2. Hypertension and Gestational Diabetes in Pregnancy

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Questions and Answers

A 28-year-old primigravid woman at 36 weeks gestation presents with a blood pressure reading of 150/95 mmHg at her routine prenatal visit. She reports no headaches or visual disturbances. A urine dipstick reveals no proteinuria. Her blood pressure was normal prior to this visit and before 20 weeks gestation. Which of the following is the most likely diagnosis?

  • Chronic hypertension
  • Transient hypertension
  • Gestational hypertension (correct)
  • Preeclampsia without severe features

A 32-year-old pregnant woman at 30 weeks gestation is diagnosed with severe preeclampsia. Which of the following clinical findings, if present, would be LEAST consistent with this diagnosis alone and warrant further investigation for another underlying condition?

  • Onset of hypertension at 12 weeks gestation (correct)
  • Proteinuria of 6 grams in 24 hours
  • Blood pressure of 170/115 mmHg
  • New onset blurred vision and headache

Gestational hypertension is associated with an increased risk of adverse outcomes for both the mother and fetus. Which of the following represents the MOST significant maternal risk directly associated with gestational hypertension, in the absence of progression to preeclampsia?

  • Increased risk of postpartum hemorrhage
  • Increased incidence of gestational diabetes in subsequent pregnancies
  • Higher likelihood of requiring a cesarean delivery
  • Elevated lifetime risk of chronic hypertension (correct)

A 38-year-old nulliparous woman with a BMI of 35 kg/m² is diagnosed with mild preeclampsia at 32 weeks gestation. While age, nulliparity, and obesity are known risk factors, which of the following additional historical factors would MOST significantly elevate her risk profile for developing preeclampsia?

<p>Maternal grandmother with a history of eclampsia (D)</p> Signup and view all the answers

A 25-year-old woman at 39 weeks gestation presents with a blood pressure of 145/92 mmHg. This is her first elevated blood pressure reading during this pregnancy. A urine protein analysis is negative. Four weeks postpartum, her blood pressure is consistently 120/80 mmHg. Based on this clinical course, which type of hypertensive disorder of pregnancy BEST describes her condition?

<p>Transient hypertension (C)</p> Signup and view all the answers

A pregnant patient at 38 weeks' gestation presents with elevated blood pressure and proteinuria, but no other signs of preeclampsia. Which of the following is the MOST appropriate next step in managing this patient?

<p>Induce labor. (D)</p> Signup and view all the answers

A pregnant patient is diagnosed with severe preeclampsia at 32 weeks gestation. After initial stabilization, which management strategy is MOST critical to implement to improve fetal outcomes?

<p>Administration of corticosteroids to enhance fetal lung maturity, followed by delivery at 34 weeks. (D)</p> Signup and view all the answers

A patient presents with Hemolysis, Elevated Liver enzymes, and Low Platelet count (HELLP) syndrome at 35 weeks gestation. What is the MOST appropriate course of action?

<p>Immediate delivery, either vaginally or via Cesarean section, depending on obstetrical factors. (B)</p> Signup and view all the answers

Which of the following symptoms, if reported by a postpartum patient, would be MOST indicative of HELLP syndrome?

<p>Severe headache, nausea/vomiting, and right upper quadrant pain. (B)</p> Signup and view all the answers

A woman with a history of gestational diabetes mellitus (GDM) is MOST at risk for developing what long-term health complication?

<p>An 8-fold increased likelihood of her child developing T2DM &amp; obesity in teens or early adulthood. (D)</p> Signup and view all the answers

A 26-year-old primigravida is screened for gestational diabetes at 26 weeks' gestation. Her 50-g glucose challenge test result is 150 mg/dL. What is the MOST appropriate next step in the evaluation of this patient?

<p>Schedule a 3-hour oral glucose tolerance test (OGTT). (C)</p> Signup and view all the answers

Which pathophysiological mechanism is MOST directly responsible for the development of gestational diabetes mellitus (GDM)?

<p>Insulin resistance due to placental secretion of hormones. (A)</p> Signup and view all the answers

A patient with gestational diabetes asks about screening recommendations after pregnancy. Which of the following is the MOST appropriate screening strategy?

<p>Screening for pre-diabetes and diabetes every 3 years for life. (B)</p> Signup and view all the answers

Which of the following blood pressure medications is typically used IV to manage severe hypertension in preeclampsia?

<p>Hydralazine. (B)</p> Signup and view all the answers

A clinician is evaluating a pregnant patient for gestational diabetes at the first prenatal visit. Which test should be performed?

<p>Urine analysis (A)</p> Signup and view all the answers

A woman with a history of gestational diabetes mellitus (GDM) in a prior pregnancy should undergo postpartum screening to assess for persistent glucose intolerance. According to guidelines, when should this screening MOST appropriately occur?

<p>4-12 weeks postpartum (A)</p> Signup and view all the answers

A 28-year-old woman, currently 26 weeks pregnant, has no known risk factors for gestational diabetes. According to standard screening guidelines, when should she be screened for gestational diabetes?

<p>Between 24-28 weeks gestation. (B)</p> Signup and view all the answers

A patient's 1-hour glucose tolerance test (GTT) result is 150 mg/dL. What is the MOST appropriate next step in evaluating this patient for gestational diabetes?

<p>Order a 3-hour glucose tolerance test (GTT). (B)</p> Signup and view all the answers

Which of the following is the FIRST-LINE therapy for managing gestational diabetes mellitus (GDM) after failing initial lifestyle modifications?

<p>Insulin. (B)</p> Signup and view all the answers

A patient with gestational diabetes has the following 3-hour GTT results after a 100-g oral glucose load: Fasting: 97 mg/dL, 1-hour: 185 mg/dL, 2-hour: 150 mg/dL, 3-hour: 135 mg/dL. What is the correct interpretation of these results?

<p>Glucose intolerance. (A)</p> Signup and view all the answers

A patient with gestational diabetes mellitus (GDM) is being managed with multiple daily insulin injections. Despite adherence to her prescribed insulin regimen and diet, her fasting blood sugar (FBS) consistently ranges from 100-110 mg/dL. Which of the following would be the MOST appropriate next step in her management?

<p>Increase the basal insulin dose and re-evaluate fasting blood sugar in 3-5 days. (A)</p> Signup and view all the answers

A pregnant patient with well-controlled gestational diabetes, managed with diet and exercise alone, reaches 39 weeks gestation without any complications. Which of the following is the MOST appropriate recommendation regarding the timing of delivery?

<p>Induction of labor should be considered between 38-39 weeks gestation. (A)</p> Signup and view all the answers

A patient with gestational diabetes delivers a macrosomic infant weighing 4600g. Which of the following complications is the infant MOST at risk for immediately after birth?

<p>Hypoglycemia (C)</p> Signup and view all the answers

A woman with a history of gestational diabetes mellitus (GDM) is seen in your office for a postpartum visit 3 months after delivery. She is currently asymptomatic and reports normal blood glucose levels when checking at home. What is the MOST appropriate recommendation for long-term monitoring of her glycemic status?

<p>She should undergo a 75-g oral glucose tolerance test (OGTT). (D)</p> Signup and view all the answers

A patient with gestational diabetes is concerned about the risk of her child developing diabetes later in life. Which of the following statements is the MOST accurate and informative to share with the patient?

<p>Children born to mothers with GDM are up to 8 times more likely to develop T2DM and obesity in their teens or early adulthood. (B)</p> Signup and view all the answers

A 30-year-old woman, with a known history of essential hypertension for 3 years, presents for her initial prenatal visit at 8 weeks gestation. Her blood pressure at this visit is 140/90 mmHg. How does the classification of her hypertensive disorder differ from gestational hypertension, assuming her blood pressure returns to normal postpartum?

<p>Gestational hypertension is diagnosed after 20 weeks of gestation, whereas her condition is classified as chronic hypertension due to pre-existing diagnosis. (C)</p> Signup and view all the answers

A 29-year-old primigravid woman at 34 weeks gestation is diagnosed with preeclampsia without severe features. Two days later, she returns to the clinic reporting new onset right upper quadrant abdominal pain and nausea. Her blood pressure is now 155/105 mmHg, and repeat urine dipstick shows 2+ protein. Which of the following laboratory findings would be MOST indicative of a progression towards severe preeclampsia and warrant immediate escalation of care?

<p>Platelet count of 90,000/µL (C)</p> Signup and view all the answers

In the context of HELLP syndrome, which of the following pathophysiological mechanisms is the MOST significant contributor to the elevated liver enzymes observed in affected patients?

<p>Hepatic sinusoidal obstruction and hepatocellular necrosis due to systemic vasospasm and microangiopathy. (B)</p> Signup and view all the answers

A 26-year-old woman at 28 weeks gestation is diagnosed with gestational diabetes mellitus (GDM) based on a 2-hour oral glucose tolerance test. Which of the following metabolic adaptations of pregnancy is the PRIMARY underlying cause of the insulin resistance that leads to GDM?

<p>Placental secretion of counter-insulin hormones such as human placental lactogen and cortisol. (D)</p> Signup and view all the answers

A 35-year-old pregnant woman at 36 weeks gestation has been managed for gestational hypertension and diet-controlled gestational diabetes. At her most recent antenatal visit, her blood pressure is 145/95 mmHg, and a fasting blood glucose is 105 mg/dL. Considering both conditions, which of the following management strategies is MOST critical to prioritize for optimizing fetal well-being in the immediate term (next 1-2 weeks)?

<p>Order a fetal biophysical profile and non-stress test to assess fetal well-being and placental function, while intensifying both hypertension and diabetes management. (D)</p> Signup and view all the answers

A 29-year-old woman, gravida 2 para 1, is diagnosed with transient hypertension at 37 weeks gestation. Which of the following characteristics is MOST indicative of transient hypertension rather than chronic hypertension superimposed on gestational hypertension?

<p>Development of hypertension after 20 weeks gestation without proteinuria, resolving within 12 weeks postpartum. (B)</p> Signup and view all the answers

A 34-year-old pregnant woman, at 28 weeks gestation, presents with a blood pressure of 155/105 mmHg and no proteinuria on urine dipstick. Two days later, her blood pressure remains elevated at 150/100 mmHg. According to the criteria outlined for gestational hypertension, what is the MINIMUM duration between blood pressure readings required to confirm the diagnosis?

<p>At least 4 hours apart, but within a one-week period. (D)</p> Signup and view all the answers

A 40-year-old woman with a history of chronic hypertension, managed with methyldopa prior to pregnancy, presents at 30 weeks gestation with a blood pressure of 165/115 mmHg and 2+ proteinuria on urine dipstick. Her pre-pregnancy blood pressure was consistently around 130/85 mmHg. Which of the following BEST describes her current hypertensive state?

<p>Chronic hypertension with superimposed preeclampsia, indicated by increased blood pressure and new-onset proteinuria. (A)</p> Signup and view all the answers

In managing mild preeclampsia before 37 weeks of gestation, expectant management is often employed. Which of the following is LEAST likely to be a component of expectant management in a stable patient with mild preeclampsia?

<p>Immediate induction of labor to prevent progression to severe preeclampsia or eclampsia. (D)</p> Signup and view all the answers

A 27-year-old primigravid woman at 33 weeks gestation is diagnosed with severe preeclampsia. Magnesium sulfate is initiated for seizure prophylaxis. Which of the following is the PRIMARY rationale for administering magnesium sulfate in severe preeclampsia?

<p>To prevent and control eclamptic seizures by acting as a central nervous system depressant. (C)</p> Signup and view all the answers

Which of the following antihypertensive medication classes is contraindicated throughout pregnancy due to the risk of fetal renal and cardiac abnormalities?

<p>Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs). (D)</p> Signup and view all the answers

A postpartum woman, who is breastfeeding her newborn, requires antihypertensive medication. Considering the recommendations for breastfeeding mothers, which of the following medications should be AVOIDED due to potential excretion into breast milk and effects on the infant?

<p>Atenolol. (C)</p> Signup and view all the answers

A 36-year-old woman at 34 weeks gestation is diagnosed with HELLP syndrome. Which of the following laboratory findings is NOT a mandatory criterion for the diagnosis of HELLP syndrome, but is frequently associated with its pathophysiology?

<p>Proteinuria of 0.3 grams or greater in a 24-hour urine specimen. (C)</p> Signup and view all the answers

A 31-year-old woman, gravida 3 para 2, develops eclampsia at 38 weeks gestation. After initial stabilization following a seizure, which of the following is the MOST critical next step in the management of eclampsia to prevent recurrence and ensure maternal and fetal well-being?

<p>Administration of intravenous magnesium sulfate bolus and maintenance dose. (C)</p> Signup and view all the answers

Which pathophysiological mechanism is MOST directly responsible for the insulin resistance observed in gestational diabetes mellitus (GDM)?

<p>Placental secretion of hormones that antagonize insulin action, causing peripheral insulin resistance. (A)</p> Signup and view all the answers

A 35-year-old woman with gestational diabetes mellitus (GDM) managed with diet and exercise delivers a healthy term infant. According to current guidelines, what is the MOST appropriate recommendation for postpartum glucose screening to assess her risk of developing type 2 diabetes?

<p>Schedule a 75-gram oral glucose tolerance test (OGTT) at 6-12 weeks postpartum. (A)</p> Signup and view all the answers

A patient with severe preeclampsia at 33 weeks gestation is being managed with magnesium sulfate and intravenous hydralazine. Despite these interventions, she develops epigastric pain and nausea. Which of the following conditions should be of HIGHEST concern given these new symptoms in the context of severe preeclampsia?

<p>HELLP syndrome, indicated by epigastric pain and potential liver involvement. (B)</p> Signup and view all the answers

A woman with a history of gestational hypertension in a prior pregnancy is now pregnant again. Which of the following strategies is LEAST effective in reducing her risk of recurrent gestational hypertension in the current pregnancy?

<p>Maintaining a low-sodium diet throughout the pregnancy. (C)</p> Signup and view all the answers

In the management of severe preeclampsia at 35 weeks gestation, delivery is generally recommended. If a patient with severe preeclampsia is hemodynamically stable and delivery is planned, which of the following is the MOST appropriate route of delivery in the absence of other obstetric contraindications?

<p>Trial of labor with vaginal delivery, as long as fetal monitoring is reassuring. (B)</p> Signup and view all the answers

A 24-year-old primigravid patient at 28 weeks gestation presents with new onset hypertension and proteinuria. Her blood pressure is 145/95 mmHg and urine protein is 350 mg in a 24-hour collection. Which of the following risk factors in her history would be MOST concerning for a higher likelihood of progressing to severe preeclampsia or adverse maternal outcomes?

<p>Previous history of preeclampsia in a prior pregnancy. (C)</p> Signup and view all the answers

Gestational diabetes mellitus (GDM) develops when the pancreas cannot compensate for increased insulin resistance during pregnancy. What is the primary physiological reason for this decompensation?

<p>Beta cell deficits (C)</p> Signup and view all the answers

A 27-year-old woman with no known risk factors for gestational diabetes is pregnant. According to screening guidelines, at what gestational age (in weeks) should she be routinely screened for GDM?

<p>24-28 weeks (D)</p> Signup and view all the answers

A pregnant woman is identified as high risk during her initial prenatal visit. Her gestational diabetes screen is negative. When should she be retested?

<p>At 24-28 weeks (B)</p> Signup and view all the answers

During a 1-hour glucose tolerance test (GTT), which glucose level is generally considered abnormal, requiring a 3-hour GTT for further evaluation?

<blockquote> <p>130-140 mg/dL (D)</p> </blockquote> Signup and view all the answers

A pregnant patient with GDM is not responding to lifestyle modifications. What is the recommended first-line therapy for this condition?

<p>Insulin (C)</p> Signup and view all the answers

Which of the following represents the MOST appropriate fasting blood sugar (FBS) target for a pregnant woman being treated for gestational diabetes mellitus (GDM)?

<p>FBS &lt; 95 mg/dL (B)</p> Signup and view all the answers

A patient with gestational diabetes is asking about oral medication options. Which of the following oral hypoglycemic agents is categorized as Pregnancy Category B?

<p>Metformin (A)</p> Signup and view all the answers

Which of the following fetal complications of gestational diabetes mellitus (GDM) presents the GREATEST immediate risk at the time of delivery, potentially requiring urgent intervention?

<p>Shoulder dystocia (A)</p> Signup and view all the answers

A patient with well-controlled gestational diabetes asks about her long-term risk. What is the approximate lifetime risk of developing type 2 diabetes mellitus (T2DM) after a pregnancy complicated by GDM?

<blockquote> <p>50% (B)</p> </blockquote> Signup and view all the answers

A 27-year-old female with no significant past medical history develops gestational diabetes. She is able to control her blood sugars with diet and exercise alone. At what gestational age should induction of labor be considered, assuming no other maternal or fetal complications?

<p>38 weeks (D)</p> Signup and view all the answers

Which of the following is NOT a subtype of hypertension discussed in the context of pregnancy?

<p>Essential Hypertension (D)</p> Signup and view all the answers

A pregnant woman is diagnosed with hypertension. Which of the following complications should clinicians be aware of?

<p>Increased risk of fetal macrosomia. (D)</p> Signup and view all the answers

What are the key components of a comprehensive treatment plan for a pregnant woman diagnosed with hypertension or gestational diabetes?

<p>Diagnostic tests, future treatments, and patient education (B)</p> Signup and view all the answers

A clinician must distinguish between hypertension present before pregnancy and that which arises during pregnancy. What is the most critical differentiating factor?

<p>Timing of onset of hypertension relative to the pregnancy. (B)</p> Signup and view all the answers

In the context of pregnancy-related hypertension, which condition is characterized by hemolysis, elevated liver enzymes, and low platelet count?

<p>HELLP Syndrome (B)</p> Signup and view all the answers

A patient at 38 weeks gestation presents with a blood pressure reading of 145/95 mmHg during a routine prenatal visit. She has no proteinuria or other symptoms. This is her first elevated blood pressure reading after 20 weeks of gestation. Which of the following is the MOST appropriate classification for her hypertensive disorder?

<p>Gestational hypertension (C)</p> Signup and view all the answers

Which of the following blood pressure thresholds, if met or exceeded during pregnancy, necessitates pharmacological treatment according to the provided guidelines?

<p>Systolic blood pressure ≥ 160 mmHg or diastolic blood pressure ≥ 110 mmHg (C)</p> Signup and view all the answers

A 29-year-old pregnant woman at 28 weeks gestation is diagnosed with mild preeclampsia. Which of the following is a component of expectant management for mild preeclampsia before 37 weeks gestation?

<p>Frequent maternal and fetal monitoring (B)</p> Signup and view all the answers

Which of the following antihypertensive medications is contraindicated during pregnancy due to the risk of fetal renal and cardiac abnormalities?

<p>ACE Inhibitors (B)</p> Signup and view all the answers

A postpartum patient is diagnosed with transient hypertension. Which characteristic is MOST consistent with transient hypertension as opposed to chronic hypertension?

<p>Blood pressure normalizes within 12 weeks postpartum (D)</p> Signup and view all the answers

Which of the following is NOT explicitly listed as a risk factor for gestational diabetes mellitus (GDM) in the provided content?

<p>History of preeclampsia (A)</p> Signup and view all the answers

A pregnant patient at 32 weeks gestation is diagnosed with severe preeclampsia. Which of the following is the MOST critical immediate management strategy to prevent maternal seizures?

<p>Intravenous magnesium sulfate (A)</p> Signup and view all the answers

HELLP syndrome is characterized by Hemolysis, Elevated Liver enzymes, and Low Platelet count. While these are diagnostic criteria, which of the following signs or symptoms, though not strictly required for diagnosis, would be MOST concerning and warrant immediate investigation for HELLP syndrome in a pregnant patient with preeclampsia?

<p>Epigastric pain (D)</p> Signup and view all the answers

Which of the following is the MOST likely underlying physiological mechanism contributing to gestational diabetes mellitus (GDM)?

<p>Physiologic insulin resistance caused by placental hormones (C)</p> Signup and view all the answers

A patient with severe preeclampsia at 35 weeks gestation is being treated with magnesium sulfate. Which of the following is the MOST definitive treatment for severe preeclampsia to prevent progression and improve maternal and fetal outcomes?

<p>Delivery of the fetus and placenta (C)</p> Signup and view all the answers

According to the provided text, what percentage of pregnancies are affected by pregnancy-induced hypertension (PIH), also known as gestational hypertension?

<p>5-10% (B)</p> Signup and view all the answers

Which of the following is the MOST appropriate initial loading dose of magnesium sulfate (MgSO4) for a patient with eclampsia, according to the provided management guidelines?

<p>4-6 grams IV (D)</p> Signup and view all the answers

A patient is diagnosed with HELLP syndrome at 30 weeks gestation. Based on the information provided, what is the MOST strongly recommended management strategy regarding delivery?

<p>Delivery is recommended at or beyond 34 weeks, but may be considered before 34 weeks in certain situations (D)</p> Signup and view all the answers

For breastfeeding mothers requiring antihypertensive medication, which class of calcium channel blockers is generally advised to be avoided according to the provided information?

<p>Amlodipine (C)</p> Signup and view all the answers

A woman with a history of gestational hypertension in a previous pregnancy is now pregnant again. Which of the following is LEAST likely to be effective in reducing her risk of recurrent gestational hypertension in the current pregnancy based on the information provided?

<p>Prophylactic magnesium sulfate administration throughout the pregnancy (C)</p> Signup and view all the answers

What distinguishes hypertension present prior to pregnancy from hypertension that arises during pregnancy?

<p>Previous history (A)</p> Signup and view all the answers

What condition is characterized by hemolysis, elevated liver enzymes, and low platelet count?

<p>HELLP syndrome (A)</p> Signup and view all the answers

Which adverse outcome is associated with hypertension during pregnancy?

<p>Placental abruption (D)</p> Signup and view all the answers

What is the classification of hypertension found during pregnancy?

<p>Pregnancy-induced HTN (A)</p> Signup and view all the answers

What is the key characteristic that differentiates transient hypertension from other hypertensive disorders in pregnancy?

<p>Postpartum normalization (B)</p> Signup and view all the answers

A patient presents with blood pressure readings above 140/90 mmHg before pregnancy. How would you classify this?

<p>Chronic hypertension (B)</p> Signup and view all the answers

What blood pressure defines severe hypertension in pregnancy?

<p>≥160/110 mmHg (D)</p> Signup and view all the answers

Which antihypertensive drug class is contraindicated during pregnancy due to potential fetal harm?

<p>ACE inhibitors (A)</p> Signup and view all the answers

What is the key diagnostic criterion, in addition to hypertension, for preeclampsia?

<p>Proteinuria (B)</p> Signup and view all the answers

A pregnant patient is diagnosed with mild preeclampsia before 37 weeks. What is the recommended management?

<p>Expectant management (C)</p> Signup and view all the answers

What characterizes HELLP syndrome?

<p>Hemolysis (A)</p> Signup and view all the answers

What is the primary cause of gestational diabetes?

<p>Insulin resistance (B)</p> Signup and view all the answers

Gestational diabetes mellitus (GDM) is characterized by the pancreas's inability to adequately compensate for increased insulin resistance during pregnancy. Which underlying physiological factor is MOST directly implicated in this decompensation?

<p>Beta cell deficits (A)</p> Signup and view all the answers

A pregnant woman is identified as low risk for gestational diabetes mellitus (GDM) at her initial prenatal visit. According to screening guidelines, at what gestational age, in weeks, should she undergo routine GDM screening?

<p>24-28 (B)</p> Signup and view all the answers

A 26-year-old primigravida undergoes a 1-hour glucose tolerance test (GTT) with a 50g glucose load as part of gestational diabetes screening. Which glucose concentration, in mg/dL, is generally considered the threshold for an abnormal result, necessitating a 3-hour GTT?

<p>130 (A)</p> Signup and view all the answers

A pregnant patient undergoes a 3-hour glucose tolerance test (GTT) with a 100g glucose load. Which of the following sets of glucose values, in mg/dL, obtained at fasting, 1-hour, 2-hour, and 3-hour intervals, respectively, indicates a diagnosis of gestational diabetes mellitus (GDM)?

<p>95, 185, 150, 135 (B)</p> Signup and view all the answers

Following a 3-hour glucose tolerance test (GTT), a pregnant woman exhibits the following glucose values: Fasting: 92 mg/dL, 1-hour: 185 mg/dL, 2-hour: 140 mg/dL, 3-hour: 130 mg/dL. According to diagnostic criteria, what is the MOST appropriate interpretation of these results?

<p>Glucose intolerance (C)</p> Signup and view all the answers

A pregnant patient with gestational diabetes mellitus (GDM) initially attempts lifestyle modifications, including diet and exercise. If these conservative measures prove insufficient to achieve glycemic control, what is considered the MOST appropriate first-line pharmacological therapy?

<p>Insulin (A)</p> Signup and view all the answers

A woman with a history of gestational diabetes mellitus (GDM) in a prior pregnancy requires postpartum screening to assess for persistent glucose intolerance and future diabetes risk. According to recommended guidelines, when should this postpartum screening PRIMARILY be conducted, in weeks?

<p>4-12 (D)</p> Signup and view all the answers

A primigravid patient at 34 weeks presents with a BP of 160/110 mmHg and new-onset thrombocytopenia (platelet count 90,000/μL). AST and ALT are mildly elevated. Which underlying mechanism is the MOST likely contributor?

<p>Vasospasm (D)</p> Signup and view all the answers

A patient with pre-existing hypertension presents at 26 weeks gestation with increased proteinuria and a BP of 155/105 mmHg, previously controlled with medication. What is the MOST appropriate classification?

<p>Superimposed preeclampsia (A)</p> Signup and view all the answers

A patient is diagnosed with gestational diabetes at 28 weeks. Despite dietary changes, fasting glucose remains elevated (95-105 mg/dL). Which of the following is the MOST appropriate next step?

<p>Start insulin (C)</p> Signup and view all the answers

Which of the following hypertensive disorders is MOST directly associated with an increased risk of placental abruption due to acute uteroplacental arteriopathy?

<p>Eclampsia (A)</p> Signup and view all the answers

A GDM patient, diet-controlled, presents at 40 weeks with estimated fetal weight >4500g. Amniocentesis reveals mature lungs. What is the MOST appropriate management strategy given risks?

<p>C-section (D)</p> Signup and view all the answers

A patient presents with hypertension, discovered after 20 weeks gestation, resolving within 12 weeks postpartum. What hypertension type is this?

<p>Transient (B)</p> Signup and view all the answers

A pregnant woman's blood pressure is ≥140/90 mmHg before pregnancy. What is the MOST accurate classification?

<p>Chronic (D)</p> Signup and view all the answers

Systolic BP is ≥ 160 mmHg, diastolic BP is ≥ 110mg Hg in a pregnant patient. Management is required to prevent what major risk?

<p>Eclampsia (A)</p> Signup and view all the answers

A pregnant patient presents with SBP ≥160mmHg OR DBP ≥110mmHg. Which action is MOST appropriate?

<p>Start Treatment (B)</p> Signup and view all the answers

Which drug class should be avoided in pregnancy due to fetal renal and cardiac abnormalities?

<p>ACE Inhibitors (A)</p> Signup and view all the answers

Criteria for preeclampsia includes meeting which blood pressure requirement in millimeters of mercury (mmHg)?

<p>≥140/90 (B)</p> Signup and view all the answers

A pregnant patient is diagnosed with mild preeclampsia before 37 weeks. What is a management?

<p>Observation (C)</p> Signup and view all the answers

What percentage of pregnancies are affected by pregnancy-induced hypertension (PIH)?

<p>5-10% (B)</p> Signup and view all the answers

Which pre-conception factor MOST significantly impairs pancreatic compensation, leading to gestational diabetes mellitus (GDM)?

<p>Beta cell deficits (A)</p> Signup and view all the answers

A 27-year-old primigravida is deemed low risk for gestational diabetes mellitus (GDM) at her initial prenatal visit. Adhering strictly to screening guidelines, at what specific gestational age, expressed in weeks, should she undergo routine GDM screening?

<p>24-28 weeks (B)</p> Signup and view all the answers

You perform an initial gestational diabetes mellitus (GDM) screening with a 50g oral glucose load on a high-risk pregnant patient at 10 weeks gestation. The result is negative. When should you retest for GDM?

<p>24-28 weeks (B)</p> Signup and view all the answers

During a 1-hour glucose tolerance test (GTT) with a 50g glucose load, which specific glucose concentration, expressed in mg/dL, generally serves as the threshold for an abnormal result, thereby necessitating a subsequent 3-hour GTT for comprehensive evaluation?

<blockquote> <p>130-140 (C)</p> </blockquote> Signup and view all the answers

A pregnant patient undergoes a 3-hour glucose tolerance test (GTT) with a 100g glucose load. Which set of glucose values, in mg/dL, obtained at fasting, 1-hour, 2-hour, and 3-hour intervals, respectively, unequivocally establishes a diagnosis of gestational diabetes mellitus (GDM)?

<blockquote> <p>95/&gt;180/&gt;155/&gt;140 (B)</p> </blockquote> Signup and view all the answers

Following a 3-hour glucose tolerance test (GTT), a pregnant woman exhibits the following glucose values: Fasting: 96 mg/dL, 1-hour: 181 mg/dL, 2-hour: 150 mg/dL, 3-hour: 139 mg/dL. According to diagnostic criteria, what is the most accurate interpretation of these results?

<p>Glucose intolerance (B)</p> Signup and view all the answers

A pregnant patient with gestational diabetes mellitus (GDM) initially attempts lifestyle modifications, encompassing dietary adjustments and a structured exercise regimen. Should these conservative measures prove insufficient in achieving optimal glycemic control, what pharmacological agent reigns supreme as the most appropriate first-line therapy?

<p>Insulin (A)</p> Signup and view all the answers

A 31-year-old primigravida at 34 weeks' gestation presents with a blood pressure of 162/112 mmHg, severe headache, visual disturbances, and right upper quadrant pain. Initial lab results reveal thrombocytopenia (platelet count 75,000/μL), elevated AST (180 U/L), and ALT (210 U/L). Urinalysis shows 3+ protein. Considering the constellation of findings, which of the following underlying pathophysiological mechanisms is MOST likely contributing to the patient's acute presentation?

<p>Endothelial dysfunction (A)</p> Signup and view all the answers

A 28-year-old G2P1 woman with a history of well-controlled essential hypertension presents at 27 weeks' gestation. Her pre-pregnancy blood pressure was consistently around 120/70 mmHg, managed with low-dose methyldopa. At today's visit, her blood pressure is 158/108 mmHg, and she has 1+ proteinuria on urine dipstick. Which classification BEST fits her current hypertensive state?

<p>Preeclampsia, superimposed (A)</p> Signup and view all the answers

A pregnant patient diagnosed with gestational diabetes mellitus (GDM) at 28 weeks' gestation has been adhering to a strict dietary regimen. Despite this, her fasting blood glucose levels consistently range between 95-105 mg/dL. Which intervention is MOST appropriate?

<p>Begin insulin therapy (D)</p> Signup and view all the answers

A 39-year-old G5P4 woman with diet-controlled GDM presents at 40 weeks' gestation. Her estimated fetal weight by ultrasound is 4600g. Amniocentesis indicates fetal lung maturity. Considering the risks and benefits, what is the MOST appropriate management strategy?

<p>Elective cesarean (C)</p> Signup and view all the answers

A 25-year-old primigravida presents with a blood pressure of 145/95 mmHg at 30 weeks gestation. There is no proteinuria. After delivery, her blood pressure returns to normal within 6 weeks postpartum. Considering that blood pressure was normal prior to pregnancy, what is the MOST accurate classification?

<p>Transient hypertension (D)</p> Signup and view all the answers

In transient hypertension, what clarifies?

<p>Postpartum resolution (B)</p> Signup and view all the answers

What BP defines severe chronic hypertension?

<p>≥160/110 mmHg (A)</p> Signup and view all the answers

PIH excludes what finding?

<p>Proteinuria (D)</p> Signup and view all the answers

What antihypertensive class is strictly avoided?

<p>ACE inhibitors (C)</p> Signup and view all the answers

Preeclampsia mandates hypertension plus what?

<p>Proteinuria (A)</p> Signup and view all the answers

Gestational diabetes is primarily caused by?

<p>Insulin resistance (A)</p> Signup and view all the answers

HELLP syndrome includes preeclampsia, plus?

<p>Thrombocytopenia (A)</p> Signup and view all the answers

When should delivery occur in HELLP syndrome?

<p>34 weeks gestation (A)</p> Signup and view all the answers

In GDM, pancreatic compensation fails 2/2?

<p>Beta cell deficits (C)</p> Signup and view all the answers

Low-risk GDM screening occurs when?

<p>24-28 weeks (C)</p> Signup and view all the answers

Which GDM patients retest 4-12 weeks postpartum?

<p>Those screen-positive in pregnancy (A)</p> Signup and view all the answers

Post-GDM, diabetes/prediabetes screening happens how often?

<p>Every 3 years (B)</p> Signup and view all the answers

A positive 1-hour GTT mandates what?

<p>3-hour GTT (D)</p> Signup and view all the answers

During a 3-hour GTT, what automatically indicates GDM?

<p>Any single value &gt;200 (A)</p> Signup and view all the answers

What's the safest first-line GDM therapy?

<p>Insulin (C)</p> Signup and view all the answers

A 27-year-old primigravida is identified as high risk for gestational diabetes mellitus (GDM) during her initial prenatal visit. Her initial GDM screening is negative. According to screening guidelines, when should she be retested?

<p>Between 24-28 weeks gestation (C)</p> Signup and view all the answers

A 25-year-old female with no prior history of gestational diabetes is undergoing a 1-hour glucose tolerance test (GTT) as part of routine screening. Following a 50g glucose load, which glucose level is generally considered abnormal, requiring a 3-hour GTT for further evaluation?

<p>$&gt;130-140 \text{ mg/dL}$ (D)</p> Signup and view all the answers

A pregnant patient with gestational diabetes mellitus (GDM) has been unsuccessfully managing her condition through lifestyle modifications, including diet and exercise. What is the recommended first-line therapy for this condition?

<p>Insulin (D)</p> Signup and view all the answers

A patient is diagnosed with gestational diabetes. The medical student asks what the diagnostic criteria is for GDM with the 3-hour GTT. Which of the following is correct regarding diagnosis?

<p>Two or more abnormal values indicates GDM diagnosis. (C)</p> Signup and view all the answers

Which of the following is least appropriate to initially recommend in a patient newly diagnosed with gestational diabetes?

<p>Insulin (D)</p> Signup and view all the answers

A patient with gestational diabetes is asking about screening recommendations after pregnancy. Which of the following is the MOST appropriate screening strategy?

<p>Retest 4-12 weeks postpartum (C)</p> Signup and view all the answers

A patient with a history of gestational diabetes is starting to think about their long term risk of having diabetes. Which of the following is the MOST appropriate screening strategy?

<p>Every 3 years (D)</p> Signup and view all the answers

Match the result to the diagnosis:

<p>Gestational DM (B)</p> Signup and view all the answers

Which of the following conditions contribute to gestational diabetes?

<p>The pancreas cannot compensate for insulin resistance. (C)</p> Signup and view all the answers

A pregnant patient presents with a blood pressure of 160/110 mmHg and proteinuria. Which of the following findings would MOST strongly suggest the development of severe preeclampsia requiring immediate intervention?

<p>Platelet count of 90,000/uL and elevated liver enzymes (B)</p> Signup and view all the answers

A pregnant patient with pre-existing hypertension is being managed with labetalol. At 36 weeks gestation, she develops superimposed preeclampsia. Which of the following signs or symptoms would necessitate the addition of magnesium sulfate to her treatment regimen?

<p>New onset severe headache, visual changes and hyperreflexia (D)</p> Signup and view all the answers

A patient presents at her initial prenatal visit with a blood pressure of 150/95 mmHg. She reports a history of elevated blood pressure prior to pregnancy, but has no records available. What step is MOST critical in differentiating chronic hypertension from gestational hypertension?

<p>Monitoring blood pressure closely throughout the pregnancy and postpartum period (D)</p> Signup and view all the answers

A 28-year-old primigravida is diagnosed with gestational diabetes at 26 weeks gestation. She is committed to lifestyle modifications. After two weeks, her fasting blood sugars remain elevated (95-105 mg/dL). What is the MOST appropriate next step in management?

<p>Start her on insulin therapy (B)</p> Signup and view all the answers

A woman with a history of gestational diabetes in a previous pregnancy is now 10 weeks pregnant. Which of the following interventions is MOST appropriate to implement prophylactically during this early stage of pregnancy?

<p>Counsel on lifestyle modifications, including diet and exercise, and monitor blood glucose. (C)</p> Signup and view all the answers

A 35-year-old G2P1 woman who is 30 weeks pregnant presents with a blood pressure of 160/110 mmHg, severe headache, visual disturbances, and right upper quadrant pain. Her labs show elevated liver enzymes and thrombocytopenia. Which of the following interventions is MOST critical to perform FIRST?

<p>Administer magnesium sulfate for seizure prophylaxis. (A)</p> Signup and view all the answers

A patient with gestational diabetes asks about the long-term implications for her child. Which statement BEST reflects the infant's risk?

<p>The child has an increased risk of obesity and glucose intolerance, requiring monitoring. (D)</p> Signup and view all the answers

A 33-year-old primigravid woman at 38 weeks gestation presents with a blood pressure of 155/105 mmHg and 2+ proteinuria on urine dipstick. She denies headache and visual changes. Considering the diagnosis of preeclampsia, which of the following findings would necessitate a change in classification to severe preeclampsia?

<p>Platelet count of 110,000/µL (B)</p> Signup and view all the answers

A 29-year-old patient, currently at 32 weeks gestation, has a history of chronic hypertension managed with methyldopa prior to pregnancy. At today's visit her blood pressure is 160/110 mmHg despite continued methyldopa use, and a urine dipstick reveals 1+ protein. How should her hypertensive disorder be classified?

<p>Chronic hypertension with superimposed preeclampsia (C)</p> Signup and view all the answers

A 25-year-old primigravida is diagnosed with gestational hypertension at 36 weeks gestation. Her blood pressure is consistently around 150/95 mmHg. She is closely monitored as an outpatient. Which of the following findings would be MOST concerning and warrant immediate hospitalization?

<p>Urine protein 1+ on dipstick (C)</p> Signup and view all the answers

A 30-year-old G2P1 woman at 35 weeks gestation is diagnosed with severe preeclampsia. She is started on magnesium sulfate for seizure prophylaxis and IV hydralazine for blood pressure control. Which assessment is MOST critical to monitor for magnesium toxicity?

<p>Deep tendon reflexes (B)</p> Signup and view all the answers

A 28-year-old woman, G1P0, presents at 39 weeks gestation with a blood pressure of 165/115 mmHg and 3+ proteinuria on urine dipstick. She denies any headache, visual changes, or abdominal pain. After confirming severe preeclampsia, what is the MOST appropriate next step in management?

<p>Initiate magnesium sulfate and prepare for delivery (D)</p> Signup and view all the answers

A 34-year-old pregnant woman with a history of well-controlled gestational diabetes managed with diet and exercise presents for a routine visit at 38 weeks gestation. Her fasting blood glucose levels have been consistently below 90 mg/dL, and her 2-hour postprandial levels are below 120 mg/dL. There are no other maternal or fetal complications. Which of the following is the MOST appropriate management approach regarding delivery?

<p>Allow the patient to go to spontaneous labor and delivery, with close fetal monitoring. (A)</p> Signup and view all the answers

A 26-year-old G1P0 woman is diagnosed with gestational diabetes at 28 weeks. She has been adhering to a diabetic diet, but her fasting blood sugars remain elevated (95-105 mg/dL). What is the MOST appropriate next step?

<p>Start insulin therapy. (B)</p> Signup and view all the answers

A 31-year-old G2P1 woman with gestational diabetes controlled by diet and exercise delivers a healthy term infant. At her postpartum follow-up visit 6 weeks later, which screening test is MOST appropriate to assess for persistent glucose intolerance?

<p>75-g oral glucose tolerance test (OGTT) (B)</p> Signup and view all the answers

A 36-year-old woman with a history of gestational hypertension in her first pregnancy is now 10 weeks pregnant with her second child. Which intervention is LEAST likely to reduce her risk of developing gestational hypertension again in this pregnancy?

<p>Implementing a sodium-restricted diet throughout the pregnancy. (C)</p> Signup and view all the answers

Flashcards

Transient Hypertension

Hypertension occurring in late pregnancy without preeclampsia features, normalizing postpartum.

Chronic Hypertension in Pregnancy

BP >140/90 mmHg before pregnancy or before 20 weeks gestation, or persisting >12 weeks postpartum.

Pregnancy Induced Hypertension (PIH)

Hypertension developing after 20 weeks of gestation without proteinuria.

Pre-eclampsia

New onset hypertension with proteinuria after 20 weeks gestation.

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Symptoms of Pre-eclampsia

Headache, visual disturbances, edema, and sudden weight gain.

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Preeclampsia Management

Expectant management for mild preeclampsia involves frequent monitoring and rest until 37 weeks, then delivery. Severe preeclampsia requires MgSO4, BP control, and delivery at/beyond 34 weeks.

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HELLP Syndrome

A life-threatening condition associated with severe preeclampsia, characterized by Hemolysis, Elevated Liver enzymes, and Low Platelet count.

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HELLP S&S

Headache, nausea/vomiting, RUQ pain, fatigue, visual disturbances.

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HELLP Rx

Delivery, typically induced or via C-section.

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GDM Pathophysiology

Insulin resistance due to placental hormones, leading to postprandial hyperglycemia and carbohydrate intolerance.

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GDM Risk Factors

Obesity, family history of DM, previous GDM, advanced maternal age, non-white ethnicity.

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GDM Screening Time

24-28 weeks gestation

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GDM Screening Test

50-gram 1-hour oral glucose challenge.

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Postpartum GDM Screening

Glucose tolerance screening 2-4 months postpartum.

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Chronic Hypertension

Hypertension diagnosed before pregnancy or before 20 weeks of gestation.

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Eclampsia

The occurrence of seizures in a woman with pre-eclampsia.

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GDM Development

Gestational Diabetes Mellitus develops when the pancreas cannot produce enough insulin to compensate for insulin resistance during pregnancy, often due to underlying beta cell dysfunction.

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GDM Screening Guidelines

Low-risk women should be screened for GDM at 24-28 weeks of gestation. High-risk women should be screened at their first prenatal visit and, if negative, retested at 24-28 weeks.

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1-Hour GTT

Involves a 50g oral glucose challenge test (1-hour GTT). An abnormal result is typically >130-140 mg/dL, prompting a 3-hour GTT.

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3-Hour GTT

Involves a 100g oral glucose tolerance test (3-hour GTT) with glucose levels measured at fasting, 1 hour, 2 hours, and 3 hours. Diagnosis requires two or more abnormal values.

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GDM Treatment

Lifestyle modifications (diet and exercise) are the first-line treatment. If these are insufficient, insulin therapy is initiated.

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GDM Glucose Goals

FBS < 95 mg/dL, 1 hr postprandial < 140 mg/dL, 2 hr postprandial < 120 mg/dL.

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Metformin for GDM

Pregnancy category B. An oral medication used to treat GDM.

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GDM Maternal Risks

Increased rate of C-section, preeclampsia, polyhydramnios, infection, placental abruption, pre term labor & PP uterine atony.

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GDM Fetal Risks

Macrosomia (>4500 g), shoulder dystocia, neonatal hypoglycemia after birth.

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Pregnancy-Induced Hypertension (PIH) Definition

Systolic BP ≥140 mmHg or Diastolic BP ≥90 mmHg on two readings one week apart, after 20 weeks gestation.

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Chronic Hypertension Management Goal

Reduce risk of cardiovascular & cerebrovascular events.

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When to treat HTN in pregnancy (BP)

Systolic BP ≥160 mmHg or Diastolic BP ≥110 mmHg.

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Hypertension Drugs to Avoid in Pregnancy

ACE Inhibitors, ARBs, Direct renin inhibitors.

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HTN Med Options for Breastfeeding Mothers

Beta-blockers, alpha-blockers, CCBs, ACE Inhibitors *

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Preeclampsia Definition

Systolic BP ≥ 140 or Diastolic BP ≥ 90 + proteinuria after 20 weeks gestation.

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Proteinuria Definition in Preeclampsia

≥ 0.3 g in 24-hour urine collection OR Urine dipstick reading of 1+.

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Severe Preeclampsia Criteria

Labs/Symptoms that indicate Preeclampsia is severe

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Risk Factors for Preeclampsia

Nulliparity, age >35, family history of eclampsia, pre-existing conditions, multiple gestation, obesity.

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Management of Mild Preeclampsia (<37 wks)

Rest, frequent monitoring; medication (Labetalol, Methyldopa, Nifedipine).

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Management of Severe Preeclampsia

Admit to L&D, MgSO4, Hydralazine/Labetalol/Nifedipine, IV fluids, Delivery.

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Eclampsia Definition

Seizures in a woman with preeclampsia, not explained by another neurologic disorder.

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Eclampsia Management

Protect airway, administer oxygen, manage BP (hydralazine/labetalol), MgSO4, await delivery.

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HELLP Syndrome Triad

Hemolysis, Elevated Liver enzymes, Low Platelet count.

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HELLP Syndrome Treatment

Delivery (natural or C-section).

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Gestational Diabetes (GDM)

A condition in which women without previously diagnosed diabetes exhibit high blood glucose levels during pregnancy.

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GDM Screening

Low-risk: 24-28 weeks. High-risk: first visit, retest at 24-28 weeks if initially negative. Postpartum: 4-12 weeks after, then every 3 years.

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1-Hour GTT in GDM Screening:

Administer a 50g oral glucose load, abnormal is >130-140mg/dL. If abnormal, proceed with a 3 hour GTT

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3-Hour GTT in GDM

Administer a 100g oral glucose load with abnormal values >95/180/155/140. One abnormal value -> glucose intolerance, Two or more -> GDM. Value >200 automatically meets criteria for GDM

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GDM Management

Frequent blood sugar monitoring (fasting & postprandial). Multiple daily insulin injections or continuous sc infusions. Goal: FBS < 95 mg/dL, 1 hr postprandial < 140 mg/dL, 2 hr postprandial < 120 mg/dL

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Metformin in GDM

Pregnancy category B oral medication used in GDM management.

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Glyburide in GDM

Pregnancy category C oral medication sometimes used in GDM management.

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Fetal Risks of GDM

Macrosomia (>4500 g), shoulder dystocia, neonatal hypoglycemia after birth.

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GDM Delivery & Postpartum

Consider induction at 38-39 weeks. C-section if estimated fetal weight >4500g. Screen 2-4 months post-partum. High recurrence risk w/ subsequent pregnancies.

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Gestational Hypertension

Hypertension after 20 weeks gestation without proteinuria.

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Chronic HTN Management Goal

Goal is to minimize cardiovascular and cerebrovascular risk.

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Treat Hypertension (BP)

Systolic BP ≥160 mmHg or diastolic BP ≥110 mmHg.

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Hypertension Drugs to Avoid

ACE Inhibitors, ARBs, Direct renin inhibitors.

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HTN Med Options (Breastfeeding)

Beta-blockers, alpha-blockers, CCBs, ACE Inhibitors.

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Proteinuria Definition

≥0.3 g in 24-hour urine or 1+ on dipstick.

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Eclampsia Occurrence

Occurs in 0.5 – 4% of patients with preeclampsia, usually within 24 hrs of delivery

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Hemolysis, Elevated Liver enzymes and Low Platelet count

HELLP Syndrome Triad

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Pregnancy-Induced Hypertension

Hypertension diagnosed after 20 weeks of gestation during pregnancy

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GDM Development Factors

GDM may occur when the pancreas cannot compensate for insulin resistance during pregnancy, potentially linked to beta cell deficits and pre-existing metabolic issues.

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GDM Follow-Up Screening

Women with a history of GDM in pregnancy should be screened for prediabetes or diabetes at least every 3 years due to increased risk of developing diabetes later in life.

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GDM: 1-hour GTT

A 50g oral glucose load is given, and blood glucose is measured after 1 hour. Abnormal: >130-140 mg/dL. Followed by a 3-hour GTT if abnormal.

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GDM: 3-hour GTT Values

A 100g oral glucose load is given, with glucose levels measured at fasting, 1, 2, and 3 hours. Abnormal values: >95/180/155/140. Two or more abnormal values indicate GDM.

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GDM Automatic Diagnosis

If any glucose value during a GTT is >200 mg/dL, it automatically meets the criteria for GDM, regardless of other values.

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GDM Initial Treatment

First-line therapy for GDM involves dietary changes with the help of a registered dietician and exercise (at least 4 hours/week).

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GDM Medication

Insulin is the preferred pharmacological treatment for GDM due to its safety profile during pregnancy.

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Hypertension in Pregnancy

High blood pressure, either chronic or pregnancy-related.

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Pregnancy-Induced HTN

Elevated blood pressure arising during pregnancy.

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Mild Chronic Hypertension

Systolic BP ≥ 140-159 mmHg or diastolic BP 90-109 mmHg.

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Severe Chronic Hypertension

Systolic BP ≥ 160 mmHg or diastolic BP ≥ 110 mmHg.

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Pregnancy Induced Hypertension (PIH) incidence

Develops in 5-10% of pregnancies. Associated with increased perinatal morbidity & mortality for mother and fetus

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Initial Eclampsia Management

Protect airway; pulse ox; O2 via face mask; fetal monitoring after mother is stable

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HELLP Syndrome Definition

Hemolysis, Elevated Liver enzymes, Low Platelet count in a woman with preeclampsia

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HELLP: Hemolysis Lab Finding

Abnormal peripheral blood smear (schistocytes, burr cells)

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HELLP: Elevated Liver Enzymes

At least twice the upper limit of normal concentration.

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GDM: Insulin Resistance

Physiologic insulin resistance occurs during pregnancy due to placental secretion of hormones.

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GDM Development Cause

GDM occurs when the pancreas cannot produce enough insulin to overcome insulin resistance during pregnancy.

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High-Risk GDM Screening

Screen at first prenatal visit. If negative, retest at 24-28 weeks.

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Post-GDM Screening Frequency

Screened 4-12 weeks postpartum, then every 3 years.

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3-Hour GTT Interpretation

One abnormal value indicates glucose intolerance, while two or more indicate GDM.

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Abnormal 3-Hour GTT Values

Fasting >95 mg/dL, 1-hour >180 mg/dL, 2-hour >155 mg/dL, 3-hour >140 mg/dL.

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First-Line GDM Treatment

Diet and exercise

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GDM Medication of choice

Safest treatment for GDM.

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Preeclampsia Diagnosis

Systolic BP ≥ 140 mmHg OR Diastolic BP ≥ 90 mmHg AND Proteinuria of 0.3 grams or greater in a 24-hour urine specimen; BP elevation on two measurements at least 6 hours apart.

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HELLP Syndrome- Maternal Complications

Placental abruption, pulmonary edema, DIC, ARDS, ARF, Hepatic Rupture, Retinal Detachment, Death

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HELLP Syndrome- Infant Complications

IUGR, Infant Respiratory Distress Syndrome

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Gestational Diabetes (GDM) Symptoms

Usually asymptomatic.

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GDM and Pancreatic Compensation

GDM can occur due to pancreatic limitations, especially when the pancreas cannot compensate for increased insulin resistance.

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Repeat GDM Screening

If initial GDM screening is negative in high-risk women, a repeat test should be done at 24-28 weeks.

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Abnormal 1-Hour GTT

An abnormal 1-hour GTT is >130-140 mg/dL, prompting a 3-hour GTT.

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GDM 3-Hour GTT Diagnosis

Diagnosis is made if two or more values are abnormal.

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GDM & Glucose >200

Any glucose value >200 during GTT automatically meets criteria for GDM.

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Initial GDM Treatment

Lifestyle modifications (diet and exercise) are the first-line treatment for GDM.

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Gestational Hypertension Definition

Elevated blood pressure identified after 20 weeks of pregnancy, without proteinuria or end-organ damage.

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Gestational Diabetes Mellitus (GDM)

Glucose intolerance first recognized during pregnancy.

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GDM Screening Purpose

To identify women who may have undiagnosed GDM for further testing.

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Chronic Hypertension Definition

BP ≥ 140/90 before pregnancy, before 20 weeks gestation, or requiring antihypertensives before pregnancy.

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Mild Preeclampsia Tx (<37 weeks)

Labetalol, methyldopa, or nifedipine, with frequent monitoring, if <37 weeks gestation.

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Severe Preeclampsia Rx

Magnesium sulfate, IV antihypertensives (hydralazine or labetalol), and delivery ≥ 34 weeks.

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HELLP Syndrome Rx

Delivery (vaginal or C-section) after maternal stabilization.

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Gestational Diabetes Features

Usually asymptomatic; screen at 24-28 weeks gestation.

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Next step after abnormal 1-hour GTT

In GDM, if the 1-hour GTT result is abnormally high (>130-140 mg/dL) after a 50g glucose load, the next step is to perform this test.

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First GDM Rx

Following a positive GDM diagnosis, this is typically the first line of action recommended.

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Preferred GDM medication

The preferred pharmacological agent in treating GDM due to its safety profile during pregnancy.

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When to screen low risk women

Women identified as low risk should undergo GDM screening during these weeks of gestation.

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Postpartum GDM retest

Following a GDM pregnancy, women should be retested for diabetes or prediabetes within this timeframe postpartum.

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Exercise for GDM

This is the exercise recommendation per week for GDM management.

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When to screen high risk women

A woman should be screened at her first prenatal visit if she is considered to be this.

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Helpful GDM specialist

This professional can assist with diet modifications after a GDM diagnosis.

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Oral Glucose Loading Dose

This is the oral glucose loading dose for the Glucose Tolerance Test to screen for GDM/Diabetes

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Study Notes

Hypertension in Pregnancy

  • Gestational HTN is also referred to as Pregnancy-Induced Hypertension (PIH).

Transient Hypertension

  • Transient HTN may be a forerunner for chronic HTN later in life.

Chronic Hypertension

  • Management goal is to reduce the risk of cardiovascular and cerebrovascular events; two criteria exist for care.
  • Medication is reserved unless systolic pressure is ≥160mmHg or diastolic pressure is ≥110mmHg

Pregnancy-Induced Hypertension (PIH)

  • Systolic BP must be ≥ 140 OR Diastolic BP ≥ 90 on two readings one week apart, while measurements are at least four hours apart.
  • Blood pressure measurement should be elevated on at least two occasions at least six hours apart.
  • 25% of PIH cases can progress to preeclampsia later in pregnancy.
  • Question: According to UpToDate, which one of the following meets the criteria for gestational hypertension (aka PIH)?
    • A patient at 36 weeks gestation with a blood pressure reading on two occasions every six hours is 142/92 with no complaints and no protein in the patient's urine.
    • A patient at her initial prenatal appointment blood pressure reading is 140/90 with elevated protein in the urine.
    • A patient at 16 weeks blood pressure reading is 150/100 with elevated protein in the urine.
    • A patient at 22 weeks gestation with a blood pressure reading of 140/90 without protein in the urine.

HTN in Pregnancy Treatment

  • Treat with Methyldopa (250 mg two to three times daily, increase every two days as needed, maximum dose 3 g/day), Labetalol (100 mg two times daily, increase by 100 mg twice daily every two to three days as needed, maximum dose 2400 mg/day), and Nifedipine (30 to 60 mg once daily as a sustained-release tablet, increase at 7 to 14-day intervals, and a maximum dose 120 mg/day) if SBP is ≥160mmHg or DBP is ≥110mmHg.
  • Question: Which of the following medications is not an appropriate treatment for hypertension in pregnancy?
    • Labetalol
    • Lisinopril
    • Nifedipine
    • Methyldopa
  • Adjunctive treatment with hydralazine can be used to prevent reflex tachycardia, beginning at 10 mg four times per day and increase 10 to 25 mg/dose every 2 to 5 days, to a maximum dose of 300 mg/day.

HTN in Pregnancy: Options for breastfeeding mothers

  • Avoid atenolol & acebutolol with beta-blockers & alpha-blockers like labetalol, propranolol, and metoprolol.
  • CCBs such as diltiazem (Cardizem), nifedipine (Procardia), nicardipine (Cardene), and verapamil (Calan); must avoid amlodipine (Norvasc).
  • ACE Inhibitors can be captopril (Capoten) and enalapril (Vasotec); diuretics can be added.

HELLP Syndrome

  • A diagnosis of HELLP syndrome requires >2 of the following: Hemolysis, Elevated Liver Enzymes(at least twice the upper limit of normal concentration), and Low Platelets (<100,000 microl)
  • S&S subside within 2-3 days postpartum.
  • Mortality rate: 1.1% in mothers, and 10-60% in infants.
  • Other S&S: headaches, worsening nausea and vomiting, RUQ pain or tenderness, fatigue, malaise, and possible visual disturbances.
  • Delivery is the best therapy to resolve HELLP.
  • Question: A 25 year-old patient at 37 weeks comes in for a new onset headache, RUQ pain, and vision changes after being relatively healthy her entire pregnancy. Labs result with the following, Hemolysis, Elevated Liver Enzymes at more than twice the upper limit of normal concentration, and a platelet count <100,000 microl. According to this information what is an appropriate intervention?
    • Bed rest and monitor labs
    • Administer Hydralazine until stable
    • Recommend delivery as soon as possible
    • Give more fluids

HELLP Syndrome: Management

  • If less than 34 weeks, evaluate the baby's lung function since management should be based on gestational age.
  • Recommend bed rest and possible inpatient stay; corticosteroid injections can help promote lung maturity.
  • Administer MgSO4 to help prevent further seizures.
  • The patient could need platelet transfusion if platelets are less than 100,000 microl.
  • Monitor blood pressure with Labetalol, Hydralazine, and Nicardipine.
  • If greater than 34 weeks, natural Childbirth or C-section is recommended.
  • Complications: maternal (pulmonary edema or placental abruption) and infant (IUGR or infant respiratory distress syndrome).

Gestational Diabetes (GDM)

  • GDM can lead to lower glucose levels, so the pancreas compensates; usually asymptomatic and diagnosed with glucose screening.
  • Consider induction for those with GDM in well-controlled patients without complications between 38 - 39 weeks, with C-section if estimated fetal weight is >4500g.
  • High Recurrence of GDM occurs; perform glucose screening from 2–4 months postpartum needs to be done with 60-90% in pregnancies.
  • Question: A patient presents and wants to know what should she expect postpartum while having GDM? a) No follow-up since disease will be resolved once baby is delivered b) 2-4 months to screen again since high percentage have recurrent. c) Stop Insulin d) Strict diet plan after delivery

Gestational Diabetes Pathophysiology: Screening

  • If high-risk, retest at 24-28 weeks gestation.
  • Those with +GDM in pregnancy: retest 4-12 weeks postpartum or lifelong GDM should be screened every 3 years.
  • If a one-hour GTT presents as abnormal with a result greater than 130-140, you should perform a 3-hour GTT and monitor glucose levels as an outpatient.
  • Low risk women should be screened at 24-28 weeks.
  • Question: According to the American Diabetes Association guidelines, which statement is most accurate:
    • Women who have a high risk GDM should not be screened since they have a high occurrence of type 2
    • Low risk screen at 24-28 weeks
    • Any positive GDM is diagnostic
    • If positive retest with Insulin

Gestational Diabetes: Treatment

  • Insulin is the first line therapy because it does not cross the placenta.
  • Consider Metformin as Pregnancy Category B and Glyburide as Pregnancy Category C.
  • Question: According to the American Diabetes Association, a patient is unable to maintain the proper Glucose levels. Which selection is accurate?
  • Start Metformin and Lifestyle Modifications
  • Start Lifestyle Modifications and Insulin as first approach
  • Consider patient is type 1 and stop testing
  • Glyburide and continue to retest

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