N715 Exam 3 New Pt 7
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Questions and Answers

Which of the following is NOT a common etiology of shock in children?

  • Myocardial hypertrophy (correct)
  • Progressive heart failure
  • Hemorrhage
  • Severe dehydration

In hypovolemic shock, what is the primary pathophysiological change that occurs?

  • Enhanced oxygen delivery
  • Obstruction of blood flow
  • Increased myocardial contractility
  • Decreased stroke volume (correct)

What characterizes distributive shock?

  • Cardiac output increase
  • Inappropriate vasodilation (correct)
  • Impaired ventricular filling
  • Decreased circulating blood volume

Which of the following conditions would likely lead to septic shock?

<p>Cytokine release (D)</p> Signup and view all the answers

Which of the following clinical manifestations might indicate myocardial depression in shock?

<p>Decreased cardiac output (D)</p> Signup and view all the answers

What occurs during obstructive shock?

<p>Impaired blood flow due to a physical obstruction (D)</p> Signup and view all the answers

In the context of shock, which type results from systemic histamine release?

<p>Distributive shock (D)</p> Signup and view all the answers

Which feature is common in both septic and anaphylactic shock?

<p>Systemic vasodilation (D)</p> Signup and view all the answers

Which statement regarding cardiogenic shock is correct?

<p>It is primarily characterized by impaired myocardial function. (C)</p> Signup and view all the answers

How does hypovolemic shock typically present in infants?

<p>Signs of dehydration and lethargy. (A)</p> Signup and view all the answers

What is a common clinical manifestation of septic shock?

<p>Hypothermia and vasodilation. (C)</p> Signup and view all the answers

Which treatment focuses are associated with neurogenic shock?

<p>Vasopressors and atropine. (A)</p> Signup and view all the answers

What is a potential complication of pediatric burns leading to shock?

<p>Progression from hypovolemic shock to septic shock. (A)</p> Signup and view all the answers

Which of the following is a characteristic finding in obstructive shock?

<p>Hypoxemia and dyspnea. (A)</p> Signup and view all the answers

What vital sign abnormality is most commonly seen in hypoVolemic shock?

<p>Tachycardia and delayed capillary refill. (A)</p> Signup and view all the answers

In patients experiencing distributive shock, what is the role of vasopressors?

<p>To increase vasomotor tone and systemic vascular resistance. (D)</p> Signup and view all the answers

What is a primary focus in the treatment of anaphylactic shock?

<p>Epinephrine and antihistamines. (D)</p> Signup and view all the answers

Which patient symptom indicates severe dehydration in a child experiencing hypovolemic shock?

<p>Cold and cyanotic extremities. (A)</p> Signup and view all the answers

Which of the following is NOT a characteristic of cardiogenic shock?

<p>Increased systemic vascular resistance (A)</p> Signup and view all the answers

What clinical manifestation is characteristic of hypovolemic shock?

<p>Cool, clammy skin (A)</p> Signup and view all the answers

Which symptom is indicative of septic shock?

<p>High fever with oliguria (D)</p> Signup and view all the answers

What is a primary cause of distributive shock?

<p>Fluid shifting to third spaces (B)</p> Signup and view all the answers

Which of the following does NOT characterize Beck's Triad in the context of cardiac tamponade?

<p>Bradycardia (D)</p> Signup and view all the answers

What complication is commonly associated with distributive shock?

<p>Widespread vasodilation (B)</p> Signup and view all the answers

What is a consequence of impaired cellular metabolism during shock?

<p>Accumulation of toxic metabolites (B)</p> Signup and view all the answers

In hypovolemic shock, which physiological response occurs first?

<p>Increased heart rate (D)</p> Signup and view all the answers

Which of the following is a classic clinical manifestation of shock?

<p>Tachycardia and tachypnea (B)</p> Signup and view all the answers

How does cardiac tamponade affect cardiac output?

<p>It decreases cardiac output due to external pressure on the heart (C)</p> Signup and view all the answers

What happens to the afterload during hypovolemic shock?

<p>Afterload increases in response to vasoconstriction (A)</p> Signup and view all the answers

Which condition describes the state of shock where blood flow is redirected due to leaky capillaries?

<p>Distributive shock (C)</p> Signup and view all the answers

Which neurohormonal response occurs during cardiogenic shock to help maintain blood pressure?

<p>Activation of the RENIN-ANGIOTENSIN-ALDOSTERONE system (C)</p> Signup and view all the answers

What is the primary treatment focus for obstructive shock?

<p>Relieving the physical obstruction (D)</p> Signup and view all the answers

Which clinical manifestation is most likely observed in infants experiencing shock?

<p>Lethargy and poor feeding (D)</p> Signup and view all the answers

What characterizes severe dehydration in children with hypovolemic shock?

<p>Cold and cyanotic extremities (B)</p> Signup and view all the answers

What physiological change occurs during obstructive shock that leads to reduced cardiac output?

<p>Mechanical obstruction affecting ventricular filling or outflow (A)</p> Signup and view all the answers

In which type of shock is the loss of sympathetic tone significant?

<p>Neurogenic shock (C)</p> Signup and view all the answers

Which vital sign change is indicative of impending cardiovascular collapse in hypovolemic shock?

<p>Severe hypotension (D)</p> Signup and view all the answers

Which of the following is a primary cause of hypovolemic shock in children?

<p>Severe dehydration (B)</p> Signup and view all the answers

In a child experiencing shock, which condition is most likely to result in progressive heart failure?

<p>Drug toxicity (C)</p> Signup and view all the answers

What is a common complication in children with burn injuries related to shock?

<p>Septic shock due to loss of skin barrier (B)</p> Signup and view all the answers

Which type of shock is primarily characterized by inappropriate vasodilation?

<p>Distributive shock (C)</p> Signup and view all the answers

What is a primary concern regarding the physiological impact of congenital heart defects in obstructive shock?

<p>Direct physical obstruction of blood flow (A)</p> Signup and view all the answers

What is the primary mechanism leading to myocardial depression during shock?

<p>Depletion of myocardial oxygen stores (A)</p> Signup and view all the answers

Which manifestation might indicate the presence of septic shock in a child?

<p>Increased temperature and tachycardia (C)</p> Signup and view all the answers

In pediatric patients, what symptom can signify hypoglycemia during shock?

<p>Mild to severe lethargy (A)</p> Signup and view all the answers

What role does the accumulation of microembolisms play in the development of shock?

<p>Causes dysfunction in coagulation and contributes to DIC (A)</p> Signup and view all the answers

Which factor is least likely to contribute to electrolyte imbalances in achieving shock?

<p>Prolonged bed rest (C)</p> Signup and view all the answers

What key factor differentiates obstructive shock from other types of shock?

<p>External compression of the heart or vessels (B)</p> Signup and view all the answers

In children, which of the following conditions is least likely to lead to shock?

<p>Chronic rashes (B)</p> Signup and view all the answers

What is the primary issue in obstructive shock?

<p>Obstruction preventing adequate cardiac output (A)</p> Signup and view all the answers

In pediatric patients, which factor typically complicates the presentation of shock?

<p>Age-related differences in physiological response (B)</p> Signup and view all the answers

What underlying mechanism is primarily involved in the development of pulmonary embolism as an obstructive shock?

<p>Physical blockage of a pulmonary artery (A)</p> Signup and view all the answers

Which clinical manifestation is least likely to be associated with obstructive shock?

<p>Severe peripheral vasoconstriction (D)</p> Signup and view all the answers

In the context of pediatric shock, which of the following symptoms is most critical to monitor?

<p>Heart rate variability (B)</p> Signup and view all the answers

What is a common misconception about hypovolemic shock?

<p>It only occurs due to blood loss (D)</p> Signup and view all the answers

Which condition is often associated with hypocalcemia in patients experiencing shock?

<p>Decreased cardiac contractility (C)</p> Signup and view all the answers

Which of the following statements regarding obstructive shock is accurate?

<p>Therapeutic interventions focus on removing the obstruction. (C)</p> Signup and view all the answers

During hypovolemic shock, which neurohormonal response is critical for maintaining blood pressure?

<p>Activation of the renin-angiotensin-aldosterone system (D)</p> Signup and view all the answers

Which symptom might indicate the physiological effects of distributive shock in a child?

<p>Warm and flushed skin despite hypotension (B)</p> Signup and view all the answers

What characterizes the hypodynamic state in shock progression?

<p>Bradycardia and low peripheral perfusion (A)</p> Signup and view all the answers

Which of the following is a potential consequence of prolonged hypocalcemia?

<p>Decreased coagulation and potential bleeding (B)</p> Signup and view all the answers

In shock states, which physiological change is indicative of a shift to anaerobic metabolism?

<p>Increased lactic acid production (B)</p> Signup and view all the answers

Flashcards

Hypovolemic Shock

A type of shock caused by loss of blood or fluids.

Cardiogenic Shock

Shock due to the heart's inability to pump effectively.

Septic Shock

Shock caused by a severe infection.

Anaphylactic Shock

Shock caused by a severe allergic reaction.

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Neurogenic Shock

Shock due to loss of sympathetic nervous system function.

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Obstructive Shock

Shock caused by a physical blockage of blood flow.

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Hypovolemic Shock in Children

Most common type of shock in children, often caused by dehydration or trauma, characterized by hypotension (low blood pressure), bradycardia (slow heart rate), and potential hypoglycemia.

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Cardiogenic Shock Cause

Impaired myocardial function or cardiac output, often related to surgery, cardiomyopathy, or myocarditis. Can arise from other types of shock (like hypovolemic shock).

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Distributive Shock Cause

Vasodilation and increased capillary permeability due to conditions like infections (septic), allergies (anaphylactic), or loss of vasomotor tone (neurogenic).

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Obstructive Shock Cause

Inadequate cardiac output due to blockage of blood flow to or from the heart or lungs. Examples include congenital heart defects, pulmonary emboli, or pneumothorax.

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Shock in Children - Most Common Causes

Severe dehydration, hemorrhage, progressive heart failure (e.g., heart defects), pulmonary hypertension, drug toxicity, electrolyte/acid-base imbalance, dysrhythmia, blood flow obstruction, and multi-organ failure.

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Distributive Shock

Inappropriate blood vessel widening reducing blood flow.

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DIC (Disseminated Intravascular Coagulation)

Blood clotting problem where the body inappropriately clots and uses clotting factors too quickly causing bleeding risk.

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Plasma Protein Activation

A process where proteins in the blood become active and potentially causing the abnormal blood clotting and excessive bleeding (such as DIC)

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Osteogenesis Imperfecta (OI)

A genetic disorder causing weak bones, prone to fractures.

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Bone Fragility

Increased risk of bone fractures due to reduced bone density and strength.

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Shock

Impaired tissue perfusion due to inadequate blood flow.

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Cardiac Output (CO)

Amount of blood pumped by the heart per minute.

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Stroke Volume (SV)

Amount of blood pumped by the heart with each beat.

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Frank-Starling Law

Increased heart stretch leads to greater stroke volume.

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Preload

Blood volume in ventricles at the end of diastole.

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Afterload

Resistance the heart must overcome to pump blood.

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Hyperdynamic Shock

Initially elevated blood pressure and heart rate in shock.

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Hypodynamic Shock

Low blood pressure and heart rate in severe shock.

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Lactic Acidosis

Increased lactic acid production during anaerobic metabolism.

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What is the main problem in hypovolemic shock?

Loss of blood or fluids in the circulatory system.

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How is cardiogenic shock treated?

Improving heart function with medications (inotropes) or procedures like angioplasty.

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What is the biggest focus in treating septic shock?

Treating the underlying infection with antibiotics and supporting blood pressure with vasopressors.

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What's the main problem in anaphylactic shock?

A severe allergic reaction causing widespread vasodilation and drop in blood pressure.

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What causes neurogenic shock?

Loss of sympathetic nervous system tone, leading to vasodilation and blood pressure drop.

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How is obstructive shock treated?

Removing the physical obstruction to blood flow, such as a blood clot or collapsed lung.

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What are the main signs of hypovolemic shock in infants and children?

Lethargy, mottled skin, tachycardia initially progressing to bradycardia and hypotension in severe cases.

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What is the most common type of shock in children?

Hypovolemic shock, often caused by dehydration or trauma.

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What are some key physical signs of severe dehydration in infants and children?

Limp, cold, cyanotic (blue), poor skin turgor, sunken fontanels/eyes, absent tears, no urine output, hypotension, bradycardia.

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What's a potential complication that can worsen shock?

Cardiogenic shock can develop as a complication of other types of shock, like hypovolemic shock.

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Shock in Children: Most Common Etiology

The most frequent causes of shock in children include severe dehydration, hemorrhage, progressive heart failure, pulmonary hypertension, drug toxicity, electrolyte/acid-base imbalance, dysrhythmia, blood flow obstruction, and multi-organ failure.

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Shock: What is it?

Shock is a life-threatening condition where the body's tissues aren't getting enough oxygen-rich blood due to inadequate blood flow.

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Hypovolemic Shock: Cause

Hypovolemic shock occurs when there's a loss of circulating blood volume, leading to insufficient blood flow to tissues.

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Septic Shock: Cause

Septic shock is a severe response to infection, involving widespread vasodilation and decreased systemic vascular resistance, leading to inadequate blood flow.

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Anaphylactic Shock: Cause

Anaphylactic shock is a severe allergic reaction characterized by widespread vasodilation and increased vascular permeability, leading to a decline in circulating volume.

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Neurogenic Shock: Cause

Neurogenic shock occurs when the sympathetic nervous system is disrupted, leading to vasodilation and bradycardia.

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What is Shock?

A state where the body's tissues aren't getting enough blood to function properly.

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How do we measure Cardiac Output?

Cardiac Output (CO) is the volume of blood pumped by the heart per minute. It's calculated as Heart Rate (HR) multiplied by Stroke Volume (SV).

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What is the Frank-Starling Law?

This law states that the more blood in the ventricle at the end of relaxation (diastole), the more blood is ejected during each heartbeat.

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What is Preload?

The volume of blood in the ventricles at the end of diastole (relaxed state).

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What is Afterload?

The resistance the left ventricle must overcome to pump blood out to the body.

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What types of shock exist?

Shock is generally categorized into four main types: Cardiogenic, Distributive, Obstructive, and Hypovolemic.

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What is Cardiogenic Shock?

Occurs when the heart cannot pump efficiently, reducing blood flow to the body.

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What is Distributive Shock?

Occurs when blood vessels dilate excessively, leading to decreased blood pressure and reduced tissue perfusion.

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What is Obstructive Shock?

Occurs when something physically blocks blood flow, reducing the heart's ability to pump effectively.

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What is Hypovolemic Shock?

Occurs when there is not enough blood volume circulating in the body.

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What is Hyperdynamic Shock?

Shock with initially high blood pressure and heart rate.

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What is Hypodynamic Shock?

Shock with very low blood pressure and heart rate.

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How does shock affect cellular metabolism?

Shock disrupts cellular metabolism, leading to shifts in energy production and build-up of toxic waste.

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What are the clinical manifestations of Cardiogenic Shock?

Symptoms include chest pain, shortness of breath, faintness, and a feeling of impending doom. Beck's Triad, representing cardiac tamponade, is also a significant sign.

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What are the clinical manifestations of Hypovolemic Shock?

Signs include poor skin turgor, thirst, decreased urine output, and rapid heart rate.

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Study Notes

Hypocalcemia: Acute Care Considerations

  • Head/Neck Surgeries can cause hypocalcemia
  • Autoimmune diseases can lead to hypocalcemia
  • Parathyroid cancer (or treatment) can cause hypocalcemia
  • Heavy metal exposure (e.g., copper) can contribute to the condition
  • Magnesium abnormalities can impact calcium homeostasis
  • Multiple drug transfusions (e.g., citrate-containing solutions) can cause hypocalcemia
  • Drugs such as < 8.8 dL/L calcium.
  • Ionized Ca < 4.7 mg/dL is a marker for hypocalcemia
  • Chronic hypocalcemia is often caused by hypoparathyroidism or vitamin D deficiency
  • Patients may be asymptomatic, making diagnosis challenging.
  • Primary hypoparathyroidism means the parathyroid gland does not adequately produce parathyroid hormone (PTH)
  • Vitamin D deficiency also hinders calcium regulation

Hypoparathyroidism, Serum PTH, 25-hydroxyvitamin D and Alkaline Phosphatase

  • Serum PTH levels are low in hypoparathyroidism
  • Vitamin D deficiency shows high PTH levels
  • PTH resistance shows very high PTH levels
  • High vitamin D resistance levels can also cause high PTH levels
  • Renal disease is associated with high PTH levels, but may show normal or low 25-hydroxyvitamin D levels
  • Hypomagnesemia: normal PTH and normal 25-hydroxyvitamin D
  • Metastatic disease is associated with elevated PTH levels and normal or low vitamin D

Hypocalcemia: Clinical Presentation

  • Paresthesias (tingling/numbness), often around the mouth is a symptom of low calcium
  • Cramping and muscle spasms (including laryngospasm) may occur
  • Altered mental status, including confusion and seizures, can occur
  • Prolonged QT intervals may indicate issues in the electrical activity of the heart
  • Chvostek's sign (facial twitching response to a tap) and Trousseau's sign (carpopedal spasms with a blood pressure cuff) may be observed
  • Slowing of the central nervous system in hypercalcemia is characteristic, but in hypocalcemia, we see symptoms that show increased CNS activity (seizures, tetany)

Diagnostic Approach to Hypocalcemia

  • Begin by checking the parathyroid hormone (PTH) level
  • Evaluate vitamin D status (25-hydroxyvitamin D)
  • Consider nutritional deficiencies or renal insufficiency/resistance
  • Look for underlying causes, such as medication side effects or other conditions

Corrected Calcium

  • Serum PTH is the most reliable indicator of calcium levels, especially in hypercalcemia context.
  • Ionized calcium is considered a more reliable measure of biologically active calcium compared to total serum calcium, particularly when individuals have abnormal levels or malnutrition/cancer issues.
  • Correcting serum calcium for albumin levels (corrected calcium) gives a value for serum calcium accounting for the bound portion of calcium to protein/albumin as a measure of active calcium
  • The diagnostic approach needs a check on comprehensive chemistry (liver and kidney function) to rule out some other possible causes such as nutritional deficiences, magnesium issues and also, check on ionized calcium

Summary (Hypocalcemia)

  • Calcium is crucial for many bodily functions
  • Indications of abnormalities in calcium regulation need to be addressed with consideration of other factors, like magnesium, phosphate and renal/liver function
  • PTH is the key in assessing the cause of hypocalcemia
  • Correcting serum calcium for albumin is necessary before interpreting the results
  • If giving IV calcium supplementation, safe and reliable access is needed (preferably central lines)

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Description

This quiz covers the clinical aspects of hypocalcemia, including causes such as head/neck surgeries, autoimmune diseases, and magnesium abnormalities. It also discusses how conditions like hypoparathyroidism and vitamin D deficiency contribute to calcium homeostasis disruptions. Test your knowledge on diagnosis and management of hypocalcemia in acute care settings.

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