Human Growth Hormone Functions Quiz

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Questions and Answers

Which hormone has direct effects on peripheral target cells and stimulates the secretion of IGF-1 by the liver?

  • Insulin
  • Glucocorticoids
  • Growth Hormone (GH) (correct)
  • Somatostatin

What is the primary factor that suppresses serum GH levels after meals high in glucose?

  • Ghrelin secretion
  • Insulin-induced hypoglycemia
  • Glucocorticoids
  • Glucose challenge (correct)

Which hormone acts at renal collecting ducts and increases water reabsorption through V2 receptors?

  • Oxytocin
  • Dopamine
  • Vasopressin (ADH) (correct)
  • IGF-1

What is a potent stimulus for vasopressin (ADH) release other than serum osmolality?

<p>Hypovolemia (B)</p> Signup and view all the answers

Which hormone is responsible for uterine contraction and breast milk secretion?

<p>Oxytocin (C)</p> Signup and view all the answers

Which substance is NOT mentioned as a stimulant for GH release in the text?

<p>Insulin (B)</p> Signup and view all the answers

What is the primary effect of dopamine D2 receptor agonists on GH-secreting tumors?

<p>Inhibit GH secretion (A)</p> Signup and view all the answers

Which hormone is synthesized in the liver and has direct effects on peripheral target cells?

<p>IGF-1 (D)</p> Signup and view all the answers

Which hormone is primarily under inhibitory control by dopamine?

<p>Prolactin (A)</p> Signup and view all the answers

What is the primary stimulatory factor for ACTH release?

<p>CRH (C)</p> Signup and view all the answers

Which hormone is mainly under inhibitory control by somatostatin?

<p>Growth Hormone (D)</p> Signup and view all the answers

Which is NOT a hormone primarily under trophic stimulation?

<p>Prolactin (A)</p> Signup and view all the answers

Which hormone activation is less important for its control by somatostatin?

<p>TSH (D)</p> Signup and view all the answers

What is the primary stimulatory factor for TSH release?

<p>CRH (C)</p> Signup and view all the answers

Which hormone is primarily under trophic stimulation?

<p>ACTH (C)</p> Signup and view all the answers

Which hormone activation is less important for its control by somatostatin?

<p>FSH (B)</p> Signup and view all the answers

What is the LR+ for defining a goitre as a mass larger than the distal phalanx of the thumb in children?

<p>3.0 (A)</p> Signup and view all the answers

What does an LR of 0.30 (95% CI 0.24-0.37) suggest about defining a goitre as a mass larger than the distal phalanx of the thumb?

<p>Low accuracy (D)</p> Signup and view all the answers

What is an alternative method for diagnosing a goitre?

<p>Measuring the size of the thyroid mass relative to the thumb (B)</p> Signup and view all the answers

What is indicated if a patient has a hot nodule on a radioisotope thyroid scan?

<p>Low chance of malignancy (C)</p> Signup and view all the answers

When should a radioisotope thyroid scan (Technetium 99) be ordered as per the text?

<p>When patient is thyrotoxic (B)</p> Signup and view all the answers

What does RAIU test measure according to the text?

<p>Iodine turnover by the thyroid gland (C)</p> Signup and view all the answers

If a patient has low iodine uptake on RAIU test, what might this indicate?

<p>Exogenous thyroid hormone use (D)</p> Signup and view all the answers

What should be done if concerning sonographic features are found after a thyroid ultrasound?

<p>Further workup required (D)</p> Signup and view all the answers

Which of the following is a common adverse effect of thionamides?

<p>Teratogenicity (B)</p> Signup and view all the answers

What is the mechanism of action of thionamides in inhibiting thyroid hormone synthesis?

<p>Inhibiting peroxidase catalyzed reactions (C)</p> Signup and view all the answers

Which medication is preferred over propylthiouracil (PTU) due to a longer duration of action?

<p>Methimazole (MMI) (A)</p> Signup and view all the answers

What should be monitored prior to considering treatment discontinuation with antithyroid medications?

<p>TSH and TKAb levels (B)</p> Signup and view all the answers

Which condition is a good predictor for long-term remission with medical therapy using thionamides?

<p>Small goitre (A)</p> Signup and view all the answers

When is it recommended to use propylthiouracil (PTU) during pregnancy?

<p>First 16 weeks of pregnancy (B)</p> Signup and view all the answers

What are the major side effects associated with antithyroid medications?

<p>Hepatotoxicity (cholestasis, hepatitis) (B)</p> Signup and view all the answers

What is the preferred treatment duration with antithyroid medications before considering treatment discontinuation for long-term remission?

<p>12-18 months (A)</p> Signup and view all the answers

What is the etiologic classification of Type 1 Diabetes Mellitus according to the text?

<p>Genetic defects of beta cell function (B)</p> Signup and view all the answers

Which of the following is NOT listed as a cause of Type 2 Diabetes Mellitus according to the text?

<p>Infections (A)</p> Signup and view all the answers

Which of the following is NOT a genetic syndrome associated with Diabetes Mellitus according to the text?

<p>Cystic fibrosis (D)</p> Signup and view all the answers

What is one of the drug-induced causes of Diabetes Mellitus mentioned in the text?

<p>Thiazides (C)</p> Signup and view all the answers

Which condition is characterized by immune-mediated or idiopathic cell destruction leading to absolute insulin deficiency?

<p>LADA (B)</p> Signup and view all the answers

What type of diabetes occurs when the body does not effectively use the insulin that is produced?

<p>Type 2 Diabetes Mellitus (D)</p> Signup and view all the answers

Which disease related to the pancreas is listed as a potential cause of Diabetes Mellitus in the text?

<p>Pancreatitis (A)</p> Signup and view all the answers

What is a common endocrinopathy associated with Diabetes Mellitus as per the text?

<p>Acromegaly (D)</p> Signup and view all the answers

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