Thyroid Gland
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Questions and Answers

Which protein has the shortest half-life among TBG, transthyretin, and albumin?

  • They all have the same half-life
  • TBG
  • Transthyretin (correct)
  • Albumin

What percentage of the circulating T4 is normally converted to RT3?

  • 5%
  • 13%
  • 45% (correct)
  • 87%

Which protein binds most of the circulating T4 under physiologic conditions?

  • None of the proteins bind T4 significantly
  • TBG (correct)
  • Albumin
  • Transthyretin

What percentage of circulating T3 is secreted by the thyroid gland?

<p>13% (B)</p> Signup and view all the answers

What is the primary function of the thyroid gland?

<p>Secreting thyroid hormones to maintain metabolism levels (C)</p> Signup and view all the answers

What can be a cause of hypothyroidism due to pituitary failure?

<p>Fetal hypopituitary hypothyroidism (C)</p> Signup and view all the answers

How does iodine deficiency lead to goiter formation?

<p>By causing thyroid hypertrophy (C)</p> Signup and view all the answers

How can hypothyroidism in adults be characterized?

<p>Poor resistance to cold and slowed mental and physical functions (C)</p> Signup and view all the answers

Which condition can drugs cause by interfering with the iodide-trapping mechanism?

<p>Thyroid hormone synthesis (A)</p> Signup and view all the answers

What are the consequences of thyroid gland dysfunction during fetal and neonatal life?

<p>Severe mental retardation and dwarfism (A)</p> Signup and view all the answers

What substance can paradoxically inhibit thyroid function under certain conditions?

<p>Iodide (C)</p> Signup and view all the answers

How is thyroid function regulated?

<p>Via thyroid-stimulating hormone (TSH) from the anterior pituitary (B)</p> Signup and view all the answers

What is the name of the mild and transient inhibition of hormone synthesis produced by large doses of iodide on the thyroid?

<p>Wolff-Chaikoff effect (A)</p> Signup and view all the answers

What are individuals called who are hypothyroid from birth or before?

<p>Cretins (A)</p> Signup and view all the answers

What happens to plasma cholesterol levels in completely athyreotic adults?

<p>Elevated (B)</p> Signup and view all the answers

What is one of the most common causes of preventable mental retardation worldwide?

<p>Congenital hypothyroidism (D)</p> Signup and view all the answers

What is the main reason why thyroid hormones need to enter cells?

<p>To increase metabolic rate (A)</p> Signup and view all the answers

Which disorder is characterized by body wasting, nervousness, and tachycardia due to an overactive thyroid gland?

<p>Graves disease (C)</p> Signup and view all the answers

What critical roles do thyroid hormones play in development, especially related to the nervous system?

<p>Aiding in normal mentation (B)</p> Signup and view all the answers

What can be done to address iodide deficiency as mentioned in the text?

<p>Adding iodized salt to the diet (D)</p> Signup and view all the answers

What is a characteristic symptom of hyperthyroidism according to the text?

<p>Fine tremor of the outstretched fingers (B)</p> Signup and view all the answers

How can congenital hypothyroidism be treated shortly after birth?

<p>Levothyroxine administration (A)</p> Signup and view all the answers

What are the primary functions of the thyroid gland?

<p>Regulate metabolism and influence body mass and mentation (D)</p> Signup and view all the answers

What is the recommended way to assess thyroid function according to the text?

<p>Uptake of tracer doses of radioactive iodine (D)</p> Signup and view all the answers

What are the consequences of thyroid dysfunction during fetal and neonatal life?

<p>Severe mental retardation and dwarfism (D)</p> Signup and view all the answers

How does excess thyroid secretion affect the body?

<p>Results in nervousness, tachycardia, tremor, and excess heat production (D)</p> Signup and view all the answers

What controls thyroid function in the body?

<p>Thyroid-stimulating hormone (TSH) from the anterior pituitary (A)</p> Signup and view all the answers

What symptoms are commonly observed in completely athyreotic adults?

<p>Coarse and sparse hair, dry and yellowish skin, intolerance to cold, slow mentation (B)</p> Signup and view all the answers

What are the consequences of congenital hypothyroidism in children?

<p>Dwarfism and mental retardation (D)</p> Signup and view all the answers

How does maternal antithyroid antibodies affect fetal thyroid function?

<p>Cross the placenta and damage the fetal thyroid (B)</p> Signup and view all the answers

What is the potential outcome for children with congenital hypothyroidism if treatment is initiated promptly after birth?

<p>Normal growth and development with avoidance of mental retardation (B)</p> Signup and view all the answers

What is the first product generated in the thyroid hormone synthesis process?

<p>MIT (A)</p> Signup and view all the answers

Which enzyme is responsible for generating reactive iodine species that attack thyroglobulin?

<p>Thyroid Peroxidase (A)</p> Signup and view all the answers

In the normal human thyroid, what is the average distribution of iodinated compounds for T4?

<p>35% (B)</p> Signup and view all the answers

How is T3 formed in the thyroid gland?

<p>Condensation of MIT with DIT (D)</p> Signup and view all the answers

What is the role of calcitonin in thyroid gland function?

<p>Regulates circulating levels of thyroid hormones (D)</p> Signup and view all the answers

How does the thyroid gland respond to high circulating levels of thyroid hormones?

<p>Undergoes negative feedback control (B)</p> Signup and view all the answers

Which enzyme is responsible for mediating the oxidation and iodide reaction in thyroglobulin?

<p>Thyroid peroxidase (A)</p> Signup and view all the answers

What is the molecular weight of thyroglobulin and its carbohydrate composition?

<p>$660 kDa, 10% carbohydrate by weight (D)</p> Signup and view all the answers

What happens to the thyroid gland when TSH stimulation is prolonged?

<p>It undergoes hypertrophy. (A)</p> Signup and view all the answers

What is the main cause of an enlarged thyroid gland known as a goiter?

<p>Overstimulation by TSH (D)</p> Signup and view all the answers

What characterizes the syndrome of adult hypothyroidism, often referred to as myxedema?

<p>Skin changes (D)</p> Signup and view all the answers

What is the immediate effect after the administration of TSH in terms of thyroid activity?

<p>Enhanced synthesis of T3 and T4 (B)</p> Signup and view all the answers

What is the primary mechanism by which thyroid hormones exert their effects within cells?

<p>Interacting directly with DNA (D)</p> Signup and view all the answers

Which of the following best describes the consequences of hypothyroidism in neonatal life?

<p>Mental retardation and dwarfism (D)</p> Signup and view all the answers

In the context of thyroid gland dysfunction, what is the primary difference between hypothyroidism and overactivity of the thyroid gland?

<p>Hypothyroidism involves a reduction in secretion of TSH, while overactivity is triggered by autoantibodies. (B)</p> Signup and view all the answers
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