Hyperthyroidism and Graves' Disease
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Questions and Answers

Which gland primarily secretes steroid hormones?

  • Thyroid gland
  • Adrenal cortex, Kidney, Gonads (correct)
  • Pancreatic islet cells
  • Adrenal medulla
  • What is the main function of the endocrine system in postnatal growth?

  • all of the above (correct)
  • Regulation of blood pressure and growth
  • Energy production
  • Pubertal development and reproduction
  • Which of the following is NOT a peptide hormone?

  • Angiotensin II
  • Insulin
  • Testosterone (correct)
  • Natriuretic peptide
  • Where does the isthmus of the thyroid gland lie?

    <p>Overlying the 2nd and 3rd rings of the trachea</p> Signup and view all the answers

    Which gland secretes amines such as epinephrine?

    <p>Adrenal medulla</p> Signup and view all the answers

    Where are peptide hormones released from?

    <p>All of the above</p> Signup and view all the answers

    Which of the following is a common cause of hyperthyroidism in children?

    <p>A and D</p> Signup and view all the answers

    In Graves' disease, which antibodies bind to the TSH receptor?

    <p>TSH receptor antibodies</p> Signup and view all the answers

    What is the preferred adrenergic blocking agent for the treatment of hyperthyroidism?

    <p>Atenolol</p> Signup and view all the answers

    Which condition can resemble hyperthyroidism clinically but differs in thyroid function studies?

    <p>Severe anemia</p> Signup and view all the answers

    What is the treatment of choice when medical therapy fails in hyperthyroidism?

    <p>Surgery</p> Signup and view all the answers

    Which of the following clinical features is associated with thyroid storm?

    <p>Profuse diaphoresis</p> Signup and view all the answers

    What is an important investigation necessary to confirm the diagnosis of hyperthyroidism?

    <p>Serum T3 and T4 levels</p> Signup and view all the answers

    What condition does Graves' disease result in?

    <p>Hyperthyroidism</p> Signup and view all the answers

    What is the peak incidence age group for Graves' disease?

    <p>11-15 years old</p> Signup and view all the answers

    What investigation confirms the diagnosis of Graves' disease?

    <p>TSH-receptor autoantibodies (TSIs)</p> Signup and view all the answers

    Which treatment modality is preferred during pregnancy and for nursing mothers in hyperthyroidism?

    <p>Propylthiouracil(PTU)</p> Signup and view all the answers

    Which of the following is a primary function of the thyroid gland?

    <p>Regulating the amount of circulating calcium</p> Signup and view all the answers

    What is the main hormone secreted by the thyroid gland?

    <p>Thyroxine</p> Signup and view all the answers

    Which hormone encourages thyroid cell growth and differentiation, increases iodine uptake, and stimulates the release of T3 and T4?

    <p>Thyroid-stimulating hormone (TSH)</p> Signup and view all the answers

    What is the effect of increased circulating levels of thyroid hormone on TSH release and TRH production?

    <p>Decreases TSH release but increases TRH production</p> Signup and view all the answers

    Which of the following is a function of thyroid hormone in the Central Nervous System (CNS)?

    <p>All of the above</p> Signup and view all the answers

    What is a common clinical manifestation of congenital hypothyroidism in infants?

    <p>Hoarse cry and hypotonia</p> Signup and view all the answers

    What is a common respiratory difficulty associated with congenital hypothyroidism?

    <p>Apneic episodes</p> Signup and view all the answers

    'Excessive sleep, hypotonia, and coarse facies' are symptoms associated with which condition?

    <p>(T3) Hypothyroidism</p> Signup and view all the answers

    What can be inferred from a roentgenograph of skeletal for a newborn with congenital hypothyroidism?

    <p>Delayed osseous development</p> Signup and view all the answers

    What is the treatment of choice for congenital hypothyroidism?

    <p>Replacement therapy with sodium-L-thyroxine, orally for life</p> Signup and view all the answers

    What condition is almost always due to autoimmune overproduction of T3 and T4 in children?

    <p>Graves' disease – hyperthyroidism</p> Signup and view all the answers

    What is the peak age group for presentation of type 1 diabetes mellitus?

    <p>5-7 years of age and at puberty</p> Signup and view all the answers

    Which genetic syndrome is associated with type 1 diabetes mellitus?

    <p>Down syndrome and klinfelter</p> Signup and view all the answers

    What component is regarded as a part of the multifactorial disorder of type 1 diabetes mellitus?

    <p>Genetic and environmental components</p> Signup and view all the answers

    Which factor is NOT listed as an environmental factor associated with type 1 diabetes mellitus?

    <p>Bacterial infections</p> Signup and view all the answers

    What defines prediabetes?

    <p>Impaired fasting glucose (IFG) level of 100-125 mg/dL</p> Signup and view all the answers

    What is the role of insulin in reducing blood glucose levels?

    <p>Slows the breakdown of fat to triglycerides and free fatty acids and Stimulates fat storage</p> Signup and view all the answers

    Which clinical presentation is the most common for childhood type 1 diabetes?

    <p>Classic new onset</p> Signup and view all the answers

    At what blood glucose level does diabetic ketoacidosis (DKA) occur?

    <p>&gt;300 mg/dl</p> Signup and view all the answers

    'DKA is a pediatric emergency' refers to which characteristic of DKA?

    <p>Altered consciousness</p> Signup and view all the answers

    'Soluble insulin is given subcutaneously at a dose of 0.5-1units/kg /day 3 times daily' refers to which phase of treatment?

    <p>'Initial phase'</p> Signup and view all the answers

    'Total dose given twice daily using about 75% of the daily insulin dose as 2/3rd at breakfast and 1/3rd at dinner' describes which phase of treatment?

    <p>'Maintenance phase'</p> Signup and view all the answers

    Study Notes

    Endocrine System

    • The adrenal gland primarily secretes steroid hormones.
    • The main function of the endocrine system in postnatal growth is to regulate growth and development.

    Thyroid Gland

    • The isthmus of the thyroid gland lies between the two lobes.
    • The thyroid gland secretes amines such as epinephrine.
    • Peptide hormones are released from the thyroid gland.
    • Thyroid storm is a clinical feature associated with hyperthyroidism.
    • An important investigation necessary to confirm the diagnosis of hyperthyroidism is thyroid function studies.
    • Graves' disease results in hyperthyroidism.
    • The peak incidence age group for Graves' disease is 20-40 years.
    • Thyroid scintigraphy confirms the diagnosis of Graves' disease.
    • The treatment of choice when medical therapy fails in hyperthyroidism is surgery.
    • Thyroid hormone increases the breakdown of nutrients to produce energy.
    • Thyroid hormone stimulates the release of T3 and T4.
    • Increased circulating levels of thyroid hormone decrease TSH release and TRH production.
    • Thyroid hormone plays a role in the development and maintenance of the CNS.

    Congenital Hypothyroidism

    • A common clinical manifestation of congenital hypothyroidism in infants is excessive sleep, hypotonia, and coarse facies.
    • A common respiratory difficulty associated with congenital hypothyroidism is respiratory distress.
    • A roentgenograph of skeletal for a newborn with congenital hypothyroidism reveals delayed bone age.
    • The treatment of choice for congenital hypothyroidism is hormone replacement therapy.

    Diabetes Mellitus

    • Type 1 diabetes mellitus is almost always due to autoimmune overproduction of T3 and T4 in children.
    • The peak age group for presentation of type 1 diabetes mellitus is 10-14 years.
    • Down syndrome is a genetic syndrome associated with type 1 diabetes mellitus.
    • Genetic susceptibility is a component of the multifactorial disorder of type 1 diabetes mellitus.
    • Vitamin D deficiency is not an environmental factor associated with type 1 diabetes mellitus.
    • Prediabetes is defined as a fasting blood glucose level of 100-125 mg/dL.
    • Insulin plays a role in reducing blood glucose levels by facilitating glucose uptake in cells.
    • The most common clinical presentation for childhood type 1 diabetes is polyuria and polydipsia.
    • Diabetic ketoacidosis (DKA) occurs at a blood glucose level of 250 mg/dL.
    • DKA is a pediatric emergency due to its rapid progression and potential for mortality.
    • Soluble insulin is given subcutaneously at a dose of 0.5-1 units/kg/day 3 times daily in the initial phase of treatment.
    • Total dose is given twice daily using about 75% of the daily insulin dose as 2/3rd at breakfast and 1/3rd at dinner in the maintenance phase of treatment.

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    Description

    Test your knowledge about hyperthyroidism, including its causes and the autoimmune disorder known as Graves' disease. Learn about the factors contributing to hyperthyroidism and its peak incidence age group.

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