Hypersensitivity Testing: In Vitro Total IgE Testing Principles
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Questions and Answers

What is the main benefit of total IgE testing compared to skin testing?

  • It is quicker to administer.
  • It is less traumatic to the patient. (correct)
  • It requires less patient preparation.
  • It is more sensitive.

    • Which type of IgE testing is commonly used to aid in diagnosing allergic rhinitis and asthma?

  • Antigen-Specific IgE testing
  • Total IgE testing (correct)
  • RAST
  • Patch test

    • What distinguishes newer antigen-specific IgE testing methods from the original RAST method?

  • They use enzyme or fluorescent labels instead of radioactivity. (correct)
  • They are less expensive.
  • They are only performed on children.
  • They involve the use of radioactive labels.

    • Why is allergen-specific IgE testing considered safer than skin testing?

    <p>It is less traumatic to patients.</p> Signup and view all the answers

    Which method is regarded as the gold standard for testing contact dermatitis?

    <p>Patch test</p> Signup and view all the answers

    When should a patch test for contact dermatitis ideally be conducted?

    <p>When the patient is symptom-free</p> Signup and view all the answers

    What is considered a positive reaction in the skin patch test described in the text?

    <p>Redness with papules or tiny blisters</p> Signup and view all the answers

    What is the purpose of conducting the final evaluation of the skin patch test at 96 to 120 hours?

    <p>To identify late-phase reactions</p> Signup and view all the answers

    Which type of hypersensitivity reaction is detected by the MELISA blood test mentioned in the text?

    <p>Type IV</p> Signup and view all the answers

    How does the oral food challenge (OFC) proceed in terms of increasing allergen dose?

    <p>Each dose administers a larger amount of protein</p> Signup and view all the answers

    What proportion of the population may be affected by Type IV hypersensitivity reactions to nickel according to the text?

    <p>20%</p> Signup and view all the answers

    What is a possible cause for false negative results in skin testing as indicated in the text?

    <p>Inadequate contact with the skin during testing</p> Signup and view all the answers

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