Human Body Physiology Overview

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Questions and Answers

What percentage of water typically composes most cells?

  • 70 to 85% (correct)
  • 85 to 90%
  • 60 to 70%
  • 50 to 60%

Which type of proteins mainly form the cytoskeleton of cells?

  • Structural proteins (correct)
  • Enzymatic proteins
  • Functional proteins
  • Membrane proteins

What structural role do carbohydrates primarily serve in cells?

  • Structural and nutritional support (correct)
  • Cell membrane formation
  • Energy storage
  • Chemical signaling

Which type of lipids is key in forming the cell membrane?

<p>Phospholipids (D)</p> Signup and view all the answers

What is the primary function of integral proteins in cell membranes?

<p>Transporting specific substances (C)</p> Signup and view all the answers

What is the characteristic of the cell membrane thickness?

<p>7.5 to 10 nanometers thick (C)</p> Signup and view all the answers

Which ion is NOT mentioned as being important in cellular functions?

<p>Iron (B)</p> Signup and view all the answers

How does the lipid composition of membranes affect substance movement?

<p>It impedes movement of water and water-soluble substances (A)</p> Signup and view all the answers

What do Baroque systems primarily contain instead of high places?

<p>Oxidizers (A)</p> Signup and view all the answers

What is the primary function of mitochondria in cells?

<p>To oxidize substances and release energy (B)</p> Signup and view all the answers

What is the composition of the mitochondria's membranes?

<p>Two lipid bilayer membranes (B)</p> Signup and view all the answers

Which of the following best describes the role of intermediate filaments?

<p>To act as a cytoskeleton for structural support (A)</p> Signup and view all the answers

How does the number of mitochondria in a cell vary?

<p>According to the energy requirements of the cell (C)</p> Signup and view all the answers

What substance is primarily synthesized as a result of oxidation in the mitochondria?

<p>Adenosine triphosphate (ATP) (D)</p> Signup and view all the answers

What message does the nucleus send to the cell?

<p>To grow, mature, replicate, or die (A)</p> Signup and view all the answers

Which structure is continuous with the nuclear membrane?

<p>Endoplasmic reticulum (A)</p> Signup and view all the answers

What is a characteristic of isotonic solutions regarding cell volume?

<p>It does not cause cells to shrink or swell. (D)</p> Signup and view all the answers

What happens to cells when placed in a hypertonic solution?

<p>Water moves out of the cells, causing them to shrink. (C)</p> Signup and view all the answers

What primarily determines the effectiveness of a saline solution in affecting cell volume?

<p>The concentration of impermeable solids in the solution. (B)</p> Signup and view all the answers

How is osmolarity typically corrected in the body after a change occurs?

<p>It is corrected within seconds to minutes. (B)</p> Signup and view all the answers

Which statement best describes the effect of a hypertonic solution on extracellular volume?

<p>It increases extracellular volume by drawing water out of cells. (A)</p> Signup and view all the answers

What condition can lead to hyponatremia?

<p>Excess water addition diluting sodium levels. (D)</p> Signup and view all the answers

What is the main effect of adding isotonic saline to extracellular fluid?

<p>It increases the extracellular fluid volume without altering cell volume. (B)</p> Signup and view all the answers

If a cell is placed in a solution with less than 0.9% sodium chloride, what is expected?

<p>Water will diffuse into the cell, causing it to swell. (C)</p> Signup and view all the answers

What occurs when the membrane potential rises towards zero?

<p>Potassium channels open and allow diffusion. (C)</p> Signup and view all the answers

Which ion has a higher conductance during the resting state compared to sodium?

<p>Potassium (A)</p> Signup and view all the answers

What initiates the positive feedback cycle during an action potential?

<p>Initial rise in membrane potential from -70mV (D)</p> Signup and view all the answers

What is the role of potassium channels during repolarization?

<p>Restore resting membrane potential by allowing potassium to exit (A)</p> Signup and view all the answers

What effect does the inactivation of sodium channels have after depolarization?

<p>Prevents further sodium entry into the cell. (D)</p> Signup and view all the answers

What occurs to sodium and potassium ions during the action potential?

<p>Sodium enters the cell, while potassium exits the cell. (C)</p> Signup and view all the answers

How is an action potential propagated along a nerve or muscle?

<p>By simultaneous ion flow in all directions (C)</p> Signup and view all the answers

What is the approximate voltage change needed to start the positive feedback loop?

<p>15 to 30mV (C)</p> Signup and view all the answers

What is the primary cause of extracellular edema?

<p>Increased leakage of fluid from plasma (A)</p> Signup and view all the answers

How does heart failure contribute to edema?

<p>By increasing capillary filtration and pressure (B)</p> Signup and view all the answers

What condition can cause a decrease in plasma colloid osmotic pressure?

<p>Nephrotic syndrome (B)</p> Signup and view all the answers

What safety factors typically prevent edema in the body?

<p>Ability of lymph flow to increase significantly (A)</p> Signup and view all the answers

What effect does high sodium chloride concentration in extracellular fluid have?

<p>It leads to leakage into interstitial spaces (C)</p> Signup and view all the answers

In which condition might substantial fluid collect in potential spaces of the body?

<p>Edema in adjacent subcutaneous tissue (C)</p> Signup and view all the answers

What physiological function is affected by hydrogen concentration changes in the body?

<p>Operation of enzyme systems (C)</p> Signup and view all the answers

What can result from blockage of phallic vessels draining potential spaces?

<p>Effusion or fluid accumulation (B)</p> Signup and view all the answers

What functions do the Starling forces serve in fluid movement?

<p>They influence both filtration and reabsorption of fluid. (D)</p> Signup and view all the answers

What is the average capillary pressure at the arterial ends of the capillary?

<p>15 to 25 mm of mercury (C)</p> Signup and view all the answers

How does interstitial fluid pressure typically affect lymph flow?

<p>It increases lymph flow when increased. (D)</p> Signup and view all the answers

What is the fate of most fluid filtered from the capillaries?

<p>It is reabsorbed back into the capillaries. (A)</p> Signup and view all the answers

What role does the lymphatic system serve in fluid regulation?

<p>It drains excess fluid from interstitial spaces back to the blood. (A)</p> Signup and view all the answers

What is the average plasma colloid osmotic pressure?

<p>28 mm of mercury (B)</p> Signup and view all the answers

What initiates fluid filtration across the capillaries?

<p>Positive net filtration pressure (B)</p> Signup and view all the answers

What is the average volume of fluid entering the lymphatic system daily?

<p>2 to 3 liters (B)</p> Signup and view all the answers

Flashcards

What are peroxisomes?

Organelles containing oxidizers that utilize hydrogen peroxide to break down substances like fatty acids. They self-replicate and can convert alcohol into fuel.

What are mitochondria?

These organelles are responsible for cellular energy production, converting nutrients into ATP. They are found in all cells and are more concentrated where energy is needed.

What is the cytoskeleton?

A network of protein filaments that provides structure and support for the cell. It helps with cell shape, movement, and contraction of muscles.

What are intermediate filaments?

Strong, rope-like filaments that work with microtubules to provide strength and support in all cells.

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What are microtubules?

Long, hollow tubes that provide a rigid structure for the cell, helping to determine its shape and allowing movement.

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What is the nucleus?

The control center of the cell, containing DNA and sending messages for growth, maturation, replication, or death.

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What is the nuclear envelope?

The nuclear envelope is actually two separate bilayer membranes. The outer membrane is continuous with the endoplasmic reticulum. It has pores that allow molecules to pass through.

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What are nuclear pores?

These pores are found on the nuclear envelope and allow molecules to pass in and out of the nucleus.

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Water in Cells

The majority of cells, excluding fat cells, are composed of 70% to 85% water, which is essential for various cellular processes.

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Important Ions in Cells

Potassium, magnesium, phosphate, sulfate, bicarbonate, and small amounts of sodium chloride and calcium play crucial roles in maintaining cellular functions.

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Proteins in Cells

Proteins, the second most abundant component of cells, constitute 10% to 20% of the cell's composition. They exist in two main forms: structural and functional.

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Structural Proteins

Structural proteins, mainly present as long filaments, are crucial for providing shape and support to the cell and its organelles. Examples include microtubules, cilia, nerve axons, and meiotic spindles.

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Functional Proteins

Functional proteins, often mobile and globular in shape, act primarily as enzymes that catalyze cellular reactions.

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Lipids in Cells

Lipids, a diverse group of substances, are grouped together due to their ability to dissolve in organic solutions but not in water. They are crucial for forming cell membranes and other barriers within the cell.

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Phospholipids

Phospholipids, a type of lipid, are mainly insoluble in water and are essential for building the cell membrane and internal membrane barriers.

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Carbohydrates in Cells

Carbohydrates are primarily used for energy and structure within the cell, although most cells don't store large amounts of them. Glucose, a simple sugar, is readily available in the surrounding extracellular fluid.

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Fluid Tonicity

The ability of a solution to cause a change in cell volume due to the concentration of impermeable solids.

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Isotonic Solution

A solution that causes no change in cell volume. The concentration of solutes inside and outside the cell are equal.

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Hypertonic Solution

A solution with a higher concentration of solutes than the cell. Water moves out of the cell, causing it to shrink.

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Hypotonic Solution

A solution with a lower concentration of solutes than the cell. Water moves into the cell, causing it to swell.

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Water Movement Across Cell Membranes

The rapid movement of water across cell membranes, often correcting osmolarity differences within seconds or minutes. However, it doesn't immediately equilibrate the whole body.

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Hyponatremia

A condition where the sodium concentration in the extracellular fluid is low. It can be caused by either losing sodium or adding excess water.

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Isotonic Saline on Extracellular Fluid

The primary effect of adding an isotonic saline solution to the extracellular fluid is an increase in the extracellular fluid volume.

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Hypertonic Solution on Extracellular Fluid

When a hypertonic solution is added to the extracellular fluid, it increases extracellular osmolarity, causing water to move out of the cells, resulting in cell shrinkage and an increase in extracellular fluid volume.

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Repolarization

The sodium channels close and the potassium channels open, allowing for the rapid loss of potassium ions to the exterior and no flow of sodium ions to the interior. This results in the action potential quickly returning to its baseline.

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Depolarization

During the early portion of the action potential, more sodium ions flow into the cell than potassium ions flow out, causing the membrane potential to become positive.

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Positive Feedback Loop

The process where an initial small rise in membrane potential triggers more sodium channels to open, causing a rapid increase in sodium influx, which further depolarizes the membrane, leading to the opening of even more sodium channels. This cycle continues until all voltage-gated sodium channels are activated.

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Threshold potential

The change in membrane potential required to trigger the positive feedback loop and initiate an action potential.

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Action Potential

The electrical signal that travels along the membrane of a nerve or muscle cell. It is caused by the rapid movement of ions across the membrane.

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Bidirectional Propagation

The ability of the action potential to travel in both directions from the point of stimulation.

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Inactivation Gate

The period during which the activation gate of the sodium channel will not reopen until the membrane potential returns towards the resting membrane potential

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Resting Membrane Potential

The state where the cell membrane is at rest. The potential difference across the membrane is maintained at a relatively constant value.

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Starling Forces

The four main forces that govern fluid movement between capillaries and interstitial fluid. These forces are responsible for the balance of fluid in our bodies.

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Capillary Hydrostatic Pressure

The pressure exerted by blood inside capillaries, pushing fluid outward.

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Interstitial Fluid Hydrostatic Pressure

The pressure exerted by fluid in the interstitial space, pushing fluid back into capillaries.

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Plasma Colloid Osmotic Pressure

The pressure exerted by proteins in the blood, pulling fluid into the capillaries.

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Interstitial Fluid Colloid Osmotic Pressure

The pressure exerted by proteins in the interstitial fluid, pulling fluid out of the capillaries.

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Net Filtration Pressure

The difference between filtration pressure and reabsorption pressure, determining the net movement of fluid.

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Lymphatic System

A network of vessels that collect excess fluid from the interstitial spaces and return it to the bloodstream.

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Reabsorption

The process of fluid moving from the interstitial spaces back into the capillaries at the venous end.

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Extracellular Edema

Abnormal leakage of fluid from blood vessels into the surrounding tissues, often due to increased pressure within blood vessels or reduced protein levels in the blood.

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Heart Failure as a Cause of Edema

A condition where the heart cannot effectively pump blood, leading to increased pressure in capillaries and fluid buildup.

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Kidney Failure and Edema

Failure of the kidneys to filter and remove excess salt and water from the body. This can lead to fluid buildup in the tissues.

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Cirrhosis and Edema

A condition where the liver is damaged, impairing its ability to produce proteins. Reduced protein levels can lead to decreased osmotic pressure and edema.

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Potential Body Spaces

Spaces between tissues that typically contain a small amount of fluid, allowing for sliding and flexibility. These spaces can fill with excessive fluid during edema.

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Acid-Base Regulation

The process of regulating the balance of acids and bases in the body, which is essential for maintaining proper cell function.

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Enzymes and Hydrogen Ion Concentration

Enzymes, which are proteins that catalyze biochemical reactions, are sensitive to changes in hydrogen ion concentration (pH).

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Study Notes

Functional Organization of the Human Body

  • Homeostasis is the maintenance of nearly constant internal conditions.
  • Disease is often a disruption of homeostasis.
  • Physiology explains how physiologic processes change in disease and injury.

Extracellular Fluid Transport

  • Fluid moves through the body in two stages:
    • Blood flow through vessels
    • Movement from capillaries to interstitial space
  • Cells are typically within 50 micrometers of a capillary.
  • Exchange between plasma and interstitial fluid occurs constantly.
  • Blood picks up oxygen in alveoli during pulmonary circulation.
  • Gastrointestinal tract absorbs carbohydrates, fatty acids, and amino acids.
  • Liver processes these substances into usable forms and eliminates waste.
  • Kidneys filter plasma, reabsorbing needed substances and excreting waste.

Nervous System

  • Three parts: sensory, central, and motor output
  • Sensory receptors detect body/environment conditions.
  • Brain processes sensory input and generates responses.
  • Motor output transmits signals to regulate body functions (organs and tissues).
  • Hormones are chemical messengers transported in the extracellular fluid to regulate cellular functions (insulin e.g.).

Immune System

  • Composed of white blood cells (WBCs), thymus, lymph nodes, and lymph vessels
  • Distinguishes self cells from foreign invaders, destroying those invaders through phagocytosis or antibodies.
  • Skin, hair, nails, and glands protect deeper tissues.
  • Plays role in temperature regulation and waste excretion.

Reproductive System

  • Contributes to maintaining homeostasis by generating new organisms.

Control Systems

  • Body has thousands of control systems (genetic, within cells, within organs, throughout body) to regulate homeostasis and conditions (e.g. oxygen, CO2, and blood pressure).
  • Negative feedback mechanisms are common in the body. Initial disruption triggers a response to return conditions to normal.
  • Positive feedback mechanisms can result in instability.

Cell Structure and Function

  • Most cells contain 70-85% water, with many ions and 10-20% proteins (e.g. enzymes).
  • Lipids are essential for membranes and cellular compartmentalization (e.g. phospholipids and cholesterol).
  • Carbohydrates provide energy and structure.
  • Organelles like mitochondria, covered in membrane, produce ATP (cellular energy).
  • Cytoskeleton provides structure and support to organelles.
  • Membranes composed of proteins and lipids control substance passage.

Membrane Proteins/Transport

  • Proteins (integral, peripheral) function as channels/pores for passage of molecules.
  • Carbohydrates and lipids create glycoproteins/glycolipids.
  • Receptors on cell surface bind specific substances (hormones, drugs) to transmit signals to the interior of a cell.

Action Potentials/Nerve Signaling

  • Nerve signals spread in the form of action potentials.
  • Sodium & potassium move across the membrane with changes in permeability of channels.
  • Positive feedback loops rapidly drive depolarization.
  • Negative feedback returns the membrane potential to resting (normal) state.
  • Myelin sheath speeds up these nerve signals.

Microcirculation and Lymphatic System

  • Capillaries are small blood vessels, allowing diffusion of substances between blood and interstitial fluid.
  • Starling forces regulate fluid movement in and out of capillaries.
  • Lymphatic system is an important route for fluid return to the circulatory system.

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