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Questions and Answers
Which of the following is NOT considered a specialized tissue group in vertebrate animals?
Which of the following is NOT considered a specialized tissue group in vertebrate animals?
What is the most basic level of organization in the human body?
What is the most basic level of organization in the human body?
What is an atom defined as?
What is an atom defined as?
Which of these is an example of an inorganic compound found in the human body?
Which of these is an example of an inorganic compound found in the human body?
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What is the primary function of carbohydrates in the human body?
What is the primary function of carbohydrates in the human body?
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Which type of lipid is a major component of stored energy?
Which type of lipid is a major component of stored energy?
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What role do some proteins play in the body?
What role do some proteins play in the body?
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Which of the following is NOT considered a major electrolyte in physiology?
Which of the following is NOT considered a major electrolyte in physiology?
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A solution labeled as 5% NaCl, contains how many grams of NaCl per 100 ml of solution?
A solution labeled as 5% NaCl, contains how many grams of NaCl per 100 ml of solution?
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Which of the following is classified as a steroid?
Which of the following is classified as a steroid?
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What does 'isotonic' mean in the context of solutions?
What does 'isotonic' mean in the context of solutions?
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Which of the following represents the highest level of organization in the human body?
Which of the following represents the highest level of organization in the human body?
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If the molecular weight of NaCl is 58.5 g/mol, what is the mass of 1 millimole (mmol) of NaCl?
If the molecular weight of NaCl is 58.5 g/mol, what is the mass of 1 millimole (mmol) of NaCl?
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What is the primary fluid environment inside cells called?
What is the primary fluid environment inside cells called?
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Which of the following is NOT a primary function of nucleic acids?
Which of the following is NOT a primary function of nucleic acids?
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How many equivalents (Eq) are in one mole of Ca2+?
How many equivalents (Eq) are in one mole of Ca2+?
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Which of the following best describes the relationship between body fat and total body water?
Which of the following best describes the relationship between body fat and total body water?
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What percentage of the total body water is classified as extracellular fluid (ECF)?
What percentage of the total body water is classified as extracellular fluid (ECF)?
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What is the fundamental unit of the human body?
What is the fundamental unit of the human body?
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What is the equivalent weight of calcium (Ca2+), given that its molecular weight is approximately 40 g/mol?
What is the equivalent weight of calcium (Ca2+), given that its molecular weight is approximately 40 g/mol?
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If a solution contains 1 mEq of Na+, how much Na+ is present, knowing that the molecular weight of Na is approximately 23 g/mol?
If a solution contains 1 mEq of Na+, how much Na+ is present, knowing that the molecular weight of Na is approximately 23 g/mol?
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What is the process by which a cell becomes specialized for a specific function?
What is the process by which a cell becomes specialized for a specific function?
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Which of the following is NOT a subcompartment of extracellular fluid (ECF)?
Which of the following is NOT a subcompartment of extracellular fluid (ECF)?
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What makes up the largest proportion of the adult body by weight?
What makes up the largest proportion of the adult body by weight?
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Which of these is NOT a major category of cell types, based on broad function?
Which of these is NOT a major category of cell types, based on broad function?
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What do differentiated cells with similar properties aggregate to form?
What do differentiated cells with similar properties aggregate to form?
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Which fluid compartment is considered the 'internal sea'?
Which fluid compartment is considered the 'internal sea'?
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Plasma makes up approximately what percentage of total body weight?
Plasma makes up approximately what percentage of total body weight?
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How many broad categories of differentiated cells are there?
How many broad categories of differentiated cells are there?
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Which of the following is a major type of tissue in the body?
Which of the following is a major type of tissue in the body?
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Which of these shows the correct order of complexity in the organization of the human body, from least to most complex?
Which of these shows the correct order of complexity in the organization of the human body, from least to most complex?
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What percentage of the adult human body is made up of fluid?
What percentage of the adult human body is made up of fluid?
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Which of the following best describes the location of interstitial fluid?
Which of the following best describes the location of interstitial fluid?
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What is the main cause of edema, as discussed in the text?
What is the main cause of edema, as discussed in the text?
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What is the primary first step in treating edema?
What is the primary first step in treating edema?
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What is the approximate percentage of extracellular fluid in the body?
What is the approximate percentage of extracellular fluid in the body?
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Which of the options is considered an extracellular fluid?
Which of the options is considered an extracellular fluid?
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What is a key function of the extracellular fluid?
What is a key function of the extracellular fluid?
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Which of the following is present in a higher concentration in extracellular fluid?
Which of the following is present in a higher concentration in extracellular fluid?
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What is the primary function of a negative feedback loop?
What is the primary function of a negative feedback loop?
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Which of the following is NOT typically controlled by a negative feedback loop in the human body?
Which of the following is NOT typically controlled by a negative feedback loop in the human body?
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Where are the pressure receptors that monitor blood pressure primarily located?
Where are the pressure receptors that monitor blood pressure primarily located?
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What part of the brain acts as the control center for blood pressure regulation?
What part of the brain acts as the control center for blood pressure regulation?
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If blood pressure is too high, what would be the immediate response of the heart, according to the homeostatic negative feedback loop?
If blood pressure is too high, what would be the immediate response of the heart, according to the homeostatic negative feedback loop?
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In a negative feedback loop, how does the response relate to the initial stimulus?
In a negative feedback loop, how does the response relate to the initial stimulus?
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What happens if there is a difference between the current blood pressure value and the reference blood pressure value?
What happens if there is a difference between the current blood pressure value and the reference blood pressure value?
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What is the role of the control center in homeostasis?
What is the role of the control center in homeostasis?
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Study Notes
Introduction to Human Physiology
- Professor Mitat KOZ is the instructor
- Room: SBF132
- Email: [email protected]
- Course Title: Introduction to Human Physiology
- Course Code: HLTS103
What is Physiology?
- Physiology is the study of how living organisms function
- It examines how the human body works
- Physiology is the study of life
- Physiologists investigate the function and integration of organisms, organ systems, organs, cells, and biomolecules within a living system.
Course Schedule
- Dates and corresponding content covered in the course
- Includes introduction to general principles in medical physiology, cellular physiology, cell membranes, blood physiology, immunity, peripheral nerve, skeletal muscle, cardiovascular, pulmonary physiology etc
- Covers topics like midterm exam weeks, and exam dates
Recommended Resources
- Ganong's Review of Medical Physiology, McGraw-Hill
- Guyton, Arthur C. Textbook of medical physiology, Elsevier Inc.
- Vander's Human Physiology: The Mechanisms Of Body Function, McGraw-Hill
- Koz M., Gelir E., Ersöz G. Fizyoloji Ders Kitabı. Nobel Yayıncılık
Evaluation
- Evaluation is 50% midterm exam grade + 50% final exam grade
Physiology is related with basic sciences
- Physiology is directly associated with biology, chemistry, physics and mathematics
The Body Organized as "Solutions"
- Cells in the body exist within an extracellular fluid (ECF).
- ECF contains necessary materials for cell survival (e.g., O2 and nutrients).
- The ECF's composition is similar to seawater.
- Inside the cells is intracellular fluid (ICF).
Water, Electrolytes, & Acid/Base
- Water (H2O) is an ideal solvent for physiological reactions
- It interacts with other H2O molecules via hydrogen bonds.
- It works as an excellent biological fluid and solute
- Electrolytes are important in body fluids
- Electrolytes in water play a significant role in health
Units for Measuring Concentration of Solutes
- Concentrations of solutes can be expressed in different ways (moles, equivalents, osmoles).
- The number of molecules, electrical charges, and particles per unit volume can be more meaningful.
- Physiologic concentrations are often expressed in moles, equivalents, or osmoles.
- % concentration is used to express the amount of solute in the solvent (grams/100ml)
Physiological Saline or Serum Physiologic
- A sterile sodium chloride solution is considered isotonic.
- Isotonic solutions have equal solute concentration to body fluids.
- These solutions are used as solvents for parenterally administered drugs
Moles
- A mole is the gram molecular weight of a substance (g/mol).
- Millimoles (mmol) represent 1/1000 of a mole.
- The molecular weight of NaCl is 58.5 g
Equivalents
- An equivalent is 1 mol of an ionized substance divided by its valence.
- The general number of equivalents formula is E = MW/charge number.
pH & Buffering
- Maintaining stable hydrogen ion concentration (H+) is crucial for life.
- pH measures the concentration of H+
- The pH of pure water at 25°C is 7.0.
- The normal pH range of blood plasma is 7.35-7.45 (slightly alkaline)
pH & Buffering (molecules)
- H+ donors are acids and H+ acceptors are bases.
- Strong acids dissociate completely in water.
- Most acids and bases in physiology are weak.
- The body's pH is stabilized by buffers.
pH & Buffering (buffers)
- Buffers are substances that can bind or release H+ to maintain stable pH.
- Biologic fluids have multiple buffers.
How Is The Body Organized? (General)
- Understanding the components of the body and their organization is crucial
- Structural (anatomy) and Functional organization should be considered
Biological Organization Levels
- The six organization levels in the human body are: chemical, cell, tissue, organ, system, and organism.
How Is The Body Organized? (Chemical Level)
- The chemical level of organization is the simplest level containing elements and molecules
- Elements are chemical substances that cannot be broken down.
- Molecules are formed when two or more atoms combine.
Major Elements in the Human Body
- Major elements in the human body include hydrogen (H), carbon (C), oxygen (O), nitrogen (N), phosphorus (P), calcium (Ca), sodium (Na), potassium (K), and chlorine (Cl).
Inorganic Compounds
- Inorganic compounds are small and simple compounds in the human body, crucial for establishing water and electrolyte balance and for membrane transport. (e.g., water, salt, HCl, ammonia).
Organic Compounds
- There are four major categories of organic compounds in the human body: carbohydrates, lipids, proteins, and nucleic acids.
Cell Organization
- Cell are the fundamental building block.
- Cells and molecules combine in different ways forming an organism.
- Each cell in an organism has particular features that aid in its specific function.
Tissues
- Tissues form by similar cells
- Different tissues combines to form organs
- Four types of tissue include muscle, nervous, epithelial, and connective tissue.
Epithelial Tissue
- Composed of epithelial cells
- Key roles of epithelial tissue include protection, secretion, absorption, and sensory functions
Epithelial Tissue: Endocrine Glands
- Endocrine glands release hormones directly into the bloodstream to affect the body.
- E.g., adrenal glands
Epithelial Tissue: Exocrine Glands
- Exocrine glands have a channel that secrete material to release material
- E.g.-sweat, saliva glands
Epithelial Tissue: Absorption
- Epithelial cells in kidney tubules reabsorb water
- Another example is absorption tissues in intestine
Epithelial Tissue: Sensory Function
- Specialized epithelial cells in taste buds and the olfactory region of the nose detect tastes and smells
Muscle Tissue
- Muscle tissue is composed of cells specialized for contraction.
- Three types of muscle tissue include skeletal muscle, cardiac muscle, and smooth muscle
Connective Tissue
- Connective tissue supports, protects, stores, and repairs structures of the body.
- Fibroblast cells play role in repairing and regeneration
- Includes Bone, cartilage, blood and lymphatic tissue
Nervous Tissue
- Makes up the nervous system
- Functions to generate and transmit electrical signals throughout the body.
- Neurons and glial cells are part of the nervous tissue
Organs
- An organ is formed when different tissues work together to perform a particular function.
- Organs in the body form systems
Systems
- Systems are composed of different organs to perform a particular task
- Organs work together to form systems (e.g. circulatory, digestive, nervous, musculoskeletal, reproductive, lymphatic & immune, respiratory, urinary)
The Organism
- An organism is the highest level of biological organization.
- It is formed when the systems work together to carry out functions.
Body Fluids (Summary)
- 60% of the human body is fluid.
- This fluid is dilute solutions found in and around cells.
- The majority of the fluid is in ICF, and ECF
- ECF is sub-categorised in Plasma and Interstitial fluid
- Extracellular fluid helps maintain stable internal body conditions
Properties of Extracellular Fluid
- Ions and nutrients in extracellular fluid are essential for cell survival
- Extracellular fluid (ECF) creates a stable internal environment.
- Cells can function as long as proper concentrations of molecules, ions, etc. are maintained
Extracellular Fluid as The Cell's Environment
- Fluid around cells is essential to maintain stable internal conditions (homeostasis)
- Cells depend on this environment for proper function
Importance of Homeostasis
- Homeostasis is crucial for proper function
- Body systems maintain internal stability in response to changes in the internal or external environment
- Homeostasis is maintained via feedback loops
How is Homeostasis Maintained & Controlled?
- Homeostasis is controlled via feedback loops, which are cycles of events to regulate an aspect of the internal environment (e.g., temperature or blood pressure)
- Physiological parameter are monitored and regulated via input, processing and output via feedback mechanism
What is a Feedback Loop?
- Receptors detect changes in a physiological variable
- The control center compares the monitored variable to a set point
- The effector produces a response
- Maintaining homeostasis requires a continual cycle of monitoring, feedback, and response.
Let's use an Air Conditioner as an Example
- Air conditioners use negative feedback loops to maintain a consistent room temperature
- The thermostat acts as the receptor and control center
- The air conditioning unit acts as the effector
Feedback Loops - types (Negative/positive)
- Negative feedback loops counteract a change to maintain an internal equilibrium such as blood pressure
- Positive feedback loops amplify or enhance a change such as contractions during labor or blood clot formation
Negative Feedback Loops in The Body
- Negative feedback loops are common in the body.
- They are essential for maintaining homeostasis in various physiological conditions, like blood pressure, glucose regulation, oxygen regulation etc
- Each system has a particular role
Blood pressure (BP)
- Blood pressure (BP) is regulated by negative feedback loops
- Receptors monitor BP, input to the brain, output back to the blood vessels to regulate
Temperature Regulation
- Body temperature is regulated by negative feedback loops
- Receptors monitor temperature, input to the brain, output (response mechanism) to regulate temp.
When Does a Negative Feedback Loop End?
- Negative feedback processes end when a stimulus or variable is back within its normal range
Positive Feedback Loops in the Body
- Positive feedback loops amplify a change to cause a significant change such as childbirth and blood clotting
What about Positive Feedback?
- Positive feedback loops are less common in maintaining homeostasis
- Positive feedback involves amplifying a change or response beyond baseline
Positive Feedback in Childbirth
- Oxytocin release during childbirth is an example of a positive feedback loop.
- Amplification of the feedback loop pushes labor towards completion
Positive Feedback in Blood Clotting
- Platelets release chemicals during blood clotting
- The chemicals cause more platelets to adhere, thus amplifying the clotting response
Dangerous Positive Feedback
- A dangerous positive feedback loop can occur when the body loses control of a variable, like unregulated body temperature increase which can cause a negative effect such as death/injury
What stops a Positive feedback loop?
- External stimuli that stop the feedback loop
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Description
Test your knowledge on human body physiology with this quiz, which covers various topics such as specialized tissue groups, levels of organization, and biochemical compounds. Answer questions about essential functions and properties of carbohydrates, lipids, proteins, and electrolytes. Perfect for students in biology or health sciences.