prevents both Slit2/Robo1&2 signaling pathways from reinforcing each other?
Signup and view all the answers
What effect does hypoxia have on PVHL interaction with HIF1⍺?
What effect does hypoxia have on PVHL interaction with HIF1⍺?
Signup and view all the answers
How is angiogenic reprogramming triggered by HIF1⍺ during hypoxia described?
How is angiogenic reprogramming triggered by HIF1⍺ during hypoxia described?
Signup and view all the answers
What is the consequence of activating Notch expression in tip cells during vascular sprouting?
What is the consequence of activating Notch expression in tip cells during vascular sprouting?
Signup and view all the answers
In hypoxia, which cells are responsible for creating new vessels along a VEGF gradient?
In hypoxia, which cells are responsible for creating new vessels along a VEGF gradient?
Signup and view all the answers
What is the outcome of removing one allele of VEGF-A during embryonic development?
What is the outcome of removing one allele of VEGF-A during embryonic development?
Signup and view all the answers
What happens if VEGF-A is overexpressed during embryonic development?
What happens if VEGF-A is overexpressed during embryonic development?
Signup and view all the answers
What is the primary function of tip cells in angiogenesis?
What is the primary function of tip cells in angiogenesis?
Signup and view all the answers
What is the primary stimulus for hypoxia-induced angiogenesis?
What is the primary stimulus for hypoxia-induced angiogenesis?
Signup and view all the answers
What is the role of VEGF-A in angiogenesis?
What is the role of VEGF-A in angiogenesis?
Signup and view all the answers
What is the function of HIF-1 in tumor biology?
What is the function of HIF-1 in tumor biology?
Signup and view all the answers
What is the significance of the 1995 paper on VEGF-A?
What is the significance of the 1995 paper on VEGF-A?
Signup and view all the answers
What is the characteristic of arteries compared to veins?
What is the characteristic of arteries compared to veins?
Signup and view all the answers
What is the main consequence of excess oxygen to the baby's brain in ocular neovascular diseases?
What is the main consequence of excess oxygen to the baby's brain in ocular neovascular diseases?
Signup and view all the answers
Why is the treatment for proliferative diabetic retinopathy aiming to selectively inhibit pathological angiogenesis?
Why is the treatment for proliferative diabetic retinopathy aiming to selectively inhibit pathological angiogenesis?
Signup and view all the answers
What can happen as a risk of laser photocoagulation in the eyes for ocular neovascular diseases treatment?
What can happen as a risk of laser photocoagulation in the eyes for ocular neovascular diseases treatment?
Signup and view all the answers
What is the primary mechanism of action of anti-VEGF therapeutics in treating proliferative diabetic retinopathy?
What is the primary mechanism of action of anti-VEGF therapeutics in treating proliferative diabetic retinopathy?
Signup and view all the answers
How often are intravitreal injections typically administered to patients with proliferative diabetic retinopathy for VEGF inhibition?
How often are intravitreal injections typically administered to patients with proliferative diabetic retinopathy for VEGF inhibition?
Signup and view all the answers
What is considered a 'success story' in the context of VEGF inhibition?
What is considered a 'success story' in the context of VEGF inhibition?
Signup and view all the answers
What is the main objective of the research described?
What is the main objective of the research described?
Signup and view all the answers
What is one of the challenges mentioned for the field of research in this text?
What is one of the challenges mentioned for the field of research in this text?
Signup and view all the answers
Which models are being used to investigate angiogenesis in this research?
Which models are being used to investigate angiogenesis in this research?
Signup and view all the answers
What is the ultimate goal of developing novel therapeutic drugs tailored to specific targets?
What is the ultimate goal of developing novel therapeutic drugs tailored to specific targets?
Signup and view all the answers
What is the key focus of the research in relation to sprouting angiogenesis?
What is the key focus of the research in relation to sprouting angiogenesis?
Signup and view all the answers
In what context are retinal vascular phenotypes being assessed according to the text?
In what context are retinal vascular phenotypes being assessed according to the text?
Signup and view all the answers
