Podcast
Questions and Answers
What is denoted by increased levels of triglycerides?
What is denoted by increased levels of triglycerides?
- Hyperlipoproteinemias
- Atherosclerosis
- Hyperlipemia (correct)
- Dyslipidemia
What type of cells are filled with cholesteryl esters as a result of endocytosis of modified lipoproteins in atherosclerosis?
What type of cells are filled with cholesteryl esters as a result of endocytosis of modified lipoproteins in atherosclerosis?
- Macrophages and smooth muscle cells (correct)
- T lymphocytes and B lymphocytes
- Plasma cells and natural killer cells
- Endothelial cells and fibroblasts
What is the primary cause of reduction in acute coronary events following vigorous lipid-lowering treatment?
What is the primary cause of reduction in acute coronary events following vigorous lipid-lowering treatment?
- Mitigation of the inflammatory activity of macrophages (correct)
- Reduction in platelet activation
- Decrease in accumulation of foam cells and collagen
- Enhanced endothelial function
What is the main effect of High Density Lipoproteins (HDL) in the context of atherosclerosis?
What is the main effect of High Density Lipoproteins (HDL) in the context of atherosclerosis?
What is the impact of diabetes as a major risk factor in the context of atherosclerosis?
What is the impact of diabetes as a major risk factor in the context of atherosclerosis?
How does cigarette smoking contribute to coronary disease in relation to High Density Lipoproteins (HDL)?
How does cigarette smoking contribute to coronary disease in relation to High Density Lipoproteins (HDL)?
Which lipoprotein is chiefly catabolized in hepatocytes and other cells through receptor mediated endocytosis?
Which lipoprotein is chiefly catabolized in hepatocytes and other cells through receptor mediated endocytosis?
What are the major clinical sequelae of hyperlipidemias?
What are the major clinical sequelae of hyperlipidemias?
Which pathway involves hydrolysis by the lipoprotein lipase (LPL) system for removal of triglycerides from chylomicrons and VLDL?
Which pathway involves hydrolysis by the lipoprotein lipase (LPL) system for removal of triglycerides from chylomicrons and VLDL?
Which lipoprotein species contain apolipoprotein B-100, conveying lipid to the arterial wall?
Which lipoprotein species contain apolipoprotein B-100, conveying lipid to the arterial wall?
What is the role of Lp(a) lipoprotein in atherosclerosis?
What is the role of Lp(a) lipoprotein in atherosclerosis?
Which cellular components in atherosclerosis are filled with cholesteryl esters due to endocytosis of modified lipoproteins?
Which cellular components in atherosclerosis are filled with cholesteryl esters due to endocytosis of modified lipoproteins?
Which type of remnant lipoprotein can contribute to atherosclerosis by entering the artery wall?
Which type of remnant lipoprotein can contribute to atherosclerosis by entering the artery wall?
What are the metabolic disorders that involve elevations in any lipoprotein species?
What are the metabolic disorders that involve elevations in any lipoprotein species?
What is formed during the catabolism of chylomicrons that can also enter the artery wall, contributing to atherosclerosis?
What is formed during the catabolism of chylomicrons that can also enter the artery wall, contributing to atherosclerosis?
Which lipoprotein contains apolipoprotein B-100, conveying lipid to the arterial wall?
Which lipoprotein contains apolipoprotein B-100, conveying lipid to the arterial wall?
What is the primary reason for treating patients with triglycerides above 700mg/dL?
What is the primary reason for treating patients with triglycerides above 700mg/dL?
What is a characteristic of patients with hypertriglyceridemia and reduced levels of HDL-C?
What is a characteristic of patients with hypertriglyceridemia and reduced levels of HDL-C?
Which proteins or factors are associated with severe lipemia in primary chylomicronemia?
Which proteins or factors are associated with severe lipemia in primary chylomicronemia?
What is the main purpose of using METFORMIN in the management of patients with hypertriglyceridemia?
What is the main purpose of using METFORMIN in the management of patients with hypertriglyceridemia?
What is not present in the serum of normal individuals who have fasted 10 hours?
What is not present in the serum of normal individuals who have fasted 10 hours?
What is a characteristic feature of atherosclerosis in relation to primary hypertriglyceridemias?
What is a characteristic feature of atherosclerosis in relation to primary hypertriglyceridemias?
What is the presumptive diagnosis for patients with lipemia who demonstrate a pronounced decrease in triglycerides 72 hours after elimination of daily dietary fat?
What is the presumptive diagnosis for patients with lipemia who demonstrate a pronounced decrease in triglycerides 72 hours after elimination of daily dietary fat?
What is a significant association with metabolic syndrome in patients with hypertriglyceridemia?
What is a significant association with metabolic syndrome in patients with hypertriglyceridemia?
Which lipoprotein species contain apolipoprotein B-100, conveying lipid to the arterial wall in atherosclerosis?
Which lipoprotein species contain apolipoprotein B-100, conveying lipid to the arterial wall in atherosclerosis?
What is the primary treatment for patients with Familial Combined Hyperlipoproteinemia (FCH) who do not normalize lipid levels with diet alone?
What is the primary treatment for patients with Familial Combined Hyperlipoproteinemia (FCH) who do not normalize lipid levels with diet alone?
Which lipoprotein is chiefly catabolized in hepatocytes and other cells through receptor-mediated endocytosis?
Which lipoprotein is chiefly catabolized in hepatocytes and other cells through receptor-mediated endocytosis?
What is denoted by increased levels of triglycerides?
What is denoted by increased levels of triglycerides?
What are the major clinical sequelae commonly associated with hyperlipidemias?
What are the major clinical sequelae commonly associated with hyperlipidemias?
Match the lipid disorder with its primary characteristic feature:
Match the lipid disorder with its primary characteristic feature:
Match the treatment approach with the corresponding lipid disorder:
Match the treatment approach with the corresponding lipid disorder:
Match the clinical feature with the associated lipid disorder:
Match the clinical feature with the associated lipid disorder:
Match the aggravating factor with the associated lipid disorder:
Match the aggravating factor with the associated lipid disorder:
Match the diagnostic feature with the corresponding lipid disorder:
Match the diagnostic feature with the corresponding lipid disorder:
Match the recommended medication with the corresponding lipid disorder:
Match the recommended medication with the corresponding lipid disorder:
Match the primary dietary approach with the corresponding lipid disorder:
Match the primary dietary approach with the corresponding lipid disorder:
Match the associated condition with the corresponding lipid disorder:
Match the associated condition with the corresponding lipid disorder:
What is the characteristic cholesterol level range in most heterozygotes with LDL receptor deficient familial hypercholesterolemia?
What is the characteristic cholesterol level range in most heterozygotes with LDL receptor deficient familial hypercholesterolemia?
What are the typical levels of cholesterol in homozygous familial hypercholesterolemia, which can lead to coronary disease in childhood?
What are the typical levels of cholesterol in homozygous familial hypercholesterolemia, which can lead to coronary disease in childhood?
What are the characteristic clinical manifestations of homozygous familial hypercholesterolemia?
What are the characteristic clinical manifestations of homozygous familial hypercholesterolemia?
What is a characteristic feature of homozygous familial hypercholesterolemia in comparison to heterozygous familial hypercholesterolemia?
What is a characteristic feature of homozygous familial hypercholesterolemia in comparison to heterozygous familial hypercholesterolemia?
What treatment approach can normalize LDL in heterozygous familial hypercholesterolemia?
What treatment approach can normalize LDL in heterozygous familial hypercholesterolemia?
Which emerging therapy employs an antisense strategy targeted at apo B-100 in patients with combined heterozygosity for alleles producing non-functional and kinetically impaired receptors?
Which emerging therapy employs an antisense strategy targeted at apo B-100 in patients with combined heterozygosity for alleles producing non-functional and kinetically impaired receptors?
Which drug may partially respond in homozygotes and those with combined heterozygosity who retain even minimal function of their receptors?
Which drug may partially respond in homozygotes and those with combined heterozygosity who retain even minimal function of their receptors?
Which enzyme therapy effectively restores the hydrolysis of cholesteryl esters in liver, normalizing plasma lipoprotein levels?
Which enzyme therapy effectively restores the hydrolysis of cholesteryl esters in liver, normalizing plasma lipoprotein levels?
What is the primary treatment for patients with familial hypoalphalipoproteinemia?
What is the primary treatment for patients with familial hypoalphalipoproteinemia?
In the presence of hypertriglyceridemia, why is HDL cholesterol low?
In the presence of hypertriglyceridemia, why is HDL cholesterol low?
What is the characteristic feature of Tangier disease and LCAT deficiency?
What is the characteristic feature of Tangier disease and LCAT deficiency?
Which medication increases HDL in many patients with low levels of HDL cholesterol?
Which medication increases HDL in many patients with low levels of HDL cholesterol?
What is the impact of PCSK9 monoclonal antibodies on levels of Lp(a) in patients?
What is the impact of PCSK9 monoclonal antibodies on levels of Lp(a) in patients?
How do fibrates or Niacin exert beneficial effects in patients with Lp(a) hyperlipoproteinemia?
How do fibrates or Niacin exert beneficial effects in patients with Lp(a) hyperlipoproteinemia?
Which lipid disorder is associated with increased atherogenesis and arterial thrombus formation?
Which lipid disorder is associated with increased atherogenesis and arterial thrombus formation?
What is the response to reductase inhibitors in patients with familial ligand-defective apolipoprotein B-100?
What is the response to reductase inhibitors in patients with familial ligand-defective apolipoprotein B-100?
In familial combined hyperlipoproteinemia, what may be necessary to add to normalize LDL?
In familial combined hyperlipoproteinemia, what may be necessary to add to normalize LDL?
What is the characteristic serum cholesterol level in some persons with familial combined hyperlipoproteinemia?
What is the characteristic serum cholesterol level in some persons with familial combined hyperlipoproteinemia?
What effect does reduction of LDL-C below 100mg/dL have on the risk attributable to Lp(a)?
What effect does reduction of LDL-C below 100mg/dL have on the risk attributable to Lp(a)?
What is the primary treatment for patients with Lp(a) hyperlipoproteinemia who demonstrate high levels of Lp(a)?
What is the primary treatment for patients with Lp(a) hyperlipoproteinemia who demonstrate high levels of Lp(a)?
Match the lipid disorder with the associated characteristic feature:
Match the lipid disorder with the associated characteristic feature:
Match the treatment approach with the corresponding lipid disorder:
Match the treatment approach with the corresponding lipid disorder:
Match the clinical feature with the associated lipid disorder:
Match the clinical feature with the associated lipid disorder:
Match the diagnostic feature with the corresponding lipid disorder:
Match the diagnostic feature with the corresponding lipid disorder:
Match the lipid disorder with its primary characteristic feature:
Match the lipid disorder with its primary characteristic feature:
Match the diagnostic feature with the corresponding lipid disorder:
Match the diagnostic feature with the corresponding lipid disorder:
Match the clinical feature with the associated lipid disorder:
Match the clinical feature with the associated lipid disorder:
Match the recommended medication with the corresponding lipid disorder:
Match the recommended medication with the corresponding lipid disorder:
Match the associated condition with the corresponding lipid disorder:
Match the associated condition with the corresponding lipid disorder:
What is the impact of omega-3 fatty acids from fish oils on triglyceride levels?
What is the impact of omega-3 fatty acids from fish oils on triglyceride levels?
What is the effect of omega-6 fatty acids present in vegetable oil on triglycerides?
What is the effect of omega-6 fatty acids present in vegetable oil on triglycerides?
How can homocysteine levels be reduced in many patients?
How can homocysteine levels be reduced in many patients?
What is the recommended action for individuals with elevated levels of Lp(a)?
What is the recommended action for individuals with elevated levels of Lp(a)?
Why should consumption of red meat be minimized?
Why should consumption of red meat be minimized?
What is the impact of alcohol on triglyceride levels in the context of hypertriglyceridemia?
What is the impact of alcohol on triglyceride levels in the context of hypertriglyceridemia?
What is the recommended limit for cholesterol intake in patients with hyperlipoproteinemia?
What is the recommended limit for cholesterol intake in patients with hyperlipoproteinemia?
In the context of dietary management, what should predominantly constitute the intake of fats?
In the context of dietary management, what should predominantly constitute the intake of fats?
What is the recommended proportion of total calories from fat in the daily intake for patients with hyperlipoproteinemia?
What is the recommended proportion of total calories from fat in the daily intake for patients with hyperlipoproteinemia?
What physiological response occurs during weight loss in relation to LDL and VLDL levels?
What physiological response occurs during weight loss in relation to LDL and VLDL levels?
Why should reductase inhibitors be avoided in pregnant and lactating women?
Why should reductase inhibitors be avoided in pregnant and lactating women?
What is the most effective function of reductase inhibitors?
What is the most effective function of reductase inhibitors?
When is it usually recommended to initiate reductase inhibitor therapy for children with heterozygous familial hypercholesterolemia?
When is it usually recommended to initiate reductase inhibitor therapy for children with heterozygous familial hypercholesterolemia?
What is the standard practice regarding the initiation of reductase inhibitor therapy after acute coronary syndromes?
What is the standard practice regarding the initiation of reductase inhibitor therapy after acute coronary syndromes?
What are Lovastatin and Simvastatin classified as?
What are Lovastatin and Simvastatin classified as?
What is the significant difference in the plasma half-life of atorvastatin compared to pravastatin?
What is the significant difference in the plasma half-life of atorvastatin compared to pravastatin?
Which statin exhibits almost complete absorption after ingestion?
Which statin exhibits almost complete absorption after ingestion?
What is the primary mechanism through which HMG-CoA reductase inhibitors reduce LDL?
What is the primary mechanism through which HMG-CoA reductase inhibitors reduce LDL?
Which factor contributes to the preferential activity of some statins in the liver?
Which factor contributes to the preferential activity of some statins in the liver?
In which patient population should special monitoring be implemented when initiating statin therapy?
In which patient population should special monitoring be implemented when initiating statin therapy?
What is the recommended daily dose range for Atorvastatin?
What is the recommended daily dose range for Atorvastatin?
Which statin is twice as potent as other statins and is given in doses of 5–80 mg daily?
Which statin is twice as potent as other statins and is given in doses of 5–80 mg daily?
In which patient population should the use of statins be restricted?
In which patient population should the use of statins be restricted?
What action did the U.S. Food and Drug Administration (FDA) take in 2011 regarding simvastatin?
What action did the U.S. Food and Drug Administration (FDA) take in 2011 regarding simvastatin?
What is the recommended daily dose range for Rosuvastatin?
What is the recommended daily dose range for Rosuvastatin?
For which statin did the U.S. Food and Drug Administration (FDA) issue labeling for scaled dosing in 2011?
For which statin did the U.S. Food and Drug Administration (FDA) issue labeling for scaled dosing in 2011?
Which statin appears to be about half as potent as lovastatin on a mass basis?
Which statin appears to be about half as potent as lovastatin on a mass basis?
What dose-response curve tends to level off in the upper part of the dosage range in patients with moderate to severe hypercholesterolemia?
What dose-response curve tends to level off in the upper part of the dosage range in patients with moderate to severe hypercholesterolemia?
Which drug may increase plasma levels of Fluvastatin and Rosuvastatin?
Which drug may increase plasma levels of Fluvastatin and Rosuvastatin?
Which statins are the statins of choice for use with verapamil, ketoconazole group of antifungal agents, macrolides, and cyclosporine?
Which statins are the statins of choice for use with verapamil, ketoconazole group of antifungal agents, macrolides, and cyclosporine?
Which enzyme therapy effectively restores the hydrolysis of cholesteryl esters in the liver, normalizing plasma lipoprotein levels?
Which enzyme therapy effectively restores the hydrolysis of cholesteryl esters in the liver, normalizing plasma lipoprotein levels?
What should be measured in patients receiving potentially interacting drug combinations?
What should be measured in patients receiving potentially interacting drug combinations?
What can reduce the plasma concentrations of the 3A4-dependent reductase inhibitors?
What can reduce the plasma concentrations of the 3A4-dependent reductase inhibitors?
Which drug increases HDL in many patients with low levels of HDL cholesterol?
Which drug increases HDL in many patients with low levels of HDL cholesterol?
Which drug may partially respond in homozygotes and those with combined heterozygosity who retain even minimal function of their receptors?
Which drug may partially respond in homozygotes and those with combined heterozygosity who retain even minimal function of their receptors?
In which patient population should special monitoring be implemented when initiating statin therapy?
In which patient population should special monitoring be implemented when initiating statin therapy?
What occurs rarely as a hypersensitivity syndrome that includes a lupus-like disorder, dermatomyositis, peripheral neuropathy, and autoimmune myopathy?
What occurs rarely as a hypersensitivity syndrome that includes a lupus-like disorder, dermatomyositis, peripheral neuropathy, and autoimmune myopathy?
Which enzyme is responsible for the catabolism of lovastatin, simvastatin, and atorvastatin?
Which enzyme is responsible for the catabolism of lovastatin, simvastatin, and atorvastatin?
What is the primary cause of hepatic toxicity associated with statins?
What is the primary cause of hepatic toxicity associated with statins?
Which statin exhibits almost complete absorption after ingestion?
Which statin exhibits almost complete absorption after ingestion?
What is the impact of long-term statin treatment on the incidence of type 2 diabetes?
What is the impact of long-term statin treatment on the incidence of type 2 diabetes?
What are the characteristic clinical manifestations of myopathy in patients receiving reductase inhibitors?
What are the characteristic clinical manifestations of myopathy in patients receiving reductase inhibitors?
How does excess intake of alcohol impact the hepatotoxic effects of statins?
How does excess intake of alcohol impact the hepatotoxic effects of statins?
What is the most effective agent for increasing HDL and reducing Lp(a) in most patients?
What is the most effective agent for increasing HDL and reducing Lp(a) in most patients?
Which medication should be avoided in patients with hepatic or renal dysfunction and used with caution in patients at higher risk such as women, obese patients, and Native Americans?
Which medication should be avoided in patients with hepatic or renal dysfunction and used with caution in patients at higher risk such as women, obese patients, and Native Americans?
What is the mechanism of action of Niacin in inhibiting VLDL secretion and decreasing production of LDL?
What is the mechanism of action of Niacin in inhibiting VLDL secretion and decreasing production of LDL?
What is the recommended daily dosage of niacin for patients with hypercholesterolemia?
What is the recommended daily dosage of niacin for patients with hypercholesterolemia?
What side effect occurs after each dose when niacin is started or the dose increased, and can be mitigated by taking aspirin beforehand?
What side effect occurs after each dose when niacin is started or the dose increased, and can be mitigated by taking aspirin beforehand?
Which adverse effects are rare for fibrates?
Which adverse effects are rare for fibrates?
Which fibrate is the fibrate of choice for use in combination with a statin?
Which fibrate is the fibrate of choice for use in combination with a statin?
What is the risk of myopathy when fibrates are given with reductase inhibitors?
What is the risk of myopathy when fibrates are given with reductase inhibitors?
Which statement about niacin's impact on lipid metabolism is true?
Which statement about niacin's impact on lipid metabolism is true?
What is the primary purpose for using Gemfibrozil or Fenofibrate?
What is the primary purpose for using Gemfibrozil or Fenofibrate?
Which drug is absorbed quantitatively from the intestine and undergoes enterohepatic circulation?
Which drug is absorbed quantitatively from the intestine and undergoes enterohepatic circulation?
Which drug is most commonly used and has a plasma half-life of 20 hours?
Which drug is most commonly used and has a plasma half-life of 20 hours?
What is the primary effect of fibrates in the liver and striated muscle?
What is the primary effect of fibrates in the liver and striated muscle?
Which lipoprotein shows only modest reductions in most patients when treated with fibrates?
Which lipoprotein shows only modest reductions in most patients when treated with fibrates?
In which patients does HDL cholesterol increase moderately when treated with fibrates?
In which patients does HDL cholesterol increase moderately when treated with fibrates?
What is the primary function of fibrates as ligands for the nuclear transcription receptor PPAR-α?
What is the primary function of fibrates as ligands for the nuclear transcription receptor PPAR-α?
What is the impact of fibrates on the oxidation of fatty acids in the liver and striated muscle?
What is the impact of fibrates on the oxidation of fatty acids in the liver and striated muscle?
What action does the liver take on some of the drug gemfibrozil?
What action does the liver take on some of the drug gemfibrozil?
What proportion of fenofibrate is excreted in the urine as glucuronide?
What proportion of fenofibrate is excreted in the urine as glucuronide?
What does fenofibrate hydrolyze completely in the intestine?
What does fenofibrate hydrolyze completely in the intestine?
What is the primary purpose of bile acid-binding resins such as colestipol and cholestyramine?
What is the primary purpose of bile acid-binding resins such as colestipol and cholestyramine?
What is the potential consequence of using bile acid-binding resins in individuals with combined hyperlipidemia?
What is the potential consequence of using bile acid-binding resins in individuals with combined hyperlipidemia?
Apart from its cholesterol-lowering effects, when might bile acid-binding resins like colestipol and cholestyramine be helpful for patients?
Apart from its cholesterol-lowering effects, when might bile acid-binding resins like colestipol and cholestyramine be helpful for patients?
What is the mechanism by which bile acid-binding resins impact the conversion of cholesterol to bile acids in the liver?
What is the mechanism by which bile acid-binding resins impact the conversion of cholesterol to bile acids in the liver?
In what scenario might colesevelam, a bile acid-binding resin, be used along with other drugs?
In what scenario might colesevelam, a bile acid-binding resin, be used along with other drugs?
What is the recommended maximum daily dose of colestipol in 1-g tablets?
What is the recommended maximum daily dose of colestipol in 1-g tablets?
How should granular resins be taken?
How should granular resins be taken?
What side effect should be frequently monitored in patients taking resins and anticoagulants?
What side effect should be frequently monitored in patients taking resins and anticoagulants?
Which drugs' absorption may be impaired by the resin?
Which drugs' absorption may be impaired by the resin?
What should be avoided in patients with diverticulitis when using resins?
What should be avoided in patients with diverticulitis when using resins?
What is the primary target of ezetimibe's mechanism of action?
What is the primary target of ezetimibe's mechanism of action?
What is the average reduction in LDL cholesterol with ezetimibe alone in patients with primary hypercholesterolemia?
What is the average reduction in LDL cholesterol with ezetimibe alone in patients with primary hypercholesterolemia?
What is the synergistic effect of ezetimibe when combined with reductase inhibitors?
What is the synergistic effect of ezetimibe when combined with reductase inhibitors?
What happens to plasma concentrations of ezetimibe when administered with fibrates?
What happens to plasma concentrations of ezetimibe when administered with fibrates?
What is the predominant route of excretion for ezetimibe?
What is the predominant route of excretion for ezetimibe?
What is the approximate peak time for ezetimibe to reach blood levels after absorption?
What is the approximate peak time for ezetimibe to reach blood levels after absorption?
What happens to the half-life of ezetimibe when it is administered with cholestyramine?
What happens to the half-life of ezetimibe when it is administered with cholestyramine?
Which drug is available but currently restricted to patients with homozygous familial hypercholesterolemia?
Which drug is available but currently restricted to patients with homozygous familial hypercholesterolemia?
What is the essential role of microsomal triglyceride transfer protein (MTP) in the liver and intestine?
What is the essential role of microsomal triglyceride transfer protein (MTP) in the liver and intestine?
What is a potential adverse effect of lomitapide in some individuals?
What is a potential adverse effect of lomitapide in some individuals?
What is the primary therapeutic target of mipomersen?
What is the primary therapeutic target of mipomersen?
What is the mechanism of action of PCSK9 inhibitors such as evolocumab and alirocumab?
What is the mechanism of action of PCSK9 inhibitors such as evolocumab and alirocumab?
In which patient population is the use of PCSK9 inhibitors restricted?
In which patient population is the use of PCSK9 inhibitors restricted?
What is the mode of administration for lomitapide?
What is the mode of administration for lomitapide?
In which patient population is the use of PCSK9 inhibitors restricted?
In which patient population is the use of PCSK9 inhibitors restricted?
What is the primary cause of reduction in acute coronary events following vigorous lipid-lowering treatment?
What is the primary cause of reduction in acute coronary events following vigorous lipid-lowering treatment?
Apart from its cholesterol-lowering effects, when might bile acid-binding resins like colestipol and cholestyramine be helpful for patients?
Apart from its cholesterol-lowering effects, when might bile acid-binding resins like colestipol and cholestyramine be helpful for patients?
Which enzyme is responsible for the catabolism of lovastatin, simvastatin, and atorvastatin?
Which enzyme is responsible for the catabolism of lovastatin, simvastatin, and atorvastatin?
What does fenofibrate hydrolyze completely in the intestine?
What does fenofibrate hydrolyze completely in the intestine?
What is the recommended maximum daily dose of colestipol in 1-g tablets?
What is the recommended maximum daily dose of colestipol in 1-g tablets?
What are the characteristic clinical manifestations of myopathy in patients receiving reductase inhibitors?
What are the characteristic clinical manifestations of myopathy in patients receiving reductase inhibitors?
What type of remnant lipoprotein can contribute to atherosclerosis by entering the artery wall?
What type of remnant lipoprotein can contribute to atherosclerosis by entering the artery wall?
What are Lovastatin and Simvastatin classified as?
What are Lovastatin and Simvastatin classified as?
What is the standard practice regarding the initiation of reductase inhibitor therapy after acute coronary syndromes?
What is the standard practice regarding the initiation of reductase inhibitor therapy after acute coronary syndromes?
What is the impact of CETP inhibition?
What is the impact of CETP inhibition?
What is the role of AMP kinase activation in cells?
What is the role of AMP kinase activation in cells?
What is the primary function of cyclodextrins?
What is the primary function of cyclodextrins?
What is the consequence of CETP inhibition on the accumulation of HDL particles?
What is the consequence of CETP inhibition on the accumulation of HDL particles?
What is the potential benefit of AMP kinase activation for management of the metabolic syndrome and diabetes?
What is the potential benefit of AMP kinase activation for management of the metabolic syndrome and diabetes?
Which lipoprotein particles are affected by CETP inhibition?
Which lipoprotein particles are affected by CETP inhibition?
What is the approved usage of cyclodextrins?
What is the approved usage of cyclodextrins?
How does AMP kinase activation affect cholesterol and triglyceride biosynthesis?
How does AMP kinase activation affect cholesterol and triglyceride biosynthesis?
What happens to the transport of cholesteryl esters to the liver when CETP is inhibited?
What happens to the transport of cholesteryl esters to the liver when CETP is inhibited?
What is a potential area for clinical trials related to AMP kinase activation?
What is a potential area for clinical trials related to AMP kinase activation?