Huntington’s Disease Overview
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Questions and Answers

Which pathway is lost first in Huntington's Disease leading to an increased UMN excitability?

  • Striatopallidal (correct)
  • Corticostriatal
  • Striatonigral
  • Thalamocortical

    • What is the characteristic movement disorder seen in Huntington's Disease?

  • Tremor
  • Dystonia
  • Bradykinesia
  • Chorea (correct)

    • What type of inheritance pattern is observed in Huntington's Disease?

  • Y-linked dominant
  • Autosomal recessive
  • X-linked recessive
  • Autosomal dominant (correct)

    • Which region undergoes structural loss in Huntington's Disease, leading to enlargement of the lateral ventricle?

    <p>Putamen</p> Signup and view all the answers

    What mutation leads to Huntington's Disease, characterized by the expansion of which triplet within the coding region of the huntingtin gene?

    <p>CAG</p> Signup and view all the answers

    What is the main cause of neuronal loss in Huntington's disease?

    <p>Mutated huntingtin protein expression</p> Signup and view all the answers

    Which type of neurons are spared in Huntington's disease?

    <p>ACh neurons</p> Signup and view all the answers

    What treatment can be used to alleviate symptoms of Huntington's disease?

    <p>Tetrabenazine</p> Signup and view all the answers

    Which chromosome experiences a genetic mutation in Huntington's disease?

    <p>4th chromosome</p> Signup and view all the answers

    What specific order does neuronal loss follow in Huntington's disease?

    <p>Corticostriatal → striatopallidal → striatonigral</p> Signup and view all the answers

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