Podcast
Questions and Answers
Which of the following statements best describes homeostasis?
Which of the following statements best describes homeostasis?
- A dynamic state of equilibrium where the internal environment varies within narrow limits. (correct)
- A static state where the internal environment is fixed.
- The absence of any change in bodily functions.
- A process that always uses positive feedback to maintain stability.
What is the primary function of the respiratory system in maintaining homeostasis?
What is the primary function of the respiratory system in maintaining homeostasis?
- Breaking down food and absorbing nutrients into the bloodstream.
- Regulating blood pressure through vasoconstriction and vasodilation.
- Filtering nitrogenous wastes from the blood to maintain osmolarity.
- Facilitating gas exchange by adding oxygen and removing carbon dioxide. (correct)
Which of these is an example of a positive feedback mechanism?
Which of these is an example of a positive feedback mechanism?
- Body temperature regulation through sweating or shivering.
- Amplification of cytokine production in immunity. (correct)
- Regulation of blood glucose levels by insulin.
- Maintaining blood pressure through the baroreceptor reflex.
Which of the following organ systems is responsible for eliminating nitrogenous wastes and maintaining acid-base balance?
Which of the following organ systems is responsible for eliminating nitrogenous wastes and maintaining acid-base balance?
Which of the following is the correct order of the structural organization in physiology, from simplest to most complex?
Which of the following is the correct order of the structural organization in physiology, from simplest to most complex?
In a homeostatic control mechanism, what is the role of the receptor?
In a homeostatic control mechanism, what is the role of the receptor?
What term describes a disturbance in homeostasis that results in disease?
What term describes a disturbance in homeostasis that results in disease?
Which of the following enables the body to sense changes and initiate a reaction?
Which of the following enables the body to sense changes and initiate a reaction?
What is the role of the effector in a homeostatic control system?
What is the role of the effector in a homeostatic control system?
Which system is the fastest-acting control system in the body?
Which system is the fastest-acting control system in the body?
What does the Greek prefix 'Homeo-' in 'Homeostasis' refer to?
What does the Greek prefix 'Homeo-' in 'Homeostasis' refer to?
Which of the following statements is correct regarding organ systems?
Which of the following statements is correct regarding organ systems?
Which of the following best describes the role of the cardiovascular system in maintaining homeostasis?
Which of the following best describes the role of the cardiovascular system in maintaining homeostasis?
The term 'Physiology' can be described as...
The term 'Physiology' can be described as...
Which statement is most accurate regarding positive feedback loops and homeostasis?
Which statement is most accurate regarding positive feedback loops and homeostasis?
The muscular system contributes to homeostasis EXCEPT by which function?
The muscular system contributes to homeostasis EXCEPT by which function?
Which statement is most accurate regarding homeostasis?
Which statement is most accurate regarding homeostasis?
Which statement is the most accurate regarding the relationship between anatomy and physiology?
Which statement is the most accurate regarding the relationship between anatomy and physiology?
Which of the following best illustrates the concept of homeostasis?
Which of the following best illustrates the concept of homeostasis?
Which of the following is an example of a negative feedback loop in the human body?
Which of the following is an example of a negative feedback loop in the human body?
Which of the following is NOT a characteristic of positive feedback loops?
Which of the following is NOT a characteristic of positive feedback loops?
Which of the following prefixes relates to the intestine?
Which of the following prefixes relates to the intestine?
Which of these is the best definition of pathophysiology?
Which of these is the best definition of pathophysiology?
Which term describes the production of glucose from non-carbohydrate sources?
Which term describes the production of glucose from non-carbohydrate sources?
Which of the following statements reflects the importance of homeostasis?
Which of the following statements reflects the importance of homeostasis?
If blood glucose levels drop too low, which process does the liver perform to restore them?
If blood glucose levels drop too low, which process does the liver perform to restore them?
Why is homeostasis described as 'dynamic'?
Why is homeostasis described as 'dynamic'?
Which of the following is an example of how multiple organ systems work together to maintain homeostasis?
Which of the following is an example of how multiple organ systems work together to maintain homeostasis?
What is the primary function of the endocrine system in maintaining homeostasis?
What is the primary function of the endocrine system in maintaining homeostasis?
Under normal physiological conditions, which type of feedback loop is least likely to maintain a physiological parameter at a constant value?
Under normal physiological conditions, which type of feedback loop is least likely to maintain a physiological parameter at a constant value?
In the context of homeostasis, what distinguishes Type 1 from Type 2 diabetes?
In the context of homeostasis, what distinguishes Type 1 from Type 2 diabetes?
Which of the following is an example of a homeostatic process that involves multiple regulatory systems working in opposition?
Which of the following is an example of a homeostatic process that involves multiple regulatory systems working in opposition?
In the below homeostatic mechanism diagram, what do the numbers 1-5 represent? (In order)
In the below homeostatic mechanism diagram, what do the numbers 1-5 represent? (In order)
Which of the following statements accurately reflects a key principle of physiology?
Which of the following statements accurately reflects a key principle of physiology?
Which is the most accurate definition of 'dynamic equilibrium' in the contact of homeostasis?
Which is the most accurate definition of 'dynamic equilibrium' in the contact of homeostasis?
According to the principles of physiology, what describes the flow of information?
According to the principles of physiology, what describes the flow of information?
In pathophysiology, when a homeostatic set point is not well-tolerated, what typically happens?
In pathophysiology, when a homeostatic set point is not well-tolerated, what typically happens?
Select the incorrect statement.
Select the incorrect statement.
What is always true of Positive Feedback Loops?
What is always true of Positive Feedback Loops?
What effect does Lipolysis have on the blood?
What effect does Lipolysis have on the blood?
Which statement best describes human physiology?
Which statement best describes human physiology?
Which of the following functions is NOT directly associated with the digestive system's role in homeostasis?
Which of the following functions is NOT directly associated with the digestive system's role in homeostasis?
Glycolysis turns glucose into pyruvate, this is broken down in what system?
Glycolysis turns glucose into pyruvate, this is broken down in what system?
With reference to the immune system, put these in order of time:
With reference to the immune system, put these in order of time:
Rank the body functions from most basic to most advanced:
Rank the body functions from most basic to most advanced:
Why is homeostasis essential for health and survival?
Why is homeostasis essential for health and survival?
According to the principles of physiology, what is the order that signals travel in?
According to the principles of physiology, what is the order that signals travel in?
Which level of structural organization is considered the most basic?
Which level of structural organization is considered the most basic?
What primarily defines human physiology?
What primarily defines human physiology?
Which of the following is the most inclusive level of structural organization in the human body?
Which of the following is the most inclusive level of structural organization in the human body?
Which of the following best describes the relationship between anatomy and physiology?
Which of the following best describes the relationship between anatomy and physiology?
Which of the following best describes the 'dynamic' aspect of homeostasis?
Which of the following best describes the 'dynamic' aspect of homeostasis?
Which two systems are most influential in maintaining homeostasis?
Which two systems are most influential in maintaining homeostasis?
What is the role of the 'control center' in a homeostatic control mechanism?
What is the role of the 'control center' in a homeostatic control mechanism?
Which system is primarily responsible for break-down and delivery of nutrients?
Which system is primarily responsible for break-down and delivery of nutrients?
What is the role of the effector of a feedback loop?
What is the role of the effector of a feedback loop?
Which of the following is NOT directly involved in maintaining blood nutrient homeostasis?
Which of the following is NOT directly involved in maintaining blood nutrient homeostasis?
The prefix 'Nephr-' refers to which organ?
The prefix 'Nephr-' refers to which organ?
Which of the following describes the function of the respiratory system?
Which of the following describes the function of the respiratory system?
Which of the following best describes the homeostatic function of the urinary system?
Which of the following best describes the homeostatic function of the urinary system?
What phrase always describes a homeostatic mechanism?
What phrase always describes a homeostatic mechanism?
Under homeostatic control, what is the likely result of increased glucagon release?
Under homeostatic control, what is the likely result of increased glucagon release?
What is the primary role of the cardiovascular system in the context of homeostasis?
What is the primary role of the cardiovascular system in the context of homeostasis?
Which of the following is LEAST associated with the muscular system's contribution to homeostasis?
Which of the following is LEAST associated with the muscular system's contribution to homeostasis?
In the context of homeostatic control, what is the definition of a 'stimulus'?
In the context of homeostatic control, what is the definition of a 'stimulus'?
Which of the following is the Greek root for 'intestine'?
Which of the following is the Greek root for 'intestine'?
In the context of the glucose regulation, what is the effector?
In the context of the glucose regulation, what is the effector?
Which of the following processes increases blood glucose levels?
Which of the following processes increases blood glucose levels?
Which organ system is primarily involved in eliminating nitrogenous wastes?
Which organ system is primarily involved in eliminating nitrogenous wastes?
Why are positive feedback loops less common in physiological systems compared to negative feedback loops?
Why are positive feedback loops less common in physiological systems compared to negative feedback loops?
How does the endocrine system primarily contribute to maintaining homeostasis?
How does the endocrine system primarily contribute to maintaining homeostasis?
Which of the following statements best describes the relationship between homeostasis and disease?
Which of the following statements best describes the relationship between homeostasis and disease?
Which statement accurately contrasts Type 1 and Type 2 diabetes in the context of homeostasis?
Which statement accurately contrasts Type 1 and Type 2 diabetes in the context of homeostasis?
In a homeostatic control system, what is the function of the afferent pathway?
In a homeostatic control system, what is the function of the afferent pathway?
In the immune system, auto-amplification of cytokines is balanced by cytokine signalling suppressors. This demonstrates how the immune system...
In the immune system, auto-amplification of cytokines is balanced by cytokine signalling suppressors. This demonstrates how the immune system...
If blood calcium levels are too high, which of the following would occur to restore homeostasis?
If blood calcium levels are too high, which of the following would occur to restore homeostasis?
Which process describes the production of glucose from non-carbohydrate sources, under homeostatic regulation?
Which process describes the production of glucose from non-carbohydrate sources, under homeostatic regulation?
Which organ is LEAST involved in water homeostasis?
Which organ is LEAST involved in water homeostasis?
Which of the following statements is true regarding positive feedback loops in the human body?
Which of the following statements is true regarding positive feedback loops in the human body?
What defines 'dynamic equilibrium' in the context of homeostasis?
What defines 'dynamic equilibrium' in the context of homeostasis?
Which characteristic is MOST likely observed in a physiological parameter regulated by multiple regulatory systems in opposition?
Which characteristic is MOST likely observed in a physiological parameter regulated by multiple regulatory systems in opposition?
What is one reason that immune therapies, such as cytokine therapies, require tight dosage windows to be effective?
What is one reason that immune therapies, such as cytokine therapies, require tight dosage windows to be effective?
Imagine someone has no homeostatic mechanisms (e.g. no sweating, cannot regulate temperature, etc.). Assuming they are not receiving any medical intervention (e.g. dialysis), in what order would these conditions kill someone, from soonest to latest?
Imagine someone has no homeostatic mechanisms (e.g. no sweating, cannot regulate temperature, etc.). Assuming they are not receiving any medical intervention (e.g. dialysis), in what order would these conditions kill someone, from soonest to latest?
Which of the following is NOT considered a primary function within human physiology?
Which of the following is NOT considered a primary function within human physiology?
Which level of structural organization includes two or more tissue types working together to perform specific, complex functions?
Which level of structural organization includes two or more tissue types working together to perform specific, complex functions?
Which of the following processes is an example of excretion?
Which of the following processes is an example of excretion?
Which example describes the function of the muscular system in contributing to homeostasis?
Which example describes the function of the muscular system in contributing to homeostasis?
What does it mean to say that homeostasis is a 'dynamic' process?
What does it mean to say that homeostasis is a 'dynamic' process?
Which of the following is the best description of Pathophysiology?
Which of the following is the best description of Pathophysiology?
Which of the following is an example of a positive feedback loop that does NOT result in homeostasis?
Which of the following is an example of a positive feedback loop that does NOT result in homeostasis?
During the human stress response, epinephrine and norepinephrine are released. What effect does this have on blood-glucose homeostasis?
During the human stress response, epinephrine and norepinephrine are released. What effect does this have on blood-glucose homeostasis?
How does the cardiovascular system assist the digestive system in maintaining nutrient homeostasis?
How does the cardiovascular system assist the digestive system in maintaining nutrient homeostasis?
In a negative feedback loop controlling body temperature, what would happen if body temperature rises above the set point?
In a negative feedback loop controlling body temperature, what would happen if body temperature rises above the set point?
Which of the following is NOT a main component of a homeostatic control system?
Which of the following is NOT a main component of a homeostatic control system?
Which organ system is most directly involved in regulating blood pressure?
Which organ system is most directly involved in regulating blood pressure?
What is the function of the 'afferent pathway' in a homeostatic control system?
What is the function of the 'afferent pathway' in a homeostatic control system?
Which of these describes the likely set-point for blood glucose in a person with poorly controlled Type 2 diabetes?
Which of these describes the likely set-point for blood glucose in a person with poorly controlled Type 2 diabetes?
If the body detects a decrease in blood volume, which of the following responses would NOT be part of the homeostatic mechanism to restore it?
If the body detects a decrease in blood volume, which of the following responses would NOT be part of the homeostatic mechanism to restore it?
Which statement accurately contrasts Type 1 and Type 2 diabetes in the maintenance of homeostasis?
Which statement accurately contrasts Type 1 and Type 2 diabetes in the maintenance of homeostasis?
What is the meaning of the prefix 'entero-'?
What is the meaning of the prefix 'entero-'?
What is the primary role of the effector in a feedback loop?
What is the primary role of the effector in a feedback loop?
Epinephrine and norepinephrine are released during the human stress response. Apart from blood-glucose homeostasis, what is the effect on the blood?
Epinephrine and norepinephrine are released during the human stress response. Apart from blood-glucose homeostasis, what is the effect on the blood?
Consider a scenario where blood pressure increases significantly. According to a negative feedback loop, which subsequent event would help restore homeostasis?
Consider a scenario where blood pressure increases significantly. According to a negative feedback loop, which subsequent event would help restore homeostasis?
Which component of a homeostatic control system is responsible for determining the appropriate response to a change in the internal environment?
Which component of a homeostatic control system is responsible for determining the appropriate response to a change in the internal environment?
What is the primary role of the respiratory system in maintaining gas homeostasis?
What is the primary role of the respiratory system in maintaining gas homeostasis?
The digestive system contributes to homeostasis by?
The digestive system contributes to homeostasis by?
Consider a scenario where the body is dehydrated. Which of the following would occur to restore fluid balance?
Consider a scenario where the body is dehydrated. Which of the following would occur to restore fluid balance?
Which of the following organ systems would have the LEAST influence on an individual's blood pressure?
Which of the following organ systems would have the LEAST influence on an individual's blood pressure?
A person's body temperature drops significantly in a cold environment. What homeostatic response is intiated?
A person's body temperature drops significantly in a cold environment. What homeostatic response is intiated?
Why are homeostatic mechanisms considered crucial for survival?
Why are homeostatic mechanisms considered crucial for survival?
If blood calcium levels drop too low, which of the following would be the most likely homeostatic response?
If blood calcium levels drop too low, which of the following would be the most likely homeostatic response?
Select the most accurate statement concerning Feedback Loops?
Select the most accurate statement concerning Feedback Loops?
Following food consumption, what processes are activated to maintain blood glucose levels?
Following food consumption, what processes are activated to maintain blood glucose levels?
In a person with poorly controlled diabetes insipidus caused by insufficient ADH (antidiuretic hormone) release, which of the following symptoms would be most prominent?
In a person with poorly controlled diabetes insipidus caused by insufficient ADH (antidiuretic hormone) release, which of the following symptoms would be most prominent?
Which example describes the communication between organ systems to maintain homeostasis?
Which example describes the communication between organ systems to maintain homeostasis?
In the context of the immune system, what differentiates a cytokine from a chemokine?
In the context of the immune system, what differentiates a cytokine from a chemokine?
How does the principle of 'controlled exchange of materials' apply to the function of the nephron in the kidney?
How does the principle of 'controlled exchange of materials' apply to the function of the nephron in the kidney?
What does it mean to say that positive feedback loops in physiology 'can shift the homeostatic set point to a new level'?
What does it mean to say that positive feedback loops in physiology 'can shift the homeostatic set point to a new level'?
Which of the following is the best explanation of why negative feedback loops are more common in physiological systems compared to positive feedback loops?
Which of the following is the best explanation of why negative feedback loops are more common in physiological systems compared to positive feedback loops?
Which of the following best describes the coordination and communication between the nervous and endocrine systems to control blood glucose levels?
Which of the following best describes the coordination and communication between the nervous and endocrine systems to control blood glucose levels?
If a person is continuously exposed to stressful stimuli, leading to chronically elevated cortisol levels, how might this affect their immune system?
If a person is continuously exposed to stressful stimuli, leading to chronically elevated cortisol levels, how might this affect their immune system?
If someone is wounded, and loses more and more blood, the body must clot the wound to survive. What is always true of the homeostatic set-point in this scenario?
If someone is wounded, and loses more and more blood, the body must clot the wound to survive. What is always true of the homeostatic set-point in this scenario?
Imagine a scenario in which a new drug completely blocks the function of the effector in a homeostatic control system. How would a person's body respond to changes in the controlled variable?
Imagine a scenario in which a new drug completely blocks the function of the effector in a homeostatic control system. How would a person's body respond to changes in the controlled variable?
Consider a situation where a person has a genetic mutation that completely disables their ability to produce chemokines. What is the most likely result?
Consider a situation where a person has a genetic mutation that completely disables their ability to produce chemokines. What is the most likely result?
A drug is given that promotes Calcium intake into bone at all costs. Why might this be damaging?
A drug is given that promotes Calcium intake into bone at all costs. Why might this be damaging?
Which of the following is the correct order of complexity in the structural organization of the human body?
Which of the following is the correct order of complexity in the structural organization of the human body?
Which of the following is the correct term for the maintenance of a stable internal environment?
Which of the following is the correct term for the maintenance of a stable internal environment?
Which organ system is responsible for the breakdown and delivery of nutrients to the body?
Which organ system is responsible for the breakdown and delivery of nutrients to the body?
What is the primary role of the respiratory system?
What is the primary role of the respiratory system?
Which of the following best describes human physiology?
Which of the following best describes human physiology?
The Greek prefix 'entero-' relates to which of the following?
The Greek prefix 'entero-' relates to which of the following?
In the context of a homeostatic control mechanism, what name is given to the component that detects changes in the regulated variable?
In the context of a homeostatic control mechanism, what name is given to the component that detects changes in the regulated variable?
Which of the following describes the relationship between anatomy and physiology?
Which of the following describes the relationship between anatomy and physiology?
Which term is most appropriate to describe homeostasis?
Which term is most appropriate to describe homeostasis?
Which of the following systems is primarily responsible for eliminating nitrogenous wastes from the body, supporting homeostasis?
Which of the following systems is primarily responsible for eliminating nitrogenous wastes from the body, supporting homeostasis?
If body temperature rises above normal, what is the body’s likely response in a negative feedback loop?
If body temperature rises above normal, what is the body’s likely response in a negative feedback loop?
During the human stress response, epinephrine and norepinephrine are released. What is the effect of these hormones on glycogenolysis?
During the human stress response, epinephrine and norepinephrine are released. What is the effect of these hormones on glycogenolysis?
The muscular system contributes to homeostasis in multiple ways. Which of the following contributes MOST to thermoregulation?
The muscular system contributes to homeostasis in multiple ways. Which of the following contributes MOST to thermoregulation?
Which of the following represents the primary function of the cardiovascular system in maintaining homeostasis?
Which of the following represents the primary function of the cardiovascular system in maintaining homeostasis?
Why is homeostasis described as being maintained by 'dynamic equilibrium'?
Why is homeostasis described as being maintained by 'dynamic equilibrium'?
What is the function of the effector in a negative feedback loop?
What is the function of the effector in a negative feedback loop?
Which of the following reflects a key principle of physiology regarding the coordination of organ systems?
Which of the following reflects a key principle of physiology regarding the coordination of organ systems?
A drop in body temperature triggers shivering, which generates heat. Which of the following components of a homeostatic control system is responsible for producing the body heat?
A drop in body temperature triggers shivering, which generates heat. Which of the following components of a homeostatic control system is responsible for producing the body heat?
After a meal, blood glucose levels increase, stimulating the release of insulin. Insulin increases glucose uptake by cells, reducing high blood glucose levels. Which component of the homeostatic control system is the stimulus?
After a meal, blood glucose levels increase, stimulating the release of insulin. Insulin increases glucose uptake by cells, reducing high blood glucose levels. Which component of the homeostatic control system is the stimulus?
The suffix '-lysis' refers to:
The suffix '-lysis' refers to:
If you have eaten a large meal and blood glucose levels are too high, which of the following is not likely to occur?
If you have eaten a large meal and blood glucose levels are too high, which of the following is not likely to occur?
Why are negative feedback loops more common in physiological systems than positive feedback loops?
Why are negative feedback loops more common in physiological systems than positive feedback loops?
In the context of homeostatic control, what is the primary distinction between Type 1 and Type 2 diabetes?
In the context of homeostatic control, what is the primary distinction between Type 1 and Type 2 diabetes?
Which statement reflects why immune therapies, such as cytokine therapies, require tight dosage windows to be effective?
Which statement reflects why immune therapies, such as cytokine therapies, require tight dosage windows to be effective?
What is the underlying relationship between homeostasis and pathophysiology?
What is the underlying relationship between homeostasis and pathophysiology?
When homeostasis cannot be maintained in the event of blood loss, what is always true regarding the set-point?
When homeostasis cannot be maintained in the event of blood loss, what is always true regarding the set-point?
Imagine someone has no homeostatic mechanisms (sweating, cannot regulate temperature, etc.). Assuming they are not receiving any medical intervention (e.g. dialysis), list the order these conditions would kill them, from soonest to latest?
Imagine someone has no homeostatic mechanisms (sweating, cannot regulate temperature, etc.). Assuming they are not receiving any medical intervention (e.g. dialysis), list the order these conditions would kill them, from soonest to latest?
Under normal physiological conditions, which type of feedback loop is least likely to cause a sustained deviation from a homeostatic set point?
Under normal physiological conditions, which type of feedback loop is least likely to cause a sustained deviation from a homeostatic set point?
If the body detects a decrease in blood osmolarity, which of the following responses would be part of the homeostatic mechanism to restore it?
If the body detects a decrease in blood osmolarity, which of the following responses would be part of the homeostatic mechanism to restore it?
Which of the following best explains 'dynamic equilibrium' in homeostasis?
Which of the following best explains 'dynamic equilibrium' in homeostasis?
With reference to the glucostatic control negative feedback look, put these events in order:
With reference to the glucostatic control negative feedback look, put these events in order:
Which activity is LEAST related to human physiology?
Which activity is LEAST related to human physiology?
The breakdown and delivery of nutrients throughout the body is primarily a function of which system?
The breakdown and delivery of nutrients throughout the body is primarily a function of which system?
Which of the following represents the correct order of complexity in the structural organization of the human body?
Which of the following represents the correct order of complexity in the structural organization of the human body?
Which of the following is NOT considered a function within human physiology?
Which of the following is NOT considered a function within human physiology?
What is a key distinction between Type 1 and Type 2 diabetes regarding regulatory systems?
What is a key distinction between Type 1 and Type 2 diabetes regarding regulatory systems?
Which of the following pairs of systems are the MOST directly involved in regulating blood pressure?
Which of the following pairs of systems are the MOST directly involved in regulating blood pressure?
In a typical negative feedback loop, what is the effect of the effector's response on the initial stimulus?
In a typical negative feedback loop, what is the effect of the effector's response on the initial stimulus?
Which statement accurately describes the relationship between organ systems in maintaining homeostasis?
Which statement accurately describes the relationship between organ systems in maintaining homeostasis?
Considering the principles of physiology, why might a drug designed to lower blood pressure also have an unintended effect on kidney function?
Considering the principles of physiology, why might a drug designed to lower blood pressure also have an unintended effect on kidney function?
In the context of homeostasis, what does it mean to say that organ systems are 'coordinated'?
In the context of homeostasis, what does it mean to say that organ systems are 'coordinated'?
If the body is becoming hyperglycemic, which of the following processes is LEAST likely to occur under normal homeostatic control?
If the body is becoming hyperglycemic, which of the following processes is LEAST likely to occur under normal homeostatic control?
What is exemplified by the interplay between the nervous and endocrine systems in glucose regulation?
What is exemplified by the interplay between the nervous and endocrine systems in glucose regulation?
Which component of a homeostatic control functions as the 'thermostat' setting the target value?
Which component of a homeostatic control functions as the 'thermostat' setting the target value?
After eating a large meal, which event would LEAST contribute to restoring blood glucose homeostasis?
After eating a large meal, which event would LEAST contribute to restoring blood glucose homeostasis?
Why is it important that positive feedback loops are typically controlled by negative feedback loops or external factors?
Why is it important that positive feedback loops are typically controlled by negative feedback loops or external factors?
Given that the suffix '-lysis' refers to 'unfastening, loose, untie', which process describes the breakdown of glycogen into glucose?
Given that the suffix '-lysis' refers to 'unfastening, loose, untie', which process describes the breakdown of glycogen into glucose?
How would continually high cortisol levels likely affect the immune response?
How would continually high cortisol levels likely affect the immune response?
Within the immune system, what is the key difference between cytokines and chemokines?
Within the immune system, what is the key difference between cytokines and chemokines?
A drug promotes calcium intake into bone at all costs. Why might this be damaging?
A drug promotes calcium intake into bone at all costs. Why might this be damaging?
What is the BEST explanation of why negative feedback loops are more prevalent across human system, rather than positive feedback loops?
What is the BEST explanation of why negative feedback loops are more prevalent across human system, rather than positive feedback loops?
Imagine a person whose body cannot produce chemokines. What is MOST LIKELY to happen?
Imagine a person whose body cannot produce chemokines. What is MOST LIKELY to happen?
In the context of blood loss, what typically happens to the homeostatic set point?
In the context of blood loss, what typically happens to the homeostatic set point?
A new drug completely blocks the function of the effector in a homeostatic control system. How would a person’s body respond to changes in the controlled variable?
A new drug completely blocks the function of the effector in a homeostatic control system. How would a person’s body respond to changes in the controlled variable?
Why do immune therapies, such as cytokine treatments, require tight dosage windows to be effective?
Why do immune therapies, such as cytokine treatments, require tight dosage windows to be effective?
Which system is responsible for both adding oxygen to the blood and removing carbon dioxide?
Which system is responsible for both adding oxygen to the blood and removing carbon dioxide?
Which of the following describes the structural organization of the body from simplest to most complex?
Which of the following describes the structural organization of the body from simplest to most complex?
The term 'physiology' is BEST described as the study of:
The term 'physiology' is BEST described as the study of:
Which organ system is primarily responsible for maintaining fluid volume and blood pressure?
Which organ system is primarily responsible for maintaining fluid volume and blood pressure?
Which of these Greek prefixes is related to the kidney?
Which of these Greek prefixes is related to the kidney?
Which of the following is the fastest-acting control system in the body, responding rapidly to internal and external changes?
Which of the following is the fastest-acting control system in the body, responding rapidly to internal and external changes?
Which statement about positive feedback loops are always true?
Which statement about positive feedback loops are always true?
What level of structural organization is liver?
What level of structural organization is liver?
What best describes an imbalance in homeostasis that results in a disease?
What best describes an imbalance in homeostasis that results in a disease?
What is the role of the 'input' pathway in a homeostatic control mechanism?
What is the role of the 'input' pathway in a homeostatic control mechanism?
Apart from blood-glucose levels, what else do Epinephrine and norepinephrine affect in relation to the blood?
Apart from blood-glucose levels, what else do Epinephrine and norepinephrine affect in relation to the blood?
What is the importance of homeostasis?
What is the importance of homeostasis?
What's always true of homeostasis?
What's always true of homeostasis?
How can a positive feedback loop cause death?
How can a positive feedback loop cause death?
Which list the levels of structural organization in the body in the correct order, from simplest to most complex?
Which list the levels of structural organization in the body in the correct order, from simplest to most complex?
The term 'dynamic equilibrium', when referring to homeostasis, means:
The term 'dynamic equilibrium', when referring to homeostasis, means:
During exercise, the body temperature rises. Which of the following initiates a negative feedback loop to maintain thermal homeostasis?
During exercise, the body temperature rises. Which of the following initiates a negative feedback loop to maintain thermal homeostasis?
Why are negative feedback loops more common in physiological homeostasis than positive feedback loops?
Why are negative feedback loops more common in physiological homeostasis than positive feedback loops?
Flashcards
What is physiology?
What is physiology?
The study of the mechanical, physical, and biochemical functions of living organisms.
What are the processes of life?
What are the processes of life?
Movement, respiration, sensitivity, nutrition, excretion, reproduction, and growth.
What is the structural organization of the body?
What is the structural organization of the body?
Molecular, cellular, tissue, organ, organ system, organism.
What is homeostasis?
What is homeostasis?
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What is homeostatic imbalance (Pathophysiology)?
What is homeostatic imbalance (Pathophysiology)?
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Muscular System Functions
Muscular System Functions
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Cardiovascular System Functions
Cardiovascular System Functions
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Respiratory System Functions
Respiratory System Functions
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Digestive System Functions
Digestive System Functions
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Nervous System Functions
Nervous System Functions
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Endocrine System Functions
Endocrine System Functions
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Urinary System Functions
Urinary System Functions
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What is 'Input' in a homeostatic control mechanism?
What is 'Input' in a homeostatic control mechanism?
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What is 'Output' in a homeostatic control mechanism?
What is 'Output' in a homeostatic control mechanism?
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What is the 'Response' in a homeostatic control mechanism?
What is the 'Response' in a homeostatic control mechanism?
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What initiates the homeostatic mechanism?
What initiates the homeostatic mechanism?
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Glucostatic control - Homeostasis
Glucostatic control - Homeostasis
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Rising Blood Glucose Level
Rising Blood Glucose Level
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Liver's Role in Glucose Regulation
Liver's Role in Glucose Regulation
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Cellular Glucose Uptake
Cellular Glucose Uptake
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Declining Blood Glucose Level
Declining Blood Glucose Level
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Liver's Response to Low Glucose
Liver's Response to Low Glucose
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High Glucose Response
High Glucose Response
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Low Glucose Response
Low Glucose Response
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What is Gluconeogenesis?
What is Gluconeogenesis?
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What is Glycogenolysis?
What is Glycogenolysis?
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What is Lipolysis?
What is Lipolysis?
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What is Glycogenesis?
What is Glycogenesis?
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What is Lipogenesis?
What is Lipogenesis?
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Negative Feedback Loops
Negative Feedback Loops
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Negative Feedback Loops
Negative Feedback Loops
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Homeostatic Set-Point
Homeostatic Set-Point
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Dynamic Equilibrium
Dynamic Equilibrium
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New Homeostatic Set-Points
New Homeostatic Set-Points
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New Homeostatic Set-Points - Examples
New Homeostatic Set-Points - Examples
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Imbalance in 'normal' homeostasis
Imbalance in 'normal' homeostasis
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System Regulation
System Regulation
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Health and Survival
Health and Survival
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Material Exchange
Material Exchange
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Chemistry and Physics.
Chemistry and Physics.
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Structure and Function
Structure and Function
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Study Notes
Learning Outcomes
- Human physiology should be described
- The structure and function of key systems should be outlined
- Homeostasis should be described
- Positive and negative feedback systems should be explained
Physiology: The Science of Life
- Physiology studies life processes
- The processes include movement, respiration, sensation, nutrition, excretion, reproduction and growth
- Movement includes movement of substances and locomotion
- Respiration involves gas exchange
- Sensation is about responsiveness and the ability to sense changes and react
- Nutrition involves the break-down and delivery of nutrients and encompasses metabolism
- Metabolism covers all chemical reactions that occur within the body, including energy production and making body structures
- Excretion is the elimination of waste from metabolic reactions
- Reproduction is the production of future generations
- Growth involves the increasing of cell size or number
Physiology: Structural Organization
- Structural Organization: Molecular, Cellular, Tissue, Organ, Organ System, Organism
- Physiology requires understanding of anatomy to explain it
Homeostasis
- Maintenance of a stable internal environment that equals a dynamic state of equilibrium
- Homeo- is greek for "The same" and -stasis is Greek for "Equilibrium" and is a dynamic process, not static
- It is essential for normal body functioning and sustaining life
- Homeostatic imbalance is a disturbance in homeostasis resulting in disease, a.k.a. pathophysiology
- Organ systems involved in homeostasis include the nervous, endocrine, blood, muscular, respiratory, cardiovascular, reproductive, digestive, skeletal, and urinary systems.
Organ System Functions
- Muscular System: Allows locomotion, facial expression, maintains posture, and produces heat through thermoregulation.
- Cardiovascular System: Transports blood via the heart and vessels regulating blood pressure; maintains nutrient balance and immunity through blood (haematology)
- Respiratory System: Maintains gas homeostasis by adding oxygen and removing carbon dioxide.
- Digestive System: Breaks down food, absorbs nutrients, maintains blood nutrient homeostasis, and eliminates indigestible material (excretion).
- Nervous System: Fast-acting control system that responds to internal and external changes, activates muscles and glands, and controls homeostasis of multiple systems.
- Endocrine System: Slower acting control system that controls sleep and wakefulness and homeostasis of multiple systems.
- Urinary System: Eliminates nitrogenous wastes, maintains acid-base balance, and maintains osmolarity.
- Organ systems are interconnected
Terminology
- Gastr- refers to the stomach
- Hepa- refers to the liver
- Nephr- refers to the kidney
- Entero- refers to the instestine
- Cerebro- refers to the brain
- Cardio- refers to the heart
- Pneumo- refers to the lung
- Derm- // Cut- refers to the skin
Homeostatic Control Mechanism
- Involves a stimulus that produces a change in a variable
- A receptor (sensor) detects the change
- Information is sent along an afferent pathway to a control center
- The control center sends information along an efferent pathway to an effector
- The effector's response feeds back to influence the magnitude of the stimulus and returns the variable to homeostasis
Glucostatic Control Example
- Homeostasis is a normal blood glucose level of about 90 mg/100 ml
- Insulin-secreting cells in the pancreas release insulin into the blood when high blood glucose levels are detected
- Most body cells then take up more glucose
- The liver takes up glucose and stores it as glycogen
- Blood glucose level declines to a set point
- The stimulus for insulin release diminishes, and the body returns to homeostasis
- Low blood glucose level detected by glucagon-releasing cells of pancreas
- Liver breaks down glycogen stores and releases glucose to the blood
- Blood glucose level rises to a set point; stimulus for glucagon release diminishes and body returns to homeostasis
Systems Working In Harmony: The Stress Response
- Blood: Epinephrine and norepinephrine are released
- Adrenergic receptor activation occurs
- Liver: Glycogenolysis and Gluconeogenesis occur
- Skeletal Muscle: Glycogenolysis occurs
- Adipose: Lipolysis occurs
- Pancreatic B-cells: Insulin synthesis and release is reduced
Feedback Loops
- Negative Feedback Loops: Most homeostatic processes use negative feedback loops
- Positive Feedback Loops: Special scenarios, e.g., blood clotting
- Positive feedback loops always have built-in or external negative feedback loops, otherwise the entire vasculature will clot
- Positive feedback loops can shift homeostatic set-point to a new level
- Homeostasis must be maintained even if this is at a different level
New Homeostatic Set-Points
- Homeostasis equals dynamic equilibrium but it is not static
- Multifactorial, with circadian rhythms, hormone rhythms, and varying environment
- Steady state varies over the course of a day, in factors like blood glucose, cortisol release, blood pressure and core body temperature
- New set points occur in both Physiology and Pathophysiology
- Usually as a response to triggers by a 'regulatory system' or failure of one
- Examples include Type II diabetes and the immune response
Immune Response - Sepsis
- Can lead to immune hyperactivity that causes damage from inflammation
- Can result in organ failure and early death
- It is complex and poorly understood, depends on immune response and hormones like cortisol
- Can lead to recurrent infections, continued organ injury, poor tissue regeneration and long-term death
- Adaptive immune suppression can cause opportunistic infections and long-term death
Other Regulatory System Examples
- Diabetes – Type 2: Insulin production and glucose sensitivity are dysfunctional
- Diabetes – Type 1: Insulin production is almost completely compromised at the end-stage
- A diabetic coma is dependent on sugar from the diet
- Loss of regulation leads to a new homeostatic set-point (dynamic), but it is not tolerated by body organs, and results in Pathophysiology
Homeostasis and Pathophysiology
- Pathophysiology is an imbalance in 'normal' homeostasis that is not tolerated.
- This can be due to:
- A new homeostatic set-point caused by an alteration in regulation, e.g., type 2 diabetes.
- An acute imbalance that overloads the system, where regulatory systems can't cope, e.g., glycotoxicity.
Principles of Physiology
- The functions of organ systems are coordinated with each other
- Most physiological systems are controlled by multiple regulatory systems, often working in opposition
- Homeostasis is essential for health and survival
- Information flow between cells, tissues and organs is essential for integrating physiological processes
- Controlled exchange of materials occurs between compartments and across cellular membranes
- Physiological processes are dictated by laws of chemistry and physics
- Physiological processes require the transfer and balance of matter and energy
- Structure is a determinant of, and has coevolved with, function
Summary
- Physiology studies processes operating within an organism
- Organ systems are interconnected and are formulated to maintain life
- Homeostasis attempts to keep the system in balance
- Positive and negative feedback maintain homeostasis by increasing or decreasing signals
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