Podcast
Questions and Answers
What is the molecular weight of Growth Hormone (GH)?
What is the molecular weight of Growth Hormone (GH)?
- 22 kDA (correct)
- 35 kDA
- 15 kDA
- 45 kDA
Which factor is NOT associated with influencing the release of Growth Hormone?
Which factor is NOT associated with influencing the release of Growth Hormone?
- Exercise
- Age-related sex steroids
- Emotional stress (correct)
- Nutritional status
What percentage of Growth Hormone is derived from the smaller mRNA with omission of a part of exon III?
What percentage of Growth Hormone is derived from the smaller mRNA with omission of a part of exon III?
- 20-25%
- 10-15% (correct)
- 5-10%
- 30-35%
During which time frame is the release of Growth Hormone primarily concentrated?
During which time frame is the release of Growth Hormone primarily concentrated?
Which of the following hormones is structurally similar to Growth Hormone?
Which of the following hormones is structurally similar to Growth Hormone?
Flashcards
What is Growth Hormone (GH)?
What is Growth Hormone (GH)?
GH is a peptide hormone produced by the anterior pituitary gland. It plays a crucial role in growth and development, particularly during childhood and adolescence. It also influences metabolism and body composition.
What are the characteristics of GH?
What are the characteristics of GH?
GH is a 191 amino acid peptide hormone with a molecular weight of approximately 22 kDa. It shares structural similarities with prolactin and chorionic somatomammotropin.
How is GH released?
How is GH released?
GH is released in pulsatile bursts throughout the day, with the highest levels occurring during deep sleep. Exercise and trauma also stimulate GH release.
What factors influence GH release?
What factors influence GH release?
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What is the normal circulating level of GH?
What is the normal circulating level of GH?
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Study Notes
Growth Hormone (GH) Structure and Characteristics
- Growth hormone (GH) is a peptide hormone composed of 191 amino acids.
- Its molecular weight is approximately 22 kDa.
- GH shares a similar structure with prolactin and chorionic somatomammotropin (a placental hormone).
- Two isoforms of GH exist, created through alternative splicing.
- Most GH isoforms include all 5 exons, translating to a 191 amino acid protein with a 22 kDa molecular weight.
- A smaller portion (10-15%) are generated from smaller mRNA molecules, missing part of exon III.
GH Production and Release
- GH is produced by somatotrophs within the anterior pituitary gland.
- GH release occurs in pulsatile bursts throughout the day, with a peak release mostly during the night, often associated with deep sleep.
- GH release is also increased during exercise and trauma.
Factors Influencing GH Release
- Nutritional status influences GH release.
- Metabolic conditions affect GH release.
- Age-related sex steroids impact GH release.
- Adrenal glucocorticoids affect GH release.
- Thyroid hormones influence GH release.
- Renal function plays a role in GH release regulation.
- Hepatic function affects GH release.
GH Circulation
- Normal circulating levels of GH are not explicitly detailed.
- Information on GH blood levels and binding is not fully included in the provided text.
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Description
Explore the fascinating structure and characteristics of growth hormone (GH), a peptide hormone vital for growth and metabolism. This quiz delves into GH production, release patterns, and the various factors influencing its levels in the body. Perfect for students interested in human physiology and endocrinology.
