Intro to Homeostasis

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Questions and Answers

Which of the following statements best describes homeostasis?

  • A dynamic state of equilibrium where the internal environment varies within narrow limits. (correct)
  • A static state where the internal environment is fixed.
  • The absence of any change in bodily functions.
  • A process that always uses positive feedback to maintain stability.

What is the primary function of the respiratory system in maintaining homeostasis?

  • Breaking down food and absorbing nutrients into the bloodstream.
  • Regulating blood pressure through vasoconstriction and vasodilation.
  • Filtering nitrogenous wastes from the blood to maintain osmolarity.
  • Facilitating gas exchange by adding oxygen and removing carbon dioxide. (correct)

Which of these is an example of a positive feedback mechanism?

  • Body temperature regulation through sweating or shivering.
  • Amplification of cytokine production in immunity. (correct)
  • Regulation of blood glucose levels by insulin.
  • Maintaining blood pressure through the baroreceptor reflex.

Which of the following organ systems is responsible for eliminating nitrogenous wastes and maintaining acid-base balance?

<p>Urinary system (B)</p> Signup and view all the answers

Which of the following is the correct order of the structural organization in physiology, from simplest to most complex?

<p>Molecular, Cellular, Tissue, Organ, Organ System, Organism (D)</p> Signup and view all the answers

In a homeostatic control mechanism, what is the role of the receptor?

<p>To detect changes in the variable and send a signal to the control center. (C)</p> Signup and view all the answers

What term describes a disturbance in homeostasis that results in disease?

<p>Pathophysiology (D)</p> Signup and view all the answers

Which of the following enables the body to sense changes and initiate a reaction?

<p>Sensation (D)</p> Signup and view all the answers

What is the role of the effector in a homeostatic control system?

<p>To carry out the response that attempts to correct the imbalance. (C)</p> Signup and view all the answers

Which system is the fastest-acting control system in the body?

<p>The Nervous System (C)</p> Signup and view all the answers

What does the Greek prefix 'Homeo-' in 'Homeostasis' refer to?

<p>Same (B)</p> Signup and view all the answers

Which of the following statements is correct regarding organ systems?

<p>Organ systems are interconnected and their functions are coordinated. (C)</p> Signup and view all the answers

Which of the following best describes the role of the cardiovascular system in maintaining homeostasis?

<p>Transport of blood, nutrients, and gases throughout the body. (A)</p> Signup and view all the answers

The term 'Physiology' can be described as...

<p>The study of life processes. (A)</p> Signup and view all the answers

Which statement is most accurate regarding positive feedback loops and homeostasis?

<p>Positive feedback loops create a deviation from the normal set point. (D)</p> Signup and view all the answers

The muscular system contributes to homeostasis EXCEPT by which function?

<p>Filtering metabolic wastes (C)</p> Signup and view all the answers

Which statement is most accurate regarding homeostasis?

<p>Homeostasis maintains the internal environment within a normal range. (C)</p> Signup and view all the answers

Which statement is the most accurate regarding the relationship between anatomy and physiology?

<p>Physiology requires understanding of anatomy. (A)</p> Signup and view all the answers

Which of the following best illustrates the concept of homeostasis?

<p>Maintaining a stable internal body temperature despite external weather conditions. (A)</p> Signup and view all the answers

Which of the following is an example of a negative feedback loop in the human body?

<p>Regulation of blood glucose levels by insulin (B)</p> Signup and view all the answers

Which of the following is NOT a characteristic of positive feedback loops?

<p>They are involved in maintaining stable conditions. (D)</p> Signup and view all the answers

Which of the following prefixes relates to the intestine?

<p>Entero- (C)</p> Signup and view all the answers

Which of these is the best definition of pathophysiology?

<p>A disturbance in homeostasis resulting in disease. (A)</p> Signup and view all the answers

Which term describes the production of glucose from non-carbohydrate sources?

<p>Gluconeogenesis (B)</p> Signup and view all the answers

Which of the following statements reflects the importance of homeostasis?

<p>It allows the body to maintain a relatively stable internal environment, which is essential for normal body functioning and to sustain life. (C)</p> Signup and view all the answers

If blood glucose levels drop too low, which process does the liver perform to restore them?

<p>Glycogenolysis (A)</p> Signup and view all the answers

Why is homeostasis described as 'dynamic'?

<p>Because the internal environment is maintained within a range and not a fixed point. (B)</p> Signup and view all the answers

Which of the following is an example of how multiple organ systems work together to maintain homeostasis?

<p>The respiratory and cardiovascular systems working together to transport oxygen to cells and remove carbon dioxide. (A)</p> Signup and view all the answers

What is the primary function of the endocrine system in maintaining homeostasis?

<p>Controlling sleep and wakefulness through hormone release. (D)</p> Signup and view all the answers

Under normal physiological conditions, which type of feedback loop is least likely to maintain a physiological parameter at a constant value?

<p>A positive feedback loop modulated by external factors. (A)</p> Signup and view all the answers

In the context of homeostasis, what distinguishes Type 1 from Type 2 diabetes?

<p>In both, the regulatory mechanism is dysfunctional, it is to a greater extent in Type 1. (B)</p> Signup and view all the answers

Which of the following is an example of a homeostatic process that involves multiple regulatory systems working in opposition?

<p>Regulating blood glucose levels using insulin and glucagon. (C)</p> Signup and view all the answers

In the below homeostatic mechanism diagram, what do the numbers 1-5 represent? (In order)

<p>Stimulus, Change detected by receptor, Input, Output, Response of Effector (C)</p> Signup and view all the answers

Which of the following statements accurately reflects a key principle of physiology?

<p>Information flow between cells, tissues, and organs is essential for physiological processes. (D)</p> Signup and view all the answers

Which is the most accurate definition of 'dynamic equilibrium' in the contact of homeostasis?

<p>The maintenance of a stable internal environment through constant adjustments. (B)</p> Signup and view all the answers

According to the principles of physiology, what describes the flow of information?

<p>Information flow between cells, tissues, and organs is essential. (A)</p> Signup and view all the answers

In pathophysiology, when a homeostatic set point is not well-tolerated, what typically happens?

<p>The condition leads to an imbalance that is Pathophysiology. (B)</p> Signup and view all the answers

Select the incorrect statement.

<p>In sepsis, immune responses maintain homeostasis, despite infection. (B)</p> Signup and view all the answers

What is always true of Positive Feedback Loops?

<p>Always have inbuilt or external negative feedback loops (C)</p> Signup and view all the answers

What effect does Lipolysis have on the blood?

<p>This is a Adipose process (A)</p> Signup and view all the answers

Which statement best describes human physiology?

<p>The study of the mechanical, physical, and biochemical functions of living organisms. (C)</p> Signup and view all the answers

Which of the following functions is NOT directly associated with the digestive system's role in homeostasis?

<p>Regulating body temperature through sweating. (D)</p> Signup and view all the answers

Glycolysis turns glucose into pyruvate, this is broken down in what system?

<p>This process happens inside all cells. (C)</p> Signup and view all the answers

With reference to the immune system, put these in order of time:

<p>Normal/homeostasis, resolution, recovery (B)</p> Signup and view all the answers

Rank the body functions from most basic to most advanced:

<p>Movement, Respiration, Sensitivity. (C)</p> Signup and view all the answers

Why is homeostasis essential for health and survival?

<p>Because internal imbalance can lead to disease. (A)</p> Signup and view all the answers

According to the principles of physiology, what is the order that signals travel in?

<p>Afferent signals before Efferent Signals. (A)</p> Signup and view all the answers

Which level of structural organization is considered the most basic?

<p>Molecular (D)</p> Signup and view all the answers

What primarily defines human physiology?

<p>The investigation of the body's functions and life processes (C)</p> Signup and view all the answers

Which of the following is the most inclusive level of structural organization in the human body?

<p>Organism (A)</p> Signup and view all the answers

Which of the following best describes the relationship between anatomy and physiology?

<p>Physiology explains anatomy (D)</p> Signup and view all the answers

Which of the following best describes the 'dynamic' aspect of homeostasis?

<p>Homeostasis involves constant adjustments to maintain equilibrium (C)</p> Signup and view all the answers

Which two systems are most influential in maintaining homeostasis?

<p>Nervous and Endocrine (B)</p> Signup and view all the answers

What is the role of the 'control center' in a homeostatic control mechanism?

<p>To analyze information and determine the appropriate response (C)</p> Signup and view all the answers

Which system is primarily responsible for break-down and delivery of nutrients?

<p>Digestive system (D)</p> Signup and view all the answers

What is the role of the effector of a feedback loop?

<p>To produce a response that changes the controlled variable (C)</p> Signup and view all the answers

Which of the following is NOT directly involved in maintaining blood nutrient homeostasis?

<p>The muscular system (C)</p> Signup and view all the answers

The prefix 'Nephr-' refers to which organ?

<p>Kidney (D)</p> Signup and view all the answers

Which of the following describes the function of the respiratory system?

<p>Gas homeostasis via oxygen and carbon dioxide exchange (A)</p> Signup and view all the answers

Which of the following best describes the homeostatic function of the urinary system?

<p>Elimination of waste products and maintenance of osmolarity (C)</p> Signup and view all the answers

What phrase always describes a homeostatic mechanism?

<p>Dynamic equilibrium (D)</p> Signup and view all the answers

Under homeostatic control, what is the likely result of increased glucagon release?

<p>Increased breakdown of glycogen (C)</p> Signup and view all the answers

What is the primary role of the cardiovascular system in the context of homeostasis?

<p>Transport of nutrients, gases and wastes (A)</p> Signup and view all the answers

Which of the following is LEAST associated with the muscular system's contribution to homeostasis?

<p>Regulation of blood pH (B)</p> Signup and view all the answers

In the context of homeostatic control, what is the definition of a 'stimulus'?

<p>A change that elicits a physiological response (B)</p> Signup and view all the answers

Which of the following is the Greek root for 'intestine'?

<p>Entero- (C)</p> Signup and view all the answers

In the context of the glucose regulation, what is the effector?

<p>Most body cells, liver and pancreas (A)</p> Signup and view all the answers

Which of the following processes increases blood glucose levels?

<p>Glycogenolysis (A)</p> Signup and view all the answers

Which organ system is primarily involved in eliminating nitrogenous wastes?

<p>Urinary system (C)</p> Signup and view all the answers

Why are positive feedback loops less common in physiological systems compared to negative feedback loops?

<p>Positive feedback tends to produce instability (D)</p> Signup and view all the answers

How does the endocrine system primarily contribute to maintaining homeostasis?

<p>Through the secretion of hormones that regulate various bodily functions (A)</p> Signup and view all the answers

Which of the following statements best describes the relationship between homeostasis and disease?

<p>Disease generally results from a disturbance in homeostasis (C)</p> Signup and view all the answers

Which statement accurately contrasts Type 1 and Type 2 diabetes in the context of homeostasis?

<p>Type 1 diabetes involves a loss of insulin production, while Type 2 involves insulin resistance (D)</p> Signup and view all the answers

In a homeostatic control system, what is the function of the afferent pathway?

<p>Carries signal from receptor to control center (A)</p> Signup and view all the answers

In the immune system, auto-amplification of cytokines is balanced by cytokine signalling suppressors. This demonstrates how the immune system...

<p>Uses both positive and negative feedback to maintain balance (D)</p> Signup and view all the answers

If blood calcium levels are too high, which of the following would occur to restore homeostasis?

<p>Decreased osteoclast activity (C)</p> Signup and view all the answers

Which process describes the production of glucose from non-carbohydrate sources, under homeostatic regulation?

<p>Gluconeogenesis (B)</p> Signup and view all the answers

Which organ is LEAST involved in water homeostasis?

<p>Spleen (C)</p> Signup and view all the answers

Which of the following statements is true regarding positive feedback loops in the human body?

<p>They usually require an outside factor to shut off the loop. (B)</p> Signup and view all the answers

What defines 'dynamic equilibrium' in the context of homeostasis?

<p>A stable internal environment achieved through constant fluctuations around a set point (B)</p> Signup and view all the answers

Which characteristic is MOST likely observed in a physiological parameter regulated by multiple regulatory systems in opposition?

<p>Large fluctuations around a fixed set point (A)</p> Signup and view all the answers

What is one reason that immune therapies, such as cytokine therapies, require tight dosage windows to be effective?

<p>Cytokines act through dynamic equilibrium which can cause a 'cytokine storm' (A)</p> Signup and view all the answers

Imagine someone has no homeostatic mechanisms (e.g. no sweating, cannot regulate temperature, etc.). Assuming they are not receiving any medical intervention (e.g. dialysis), in what order would these conditions kill someone, from soonest to latest?

<p>Temperature dysregulation, Blood pressure, Increased Blood waste (A)</p> Signup and view all the answers

Which of the following is NOT considered a primary function within human physiology?

<p>Hibernation (B)</p> Signup and view all the answers

Which level of structural organization includes two or more tissue types working together to perform specific, complex functions?

<p>Organ level (B)</p> Signup and view all the answers

Which of the following processes is an example of excretion?

<p>Elimination of metabolic waste via the kidneys (B)</p> Signup and view all the answers

Which example describes the function of the muscular system in contributing to homeostasis?

<p>Generating heat through thermoregulation (B)</p> Signup and view all the answers

What does it mean to say that homeostasis is a 'dynamic' process?

<p>Internal conditions fluctuate within a normal range (B)</p> Signup and view all the answers

Which of the following is the best description of Pathophysiology?

<p>The study of how disease or injury alters physiological processes. (B)</p> Signup and view all the answers

Which of the following is an example of a positive feedback loop that does NOT result in homeostasis?

<p>Uncontrolled inflammation (A)</p> Signup and view all the answers

During the human stress response, epinephrine and norepinephrine are released. What effect does this have on blood-glucose homeostasis?

<p>Increased glycogenolysis in the liver (B)</p> Signup and view all the answers

How does the cardiovascular system assist the digestive system in maintaining nutrient homeostasis?

<p>By transporting absorbed nutrients to body cells (C)</p> Signup and view all the answers

In a negative feedback loop controlling body temperature, what would happen if body temperature rises above the set point?

<p>Sweat glands are activated to increase heat loss (D)</p> Signup and view all the answers

Which of the following is NOT a main component of a homeostatic control system?

<p>Oscillator (B)</p> Signup and view all the answers

Which organ system is most directly involved in regulating blood pressure?

<p>Cardiovascular system (B)</p> Signup and view all the answers

What is the function of the 'afferent pathway' in a homeostatic control system?

<p>Carries information from the receptor <strong>to</strong> the control center (C)</p> Signup and view all the answers

Which of these describes the likely set-point for blood glucose in a person with poorly controlled Type 2 diabetes?

<p>Higher than healthy individuals, leading to hyperglycemia (A)</p> Signup and view all the answers

If the body detects a decrease in blood volume, which of the following responses would NOT be part of the homeostatic mechanism to restore it?

<p>Increased vasodilation in the skin (D)</p> Signup and view all the answers

Which statement accurately contrasts Type 1 and Type 2 diabetes in the maintenance of homeostasis?

<p>Type 1 diabetes is characterized by a lack of insulin production, while type 2 diabetes involves insulin resistance. (D)</p> Signup and view all the answers

What is the meaning of the prefix 'entero-'?

<p>Intestine (A)</p> Signup and view all the answers

What is the primary role of the effector in a feedback loop?

<p>Generates a response that counteracts the initial change (A)</p> Signup and view all the answers

Epinephrine and norepinephrine are released during the human stress response. Apart from blood-glucose homeostasis, what is the effect on the blood?

<p>Increased Lipolysis (D)</p> Signup and view all the answers

Consider a scenario where blood pressure increases significantly. According to a negative feedback loop, which subsequent event would help restore homeostasis?

<p>Decreased cardiac output (C)</p> Signup and view all the answers

Which component of a homeostatic control system is responsible for determining the appropriate response to a change in the internal environment?

<p>Control center (B)</p> Signup and view all the answers

What is the primary role of the respiratory system in maintaining gas homeostasis?

<p>Adding oxygen and removing carbon dioxide from the blood (C)</p> Signup and view all the answers

The digestive system contributes to homeostasis by?

<p>Breaking down food and absorbing nutrients (C)</p> Signup and view all the answers

Consider a scenario where the body is dehydrated. Which of the following would occur to restore fluid balance?

<p>Increased water reabsorption in the kidneys (C)</p> Signup and view all the answers

Which of the following organ systems would have the LEAST influence on an individual's blood pressure?

<p>Digestive System (C)</p> Signup and view all the answers

A person's body temperature drops significantly in a cold environment. What homeostatic response is intiated?

<p>Shivering. (B)</p> Signup and view all the answers

Why are homeostatic mechanisms considered crucial for survival?

<p>They ensure that the internal environment remains stable despite external changes. (D)</p> Signup and view all the answers

If blood calcium levels drop too low, which of the following would be the most likely homeostatic response?

<p>Increased parathyroid hormone (PTH) secretion (A)</p> Signup and view all the answers

Select the most accurate statement concerning Feedback Loops?

<p>Positive Feedback Loops always amplify the initial trigger. (B)</p> Signup and view all the answers

Following food consumption, what processes are activated to maintain blood glucose levels?

<p>Increased insulin secretion (A)</p> Signup and view all the answers

In a person with poorly controlled diabetes insipidus caused by insufficient ADH (antidiuretic hormone) release, which of the following symptoms would be most prominent?

<p>Excessive thirst and frequent urination (D)</p> Signup and view all the answers

Which example describes the communication between organ systems to maintain homeostasis?

<p>The endocrine system using hormones to communicate with distant target cells (C)</p> Signup and view all the answers

In the context of the immune system, what differentiates a cytokine from a chemokine?

<p>Chemokines attract immune cells to a particular site, while cytokines have broader effects on immune cells (D)</p> Signup and view all the answers

How does the principle of 'controlled exchange of materials' apply to the function of the nephron in the kidney?

<p>The nephron selectively reabsorbs essential substances and excretes waste products. (D)</p> Signup and view all the answers

What does it mean to say that positive feedback loops in physiology 'can shift the homeostatic set point to a new level'?

<p>The parameter is never brought back to its original value. (D)</p> Signup and view all the answers

Which of the following is the best explanation of why negative feedback loops are more common in physiological systems compared to positive feedback loops?

<p>Negative feedback provides stability &amp; maintains conditions within a narrow range. (B)</p> Signup and view all the answers

Which of the following best describes the coordination and communication between the nervous and endocrine systems to control blood glucose levels?

<p>The nervous system can stimulate hormone release and influence target cell sensitivity to hormones, providing rapid adjustments, while the endocrine system sustains longer-term control. (A)</p> Signup and view all the answers

If a person is continuously exposed to stressful stimuli, leading to chronically elevated cortisol levels, how might this affect their immune system?

<p>Cortisol-induced immune suppression could increase susceptibility to infections. (B)</p> Signup and view all the answers

If someone is wounded, and loses more and more blood, the body must clot the wound to survive. What is always true of the homeostatic set-point in this scenario?

<p>The setpoint may need to be shifted to a different quantity. (A)</p> Signup and view all the answers

Imagine a scenario in which a new drug completely blocks the function of the effector in a homeostatic control system. How would a person's body respond to changes in the controlled variable?

<p>The effector will be unable to generate the appropriate response. (C)</p> Signup and view all the answers

Consider a situation where a person has a genetic mutation that completely disables their ability to produce chemokines. What is the most likely result?

<p>Reduced ability to direct immune cells to sites of infection (B)</p> Signup and view all the answers

A drug is given that promotes Calcium intake into bone at all costs. Why might this be damaging?

<p>Calcium is always needed in the blood to survive. (A)</p> Signup and view all the answers

Which of the following is the correct order of complexity in the structural organization of the human body?

<p>Molecular, Cellular, Tissue, Organ, Organ System, Organism (C)</p> Signup and view all the answers

Which of the following is the correct term for the maintenance of a stable internal environment?

<p>Homeostasis (D)</p> Signup and view all the answers

Which organ system is responsible for the breakdown and delivery of nutrients to the body?

<p>Digestive System (D)</p> Signup and view all the answers

What is the primary role of the respiratory system?

<p>Gas homeostasis (B)</p> Signup and view all the answers

Which of the following best describes human physiology?

<p>The study of how the human body functions (C)</p> Signup and view all the answers

The Greek prefix 'entero-' relates to which of the following?

<p>Intestine (D)</p> Signup and view all the answers

In the context of a homeostatic control mechanism, what name is given to the component that detects changes in the regulated variable?

<p>Receptor (C)</p> Signup and view all the answers

Which of the following describes the relationship between anatomy and physiology?

<p>Physiology explains anatomy. (C)</p> Signup and view all the answers

Which term is most appropriate to describe homeostasis?

<p>Dynamic Equilibrium (C)</p> Signup and view all the answers

Which of the following systems is primarily responsible for eliminating nitrogenous wastes from the body, supporting homeostasis?

<p>Urinary System (D)</p> Signup and view all the answers

If body temperature rises above normal, what is the body’s likely response in a negative feedback loop?

<p>Sweating to dissipate heat (C)</p> Signup and view all the answers

During the human stress response, epinephrine and norepinephrine are released. What is the effect of these hormones on glycogenolysis?

<p>Glycogenolysis is increased. (D)</p> Signup and view all the answers

The muscular system contributes to homeostasis in multiple ways. Which of the following contributes MOST to thermoregulation?

<p>Production of heat (C)</p> Signup and view all the answers

Which of the following represents the primary function of the cardiovascular system in maintaining homeostasis?

<p>Transport of blood, nutrients, and gases (B)</p> Signup and view all the answers

Why is homeostasis described as being maintained by 'dynamic equilibrium'?

<p>Because internal conditions vary within a narrow range. (B)</p> Signup and view all the answers

What is the function of the effector in a negative feedback loop?

<p>To reverse the initial change and restore homeostasis (B)</p> Signup and view all the answers

Which of the following reflects a key principle of physiology regarding the coordination of organ systems?

<p>The functions of organ systems are coordinated with each other. (D)</p> Signup and view all the answers

A drop in body temperature triggers shivering, which generates heat. Which of the following components of a homeostatic control system is responsible for producing the body heat?

<p>The effector (C)</p> Signup and view all the answers

After a meal, blood glucose levels increase, stimulating the release of insulin. Insulin increases glucose uptake by cells, reducing high blood glucose levels. Which component of the homeostatic control system is the stimulus?

<p>Elevated blood glucose (D)</p> Signup and view all the answers

The suffix '-lysis' refers to:

<p>Breakdown (A)</p> Signup and view all the answers

If you have eaten a large meal and blood glucose levels are too high, which of the following is not likely to occur?

<p>Insulin release diminishes. (E)</p> Signup and view all the answers

Why are negative feedback loops more common in physiological systems than positive feedback loops?

<p>Negative feedback loops maintain stability. (A)</p> Signup and view all the answers

In the context of homeostatic control, what is the primary distinction between Type 1 and Type 2 diabetes?

<p>Type 1 diabetes involves a lack of insulin production, while Type 2 involves insulin resistance. (C)</p> Signup and view all the answers

Which statement reflects why immune therapies, such as cytokine therapies, require tight dosage windows to be effective?

<p>Homeostatic balance is crucial for effective biological function; over- or under-stimulation could be damaging (D)</p> Signup and view all the answers

What is the underlying relationship between homeostasis and pathophysiology?

<p>Pathophysiology arises when the body deviates from its homeostatic set-point, resulting in disease states. (B)</p> Signup and view all the answers

When homeostasis cannot be maintained in the event of blood loss, what is always true regarding the set-point?

<p>The homeostatic set-point is altered to permit survival, even if at a different level (C)</p> Signup and view all the answers

Imagine someone has no homeostatic mechanisms (sweating, cannot regulate temperature, etc.). Assuming they are not receiving any medical intervention (e.g. dialysis), list the order these conditions would kill them, from soonest to latest?

<p>Overheating &gt; Dehydration &gt; Toxin build-up (A)</p> Signup and view all the answers

Under normal physiological conditions, which type of feedback loop is least likely to cause a sustained deviation from a homeostatic set point?

<p>Negative feedback because it opposes deviations from the set point. (D)</p> Signup and view all the answers

If the body detects a decrease in blood osmolarity, which of the following responses would be part of the homeostatic mechanism to restore it?

<p>Increased water reabsorption in the kidneys promoted by ADH. (B)</p> Signup and view all the answers

Which of the following best explains 'dynamic equilibrium' in homeostasis?

<p>Physiological parameters fluctuate, but are maintained within a limited range. (A)</p> Signup and view all the answers

With reference to the glucostatic control negative feedback look, put these events in order:

<p>High blood glucose level detected by insulin-secreting cells of pancreas &gt; Insulin-secreting cells of pancreas stimulated to release insulin into the blood &gt; Most body cells take up more glucose (D)</p> Signup and view all the answers

Which activity is LEAST related to human physiology?

<p>Studying the microscopic structure of bone tissue. (B)</p> Signup and view all the answers

The breakdown and delivery of nutrients throughout the body is primarily a function of which system?

<p>Digestive System (D)</p> Signup and view all the answers

Which of the following represents the correct order of complexity in the structural organization of the human body?

<p>Molecular level, cellular level, tissue level, organ level (A)</p> Signup and view all the answers

Which of the following is NOT considered a function within human physiology?

<p>Fossilization (C)</p> Signup and view all the answers

What is a key distinction between Type 1 and Type 2 diabetes regarding regulatory systems?

<p>In Type 1 diabetes the regulatory system is completely absent due to lack of insulin production, whereas Type 2 involves impaired sensitivity. (A)</p> Signup and view all the answers

Which of the following pairs of systems are the MOST directly involved in regulating blood pressure?

<p>Cardiovascular and Urinary Systems (B)</p> Signup and view all the answers

In a typical negative feedback loop, what is the effect of the effector's response on the initial stimulus?

<p>It offsets the initial stimulus, moving the variable back toward the set point. (D)</p> Signup and view all the answers

Which statement accurately describes the relationship between organ systems in maintaining homeostasis?

<p>Organ systems work in a coordinated manner to maintain a stable internal environment. (A)</p> Signup and view all the answers

Considering the principles of physiology, why might a drug designed to lower blood pressure also have an unintended effect on kidney function?

<p>Because the cardiovascular and urinary systems are interconnected and blood pressure regulation affects kidney function. (B)</p> Signup and view all the answers

In the context of homeostasis, what does it mean to say that organ systems are 'coordinated'?

<p>Organ systems work together, with their functions influencing each other to maintain overall internal stability. (D)</p> Signup and view all the answers

If the body is becoming hyperglycemic, which of the following processes is LEAST likely to occur under normal homeostatic control?

<p>Increased glycogen breakdown in the liver. (B)</p> Signup and view all the answers

What is exemplified by the interplay between the nervous and endocrine systems in glucose regulation?

<p>The coordinated function of multiple organ systems. (A)</p> Signup and view all the answers

Which component of a homeostatic control functions as the 'thermostat' setting the target value?

<p>The control center (C)</p> Signup and view all the answers

After eating a large meal, which event would LEAST contribute to restoring blood glucose homeostasis?

<p>Increased glycogenolysis (A)</p> Signup and view all the answers

Why is it important that positive feedback loops are typically controlled by negative feedback loops or external factors?

<p>Uncontrolled positive feedback loops can cause drastic changes that are incompatible with maintaining homeostasis. (A)</p> Signup and view all the answers

Given that the suffix '-lysis' refers to 'unfastening, loose, untie', which process describes the breakdown of glycogen into glucose?

<p>Glycogenolysis (B)</p> Signup and view all the answers

How would continually high cortisol levels likely affect the immune response?

<p>It would suppress certain aspects of the immune system, increasing susceptibility to infection. (A)</p> Signup and view all the answers

Within the immune system, what is the key difference between cytokines and chemokines?

<p>Cytokines are primarily involved in cell-to-cell communication, whereas chemokines primarily direct cell movement. (C)</p> Signup and view all the answers

A drug promotes calcium intake into bone at all costs. Why might this be damaging?

<p>Because the calcium set point is overridden, and normal function disrupted. (A)</p> Signup and view all the answers

What is the BEST explanation of why negative feedback loops are more prevalent across human system, rather than positive feedback loops?

<p>Because positive feedback loops can cause rapid large change that are life threatening. (D)</p> Signup and view all the answers

Imagine a person whose body cannot produce chemokines. What is MOST LIKELY to happen?

<p>Ineffective immune responses due to the impaired ability to direct immune cells to sites of infection. (A)</p> Signup and view all the answers

In the context of blood loss, what typically happens to the homeostatic set point?

<p>The set point is actively altered to prioritize immediate survival, potentially at the cost of other functions. (D)</p> Signup and view all the answers

A new drug completely blocks the function of the effector in a homeostatic control system. How would a person’s body respond to changes in the controlled variable?

<p>The controlled variable would fluctuate without regulation. (C)</p> Signup and view all the answers

Why do immune therapies, such as cytokine treatments, require tight dosage windows to be effective?

<p>Because cytokine signalling is balanced by signalling suppressors to maintain homeostasis. (B)</p> Signup and view all the answers

Which system is responsible for both adding oxygen to the blood and removing carbon dioxide?

<p>Respiratory system (D)</p> Signup and view all the answers

Which of the following describes the structural organization of the body from simplest to most complex?

<p>Molecular, cellular, tissue, organ, organ system, organism (C)</p> Signup and view all the answers

The term 'physiology' is BEST described as the study of:

<p>The function of the human body (A)</p> Signup and view all the answers

Which organ system is primarily responsible for maintaining fluid volume and blood pressure?

<p>Urinary system (A)</p> Signup and view all the answers

Which of these Greek prefixes is related to the kidney?

<p>Nephr- (C)</p> Signup and view all the answers

Which of the following is the fastest-acting control system in the body, responding rapidly to internal and external changes?

<p>Nervous system (A)</p> Signup and view all the answers

Which statement about positive feedback loops are always true?

<p>Positive feedback loops are always countered by negative feedback loops. (A)</p> Signup and view all the answers

What level of structural organization is liver?

<p>An organ (D)</p> Signup and view all the answers

What best describes an imbalance in homeostasis that results in a disease?

<p>pathophysiology (B)</p> Signup and view all the answers

What is the role of the 'input' pathway in a homeostatic control mechanism?

<p>Sending information along afferent pathway to a control system. (D)</p> Signup and view all the answers

Apart from blood-glucose levels, what else do Epinephrine and norepinephrine affect in relation to the blood?

<p>Increase heart rate (B)</p> Signup and view all the answers

What is the importance of homeostasis?

<p>Homeostasis maintains a stable internal environment, which is essential for normal body functioning and to sustain life (A)</p> Signup and view all the answers

What's always true of homeostasis?

<p>It has a set point (A)</p> Signup and view all the answers

How can a positive feedback loop cause death?

<p>The cycle becomes self-perpetuating and harmful. (C)</p> Signup and view all the answers

Which list the levels of structural organization in the body in the correct order, from simplest to most complex?

<p>Molecular, cellular, tissue, organ, organ system, organism. (B)</p> Signup and view all the answers

The term 'dynamic equilibrium', when referring to homeostasis, means:

<p>The internal environment varies, but within set limits. (A)</p> Signup and view all the answers

During exercise, the body temperature rises. Which of the following initiates a negative feedback loop to maintain thermal homeostasis?

<p>Sweating to increase heat loss. (B)</p> Signup and view all the answers

Why are negative feedback loops more common in physiological homeostasis than positive feedback loops?

<p>Negative feedback loops stabilize conditions, while positive loops amplify changes. (A)</p> Signup and view all the answers

Flashcards

What is physiology?

The study of the mechanical, physical, and biochemical functions of living organisms.

What are the processes of life?

Movement, respiration, sensitivity, nutrition, excretion, reproduction, and growth.

What is the structural organization of the body?

Molecular, cellular, tissue, organ, organ system, organism.

What is homeostasis?

The maintenance of a stable internal environment in the body.

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What is homeostatic imbalance (Pathophysiology)?

A disturbance in homeostasis resulting in disease.

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Muscular System Functions

Allows locomotion, facial expression, maintains posture, thermoregulation.

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Cardiovascular System Functions

Transports blood and controls blood pressure; maintains nutrient balance and immunity.

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Respiratory System Functions

Gas homeostasis; adds oxygen and removes carbon dioxide.

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Digestive System Functions

Breaks down food, absorbs nutrients, maintains blood nutrient homeostasis, eliminates indigestible material.

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Nervous System Functions

Fast-acting; responds to internal and external changes; activates muscles and glands; controls homeostasis.

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Endocrine System Functions

Slower acting; controls sleep and wakefulness; controls homeostasis.

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Urinary System Functions

Eliminates nitrogenous wastes, maintains acid-base balance, maintains osmolarity.

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What is 'Input' in a homeostatic control mechanism?

Information sent along afferent pathway to control center.

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What is 'Output' in a homeostatic control mechanism?

Information sent along efferent pathway to effector.

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What is the 'Response' in a homeostatic control mechanism?

Response of effector feeds back to influence magnitude of stimulus, returning variable to homeostasis.

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What initiates the homeostatic mechanism?

The stimulus produces change in variable.

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Glucostatic control - Homeostasis

Normal blood glucose level (about 90 mg/100 ml).

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Rising Blood Glucose Level

Stimulates insulin release.

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Liver's Role in Glucose Regulation

Takes up glucose and stores it as glycogen.

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Cellular Glucose Uptake

Most body cells take up more glucose.

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Declining Blood Glucose Level

Stimulates glucagon release.

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Liver's Response to Low Glucose

Breaks down glycogen stores and releases glucose to the blood.

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High Glucose Response

Pancreas releases insulin.

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Low Glucose Response

Pancreas releases glucagon.

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What is Gluconeogenesis?

Formation of glucose from non-carbohydrate sources.

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What is Glycogenolysis?

Breakdown of glycogen to glucose.

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What is Lipolysis?

Breakdown of lipids (fats).

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What is Glycogenesis?

Formation of glycogen from glucose.

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What is Lipogenesis?

Formation of lipids (fats).

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Negative Feedback Loops

Most homeostatic processes include this.

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Negative Feedback Loops

Always have inbuilt or external negative feedback loops

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Homeostatic Set-Point

Positive feedback loops can shift this to a new level

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Dynamic Equilibrium

Internal conditions change throughout the day.

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New Homeostatic Set-Points

New set points occur in physiology and pathophysiology.

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New Homeostatic Set-Points - Examples

Type II diabetes and the immune response

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Imbalance in 'normal' homeostasis

Pathophysiology results from this.

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System Regulation

Physiological systems are controlled by multiple regulatory systems, often working in opposition.

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Health and Survival

Homeostasis is essential for this.

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Material Exchange

Controlled exchange of materials occurs between compartments and across cellular membranes.

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Chemistry and Physics.

Physiological Processes dictated by the laws of chemistry and physics.

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Structure and Function

Structure is a determinant of – and has coevolved with – function.

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Study Notes

Learning Outcomes

  • Human physiology should be described
  • The structure and function of key systems should be outlined
  • Homeostasis should be described
  • Positive and negative feedback systems should be explained

Physiology: The Science of Life

  • Physiology studies life processes
  • The processes include movement, respiration, sensation, nutrition, excretion, reproduction and growth
  • Movement includes movement of substances and locomotion
  • Respiration involves gas exchange
  • Sensation is about responsiveness and the ability to sense changes and react
  • Nutrition involves the break-down and delivery of nutrients and encompasses metabolism
  • Metabolism covers all chemical reactions that occur within the body, including energy production and making body structures
  • Excretion is the elimination of waste from metabolic reactions
  • Reproduction is the production of future generations
  • Growth involves the increasing of cell size or number

Physiology: Structural Organization

  • Structural Organization: Molecular, Cellular, Tissue, Organ, Organ System, Organism
  • Physiology requires understanding of anatomy to explain it

Homeostasis

  • Maintenance of a stable internal environment that equals a dynamic state of equilibrium
  • Homeo- is greek for "The same" and -stasis is Greek for "Equilibrium" and is a dynamic process, not static
  • It is essential for normal body functioning and sustaining life
  • Homeostatic imbalance is a disturbance in homeostasis resulting in disease, a.k.a. pathophysiology
  • Organ systems involved in homeostasis include the nervous, endocrine, blood, muscular, respiratory, cardiovascular, reproductive, digestive, skeletal, and urinary systems.

Organ System Functions

  • Muscular System: Allows locomotion, facial expression, maintains posture, and produces heat through thermoregulation.
  • Cardiovascular System: Transports blood via the heart and vessels regulating blood pressure; maintains nutrient balance and immunity through blood (haematology)
  • Respiratory System: Maintains gas homeostasis by adding oxygen and removing carbon dioxide.
  • Digestive System: Breaks down food, absorbs nutrients, maintains blood nutrient homeostasis, and eliminates indigestible material (excretion).
  • Nervous System: Fast-acting control system that responds to internal and external changes, activates muscles and glands, and controls homeostasis of multiple systems.
  • Endocrine System: Slower acting control system that controls sleep and wakefulness and homeostasis of multiple systems.
  • Urinary System: Eliminates nitrogenous wastes, maintains acid-base balance, and maintains osmolarity.
  • Organ systems are interconnected

Terminology

  • Gastr- refers to the stomach
  • Hepa- refers to the liver
  • Nephr- refers to the kidney
  • Entero- refers to the instestine
  • Cerebro- refers to the brain
  • Cardio- refers to the heart
  • Pneumo- refers to the lung
  • Derm- // Cut- refers to the skin

Homeostatic Control Mechanism

  • Involves a stimulus that produces a change in a variable
  • A receptor (sensor) detects the change
  • Information is sent along an afferent pathway to a control center
  • The control center sends information along an efferent pathway to an effector
  • The effector's response feeds back to influence the magnitude of the stimulus and returns the variable to homeostasis

Glucostatic Control Example

  • Homeostasis is a normal blood glucose level of about 90 mg/100 ml
  • Insulin-secreting cells in the pancreas release insulin into the blood when high blood glucose levels are detected
  • Most body cells then take up more glucose
  • The liver takes up glucose and stores it as glycogen
  • Blood glucose level declines to a set point
  • The stimulus for insulin release diminishes, and the body returns to homeostasis
  • Low blood glucose level detected by glucagon-releasing cells of pancreas
  • Liver breaks down glycogen stores and releases glucose to the blood
  • Blood glucose level rises to a set point; stimulus for glucagon release diminishes and body returns to homeostasis

Systems Working In Harmony: The Stress Response

  • Blood: Epinephrine and norepinephrine are released
  • Adrenergic receptor activation occurs
  • Liver: Glycogenolysis and Gluconeogenesis occur
  • Skeletal Muscle: Glycogenolysis occurs
  • Adipose: Lipolysis occurs
  • Pancreatic B-cells: Insulin synthesis and release is reduced

Feedback Loops

  • Negative Feedback Loops: Most homeostatic processes use negative feedback loops
  • Positive Feedback Loops: Special scenarios, e.g., blood clotting
  • Positive feedback loops always have built-in or external negative feedback loops, otherwise the entire vasculature will clot
  • Positive feedback loops can shift homeostatic set-point to a new level
  • Homeostasis must be maintained even if this is at a different level

New Homeostatic Set-Points

  • Homeostasis equals dynamic equilibrium but it is not static
  • Multifactorial, with circadian rhythms, hormone rhythms, and varying environment
  • Steady state varies over the course of a day, in factors like blood glucose, cortisol release, blood pressure and core body temperature
  • New set points occur in both Physiology and Pathophysiology
  • Usually as a response to triggers by a 'regulatory system' or failure of one
  • Examples include Type II diabetes and the immune response

Immune Response - Sepsis

  • Can lead to immune hyperactivity that causes damage from inflammation
  • Can result in organ failure and early death
  • It is complex and poorly understood, depends on immune response and hormones like cortisol
  • Can lead to recurrent infections, continued organ injury, poor tissue regeneration and long-term death
  • Adaptive immune suppression can cause opportunistic infections and long-term death

Other Regulatory System Examples

  • Diabetes – Type 2: Insulin production and glucose sensitivity are dysfunctional
  • Diabetes – Type 1: Insulin production is almost completely compromised at the end-stage
  • A diabetic coma is dependent on sugar from the diet
  • Loss of regulation leads to a new homeostatic set-point (dynamic), but it is not tolerated by body organs, and results in Pathophysiology

Homeostasis and Pathophysiology

  • Pathophysiology is an imbalance in 'normal' homeostasis that is not tolerated.
  • This can be due to:
    • A new homeostatic set-point caused by an alteration in regulation, e.g., type 2 diabetes.
    • An acute imbalance that overloads the system, where regulatory systems can't cope, e.g., glycotoxicity.

Principles of Physiology

  • The functions of organ systems are coordinated with each other
  • Most physiological systems are controlled by multiple regulatory systems, often working in opposition
  • Homeostasis is essential for health and survival
  • Information flow between cells, tissues and organs is essential for integrating physiological processes
  • Controlled exchange of materials occurs between compartments and across cellular membranes
  • Physiological processes are dictated by laws of chemistry and physics
  • Physiological processes require the transfer and balance of matter and energy
  • Structure is a determinant of, and has coevolved with, function

Summary

  • Physiology studies processes operating within an organism
  • Organ systems are interconnected and are formulated to maintain life
  • Homeostasis attempts to keep the system in balance
  • Positive and negative feedback maintain homeostasis by increasing or decreasing signals

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