Human Parasitology: Hookworm Infections
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Questions and Answers

What initiates the infection process of hookworms in humans?

  • Ingestion of contaminated food
  • Exposure to contaminated water
  • Penetration of skin by filariform larvae (correct)
  • Airborne transmission of larvae

What is a significant consequence of heavy hookworm infection?

  • Increased appetite
  • Skin rash resolution
  • Iron deficiency anemia (correct)
  • Rapid weight gain

Where do the adult hookworms mature after penetrating the skin?

  • In the small intestine (correct)
  • In the liver
  • In the colon
  • In the lungs

What symptom is more common with Ancylostoma species than with Necator hookworms?

<p>Ground itch (A)</p> Signup and view all the answers

What is the primary mechanism by which filariform larvae cause pulmonary infiltrates?

<p>Embolization from venules (D)</p> Signup and view all the answers

Which of the following is true about the filariform larvae of hookworms?

<p>They are not infective until they penetrate skin. (C)</p> Signup and view all the answers

What is a common early symptom of hookworm infection?

<p>Pruritus at the site of penetration (B)</p> Signup and view all the answers

What is the size range of third-stage filariform larvae?

<p>500-700 µm (D)</p> Signup and view all the answers

How long does Necator typically live in the host?

<p>5 years (C)</p> Signup and view all the answers

What is a common symptom associated with iron-deficiency anemia from hookworm infection?

<p>Nausea (C)</p> Signup and view all the answers

Which of the following is a method for diagnosing hookworm infection?

<p>Stool culture using the Harada Mori technique (C)</p> Signup and view all the answers

What is the primary treatment for hookworm infections?

<p>Albendazole and Mebendazole (D)</p> Signup and view all the answers

What describes cutaneous larva migrans?

<p>A skin condition caused by hookworm larvae (A)</p> Signup and view all the answers

Which demographic is most susceptible to symptomatic anemia related to hookworm infections?

<p>Young women, particularly those who are pregnant (A)</p> Signup and view all the answers

Which of the following species is NOT associated with causing cutaneous larva migrans?

<p>Necator americanus (B)</p> Signup and view all the answers

How much blood does each Ancylostoma worm consume daily?

<p>0.2 mL (A)</p> Signup and view all the answers

What condition can result from scratching due to itching caused by Strongyloides stercoralis?

<p>Secondary bacterial infection (D)</p> Signup and view all the answers

What treatment is considered effective for Strongyloides stercoralis infection?

<p>Albendazole or Ivermectin (C)</p> Signup and view all the answers

In immunocompromised individuals, what is the mortality rate associated with Strongyloides stercoralis infection?

<p>60-85% (D)</p> Signup and view all the answers

What form of larvae does Strongyloides stercoralis secrete in feces?

<p>Rhabditiform larvae (C)</p> Signup and view all the answers

How can infection with Strongyloides stercoralis occur?

<p>Exposure of skin to contaminated soil (A)</p> Signup and view all the answers

After larvae penetrates the skin, where do they migrate first?

<p>Pulmonary circulation (C)</p> Signup and view all the answers

What is a characteristic of the adult female Strongyloides stercoralis?

<p>Undergoes parthenogenic reproduction (D)</p> Signup and view all the answers

Under certain conditions, where can Strongyloides larvae molt into infective filariform larvae?

<p>Within the intestinal lumen (D)</p> Signup and view all the answers

What is the primary route of infection for hookworms?

<p>Skin penetration by larvae in contaminated soil (C)</p> Signup and view all the answers

Which population is at higher risk for hookworm infection?

<p>Agricultural laborers (C)</p> Signup and view all the answers

What is a significant consequence of hookworm infection?

<p>Anemia in approximately 10% of those infected (B)</p> Signup and view all the answers

What differentiates the buccal capsules of Ancylostoma duodenale from those of Necator americanus?

<p>A. duodenale has teeth whereas N. americanus has cutting plates. (A)</p> Signup and view all the answers

In what geographical areas is hookworm infection most prevalent?

<p>Tropical and subtropical areas (C)</p> Signup and view all the answers

What characteristic of hookworm larvae makes them infective?

<p>They are longer and able to penetrate skin. (A)</p> Signup and view all the answers

What has been observed in countries as they develop with regard to hookworm infestations?

<p>Infections decrease with improvements in sanitation. (D)</p> Signup and view all the answers

Which of the following best describes the ova of hookworms?

<p>They have a thin, clear, smooth, colorless shell enclosing the embryo. (C)</p> Signup and view all the answers

What is the mortality rate for patients requiring hospitalization due to Strongyloides infection?

<p>16.7% (B)</p> Signup and view all the answers

Which of the following regions is NOT considered endemic for Strongyloides infection?

<p>Northern Europe (C)</p> Signup and view all the answers

What symptom is commonly associated with skin penetration by Strongyloides infective larvae?

<p>Ground itch (B)</p> Signup and view all the answers

How does the filariform larva enter the body to cause infection?

<p>Penetration of the skin (C)</p> Signup and view all the answers

Which of the following best describes the rash known as larva currens?

<p>A serpiginous urticarial rash (A)</p> Signup and view all the answers

What is a significant risk factor for the initial occurrence of Strongyloides infection?

<p>Playing outdoors in contaminated soil (B)</p> Signup and view all the answers

What does the term hyperinfection refer to in the context of Strongyloides?

<p>An accelerated autoinfectious cycle (B)</p> Signup and view all the answers

What percentage of the population might be infected with Strongyloides in endemic areas?

<p>2-20% (D)</p> Signup and view all the answers

Flashcards

Hookworms

Hookworms are parasites that infect the intestines, causing anemia and developmental issues in children. They thrive in warm, moist climates and are commonly found in areas with poor sanitation.

Hookworm Species

Ancylostoma duodenale and Necator americanus are the two main types of hookworms that infect humans.

Hookworm Infection

Hookworm infection is acquired through skin contact with larvae in contaminated soil.

Hookworm Characteristics

Hookworms are typically 10-15mm long and have specialized mouth structures called buccal capsules for attaching to the intestinal wall.

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Hookworm Mouth Structures

Ancylostoma duodenale has two pairs of teeth, while Necator americanus has cutting plates that help them latch onto the intestinal lining.

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Hookworm Eggs

The eggs of both hookworm species look very similar - small, clear, and smooth.

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Hookworm Larval Stages

After hatching in soil, the first stage rhabditiform larvae develop into the infectious filariform larvae.

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Hookworm and Poverty

Hookworm infection often occurs in impoverished communities with inadequate sanitation, poor housing, and limited access to healthcare.

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Hookworm Reproduction

Adult female hookworms begin producing eggs approximately 5-10 weeks after penetrating the skin.

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What is a filariform larva?

The stage of the hookworm larva capable of infecting humans through skin penetration. It is longer and thinner than the rhabditiform larva.

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Hookworm Anemia

Hookworm infection can cause iron deficiency anemia due to blood loss from the host's intestines.

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Hookworm Prevalence

Hookworm infection is more common in areas with poor sanitation, limited access to healthcare, and warm, moist climates.

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What is cutaneous larva migrans?

A type of hookworm infection caused by the migration of hookworm larvae under the skin, resulting in a characteristic itchy rash.

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Cutaneous Larva Migrans (CLM)

Cutaneous larva migrans (CLM) is a skin disease caused by hookworm larvae that penetrate the skin but can't reach the intestines.

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How do hookworm larvae reach the intestines?

The process by which hookworm larvae travel from the lungs to the intestines. This involves them being coughed up and then swallowed.

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CLM Causing Species

The common species causing CLM are Ancylostoma braziliense, Ancylostoma ceylanicum, and Ancylostoma caninum, which are parasites of dogs and cats.

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What is Loeffler's Syndrome?

This syndrome involves inflammation of the alveoli in the lungs, often caused by parasitic infections like hookworm. It presents with symptoms like fever, coughing, and wheezing.

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What are the symptoms of hookworm infection?

They typically cause ground itch at the site of skin penetration and can lead to anemia due to blood loss.

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CLM Presentation

CLM presents as a red, itchy, and often serpentine rash caused by the migrating larvae.

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How is hookworm infection transmitted?

Hookworm infection results from contact with contaminated soil containing infectious larvae. This usually occurs through bare feet.

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Why are hookworms a concern for public health?

They are commonly found in areas with poor sanitation and can cause severe health problems, particularly in children.

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What are filariform larvae?

They are the third-stage larvae of hookworms, characterized by their length (500-700 µm) and ability to burrow into human skin.

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Strongyloides stercoralis

A type of parasitic worm that can cause both intestinal and cutaneous infections. It is known for its complex life cycle that involves both free-living and parasitic stages.

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Filariform Larva

The infective stage of Strongyloides stercoralis, characterized by its ability to penetrate the skin, migrate through the body, and reach the intestines.

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Larva Currens

A condition caused by the migration of Strongyloides larvae under the skin, often presenting as a serpiginous rash that resembles a creeping line.

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Autoinfection

The ability of Strongyloides stercoralis to reproduce within the host without the need for reinfection. This occurs when larvae develop within the host and complete their life cycle without leaving the body.

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Hyperinfection

A condition of severe Strongyloides infection that occurs in immunocompromised individuals. This is characterized by widespread larval invasion and can be life-threatening.

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Skin Penetration

The initial stage of Strongyloides infection, typically occurring on the feet or any skin area that comes into contact with contaminated soil.

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Lung Migration

The migration of Strongyloides larvae through the lungs, similar to the pattern observed with other parasitic infections like hookworm.

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Indirect Cycle

The process by which Strongyloides larvae develop in the soil into free-living male and female worms, which can produce eggs and more infective larvae.

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What is Strongyloides stercoralis?

Strongyloides stercoralis is a type of roundworm that can cause strongyloidiasis, a parasitic infection in humans. The adult female worm reproduces asexually (parthenogenesis) and releases eggs that hatch into larvae in the intestines. These larvae can then travel throughout the body, potentially leading to severe complications in immunocompromised individuals.

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What is the common name for the Strongyloides stercoralis parasite?

Strongyloides stercoralis, also known as threadworm, is a common intestinal parasite that can cause a serious infection called strongyloidiasis. It's particularly dangerous for people with weakened immune systems.

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What disease does Strongyloides stercoralis cause?

Strongyloides stercoralis is a parasitic roundworm that infects the intestines and can cause a disease called strongyloidiasis. This disease can be very dangerous, especially for people with weakened immune systems.

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How is Strongyloides stercoralis infection transmitted?

Strongyloides stercoralis infection, also known as strongyloidiasis, can spread through contact with contaminated soil. When the larvae of the parasite penetrate the skin, they travel through the body until they reach the intestines and mature into adult worms.

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Who is at high risk for severe Strongyloides stercoralis infection?

Strongyloides stercoralis infection is more likely to be serious in individuals with weakened immune systems. These individuals are at higher risk of developing severe complications such as lung infections and sepsis.

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What are the two forms of Strongyloides stercoralis larvae?

Strongyloides stercoralis larvae can live in two forms: filariform larvae (infective) and rhabditiform larvae (free-living). Filariform larvae infect humans through skin contact, while rhabditiform larvae live in the soil.

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Describe the life cycle of Strongyloides stercoralis.

The life cycle of Strongyloides stercoralis involves two main stages: 1) The infective filariform larvae penetrate the skin and travel to the lungs, where they are coughed up and swallowed 2) They develop into adult female worms in the intestines, which reproduce asexually and release larvae that can reinfect the host or be released in feces.

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How do Strongyloides stercoralis larvae infect humans?

The filariform larvae of Strongyloides stercoralis can penetrate the skin and travel throughout the body, eventually reaching the intestines where they develop into adult worms.

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Study Notes

Soil Transmitted Helminths (STH 2)

  • STH are parasitic worms transmitted through soil contaminated with human feces.
  • Two main species of hookworms are Ancylostoma duodenale and Necator americanus.
  • Hookworms infect an estimated 576-740 million people, causing anemia in about 10% of infected individuals.
  • Infection can persist for many years, impairing physical and intellectual development of children, and impacting economic communities.
  • Hookworms are widely distributed in tropical and subtropical regions, with prevalence in some communities reaching 90%.
  • Rural communities, often with poor sanitation and moist soil, see high hookworm prevalence.
  • Agricultural workers are traditionally at high risk of hookworm infection due to exposure.

Hookworm Distribution

  • Hookworm transmission is linked with inadequate sanitation, poor housing, lack of access to medical care, and generally poor socioeconomic conditions.
  • Infection frequency often drops as countries improve economically.
  • Prevalence greatly influences hookworm presence.

Hookworm Route of Infection

  • Hookworm infection occurs through skin penetration by larvae found in soil contaminated with human feces.
  • Adults, specifically agricultural workers, face a comparable or greater risk of exposure than children.
  • The infection route is important to hookworm epidemiology.

Hookworms

  • Two significant species are Necator americanus and Ancylostoma duodenale.
  • Adult hookworms are 10-15mm in size.
  • Hookworms possess buccal capsules that aid in their attachment to the intestinal mucosa.
  • Ancylostoma duodenale possesses two pairs of teeth; Necator americanus has cutting plates, enabling firm intestinal mucosal attachment.

Hookworm Eggs

  • The eggs of Ancylostoma duodenale and Necator americanus are similar in morphology.
  • The eggs have a thin, clear, smooth, and colorless shell that encapsulates the embryo.

Hookworm Life Cycle

  • The first-stage larva (rhabditiform larva) is short and non-infective in the soil.
  • The third-stage larva (filariform larva) is longer and more infectious.
  • The larvae penetrate the skin to initiate the infection.

Hookworm Larval Development

  • Migrating larvae enter the alveoli, are carried to the bronchi and trachea, and are swallowed.
  • The larvae then attach to the small intestine and feed on blood.
  • The infection occurs through skin penetration with the larvae, then migration through the circulatory system, and onto the lungs.
  • Rhabditiform larvae develop into filariform larvae in the soil.
  • Hookworm Life Cycle

Hookworm Pathogenesis

  • Mild infections usually do not cause symptoms.
  • Heavy infections can cause nausea, fatigue, vomiting, abdominal pain, anorexia, diarrhea, and iron deficiency anemia.
  • Larval migration through skin, potentially resulting in cutaneous larva migrans (CLM).
  • Severe anemia affects intellectual and physical development in children and cardiovascular performance in adults.

Hookworm Diagnosis and Treatment

  • Diagnosis involves identifying eggs or larvae in feces.
  • Stool cultures use the Harada-Mori technique.
  • Therapy includes albendazole, mebendazole, and others.
  • Prevention measures include wearing shoes, gloves when working outdoors, and proper sanitation practices.

Cutaneous Larva Migrans (CLM)

  • Animal hookworm larvae, like Ancylostoma braziliense, Ancylostoma ceylanicum, and Ancylostoma caninum, can cause serpentine skin lesions known as CLM or creeping eruptions.
  • CLM is a skin condition caused by hookworm larvae, and the larvae are often found in sandy soil.
  • Characteristic skin lesions include itching, erythema, or blisters.

Strongyloides stercoralis

  • Strongyloides stercoralis is a common enteric helminth of global importance.
  • Typically, infection is asymptomatic or causes mild gastrointestinal symptoms.
  • Immunocompromised individuals often experience significantly severe infections, with a high mortality rate (60-85%).
  • Strongyloides stercoralis larvae exist in two forms: filariform (infective) and rhabditiform (free living).
  • Infection occurs when exposed skin contacts contaminated soil, causing the larvae to penetrate the skin, and migrate to the lungs. Upon migration to the lungs, the larvae migrate directly to the intestinal system and mature into adult females and reproduce parthenogenetically.
  • Larvae are often found in feces approximately one month after skin penetration.
  • Under certain conditions, like constipation and decreases in bowel motility, larvae can return to the small intestine in a process called autoinfection.

Strongyloides stercoralis Life Cycle

  • The cycle repeats and can potentially result in recurrent or continuous infection.
  • Feces typically contain rhabditiform larvae, and not eggs
  • Strongyloides stercoralis Life Cycle

Strongyloides stercoralis Pathogenesis

  • Skin penetration may cause allergic reactions or eruptions like larva currens
  • Symptoms of infection may include diarrhea, abdominal pain, vomiting, weight loss, and pulmonary symptoms, such as a cough and shortness of breath.
  • Autoinfection can lead to hyperinfection syndrome, particularly in immunocompromised individuals (e.g., HIV/AIDS).
  • Larvae can be found in multiple organs like in the lungs, liver, and the heart.

Strongyloides stercoralis Diagnosis and Treatment

  • Diagnosis often requires identifying rhabditiform or filariform larvae in human feces, which can be achieved via stool culture or "Harada Mori" method or "Sand culture".
  • Treatment typically involves thiabendazole.
  • Prevention measures include proper sanitation practices and avoiding walking barefoot in areas with contaminated soil.

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Test your knowledge on hookworm infections in humans with this quiz. Questions cover initiation of infection, symptoms, treatment, and diagnosis associated with hookworms. Perfect for students of human parasitology or those interested in infectious diseases.

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