Causes of Hypothyroidism and Congenital Hypothyroidism
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Questions and Answers

What regulates circulating levels of calcium?

  • Calcitonin (correct)
  • Thyroid peroxidase
  • Thyroglobulin
  • Thyrotropin releasing hormone

Which enzyme is responsible for the oxidation and reaction of iodide in the thyroid gland?

  • Thyrotropin releasing hormone
  • Thyroglobulin
  • Thyroxine
  • Thyroid peroxidase (correct)

What is the function of thyrotropin releasing hormone (TRH) on thyroid hormone secretion?

  • Stimulates thyroid hormone secretion (correct)
  • Triggers negative feedback control
  • Inhibits thyroid hormone secretion
  • Enhances calcitonin production

What is the role of high circulating levels of thyroid hormones in the feedback control mechanism?

<p>Control thyroid hormone secretion (C)</p> Signup and view all the answers

What is the primary protein that most of the circulating T4 binds to?

<p>Thyroxine-binding globulin (TBG) (D)</p> Signup and view all the answers

Which protein has the shortest half-life among TBG, transthyretin, and albumin?

<p>Transthyretin (D)</p> Signup and view all the answers

What percentage of the circulating T4 is converted to T3 in adult humans?

<p>33% (A)</p> Signup and view all the answers

Which organ does not play a role in deiodinating T4 and T3?

<p>Brain (A)</p> Signup and view all the answers

What is a cause of congenital hypothyroidism according to the text?

<p>Maternal antithyroid antibodies (A)</p> Signup and view all the answers

How do drugs inhibit thyroid function according to the text?

<p>By blocking iodide-trapping mechanism (A)</p> Signup and view all the answers

What happens when dietary iodine intake falls below 50 μg/day according to the text?

<p>The thyroid hypertrophies (B)</p> Signup and view all the answers

How are hypothyroidism and goiter related according to the text?

<p>Hypothyroidism leads to goiter (C)</p> Signup and view all the answers

Which of the following compounds inhibit the iodination of monoiodotyrosine and block the coupling reaction in hyperthyroidism?

<p>Propylthiouracil and methimazole (B)</p> Signup and view all the answers

Which medication inhibits the conversion of T4 to T3 in many extrathyroidal tissues?

<p>Propylthiouracil (C)</p> Signup and view all the answers

What is the primary cause of hyperthyroidism in Hashimoto thyroiditis during the early stage?

<p>Excess thyroid hormone secretion (B)</p> Signup and view all the answers

How does radioactive iodine help in treating severe cases of hyperthyroidism?

<p>It accumulates in the gland and partially destroys it (B)</p> Signup and view all the answers

What is the function of calcitonin secreted by the thyroid gland?

<p>Regulating circulating levels of calcium (A)</p> Signup and view all the answers

How is thyroglobulin synthesized and secreted in the thyroid gland?

<p>Exocytosis of granules (C)</p> Signup and view all the answers

What enzyme mediates the oxidation and reaction of iodide with thyroglobulin in the thyroid gland?

<p>Thyroid peroxidase (B)</p> Signup and view all the answers

How long can humans go without dietary iodide before a decline in circulating thyroid hormone levels is observed?

<p>2 months (A)</p> Signup and view all the answers

Which plasma protein has the smallest capacity to bind T4 among albumin, transthyretin, and TBG?

<p>TBG (C)</p> Signup and view all the answers

What is the approximate daily secretion of T3 by the human thyroid?

<p>4 μg (7 nmol) (A)</p> Signup and view all the answers

In normal adult humans, what is the approximate plasma T3 level in μg/dL?

<p>0.15 (D)</p> Signup and view all the answers

Which thyroid hormone is relatively lipophilic and has a larger pool of protein-bound forms in plasma and tissues?

<p>T4 (C)</p> Signup and view all the answers

What is the initial product formed during thyroid hormone synthesis?

<p>MIT (C)</p> Signup and view all the answers

Which enzyme is responsible for generating reactive iodine species in the thyroid gland?

<p>Thyroid peroxidase (A)</p> Signup and view all the answers

How is T3 formed in the thyroid gland?

<p>By condensation of MIT with DIT (A)</p> Signup and view all the answers

What is the approximate percentage distribution of iodinated compounds in the normal human thyroid?

<p>3% MIT, 33% DIT, 35% T4, 7% T3 (B)</p> Signup and view all the answers

What is the recommended treatment for iodide deficiency?

<p>Adding iodized salt to the diet (B)</p> Signup and view all the answers

Which of the following symptoms is NOT characteristic of hyperthyroidism?

<p>Cold intolerance (A)</p> Signup and view all the answers

How does hypothyroidism in the mother affect mental deficiency in offspring?

<p>Results in more severe mental deficiency in offspring (C)</p> Signup and view all the answers

What is the primary mechanism for treating congenital hypothyroidism soon after birth?

<p>Administration of levothyroxine (D)</p> Signup and view all the answers

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