Hypothesis Testing: Comparing Two Population Means

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Questions and Answers

What are the forces referred to when describing the strongest forces for biomolecules?

  • Van der Waals forces.
  • Polar covalent bonds.
  • Hydrogen bonds. (correct)
  • Ionic bonds.

Which of the following best describes the role of functional groups in organic molecules?

  • To render the molecule inert and unreactive.
  • To impart specific properties and reactivity to the molecule. (correct)
  • To determine the molecule's size and structural integrity.
  • To shield the molecule from interacting with water.

How do buffers contribute to maintaining pH stability in biological systems?

  • By continuously producing hydrogen ions to counteract alkalinity.
  • By preventing any change in pH, regardless of external conditions.
  • By directly neutralizing all acids in the system.
  • By minimizing pH changes through weak acid-base combinations. (correct)

What is the role of enzymes in biochemical reactions?

<p>To catalyze reactions by reducing the activation energy. (B)</p> Signup and view all the answers

Which statement accurately contrasts hydrolysis and condensation reactions involving complex biomolecules?

<p>Hydrolysis breaks down polymers by adding water; condensation combines monomers by removing water. (B)</p> Signup and view all the answers

Which characteristic of water contributes to its ability to dissolve polar substances?

<p>Water's polarity and its capacity to form hydrogen bonds. (D)</p> Signup and view all the answers

If a cell is put in a hypertonic environment, how would this impact the cell's structure?

<p>The cell will shrink due to water loss. (C)</p> Signup and view all the answers

Within a cell membrane, what is the primary role of transport proteins regarding substance movement?

<p>To facilitate the movement of specific molecules across the membrane. (C)</p> Signup and view all the answers

How does allosteric control primarily regulate enzyme activity within the body?

<p>By inducing conformational changes through molecule binding. (A)</p> Signup and view all the answers

What role do receptors play in the function of a cell membrane?

<p>Mediate cell communication by binding to specific molecules. (C)</p> Signup and view all the answers

Flashcards

Electronegativity

Atoms with stronger electronegativity steal or share unequally electrons from the weaker ones.

Ionic bond

A positive and negative ion are attracted by opposite charges.

Covalent Bond (Non-Polar)

Two atoms share electrons equally, no dipoles in bond (C-C, C-H).

Polar Covalent Bond

Electrons are shared unequally, dipoles are formed (O or N with C or H).

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Van der Waals forces

Not chemical bonds, but attractions between molecules.

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Water properties

Polar, excellent solvent, high heat capacity, cohesion, density, and colorless.

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Enzymes

Proteins that catalyze reactions by reducing the activation energy.

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Cell Membranes

Formed by a phospholipid bilayer, transport proteins, glycoproteins, receptors, and cholesterol.

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Study Notes

Hypothesis Testing for 2 Population Means

  • Objective is to compare the means of two populations.

Case 1: Known Population Standard Deviations ($\sigma_1, \sigma_2$)

  • Null hypothesis: $H_0: \mu_1 = \mu_2$
  • Alternative hypothesis: $H_1: \mu_1 \neq \mu_2$ or $\mu_1 > \mu_2$ or $\mu_1 < \mu_2$
  • Test statistic: $Z = \frac{(\bar{x}_1 - \bar{x}_2) - (\mu_1 - \mu_2)}{\sqrt{\frac{\sigma_1^2}{n_1} + \frac{\sigma_2^2}{n_2}}}$

Case 2: Unknown but Equal Population Standard Deviations ($\sigma_1 = \sigma_2 = \sigma$)

  • Null hypothesis: $H_0: \mu_1 = \mu_2$
  • Alternative hypothesis: $H_1: \mu_1 \neq \mu_2$ or $\mu_1 > \mu_2$ or $\mu_1 < \mu_2$
  • Test statistic: $T = \frac{(\bar{x}_1 - \bar{x}_2) - (\mu_1 - \mu_2)}{S_p \sqrt{\frac{1}{n_1} + \frac{1}{n_2}}}$
  • $S_p^2 = \frac{(n_1 - 1)S_1^2 + (n_2 - 1)S_2^2}{n_1 + n_2 - 2}$ is the pooled variance estimator.
  • Degrees of freedom: $n_1 + n_2 - 2$

Case 3: Unknown and Unequal Population Standard Deviations ($\sigma_1 \neq \sigma_2$)

  • Null hypothesis: $H_0: \mu_1 = \mu_2$
  • Alternative hypothesis: $H_1: \mu_1 \neq \mu_2$ or $\mu_1 > \mu_2$ or $\mu_1 < \mu_2$
  • Test statistic: $T = \frac{(\bar{x}_1 - \bar{x}_2) - (\mu_1 - \mu_2)}{\sqrt{\frac{S_1^2}{n_1} + \frac{S_2^2}{n_2}}}$
  • Degrees of freedom: $d.f. = \frac{(\frac{S_1^2}{n_1} + \frac{S_2^2}{n_2})^2}{\frac{(\frac{S_1^2}{n_1})^2}{n_1 - 1} + \frac{(\frac{S_2^2}{n_2})^2}{n_2 - 1}}$

Matched Pair Hypothesis Test

  • Examines the mean difference between paired observations
  • $d_i = x_{1i} - x_{2i}$
  • Null hypothesis: $H_0: \mu_d = 0$
  • Alternative hypothesis: $H_1: \mu_d \neq 0$ or $\mu_d > 0$ or $\mu_d < 0$
  • Test statistic: $T = \frac{\bar{d} - \mu_d}{S_d / \sqrt{n}}$
  • Degrees of freedom: $n - 1$

Hypothesis Testing for 2 Population Proportions

  • Aims to compare the proportions of two populations
  • Null hypothesis: $H_0: p_1 = p_2$
  • Alternative hypothesis: $H_1: p_1 \neq p_2$ or $p_1 > p_2$ or $p_1 < p_2$
  • Test statistic: $Z = \frac{(\hat{p}_1 - \hat{p}_2) - (p_1 - p_2)}{\sqrt{\hat{p}(1 - \hat{p})(\frac{1}{n_1} + \frac{1}{n_2})}}$
  • $\hat{p} = \frac{x_1 + x_2}{n_1 + n_2}$

Fourier Series

Periodic Functions

  • A function $f(x)$ is periodic if $f(x + T) = f(x)$.
  • $T$ represents the period of $f$.
  • Examples of periodic functions include $\sin x$, $\cos x$ (period $2\pi$), and $\tan x$ (period $\pi$).

Fourier Series Representation

  • Used for periodic functions with period $2L$
  • $f(x) = \frac{a_0}{2} + \sum_{n=1}^{\infty} \left( a_n \cos \frac{n \pi x}{L} + b_n \sin \frac{n \pi x}{L} \right)$
  • Fourier coefficients are:
    • $a_0 = \frac{1}{L} \int_{-L}^{L} f(x) , dx$
    • $a_n = \frac{1}{L} \int_{-L}^{L} f(x) \cos \frac{n \pi x}{L} , dx$
    • $b_n = \frac{1}{L} \int_{-L}^{L} f(x) \sin \frac{n \pi x}{L} , dx$

Convergence of Fourier Series

  • Relies on Dirichlet Conditions
    • $f(x)$ is defined on the interval $(-L, L)$.
    • $f(x)$ is piecewise continuous on the interval $(-L, L)$.
    • $f(x)$ has a finite number of maxima and minima on the interval $(-L, L)$.
  • Converges to $f(x)$ at points where $f$ is continuous.
  • Converges to $\frac{f(x^+) + f(x^-)}{2}$ at points of discontinuity.

Example: Square Wave

  • $f(x) = \begin{cases} -1, & -\pi < x < 0 \ 1, & 0 < x < \pi \end{cases}$
  • $f(x + 2\pi) = f(x)$
  • Fourier Series Representation: $f(x) = \frac{4}{\pi} \sum_{k=0}^{\infty} \frac{\sin((2k+1)x)}{2k+1}$

Properties of Fourier Series

  • Linearity: Coefficients scale linearly with function scaling ($a_n, b_n$ become $\alpha a_n + \beta c_n$ and $\alpha b_n + \beta d_n$ for $\alpha f(x) + \beta g(x)$)
  • Time Shifting: Shifted coefficients are computed using trigonometry identities
    • $a_n' = a_n \cos \frac{n \pi x_0}{L} + b_n \sin \frac{n \pi x_0}{L}$
    • $b_n' = -a_n \sin \frac{n \pi x_0}{L} + b_n \cos \frac{n \pi x_0}{L}$
  • Time Scaling: $f(ax)$ has period $\frac{2L}{a}$
  • Differentiation: Term-by-term differentiation yields $f'(x)$ if conditions are met.
  • Integration: Term-by-term integration to get $\int f(x) , dx$.

Parseval's Theorem

  • Relates the energy of $f(x)$ to its Fourier coefficients
  • $\frac{1}{2L} \int_{-L}^{L} |f(x)|^2 , dx = \frac{|a_0|^2}{4} + \frac{1}{2} \sum_{n=1}^{\infty} (|a_n|^2 + |b_n|^2)$

Gibbs Phenomenon

  • At jump discontinuities, overshoot occurs, not disappearing with more terms, reaching ~9% of the jump size.

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