Human Digestive System Lecture 2

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Questions and Answers

What does absorption refer to in the digestive process?

  • The breakdown of food into simpler molecules
  • The movement of molecules into the blood and lymphatic vessels (correct)
  • The elimination of waste from the body
  • The secretion of digestive enzymes

Which of the following describes hyperglycemia?

  • A condition of low blood sugar levels
  • Presence of glucose in the urine
  • An increase in blood sugar concentration (correct)
  • A tumor resulting in high insulin production

What is the primary role of carbohydrates in human nutrition?

  • To transport oxygen in the bloodstream
  • To aid in the digestion of proteins
  • To serve as the main source of energy (correct)
  • To provide structural support in cells

Which monosaccharide is known as a hexose?

<p>Galactose (B)</p>
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What occurs during defecation?

<p>The elimination of undigested material (B)</p>
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In which condition is there a decreased secretion of insulin?

<p>Hypoinsulinism (D)</p>
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Which of the following carbohydrates is primarily found in plant cells?

<p>Cellulose (B)</p>
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Which condition results from the presence of glucose in the urine?

<p>Glucosuria (C)</p>
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Which organs are primarily responsible for carbohydrate storage in the body?

<p>Liver and muscle (D)</p>
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How long can the body's stored carbohydrate typically meet energy needs?

<p>One-half day (A)</p>
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Which of the following tissues is the most important consumer of glucose?

<p>Brain (A)</p>
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What is gluconeogenesis?

<p>The process of converting amino acids into glucose (A)</p>
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What hormone is essential for facilitating glucose transfer into cells?

<p>Insulin (A)</p>
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Which cells depend almost entirely on glucose for energy under fasting conditions?

<p>Glucose-dependent cells (D)</p>
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What metabolic process helps maintain blood glucose levels during fasting?

<p>Gluconeogenesis (B)</p>
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Which of the following is NOT a source of gluconeogenesis?

<p>Sucrose (A)</p>
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What is the storage form of carbohydrates in plants?

<p>Starch (A)</p>
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Which polysaccharide acts as an anticoagulant and is stored in mast cells?

<p>Heparin (B)</p>
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Which of the following is a characteristic of glycogen?

<p>Highly branched and stored in liver and skeletal muscle (C)</p>
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What role does cellulose play in the diet?

<p>Indigestible fiber aiding in bowel elimination (D)</p>
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Which property makes inulin a good index for assessing glomerular filtration rate (GFR)?

<p>It is not altered, reabsorbed, or secreted in the body (C)</p>
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What is the normal concentration of glucose in the blood?

<p>100 mg/dl (A), 70 mg/dl (D)</p>
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Which of the following sugars is the sweetest and most soluble?

<p>Fructose (D)</p>
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What is galactose primarily derived from?

<p>Lactose hydrolysis (B)</p>
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Which condition is associated with the inability to metabolize fructose?

<p>Fructosemia (D)</p>
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Which disaccharide is composed of glucose and galactose?

<p>Lactose (C)</p>
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What is the primary composition of maltose?

<p>Two glucose units (D)</p>
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Polysaccharides are primarily characterized by being:

<p>Very long chains of monosaccharides (B)</p>
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What condition is associated with glucose excretion in urine?

<p>Diabetes Mellitus (C)</p>
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What is the normal fasting blood sugar (FBS) level considered to be?

<p>&lt; 100 mg/dl (C)</p>
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What condition is assessed using Random Blood Sugar (RBS) testing?

<p>Insulin shock or hyperglycemic ketonic coma (A)</p>
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What does a Hemoglobin A1c (HbA1c) level of 6.5% or higher indicate?

<p>Diabetes (D)</p>
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What parameter is used to diagnose gestational diabetes during pregnancy?

<p>Oral Glucose Tolerance Test (OGTT) (D)</p>
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What is the significance of a blood sugar level of ≤ 60 mg/dl?

<p>Strongly suggests hypoglycemia (A)</p>
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What are symptoms of hypoglycemia that may appear around 50-55 mg/dl?

<p>Increased hunger and sweating (B)</p>
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Which type of carbohydrate cannot be hydrolyzed into simpler sugars?

<p>Monosaccharides (A)</p>
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Which of the following is the normal value range for a 2-hour postprandial blood sugar test (2-HPPBS)?

<p>≤ 140 mg/dl (D)</p>
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Study Notes

Digestive Processes

  • Absorption: Movement of molecules via passive diffusion or active transport from the digestive tract to blood and lymphatic vessels; crucial for entering digested food into the body.
  • Defecation: Elimination of undigested materials through the anus.

Carbohydrates Overview

  • Composed of hydrogen, carbon, and oxygen.
  • Major dietary component and important energy source for the body.
  • Stored primarily as glycogen in muscles (0.5% of wet weight) and the liver (up to 10% of wet weight).
  • Total glycogen storage supports energy needs for about half a day.

Key Terms

  • Hyperglycemia: Elevated glucose levels in the blood.
  • Hypoglycemia: Reduced glucose levels in the blood.
  • Glycosuria: Presence of glucose in urine.
  • Hyperinsulinism: Increased secretion of insulin.
  • Hypoinsulinism: Decreased secretion of insulin.
  • Insulinoma: Tumor in the pancreas causing increased insulin production.

Carbohydrate Classification

  • Based on the number of carbon atoms: triose (3), tetrose (4), pentose (5), hexose (6).
  • Monosaccharides (simple sugars) include glucose, fructose, and galactose; significant in nutrition.
  • Dietary carbohydrates exist mainly as sugars and starches.

Glucose Utilization

  • Glucose is the principal carbohydrate in blood and a primary energy source for glucose-dependent cells like the brain, red blood cells, and others.
  • Under fasting conditions, gluconeogenesis occurs, using proteins from muscles to generate glucose.
  • Liver gluconeogenesis is crucial for maintaining blood glucose levels during fasting.

Diabetes Mellitus

  • Associated with inadequate insulin levels, affecting glucose transport into cells.
  • Brain is particularly vulnerable to low blood sugar levels.

Laboratory Tests for Carbohydrate Metabolism

  • FBS (Fasting Blood Sugar): Required fasting for 6-8 hours; normal value < 100 mg/dl.
  • RBS (Random Blood Sugar): Collected anytime; normal value < 140 mg/dl.
  • 2-HPPBS (2-hour Post Prandial Blood Sugar): Monitors insulin response; normal value < 140 mg/dl.
  • HbA1c: Indicates average glucose levels over 2-4 months; normal < 5.7%.
  • OGTT/IVGTT: Tests for gestational diabetes.

Normal Value Ranges for Blood Sugar

  • Hyperglycemic hormone release at 65-70 mg/dl.
  • Hypoglycemia suggested at ≤ 60 mg/dl.
  • Symptoms of hypoglycemia may appear at around 50-55 mg/dl.

Functions of Carbohydrates

  • Serve as major energy sources.
  • Structural components in biological systems.
  • Function as energy reserves, sparing proteins during metabolism.

Polysaccharides Classification

  • Starch: Storage form in plants, consisting of amylose (linear) and amylopectin (branched).
  • Glycogen: Storage form in animals, highly branched structure.
  • Cellulose: Indigestible polysaccharide aiding bowel movement.

Examples of Sugars

  • Glucose: Blood sugar with a normal concentration < 100 mg/dl; excess is converted to glycogen or fat.
  • Fructose: Found in honey, sweetest of sugars; related condition: fructosemia.
  • Galactose: Present in glycoproteins; related condition: galactosemia.

Disaccharides

  • Lactose: Composed of glucose and galactose; found in milk.
  • Maltose: Contains two glucose units; forms during starch digestion.
  • Sucrose: Composed of glucose and fructose; known as table sugar.

Understanding carbohydrates helps in grasping their role in nutrition, energy regulation, and their impact on health conditions like diabetes.

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