Podcast
Questions and Answers
What regulates circulating levels of calcium?
What regulates circulating levels of calcium?
Which enzyme is responsible for the oxidation and reaction of iodide in the thyroid gland?
Which enzyme is responsible for the oxidation and reaction of iodide in the thyroid gland?
What is the function of thyrotropin releasing hormone (TRH) on thyroid hormone secretion?
What is the function of thyrotropin releasing hormone (TRH) on thyroid hormone secretion?
What is the role of high circulating levels of thyroid hormones in the feedback control mechanism?
What is the role of high circulating levels of thyroid hormones in the feedback control mechanism?
Signup and view all the answers
What is the primary protein that most of the circulating T4 binds to?
What is the primary protein that most of the circulating T4 binds to?
Signup and view all the answers
Which protein has the shortest half-life among TBG, transthyretin, and albumin?
Which protein has the shortest half-life among TBG, transthyretin, and albumin?
Signup and view all the answers
What percentage of the circulating T4 is converted to T3 in adult humans?
What percentage of the circulating T4 is converted to T3 in adult humans?
Signup and view all the answers
Which organ does not play a role in deiodinating T4 and T3?
Which organ does not play a role in deiodinating T4 and T3?
Signup and view all the answers
What is a cause of congenital hypothyroidism according to the text?
What is a cause of congenital hypothyroidism according to the text?
Signup and view all the answers
How do drugs inhibit thyroid function according to the text?
How do drugs inhibit thyroid function according to the text?
Signup and view all the answers
What happens when dietary iodine intake falls below 50 μg/day according to the text?
What happens when dietary iodine intake falls below 50 μg/day according to the text?
Signup and view all the answers
How are hypothyroidism and goiter related according to the text?
How are hypothyroidism and goiter related according to the text?
Signup and view all the answers
Which of the following compounds inhibit the iodination of monoiodotyrosine and block the coupling reaction in hyperthyroidism?
Which of the following compounds inhibit the iodination of monoiodotyrosine and block the coupling reaction in hyperthyroidism?
Signup and view all the answers
Which medication inhibits the conversion of T4 to T3 in many extrathyroidal tissues?
Which medication inhibits the conversion of T4 to T3 in many extrathyroidal tissues?
Signup and view all the answers
What is the primary cause of hyperthyroidism in Hashimoto thyroiditis during the early stage?
What is the primary cause of hyperthyroidism in Hashimoto thyroiditis during the early stage?
Signup and view all the answers
How does radioactive iodine help in treating severe cases of hyperthyroidism?
How does radioactive iodine help in treating severe cases of hyperthyroidism?
Signup and view all the answers
What is the function of calcitonin secreted by the thyroid gland?
What is the function of calcitonin secreted by the thyroid gland?
Signup and view all the answers
How is thyroglobulin synthesized and secreted in the thyroid gland?
How is thyroglobulin synthesized and secreted in the thyroid gland?
Signup and view all the answers
What enzyme mediates the oxidation and reaction of iodide with thyroglobulin in the thyroid gland?
What enzyme mediates the oxidation and reaction of iodide with thyroglobulin in the thyroid gland?
Signup and view all the answers
How long can humans go without dietary iodide before a decline in circulating thyroid hormone levels is observed?
How long can humans go without dietary iodide before a decline in circulating thyroid hormone levels is observed?
Signup and view all the answers
Which plasma protein has the smallest capacity to bind T4 among albumin, transthyretin, and TBG?
Which plasma protein has the smallest capacity to bind T4 among albumin, transthyretin, and TBG?
Signup and view all the answers
What is the approximate daily secretion of T3 by the human thyroid?
What is the approximate daily secretion of T3 by the human thyroid?
Signup and view all the answers
In normal adult humans, what is the approximate plasma T3 level in μg/dL?
In normal adult humans, what is the approximate plasma T3 level in μg/dL?
Signup and view all the answers
Which thyroid hormone is relatively lipophilic and has a larger pool of protein-bound forms in plasma and tissues?
Which thyroid hormone is relatively lipophilic and has a larger pool of protein-bound forms in plasma and tissues?
Signup and view all the answers
What is the initial product formed during thyroid hormone synthesis?
What is the initial product formed during thyroid hormone synthesis?
Signup and view all the answers
Which enzyme is responsible for generating reactive iodine species in the thyroid gland?
Which enzyme is responsible for generating reactive iodine species in the thyroid gland?
Signup and view all the answers
How is T3 formed in the thyroid gland?
How is T3 formed in the thyroid gland?
Signup and view all the answers
What is the approximate percentage distribution of iodinated compounds in the normal human thyroid?
What is the approximate percentage distribution of iodinated compounds in the normal human thyroid?
Signup and view all the answers
What is the recommended treatment for iodide deficiency?
What is the recommended treatment for iodide deficiency?
Signup and view all the answers
Which of the following symptoms is NOT characteristic of hyperthyroidism?
Which of the following symptoms is NOT characteristic of hyperthyroidism?
Signup and view all the answers
How does hypothyroidism in the mother affect mental deficiency in offspring?
How does hypothyroidism in the mother affect mental deficiency in offspring?
Signup and view all the answers
What is the primary mechanism for treating congenital hypothyroidism soon after birth?
What is the primary mechanism for treating congenital hypothyroidism soon after birth?
Signup and view all the answers
