Hypothyroidism Management

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Questions and Answers

An Advanced Practice Nurse (APN) is determining the appropriate T4 replacement dosage for a 35-year-old woman diagnosed with hypothyroidism. Which patient factor is MOST crucial for the APN to consider when establishing a euthyroid state?

  • Patient's occupation and level of physical activity.
  • Patient's ethnicity and dietary habits.
  • Patient's weight, lean body mass, and the severity of hypothyroid symptoms. (correct)
  • Patient's age and family history of thyroid disease.

Which laboratory finding is MOST commonly associated with hypothyroidism?

  • Elevated white blood cell count.
  • Decreased blood glucose.
  • Decreased serum creatinine.
  • Elevated TSH (thyroid-stimulating hormone). (correct)

In the progression of hypothyroidism, when is a decrease in serum free T4 concentration typically observed?

  • Concurrently with an increase in TSH levels.
  • Before any changes in TSH levels.
  • Independently of TSH level changes.
  • After TSH levels have been elevated for an extended period. (correct)

Following the initiation of thyroid replacement therapy, what is the generally recommended timeframe for measuring TSH levels to assess the effectiveness of the treatment?

<p>4-6 weeks (A)</p> Signup and view all the answers

A 75-year-old patient with newly diagnosed hypothyroidism and weighs 155 pounds requires thyroid replacement therapy. Considering the patient's age and lack of significant medical history, which of the following levothyroxine dosages is MOST appropriate to initiate?

<p>25 mcg daily (D)</p> Signup and view all the answers

A 70-year-old woman presents with symptoms of weight loss, palpitations, and constipation. Her laboratory results show a TSH of 0.03 mIU/L (reference range: 0.4-4.0 mIU/L) and a free T4 of 33 pmol/L (reference range 9-25 pmol/L). What is the MOST appropriate next step in evaluating her thyroid function?

<p>Measure T3 levels to assess for T3 thyrotoxicosis. (C)</p> Signup and view all the answers

A patient with a known history of hypothyroidism has been stable on levothyroxine for several years. The patient reports starting a new medication for cholesterol management. Which of the following cholesterol medications is MOST likely to interfere with the absorption of levothyroxine, potentially requiring a dosage adjustment?

<p>Cholestyramine (A)</p> Signup and view all the answers

A pregnant woman with pre-existing hypothyroidism requires careful monitoring and adjustment of her levothyroxine dosage. During which trimester of pregnancy is it MOST likely that her levothyroxine dosage will need to be increased?

<p>First Trimester (D)</p> Signup and view all the answers

Which laboratory assay is MOST sensitive for screening an ambulatory patient for primary hypothyroidism?

<p>TSH (Thyroid Stimulating Hormone) (C)</p> Signup and view all the answers

Bariatric surgery is typically recommended for patients with obesity who meet specific criteria. Which of the following BEST represents a common criterion?

<p>BMI ≥ 30 kg/m² with obesity-related comorbidities or BMI ≥ 40 kg/m² (B)</p> Signup and view all the answers

The diagnostic criteria for metabolic syndrome include several key findings. Which of the following is NOT typically included in the diagnostic criteria?

<p>Elevated LDL cholesterol (D)</p> Signup and view all the answers

In patients with metabolic syndrome, which of the following findings would be expected LAST, typically developing over time if the syndrome is unmanaged?

<p>Atherosclerotic cardiovascular disease (D)</p> Signup and view all the answers

Meglitinide analogs (e.g., Prandin) are used in type 2 diabetes to help minimize the risk of what?

<p>Hypoglycemia (D)</p> Signup and view all the answers

A 40-year-old patient who has been newly diagnosed with type 2 diabetes mellitus is started on metformin, which is titrated to 1000 mg twice daily. The patient's latest HbA1c is 8.1%. What would be the MOST appropriate next step?

<p>Add a DPP-4 inhibitor to the existing medication regimen (B)</p> Signup and view all the answers

An active 72-year-old patient with type 2 diabetes is currently well-managed with metformin 500 mg twice daily. The patient's follow-up HbA1c is 7.4%. What would you recommend?

<p>Maintain current therapy and lifestyle modifications (D)</p> Signup and view all the answers

When initiating pharmacological treatment for Alzheimer's disease in an older adult, which medication class is typically considered the first-line choice?

<p>Cholinesterase inhibitors (D)</p> Signup and view all the answers

In which of the following patients would a thiazolidinedione (TZD) drug be MOST appropriate?

<p>A patient with insulin resistance and no contraindications (C)</p> Signup and view all the answers

In managing a patient with dementia, what is the primary benefit expected from using a cholinesterase inhibitor?

<p>Modest symptomatic improvement in cognition and function (D)</p> Signup and view all the answers

Which assessment tool is most appropriate for evaluating an elderly patient presenting with memory problems, specifically to gather information on their ability to perform complex activities of daily living?

<p>Functional Activities Questionnaire (FAQ) (D)</p> Signup and view all the answers

Which of the following is typically not included as part of a standard nurse practitioner's assessment for Alzheimer's disease?

<p>Genetic testing for specific Alzheimer's-related genes for all patients (A)</p> Signup and view all the answers

When evaluating a patient for dementia, which initial tests are most appropriate to include? (Select three that apply)

<p>Vitamin B12 level (B), Thyroid-stimulating hormone (TSH) (C), Complete blood count (CBC) (E)</p> Signup and view all the answers

A 60-year-old patient with moderate cognitive deficits due to Alzheimer's disease has started taking a cholinesterase inhibitor. What is the primary expected outcome of this medication?

<p>To slow the decline in cognitive function and improve daily living activities (A)</p> Signup and view all the answers

A patient presents with an elevated TSH level and a normal T4 level. Which of the following is the most likely diagnosis?

<p>Subclinical hypothyroidism (B)</p> Signup and view all the answers

Which of the following criteria are used in the diagnosis of type 2 diabetes? (Select three that apply)

<p>A1c ≥ 6.5% (C), Symptoms of hyperglycemia and a random plasma glucose ≥ 200 mg/dL (D), Fasting plasma glucose ≥ 126 mg/dL (E)</p> Signup and view all the answers

An APN is assessing an older adult diagnosed with Alzheimer's disease. Which of the following manifestations is LEAST likely to be seen in this client?

<p>Sudden and fluctuating cognitive impairment (A)</p> Signup and view all the answers

How does delirium differ from dementia?

<p>Delirium has a sudden onset and fluctuating course, while dementia has a gradual onset and progressive course. (A)</p> Signup and view all the answers

Which of the following is NOT typically a characteristic of delirium in an elderly patient?

<p>Gradual and progressive memory loss (D)</p> Signup and view all the answers

When initiating pharmacological treatment for a male patient with Alzheimer's disease, which class of medication is typically the initial choice for a primary care nurse practitioner?

<p>Cholinesterase Inhibitors (B)</p> Signup and view all the answers

When managing a patient with dementia, how do cholinesterase inhibitors provide the greatest benefit?

<p>By temporarily improving cognitive function and reducing some behavioral symptoms. (C)</p> Signup and view all the answers

Which assessment tool provides information about an elderly patient's functional performance of complex activities and is most appropriate for the initial assessment of a memory problem?

<p>Functional Activities Questionnaire (FAQ) (A)</p> Signup and view all the answers

Which of the following assessments is LEAST likely to be included as part of a nurse practitioner's comprehensive assessment for Alzheimer's disease?

<p>Evaluation of cranial nerve function only (D)</p> Signup and view all the answers

Why is Metformin typically discontinued around the time of surgery or procedures involving contrast dye?

<p>To minimize the risk of lactic acidosis due to potential kidney complications from the contrast dye. (A)</p> Signup and view all the answers

What intervention is most effective for managing microalbuminuria in a patient with diabetes mellitus?

<p>Initiating or optimizing ACE inhibitor or ARB therapy. (B)</p> Signup and view all the answers

A 60-year-old patient with moderate cognitive deficits attributed to Alzheimer's disease has been started on a cholinesterase inhibitor. What is the primary purpose of this medication?

<p>To improve cognitive function and reduce behavioral symptoms. (A)</p> Signup and view all the answers

A patient on insulin therapy experiences elevated morning blood glucose levels but reports low blood glucose at 3:00 AM. What phenomenon is most likely occurring, and how should it be managed?

<p>Somogyi effect; reduce the evening dose of long-acting insulin. (D)</p> Signup and view all the answers

A 66-year-old male patient at average risk for colon cancer had a colonoscopy 10 years ago. According to current guidelines, what is the most appropriate recommendation for follow-up screening?

<p>Colonoscopy every 10 years. (A)</p> Signup and view all the answers

What is an example of secondary prevention for an elderly adult?

<p>Screening for and managing hypertension to prevent cardiovascular events. (D)</p> Signup and view all the answers

What test can differentiate between Type 1 and Type 2 Diabetes Mellitus?

<p>Autoantibody Testing (D)</p> Signup and view all the answers

What is the goal HGB A1C for maintenance of DM treatment in most non-pregnant adults?

<p>Less than 7.0% (B)</p> Signup and view all the answers

A person was recently diagnosed with Type 1 DM and weights 120 Kilograms. What is the appropriate initial dose of insulin they should be started on?

<p>60 units (B)</p> Signup and view all the answers

A 72-year-old male with hypertension is prescribed amlodipine 5mg, lisinopril 5mg, and enalapril 5mg daily. According to prescribing guidelines, which best describes an applicable consideration for this patient's medication regimen?

<p>The combination of ACE inhibitors (lisinopril and enalapril) increases the risk of hyperkalemia and hypotension, warranting consideration for deprescribing one. (A)</p> Signup and view all the answers

An 81-year-old patient is taking seven medications and the nurse practitioner suspects medication adherence issues. What is the MOST appropriate initial intervention?

<p>Conduct a thorough medication reconciliation and assessment of the patient's understanding of each medication's purpose and schedule. (B)</p> Signup and view all the answers

A 78-year-old patient scores 22 on the MMSE (Mini-Mental State Examination). How should this result to be interpreted?

<p>Moderate cognitive impairment. (C)</p> Signup and view all the answers

A 77-year-old patient received a tetanus and diphtheria (Td) vaccine six years ago and a flu shot in November. Which immunizations should be recommended today?

<p>Pneumococcal vaccine (PPSV23) and Tdap (B)</p> Signup and view all the answers

Which interventions are most appropriate for an 80-year-old woman with a history of two falls in the past year?

<p>Recommending a cane. and starting Vitamin D supplementation (B)</p> Signup and view all the answers

During fall prevention education, which statement by a 70-year-old patient indicates a NEED for further teaching?

<p>&quot;I don't need to worry about my vision because I had Lasik surgery 20 years ago.&quot; (A)</p> Signup and view all the answers

A 77-year-old patient had an unwitnessed fall and states, "I suddenly found myself on the floor" without attempting to break the fall. What does this statement suggest?

<p>The patient experienced a syncopal episode or drop attack. (D)</p> Signup and view all the answers

What would be the focus of care when assessing an older adult with Alzheimer's disease?

<p>Managing symptoms and functional decline, and addressing caregiver needs. (B)</p> Signup and view all the answers

Flashcards

T4 replacement dosage considerations

Weight, age, cardiac status, other medications.

Common lab abnormality in hypothyroidism

Hyponatremia (low sodium).

What happens to TSH when free T4 falls?

TSH rises.

Timing for TSH recheck.

6-8 weeks after initiating or changing the dose.

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Levothyroxine starting dose in elderly

Start low (12.5-25 mcg) and go slow.

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Next step with low TSH, high T4

Check T3 level

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Metformin and Contrast

Acute kidney injury due to contrast-induced nephropathy.

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Type 1 DM Insulin Start

0.4-1 unit/kg/day. Divide into basal/bolus or multiple daily injections.

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Differentiating DM Types

C-peptide levels. This helps determine insulin production.

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Microalbuminuria Intervention

ACE inhibitors or ARBs

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Early Morning Hyperglycemia

Dawn phenomenon

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HGB A1C Testing Frequency

At least two times per year in patients who are meeting treatment goals.

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DM Treatment Goal (A1C)

<7%

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Rebound Hyperglycemia

Somogyi effect. Reduce insulin dose.

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Most sensitive test for hypothyroid screening

TSH (thyroid-stimulating hormone)

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Bariatric surgery weight loss recommendation

BMI ≥40 or BMI ≥35 with obesity-related comorbidities

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Metabolic syndrome criteria EXCEPT

Elevated HDL cholesterol

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Expected finding in Metabolic Syndrome

Insulin resistance

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Meglitinides minimize risk of what?

Hypoglycemia (low blood sugar)

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Next step, A1C 8.1% on max metformin

Add another medication to metformin (dual therapy)

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A1C 7.4% on metformin

Continue current treatment (metformin 500mg BID).

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TZD contraindication

Patients with heart failure

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Medication Metabolism in Elderly

Age-related changes affect medication metabolism in elderly patients.

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Beers & STOPP2 Guidelines

Beers criteria and STOPP2 guidelines can identify potentially inappropriate medications in elderly patients.

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Improving Medication Adherence

Medication reconciliation, pill organizers, and simplifying regimens can improve adherence.

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MMSE Score of 22

A score of 22 on the MMSE indicates possible cognitive impairment.

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Recommended Immunizations

Annual influenza vaccine and a booster for Tdap are recommended.

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Fall Prevention Interventions

Assess home safety, encourage exercise, and review medications.

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Unexpected Fall Suggests?

Saying "I suddenly found myself on the floor" raises suspicion for syncope.

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Assessing Alzheimer's Disease

Assess cognitive function, functional status, and behavioral changes.

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Alzheimer's Manifestations

The APN is assessing an older adult with the diagnosis of Alzheimer's disease. An appropriate manifestation may be seen in this client.

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Delirium vs. Dementia

Delirium is acute and fluctuating, whereas dementia is chronic and progressive.

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Dementia Treatment

Cholinesterase inhibitors may provide some cognitive benefit for patients with dementia.

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Memory Problem Assessment

Functional performance of more complex activities

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Cholinesterase Inhibitor Purpose

The purpose of Cholinesterase inhibitors is to improve cognition and function.

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Subclinical Hypothyroidism

High TSH and normal T4 indicates subclinical hypothyroidism.

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Type 2 Diabetes Diagnosis

Criteria for the diagnosis of type 2 diabetes include: Fasting plasma glucose >= 126 mg/dL, A1C >= 6.5%, Two-hour plasma glucose >= 200 mg/dL during an oral glucose tolerance test.

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Is not a characteristic of Delirium

Increased or decreased level of consciousness.

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Cholinesterase Inhibitors Use

Cholinesterase inhibitors may provide a modest benefit in managing dementia symptoms.

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Initial Alzheimer's Drug

A cholinesterase inhibitor, such as donepezil (Aricept), is often the initial choice.

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Alzheimer's Assessment Components

Cognitive testing, neurological exam, and psychiatric assessment.

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Initial Dementia Tests

CBC, CMP, TSH, B12.

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Cholinesterase Inhibitor Goal

Cholinesterase inhibitors increase acetylcholine levels in the brain, which can help improve cognitive function.

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High TSH, Normal T4

Subclinical hypothyroidism.

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Type 2 DM Diagnosis Criteria

A1C ≥ 6.5%, FPG ≥ 126 mg/dL, 2-hour PG ≥ 200 mg/dL during OGTT

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Study Notes

  • To determine the appropriate T4 replacement for a 35 y/o hypothyroid woman to achieve a euthyroid state, the Advance Practice Nurse considers the patients needs.
  • A common laboratory abnormality found in hypothyroid patients:
  • Serum free T4 concentrations will fall in hypothyroid patients.
  • The optimal time to measure TSH after initiating thyroid replacement therapy.
  • A 75-year-old patient without significant medical history, weighing 155 pounds, is diagnosed with hypothyroidism and requires medication at the appropriate dosage.
  • Evaluate a 70-year-old woman presenting with weight loss, palpitations, and constipation with a TSH of 0.03 and T4 of 33.

Hypothyroidism Screening

  • The most sensitive laboratory assay for screening an ambulatory patient for primary hypothyroidism.

Diabetes Mellitus

  • Meglitinide analogs like Prandin minimize the risk for patients in type 2 diabetes mellitus care
  • Next step is to assess a newly diagnosed type 2 DM 40 y/o patient started on metformin at 1000 mg BID his latest HGb MoveA1C was 8.1%
  • With an active 72 year old patient with DM2 feeling well, on metformin 500 mg BID with HGB A1C up 7.4% for follow up.
  • A Thiazolidinedione TZD drug can be prescribed.
  • A 42 years old diabetic patient is on metformin/sulfonylurea his HGbA1C is 6.5% and complains of dizziness with low blood sugar episodes
  • A 55 years old with type 2 DM, HbA1C of 9.8% and is 120 kg.
  • A 38 year old female patient is in good health & presents to the clinic.
  • A 45 years old patient has been diabetic for 5 years and on metformin.
  • A GLP-1 receptor agonist(Byetta) can assist Dan, 45 years old obese patient with type 2 DM in weight loss for HGbA1C control
  • Metformin should be discontinued the day of/48 hours after surgery or a procedure when using contrast agents due to the increased risk.
  • An appropriate initial dose for a recently diagnosed type 1 DM weighing 120 kilograms when starting insulin therapy.
  • Least useful step in initial evaluation of a patient that has recently been diagnosed with DM2.
  • Includes intervention for microalbuminuria for a person with DM

Blood Sugar

  • Early morning rises
  • HGB A1C recommended testing.

Maintenance Goal of DM Treatment

  • The maintenance goal of DM treatment in most non-pregnant adults.
  • Test to differentiate type 1 and type 2 DM.
  • A diabetic patient on insulin has elevated blood sugar levels despite taking the medication.

Cancer Screening

  • Follow up based on the 66 year old John having a normal colonoscopy 10 years ago.
  • Recommended guidelines for 68 year old Mary's checkup screening for her annual wellness exam.

Geriatrics and Falls

  • Secondary prevention for a 65 year old patient.
  • In prescribing medication for the elderly, consider age-related changes affecting medication metabolism.
  • Mr. Stevens is a 72 years old being treated for hypertension.
  • Intervention to assist 81 year old Meyers who takes 7 forms of medicine and forgets to take them.
  • Scoring 22 on the MMSE of 78 year old John.
  • Immunization recommendations for 767 year old Bill who is here for a physical exam.
  • An appropriate intervention if 80 year old Mrs. Smith has experienced 2 falls in the past year Further teaching is needed on fall prevention.

Falls and Dementia

  • Falls; The suggestion that a 77 year old patient didn't attempt to break after the fall could mean.
  • An APN assessment for an older adult with Alzheimer's
  • The way Delirium is different from Dementia.
  • A description of a non-characteristic of Delirium for elderly patients.
  • Which drug is the appropriate initial choice for primary care when treating older adult male that has Alzheimer's disease
  • The greatest benefit for a patient dealing with dementia is Cholinesterase inhibitor.
  • Provide information on the assessment test of an elderly patient with memory problems in functional performance of more complex activities
  • What should the nurse practitioner not include when assessing a client for Alzheimer's
  • The initial appropriate tests when evaluating a patient for dementia
  • Purpose of Cholinesterase inhibitor with a 60 year old Alzheimer's patient who has moderate cognitive deficit
  • A patient who has a High TSH and a normal T4.

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