Growth and Development

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Questions and Answers

Which stage of development is the embryo most susceptible to toxic agents?

  • Critical period (correct)
  • Embryo period
  • Germinal period
  • Foetus period

What is the period of rapid growth in foetal development?

  • Day 20-30
  • Day 10-20 (correct)
  • Day 1-10
  • Day 30-40

Which hormone is involved in protein accumulation during foetal development?

  • Gonadotropin-releasing hormone (GnRH)
  • GH (Growth Hormone)
  • Thyroid hormone
  • IGF-1 (Insulin like Growth Factor 1) (correct)

What is the term for the stage of development where three germ layers are formed?

<p>Gastrulation (D)</p> Signup and view all the answers

Which of the following is a derivative of the ectoderm germ layer?

<p>Nervous system (D)</p> Signup and view all the answers

What is the period of development when the embryo is most susceptible to Thalidomide?

<p>Critical period (B)</p> Signup and view all the answers

Which germ layer gives rise to the urogenital organs (except urinary bladder)?

<p>Mesoderm (B)</p> Signup and view all the answers

What is the stage of development when the foetus accumulates fat?

<p>Day 30-40 (B)</p> Signup and view all the answers

Which hormone is involved in the regulation of growth and development?

<p>GH (Growth Hormone) (C)</p> Signup and view all the answers

What is the term for the stage of development when the embryo implants in the uterus?

<p>Implantation (C)</p> Signup and view all the answers

What is the primary mechanism by which cells 'count' their divisions to prevent uncontrolled replication?

<p>Telomere shortening (C)</p> Signup and view all the answers

What is the function of telomerase in stem cells?

<p>To allow for replication without loss of telomere (D)</p> Signup and view all the answers

What is the consequence of telomere loss in cells with intact p53?

<p>Ageing (B)</p> Signup and view all the answers

What is the primary difference between stem cells and most other cells in terms of telomere expression?

<p>Stem cells express higher levels of telomerase (D)</p> Signup and view all the answers

What is the role of p53 in response to DNA damage?

<p>To stop the cell cycle and induce DNA repair (B)</p> Signup and view all the answers

What is the function of the repetitive DNA sequences at the end of chromosomes in human cells?

<p>To form a loop that is not recognized as broken DNA (C)</p> Signup and view all the answers

What is the consequence of telomere loss in cells with dysfunctional p53?

<p>Cancer (B)</p> Signup and view all the answers

What is the relationship between telomere length and cell division?

<p>Telomere length decreases with each cell division (D)</p> Signup and view all the answers

What is the characteristic of iPS cells that allows them to proliferate?

<p>They express high levels of telomerase (B)</p> Signup and view all the answers

What is the mechanism by which mitochondrial mutations occur at a higher rate than gene mutations?

<p>Reactive oxygen species (ROS) cause mitochondrial mutations (A)</p> Signup and view all the answers

What is the primary role of IGF-1 in relation to Growth Hormone (GH)?

<p>Produced in the liver (D)</p> Signup and view all the answers

Which cell type cannot renew by any mechanism?

<p>Photoreceptor cells (D)</p> Signup and view all the answers

What is the consequence of GH stimulating lipolysis?

<p>Increased plasma glucose levels (C)</p> Signup and view all the answers

Which type of stem cell has the ability to differentiate into multiple cell types, but not all types?

<p>Adult stem cells (A)</p> Signup and view all the answers

Which of the following is an effect of increased GnRH activity in males?

<p>Increase in spermatogenesis (D)</p> Signup and view all the answers

Which of the following is NOT a hallmark of ageing?

<p>Stimulation of lipolysis (D)</p> Signup and view all the answers

Which cells rely on stem cells for renewal?

<p>Blood cells (A)</p> Signup and view all the answers

Which type of stem cell is located at the margin of the cornea?

<p>Limbal stem cells (D)</p> Signup and view all the answers

What describes the condition when cells are metabolically active but unable to divide?

<p>Senescence (C)</p> Signup and view all the answers

What factor does NOT contribute to the hallmark of ageing known as genomic instability?

<p>Deregulated nutrient-sensing (A)</p> Signup and view all the answers

What is the term for the period of development when the embryo is most susceptible to teratogen?

<p>Critical period (C)</p> Signup and view all the answers

Which germ layer gives rise to the nervous system?

<p>Ectoderm (B)</p> Signup and view all the answers

What is the primary function of GH in relation to growth and development?

<p>Regulating IGF-1 production (B)</p> Signup and view all the answers

During which stage of development do the three germ layers form?

<p>Gastrulation (A)</p> Signup and view all the answers

What is the term for the stage of development when the embryo implants in the uterus?

<p>Implantation (B)</p> Signup and view all the answers

What is the effect of Growth Hormone (GH) on glucose levels in the liver?

<p>Stimulates glycogenolysis and raises plasma glucose levels (D)</p> Signup and view all the answers

Which hormone is involved in the regulation of fat accumulation during fetal development?

<p>GH (B)</p> Signup and view all the answers

What is the result of increased Gonadotropin-releasing Hormone (GnRH) activity in females?

<p>Stimulation of FSH and LH production, leading to ovarian follicle maturation (A)</p> Signup and view all the answers

What is the term for the stage of development when the embryo undergoes rapid growth?

<p>Day 10-20 (D)</p> Signup and view all the answers

Which of the following is a derivative of the mesoderm germ layer?

<p>Muscle (C)</p> Signup and view all the answers

Which type of stem cell can differentiate into multiple cell types, but not all?

<p>Adult stem cell (A)</p> Signup and view all the answers

What is the term for the stage of development when the embryo undergoes protein accumulation?

<p>Day 20-30 (D)</p> Signup and view all the answers

What is the characteristic of cells in senescence?

<p>Metabolically active and unable to divide (D)</p> Signup and view all the answers

What is the hallmark of ageing characterized by the accumulation of mutations and epigenetic factors in the genome?

<p>Genomic instability (D)</p> Signup and view all the answers

Which of the following is a teratogen?

<p>All of the above (D)</p> Signup and view all the answers

What is the primary role of Insulin-like Growth Factor-1 (IGF-1) in relation to Growth Hormone (GH)?

<p>Being produced in response to GH stimulation (A)</p> Signup and view all the answers

Which cell type relies on stem cells for renewal?

<p>Skin epidermal cells (A)</p> Signup and view all the answers

What is the characteristic of cells in quiescence?

<p>Metabolically inactive and unable to divide (D)</p> Signup and view all the answers

What is the effect of Growth Hormone (GH) on lipolysis?

<p>Stimulating lipolysis and increasing glucose production (D)</p> Signup and view all the answers

What is the type of stem cell located at the margin of the cornea?

<p>Limbal stem cell (D)</p> Signup and view all the answers

What process is most directly affected by telomere shortening in human cells?

<p>Cell division (B)</p> Signup and view all the answers

What mechanism allows stem cells to avoid the consequences of telomere shortening?

<p>Expression of telomerase (C)</p> Signup and view all the answers

Which enzyme is essential for the replication of telomeres?

<p>Telomerase (C)</p> Signup and view all the answers

What is the significance of the loop formed by telomeres at the ends of chromosomes?

<p>It prevents recognition as broken DNA (C)</p> Signup and view all the answers

Which factor leads to an increased incidence of mitochondrial mutations?

<p>Reactive oxygen species (ROS) (A)</p> Signup and view all the answers

What happens when telomeres become critically short in most human cells?

<p>Activation of p53 and cell cycle arrest (D)</p> Signup and view all the answers

Which of the following most correctly describes the role of p53 in a cell with short telomeres?

<p>Induces apoptosis and DNA repair (C)</p> Signup and view all the answers

Which cell type is most likely to regain telomerase activity due to gene reprogramming?

<p>iPS cells (B)</p> Signup and view all the answers

What is the primary role of telomerase in cells?

<p>To maintain the length of telomeres during replication (D)</p> Signup and view all the answers

Which statement best explains why cancer cells can divide indefinitely?

<p>Increased telomerase expression (A)</p> Signup and view all the answers

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