Human Physiology Chapter on Kidney Function
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Questions and Answers

What type of cells line the proximal convoluted tubule (PCT)?

  • Ciliated epithelial cells
  • Cuboidal epithelial cells (correct)
  • Columnar epithelial cells
  • Squamous epithelial cells
  • Which process is primarily responsible for the formation of urine?

  • Exocytosis
  • Osmosis
  • Glomerular filtration (correct)
  • Passive diffusion
  • What is the role of the macula densa in the distal convoluted tubule (DCT)?

  • Detects changes in NaCl concentration (correct)
  • Absorbs glucose
  • Secretes potassium
  • Regulates water reabsorption
  • Which structure continues from the proximal convoluted tubule to form the Loop of Henle?

    <p>Henle's loop (D)</p> Signup and view all the answers

    What is present in the descending limb of Henle's loop?

    <p>Thin segment lined by squamous cells (A)</p> Signup and view all the answers

    What part of the nephron is lined by specialized cuboidal epithelium with very few microvilli?

    <p>Collecting ducts (B)</p> Signup and view all the answers

    The DCT is located near which of the following structures in the kidney?

    <p>Renal corpuscle (B)</p> Signup and view all the answers

    Which of the following correctly describes the tubular reabsorption process?

    <p>It involves active and passive transport of substances (C)</p> Signup and view all the answers

    Which nitrogenous waste is the most toxic and requires a large amount of water for elimination?

    <p>Ammonia (B)</p> Signup and view all the answers

    Which nitrogenous waste can be stored in the body for a longer time due to its lower toxicity?

    <p>Urea (A)</p> Signup and view all the answers

    What is the least toxic nitrogenous waste that is almost insoluble in water?

    <p>Uric acid (A)</p> Signup and view all the answers

    How is carbon dioxide primarily eliminated from the body?

    <p>Through the lungs (A)</p> Signup and view all the answers

    Which of the following substances is NOT a major nitrogenous waste product excreted by the human body?

    <p>Glucose (D)</p> Signup and view all the answers

    Which type of excretion is characterized by the elimination of ammonia?

    <p>Ammonotelism (A)</p> Signup and view all the answers

    Which of the following organisms primarily exhibits ureotelism?

    <p>Cartilaginous fishes (A)</p> Signup and view all the answers

    What type of waste includes excess minerals and pigments in the body?

    <p>Non-nitrogenous waste (C)</p> Signup and view all the answers

    Which process is involved in excretion and osmotic regulation to maintain homeostasis in the body?

    <p>Excretion (C)</p> Signup and view all the answers

    In which structure are flame cells found?

    <p>Protonephridia (C)</p> Signup and view all the answers

    Uric acid is primarily formed from the metabolism of which of the following?

    <p>Purines (C)</p> Signup and view all the answers

    What is the main nitrogenous waste product excreted by uricotelic animals?

    <p>Uric acid (C)</p> Signup and view all the answers

    Which of the following animals utilize ammonotelism for nitrogenous waste excretion?

    <p>Lungfishes (B)</p> Signup and view all the answers

    What is the main function of protonephridia?

    <p>Osmoregulation (A)</p> Signup and view all the answers

    Which group of animals typically excretes nitrogenous waste in the form of uric acid?

    <p>Most insects and birds (B)</p> Signup and view all the answers

    What is a key characteristic of ammonotelic organisms?

    <p>They excrete ammonia. (A)</p> Signup and view all the answers

    Which excretory product is associated with organisms that exhibit ammonotelism?

    <p>Ammonia (C)</p> Signup and view all the answers

    What is the primary function of nephridia in annelids?

    <p>Excretion of nitrogenous waste and osmoregulation (A)</p> Signup and view all the answers

    Which mode of excretion requires the least amount of water?

    <p>Uricotelism (B)</p> Signup and view all the answers

    Which of the following structures functions in both excretion and osmoregulation in insects?

    <p>Malpighian tubules (C)</p> Signup and view all the answers

    What is the toxic nature and solubility of urea compared to ammonia?

    <p>Less toxic and more soluble (D)</p> Signup and view all the answers

    Which of the following organisms primarily utilizes antennal glands for excretion?

    <p>Prawn (A)</p> Signup and view all the answers

    The excretory structure that consists of a ciliated funnel-shaped opening is known as?

    <p>Nephrostome (D)</p> Signup and view all the answers

    Which excretory product do terrestrial insects primarily excrete?

    <p>Uric acid (A)</p> Signup and view all the answers

    Which hormone stimulates the reabsorption of NaCl and water in the proximal convoluted tubule?

    <p>Angiotensin II (B)</p> Signup and view all the answers

    What is the primary action of Atrial Natriuretic Factor (ANF)?

    <p>Act as a vasodilator (A)</p> Signup and view all the answers

    What mechanism does ANF inhibit to help regulate blood volume?

    <p>Renin-angiotensin-aldosterone system (A)</p> Signup and view all the answers

    What triggers the sensation of micturition?

    <p>Signals from sensory stretch receptors (D)</p> Signup and view all the answers

    Which muscle is under autonomic control and regulates bladder contraction during urination?

    <p>Detrusor muscle (B)</p> Signup and view all the answers

    When does the urinary bladder typically signal the need to urinate?

    <p>After filling with about 500 ml of urine (D)</p> Signup and view all the answers

    What effect does sympathetic nerve activation have on the urinary bladder?

    <p>Stimulates relaxation of the detrusor muscle (D)</p> Signup and view all the answers

    Which structure temporarily stores urine until a signal is received for its expulsion?

    <p>Urinary bladder (C)</p> Signup and view all the answers

    What triggers the relaxation of the external urethral sphincter during micturition?

    <p>Inhibition of the pudendal nerve (D)</p> Signup and view all the answers

    What is the primary pigment found in urine and its origin?

    <p>Urochrome from the breakdown of hemoglobin (D)</p> Signup and view all the answers

    What type of urine is excreted when the body is in a state of excess water?

    <p>Hypotonic urine (B)</p> Signup and view all the answers

    Which of the following is NOT considered an abnormal constituent of urine?

    <p>Urea (B)</p> Signup and view all the answers

    What is the primary role of the kidneys in relation to nitrogenous waste?

    <p>Filter out nitrogenous wastes from the blood (C)</p> Signup and view all the answers

    What happens to urine composition when the body is dehydrated?

    <p>Urine becomes hypertonic and darker (B)</p> Signup and view all the answers

    Which of the following substances is classified as a non-nitrogenous substance in urine?

    <p>Oxalic acid (A)</p> Signup and view all the answers

    How do diuretics affect urine formation?

    <p>Increase urine volume by enhancing secretion (D)</p> Signup and view all the answers

    Flashcards

    Excretion

    The process of removing metabolic waste products from the body.

    Defecation

    The removal of undigested food and other waste products from the digestive tract.

    Ammonia

    A toxic form of nitrogenous waste produced from protein breakdown. It's highly soluble in water, making it difficult to store in the body.

    Urea

    A nitrogenous waste product that is less toxic than ammonia. It's formed in the liver and is excreted in urine.

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    Uric Acid

    A nitrogenous waste product that is the least toxic of the three. It's almost insoluble in water and is excreted in feces.

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    Carbon Dioxide

    The primary non-nitrogenous waste product in the human body. It's eliminated through the lungs during respiration.

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    Osmoregulation

    A process that helps maintain the balance of water and electrolytes in the body.

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    Homeostasis

    The process of maintaining a stable internal environment in the body, despite changes in the external environment.

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    Ammonotelic

    Animals that excrete ammonia as their primary nitrogenous waste product.

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    Ammonotelism

    The process of excreting ammonia as the primary nitrogenous waste product. Common in aquatic animals.

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    Ureotelic

    Animals that excrete urea as their primary nitrogenous waste product.

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    Ureotelism

    The process of excreting urea as the primary nitrogenous waste product. Common in terrestrial animals.

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    Uricotelic

    Animals that excrete uric acid as their primary nitrogenous waste product.

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    Uricotelism

    The process of excreting uric acid as the primary nitrogenous waste product. Common in birds and reptiles.

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    Protonephridia

    A simple excretory system found in some invertebrates like flatworms. It consists of a network of tubules with flame cells.

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    Flame cells

    Specialized cells in protonephridia, containing cilia that create a current to draw water into the tubules.

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    Renette or Giant Cell

    A network of canals that form the excretory system in roundworms. The canals are connected by a bridge called canaliculi.

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    Canaliculi

    A bridge-like structure that connects the canals of the renette system. Located beneath the pharynx.

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    Nephridia

    Excretory organs in earthworms. They have a funnel-shaped opening called a nephrostome and drain waste through a nephridiopore.

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    Malpighian Tubules

    Excretory organs found in insects. Group of tubes that connect to the digestive system.

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    Antennal Glands (Green Glands)

    Excretory organs in crustaceans. They function in both excretion and osmoregulation.

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    What is the Proximal Convoluted Tubule (PCT)?

    The highly coiled network of tubules that starts after Bowman's capsule and is responsible for active absorption and secretion of materials from the glomerular filtrate.

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    What types of cells line the PCT?

    Specialized cuboidal epithelial cells that line the PCT. They have long microvilli to increase surface area for maximum reabsorption.

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    What is Henle's Loop?

    The hairpin-shaped loop that connects the PCT to the DCT. It has a descending limb and an ascending limb.

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    What is the Descending Limb of Henle's Loop?

    The part of Henle's Loop that descends into the medulla, where water reabsorption occurs.

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    What is the Ascending Limb of Henle's Loop?

    The part of Henle's Loop that ascends back towards the cortex, responsible for active salt reabsorption.

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    What is the Macula Densa?

    A specialized region of the DCT near the malpighian corpuscle, sensitive to changes in NaCl.

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    What are Collecting Ducts?

    Large tubules that collect filtered fluid from multiple nephrons before sending it to the renal pelvis.

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    What are the Ducts of Bellini?

    The main urine-carrying tubes that empty into the renal pelvis and eventually lead to the ureter.

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    Micturition reflex

    The involuntary process of emptying the urinary bladder, controlled by a reflex triggered by bladder distension.

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    Urochrome

    A pigment produced by the breakdown of hemoglobin from worn-out red blood cells, responsible for the yellow color of urine.

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    Diuretics

    Substances that increase urine formation, promoting water excretion from the body. Used to treat conditions like high blood pressure and edema.

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    Kidney filtration

    The process of removing waste products like urea and creatinine from the blood, ensuring proper blood composition and preventing buildup of harmful substances.

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    Abnormal constituents in urine

    Abnormal components found in urine, often indicating metabolic disorders or kidney dysfunction. Examples include glucose, albumin, and blood cells.

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    Regulation of salt balance

    The ability of the kidneys to control the balance of sodium and potassium ions in the body, crucial for nerve and muscle function.

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    Micturition

    The process of releasing urine from the urinary bladder, involving both voluntary and involuntary muscle control.

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    Atrial Natriuretic Factor (ANF)

    A hormone produced by the walls of the atria of the heart in response to an increase in blood volume and pressure. It helps regulate blood volume and pressure by acting as a vasodilator, inhibiting renin release, and reducing aldosterone secretion.

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    Vasodilation

    The expansion of blood vessels, resulting in a decrease in blood pressure.

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    Renin-Angiotensin-Aldosterone System (RAAS)

    A complex hormonal system that regulates blood pressure and volume by controlling the constriction and dilation of blood vessels, the reabsorption of sodium and water, and the release of aldosterone.

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    Juxtaglomerular Apparatus (JGA)

    The specialized region in the kidney that senses changes in blood pressure and salt levels.

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    Detrusor Muscle

    The smooth muscle in the wall of the urinary bladder, responsible for contracting to expel urine during micturition.

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    Internal Sphincter

    The internal sphincter of the urinary bladder, which controls the involuntary release of urine. It is under autonomic nervous system control.

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    External Sphincter

    The external sphincter of the urinary bladder, which controls the voluntary release of urine. It is under the control of the central nervous system.

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    Study Notes

    Excretory Products and Their Elimination

    • Organisms carry out many metabolic reactions, producing waste products.
    • Excretion is the process of eliminating metabolic wastes and unused materials.
    • Defecation is the removal of undigested food.
    • Osmoregulation is regulating the salt and water concentration in the body.
    • Nitrogenous wastes include ammonia, urea, and uric acid.
    • Ammonia is highly toxic and soluble in water, thus requiring a large amount of water for its removal.
    • Urea is less toxic than ammonia and less soluble in water.
    • Uric acid is the least toxic and nearly insoluble in water.
    • Non-nitrogenous wastes include carbon dioxide, non-metabolised minerals, vitamins, excess water, pigments, and drugs.
    • Carbon dioxide is eliminated through the lungs.
    • Water is removed through perspiration and urination.
    • Excess minerals, vitamins, or pigments, are excreted via urine, sweat, or faeces.
    • Major modes of excretion include ammonotelism, ureotelism, and uricotelism.
    • Ammonotelism is observed in animals excreting ammonia (e.g., aquatic animals).
    • Ureotelism is observed in animals excreting urea (e.g., cartilaginous fishes, mammals).
    • Uricotelism is observed in animals excreting uric acid (e.g., birds, reptiles).
    • Minor modes of excretion include aminotelism and guanotelism.

    Structures involved in excretion

    • Protonephridia are a network of tubules that help in osmoregulation and excretion, found in flatworms, rotifers, and other invertebrates.
    • Nephridia are excretory structures in annelids (e.g., earthworms).
    • Malpighian tubules are the main excretory structures in insects.
    • Kidneys are bean-shaped organs found in vertebrates, especially humans.

    Human Excretory System

    • Kidneys (2), ureters (2), urinary bladder, and urethra are components of the system.
    • Kidneys perform primary function of excretion.
    • The kidney includes an outer cortex and an inner medulla.
    • The functional unit of the kidney is the nephron.
    • Nephrons are composed of glomerulus and renal tubule.
    • Renal tubule consists of four parts; proximal convoluted tubule (PCT), loop of Henle, distal convoluted tubule (DCT), and collecting duct.
    • Glomerulus is a tuft of capillaries within Bowman's capsule.
    • Blood is filtered, creating filtrate, through Bowman's capsule.
    • Most substances are reabsorbed in tubules, and waste products are secreted.
    • Urine formation involves three processes: glomerular filtration, tubular reabsorption, and tubular secretion.

    Regulation of Kidney Function

    • Antidiuretic hormone (ADH) controls water reabsorption in the distal convoluted tubule.
    • Juxtaglomerular apparatus (JGA), a part of nephron, releases renin which regulates blood pressure and glomerular filtration rate.
    • Atrial natriuretic factor (ANF) causes a decrease in glomerular blood pressure and results in increased urination by dialating vessels.

    Abnormal constituents in urine

    • Proteinuria (or albuminuria) indicates inflammation of the glomeruli.
    • Ketonuria indicates increased metabolism of fats.
    • Glycosuria indicates high blood glucose and diabetes.
    • Haematuria indicates presence of blood or blood cells.
    • Pyuria indicates presence of WBCs.
    • Haemoglobinuria indicates presence of hemoglobin.

    Renal Failure

    • Renal failure refers to the inability of the kidneys to adequately filter waste products and maintain fluid balance.

    Kidney Transplantation

    • A kidney can be transplanted from a compatible living or deceased donor to a recipient.
    • Success of the procedure often depends on the compatibility of the donor and recipient tissues.

    Hemodialysis

    • Helps remove waste products and excess fluid from the blood when the kidneys are not functioning properly. A mechanical dialysis unit is needed.

    Excretory Products

    • Ammonia, urea, uric acid, carbon dioxide, water, salts, pigments, hormones, and drugs are excretory products.

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    Description

    Test your knowledge on the functions and structures of the nephron in this quiz. It covers the proximal convoluted tubule, distal convoluted tubule, and processes involved in urine formation. Challenge yourself with questions about tubular reabsorption and nitrogenous waste elimination.

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