Human Blood Anatomy and Functions Quiz
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Questions and Answers

What is the main function of macrophages in the spleen, liver, and red bone marrow?

  • To produce red blood cells (RBCs)
  • To break down old and damaged RBCs (correct)
  • To store iron (Fe)
  • To transport oxygen to the tissues
  • What is the average lifespan of a red blood cell?

  • 120 days (correct)
  • 60 days
  • 30 days
  • 90 days
  • What is bilirubin?

  • A hormone that stimulates red blood cell production
  • A pigment produced during the breakdown of heme (correct)
  • A protein that carries oxygen in the blood
  • A type of white blood cell
  • What is the name of the process by which red blood cells rupture in the bloodstream?

    <p>Hemolysis (A)</p> Signup and view all the answers

    What happens to the alpha and beta chains of hemoglobin after the heme is broken down?

    <p>They are eliminated in urine (C)</p> Signup and view all the answers

    Which of the following is NOT a function of blood?

    <p>Production of hormones (B)</p> Signup and view all the answers

    What is the approximate blood volume of a 75-kg individual?

    <p>5.25 liters (A)</p> Signup and view all the answers

    What is the process of separating blood into plasma and formed elements called?

    <p>Fractionation (D)</p> Signup and view all the answers

    What is the primary component of plasma?

    <p>Water (D)</p> Signup and view all the answers

    Which type of plasma protein is responsible for maintaining plasma osmolarity?

    <p>Albumins (A)</p> Signup and view all the answers

    Which of the following formed elements is NOT found in the buffy coat?

    <p>Red blood cells (B)</p> Signup and view all the answers

    What is the approximate pH range of blood?

    <p>7.35-7.45 (D)</p> Signup and view all the answers

    What is the normal temperature of blood?

    <p>38ºC (100.4ºF) (C)</p> Signup and view all the answers

    What is the primary function of platelets in the platelet phase of hemostasis?

    <p>To form a plug that closes small breaks in blood vessels. (E)</p> Signup and view all the answers

    What is the role of exposed collagen fibers in the platelet phase?

    <p>They promote the adhesion and aggregation of platelets. (C)</p> Signup and view all the answers

    Which of the following is NOT a chemical released by activated platelets?

    <p>Fibrinogen (B)</p> Signup and view all the answers

    What is the approximate time frame for platelet aggregation to begin after an injury?

    <p>Within 15 seconds (B)</p> Signup and view all the answers

    What is the main difference between the vascular spasm and the platelet phase of hemostasis?

    <p>All of the above statements are correct. (D)</p> Signup and view all the answers

    What are the primary substances responsible for identifying cells to the immune system?

    <p>Surface antigens (C)</p> Signup and view all the answers

    Which blood type contains both anti-A and anti-B antibodies?

    <p>Type O (B)</p> Signup and view all the answers

    What happens to the alpha and beta chains of hemoglobin that are not phagocytized?

    <p>They are eliminated in the urine (B)</p> Signup and view all the answers

    What is the name given to the antibodies in plasma that attack antigens on foreign red blood cells?

    <p>Agglutinins (B)</p> Signup and view all the answers

    Which blood type is considered the universal recipient?

    <p>Type AB+ (B)</p> Signup and view all the answers

    Why is a cross-match test performed before a blood transfusion?

    <p>To detect potential cross-reactions between donor's RBCs and recipient's plasma (C)</p> Signup and view all the answers

    What is the significance of the Rh antigen in blood typing?

    <p>It can cause hemolytic disease of the newborn (A)</p> Signup and view all the answers

    What is the name given to the breakdown product of bilirubin that is found in urine?

    <p>Urobilins (D)</p> Signup and view all the answers

    What is the primary function of the liver in relation to bilirubin?

    <p>Excretion of bilirubin (A)</p> Signup and view all the answers

    What happens to bilirubin in the large intestine?

    <p>It is converted to urobilins and stercobilins (D)</p> Signup and view all the answers

    What is the name of the process that results in the clumping of red blood cells during a transfusion reaction?

    <p>Agglutination (C)</p> Signup and view all the answers

    What is the fate of bilirubin in the bloodstream?

    <p>It is transported to the liver for excretion (B)</p> Signup and view all the answers

    What are the surface antigens on red blood cells called?

    <p>Agglutinogens (C)</p> Signup and view all the answers

    Which type of blood does not produce either anti-A or anti-B antibodies?

    <p>Type AB (C)</p> Signup and view all the answers

    What are the main components of blood?

    <p>Red blood cells, white blood cells, platelets, and plasma (D)</p> Signup and view all the answers

    What causes hemolytic disease of the newborn?

    <p>The mother's production of antibodies against the fetus's Rh antigen (A)</p> Signup and view all the answers

    Which clotting factor is NOT involved in the intrinsic pathway?

    <p>Factor VII (A)</p> Signup and view all the answers

    Which of the following is NOT a consequence of Thrombocytopenia?

    <p>Increased risk of blood clots (B)</p> Signup and view all the answers

    What is the role of Factor X in the coagulation process?

    <p>Activation of prothrombin (A)</p> Signup and view all the answers

    Which statement accurately describes the role of Vitamin K in the clotting process?

    <p>Vitamin K is essential for the synthesis of various clotting factors (C)</p> Signup and view all the answers

    What is the function of the common pathway in the coagulation process?

    <p>Converts fibrinogen to fibrin using thrombin (D)</p> Signup and view all the answers

    Which of the following statements accurately describes the intrinsic pathway of coagulation?

    <p>Activated by contact with collagen and other negatively charged surfaces (D)</p> Signup and view all the answers

    How does the formation of a blood clot help in hemostasis?

    <p>By sealing off the damaged portion of the vessel to prevent further blood loss (D)</p> Signup and view all the answers

    What is the role of calcium ions (Ca2+) in the coagulation process?

    <p>Ca2+ acts as a cofactor for many clotting factors (C)</p> Signup and view all the answers

    Which of these statements describes Hemophilia?

    <p>A genetic condition affecting the ability of blood to clot properly (B)</p> Signup and view all the answers

    Which of the following is a characteristic of both the extrinsic and intrinsic pathways of coagulation?

    <p>Both pathways involve the final activation of Factor X (A)</p> Signup and view all the answers

    What is the primary reason for clot retraction?

    <p>To stabilize the injury site and pull the torn edges of the vessel closer together. (B)</p> Signup and view all the answers

    Which of these is NOT a direct participant in clot retraction?

    <p>Thrombin (A)</p> Signup and view all the answers

    What is the role of plasmin in the process of fibrinolysis?

    <p>Plasmin digests fibrin strands, dissolving the clot. (B)</p> Signup and view all the answers

    Which of these is a characteristic of thrombophilia?

    <p>Increased tendency for blood to form clots. (C)</p> Signup and view all the answers

    What is the primary difference between clot retraction and fibrinolysis?

    <p>Clot retraction strengthens and stabilizes the clot, while fibrinolysis breaks it down. (C)</p> Signup and view all the answers

    Flashcards

    Macrophages

    Immune cells that engulf and digest cellular debris and pathogens.

    Transferrin

    A protein that transports iron (Fe2+) in the bloodstream.

    Hemolysis

    The rupture of red blood cells (RBCs), releasing their contents.

    Bilirubin

    A yellow compound that occurs from the breakdown of hemoglobin, often bound to albumin.

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    RBC Lifespan

    The average lifespan of red blood cells is approximately 120 days.

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    Cardiovascular system

    System consisting of the heart, blood vessels, and blood.

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    Blood

    Specialized connective tissue containing cells in a fluid matrix.

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    Functions of blood

    Transport, regulation, restriction, defense, and stabilization.

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    Blood characteristics

    High viscosity, slightly alkaline, with a temperature of 38ºC.

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    Fractionation

    Separation of whole blood into plasma and formed elements.

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    Plasma

    Fluid component of blood, making up 55% of its volume.

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    Formed elements

    Cells and cell fragments in blood, including RBCs and WBCs.

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    Plasma proteins

    Proteins in plasma, including albumins that regulate osmolarity.

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    Phases of Hemostasis

    The processes involved in stopping bleeding, including Vascular, Platelet, Coagulation, and Clot Retraction phases.

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    Vascular phase

    The initial response to blood vessel injury characterized by contraction of endothelial cells and vascular spasm to reduce blood flow.

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    Platelet adhesion

    The process where platelets attach to damaged blood vessel surfaces, starting the formation of a platelet plug.

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    Platelet aggregation

    The sticking of activated platelets together to form a temporary plug at the site of a blood vessel injury.

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    Activated platelets

    Platelets that, upon injury, release chemicals promoting clotting, aggregation, and vascular repair.

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    Thrombophilia

    A condition where blood has an increased tendency to form clots.

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    Deep vein thrombosis (DVT)

    A blood clot formed in one or more deep veins, usually in the legs.

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    Clot retraction

    The process where platelets contract, pulling vessel edges together to stabilize an injury.

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    Fibrinolysis

    The gradual process of dissolving a blood clot after healing occurs.

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    Hemostasis

    The process that prevents and stops bleeding, maintaining blood in a fluid state.

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    Fibrin

    A protein that forms a fibrous network to generate blood clots.

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    Prothrombin

    A protein that is converted to thrombin during the clotting process.

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    Thrombin

    An enzyme that converts fibrinogen to fibrin and activates platelets in clotting.

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    Calcium ions (Ca2+)

    Essential ions needed in various stages of blood coagulation.

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    Vitamin K

    A vitamin required for synthesizing several clotting factors.

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    Thrombocytopenia

    A condition characterized by an abnormally low level of platelets.

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    Hemophilia

    An inherited bleeding disorder where blood doesn't clot properly.

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    Intrinsic pathway

    One of the pathways leading to coagulation that begins with damage to the vessel.

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    Extrinsic pathway

    The pathway that begins with external trauma leading to clotting.

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    Surface antigens

    Substances on cell membranes that identify cells to the immune system.

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    Blood type

    Classification of blood based on surface antigens present on RBCs (A, B, AB, O).

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    Agglutinogens

    Surface antigens on red blood cells that determine blood type.

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    Agglutinins

    Antibodies present in plasma that attack foreign RBC antigens.

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    Type O blood

    A blood type that lacks A and B surface antigens and has both anti-A and anti-B antibodies.

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    Rh blood group

    Classification based on presence (Rh+) or absence (Rh-) of the Rh antigen.

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    Cross-reaction

    A transfusion reaction that occurs if blood types are incompatible.

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    Universal donor

    Type O- blood, which can be given to any blood type without causing reactions.

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    Universal recipient

    Type AB+ blood, which can receive any blood type.

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    Compatibility testing

    Tests conducted prior to transfusions to find compatible blood types.

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    Hemolytic Disease of the Newborn

    Condition occurring when an Rh- mother has an Rh+ fetus, leading to immune response in subsequent pregnancies.

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    Rh+ mother

    A mother with the Rh antigen, typically does not cause issues with pregnancy.

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    Anti-Rh antibodies

    Antibodies produced by Rh- mothers after exposure to Rh+ blood, can affect future pregnancies.

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    Study Notes

    Cardiovascular System

    • Consists of a pump (the heart), a series of conducting hoses (blood vessels), and fluid connective tissue (blood).

    Blood

    • Specialized connective tissue, with cells suspended in a fluid matrix.

    Functions of Blood

    • Transports dissolved gases, nutrients, hormones, and metabolic wastes.
    • Regulates pH, ion composition of interstitial fluids.
    • Restricts fluid losses at injury sites.
    • Defends against toxins and pathogens.
    • Stabilizes body temperature.

    Characteristics of Blood

    • 38°C (100.4°F).
    • High viscosity.
    • Slightly alkaline (pH of 7.35-7.45).
    • Blood volume is 7 percent of body weight (in liters).

    Blood Fractionation

    • Process of separating whole blood into plasma and formed elements.
    • Whole blood: Plasma (55% total volume), Buffy coat (<1% total volume), Erythrocytes (45% total volume).

    Plasma

    • Makes up about 55 percent of blood volume.
    • More than 90 percent of plasma is water.
    • Dissolved plasma proteins and other solutes.
    • Similar in composition to interstitial fluid.

    Plasma Proteins

    • Albumins (60 percent): Major contributors to plasma osmolarity, Transport fatty acids, thyroid hormones, some steroid hormones.
    • Globulins (35 percent): Antibodies, Transport globulins (hormone-binding proteins, lipoproteins, and steroid-binding proteins)
    • Fibrinogen (4 percent): Soluble protein that functions in clotting. Converted to insoluble fibrin.
    • Other plasma proteins (1 percent): Varying concentrations of enzymes and hormones.

    Plasma Proteins: Origins

    • More than 90 percent made in the liver (including all albumins, fibrinogen, most globulins, and various proenzymes).
    • Antibodies made by plasma cells.
    • Peptide hormones made by endocrine organs.

    Hemopoiesis

    • Process of producing formed elements (red blood cells, white blood cells, cell fragments (platelets)).

    Red Blood Cells (RBCs)

    • Also called erythrocytes.

    • Make up 99.9 percent of formed elements.

    • Contains hemoglobin (red pigment that gives whole blood its color).

    • Binds and transports oxygen and carbon dioxide.

    • Normal red blood cell counts: Adult male (4.5-6.3 million per microliter), Adult female (4.2-5.5 million per microliter).

    • Packed cell volume (PCV) (Hematocrit): Adult male (46), Adult female (42).

    RBC Structure

    • Small, highly specialized cells.
    • Biconcave discs.
    • Thin central region and thicker outer margin.

    Important Effects of RBC Structure on Function

    • Large surface area-to-volume ratio: Quickly absorb and release oxygen.
    • Form stacks (rouleaux): Smooth blood flow through narrow blood vessels.
    • Bend and flex easily: Pass through small capillaries (7.8-µm RBC can pass through a 4-µm capillary).

    Mature RBCs

    • Anucleate (Lack nuclei).
    • Lack mitochondria and ribosomes.
    • Unable to divide, synthesize proteins, or repair damage.
    • Live about 120 days.

    Hemoglobin

    • Protein in RBCs that transports respiratory gases.
    • Normal Hemoglobin: Adult male (14-18 g/dL), Adult female (12-16 g/dL).
    • Hb molecules contain iron.
    • Iron + oxygen= oxyhemoglobin
    • Hb without oxygen = deoxyhemoglobin

    Hemoglobin Function

    • Each RBC contains approximately 280 million Hb molecules.
    • In peripheral capillaries, where oxygen is low, hemoglobin releases oxygen.
    • Binds CO2, forming carbaminohemoglobin.
    • In the lungs, where oxygen is high, hemoglobin binds oxygen, and releases CO2.
    • Fetal hemoglobin (form of hemoglobin in the embryo or fetus): Binds oxygen more readily than adult hemoglobin.

    Anemia

    • Results when hematocrit or Hb content of RBCs is reduced.
    • Interferes with oxygen delivery to peripheral tissues.
    • Approximately 1 percent of circulating RBCs are replaced per day (about 3 million enter the blood stream each second)

    Erythropoiesis

    • Red blood cell formation.
    • In embryos, embryonic blood cells move from the bloodstream to the liver, spleen, thymus, and bone marrow.
    • Differentiate into stem cells.
    • In adults, occurs only in myeloid tissue (red bone marrow). Hemopoietics stem cells (HSCs) are also involved, giving rise to myeloid tissue producing progenitor cells that then give rise to RBCs.
    • Specific stages are identified by hematologists: Myeolid stem cell, Proerythroblast, Erythroblast stages, Reticulocyte, and Mature RBC.
    • Stimulated by erythropoietin (EPO), secreted by the kidneys and liver when oxygen in peripheral tissues is low (hypoxia).

    Blood Doping

    • Dangerous practice used by athletes.
    • Re-infuse packed RBCs to elevate hematocrit.

    Hemoglobin Recycling

    • Macrophages of the spleen, liver, and red bone marrow engulf aged RBCs, remove Hb molecules from hemolyzed (ruptured) RBCs, and break Hb into components.
    • Iron from the heme unit is recycled.
    • Residual bilirubin bound to albumin is excreted in bile; metabolized by intestinal bacteria to stercobilin/urobilins and excreted in feces or urine.

    WBCs

    • Also called leukocytes.

    • Have nuclei and other organelles.

    • Lack hemoglobin.

    • Defend the body against pathogens.

    • Remove toxins and wastes, and attack abnormal or damaged cells.

    • Some WBCs circulate in the blood.

    • Most WBCs are in connective tissues proper and organs of the lymphatic system.

    • WBC count: 5000-10,000 per microliter of blood.

    WBC types

    • Neutrophils: 50-70% (most abundant); defend body against pathogens, phagocytic, attack and digest bacteria, degranulation (release enzymes to destroy pathogens), live in blood stream for 10 hours, and contribute to pus.
    • Eosinophils: 2-4% (engulf bacteria, protozoa, and cellular debris, attack parasites).
    • Basophils: less than 1% (cross capillary endothelium, concentrate in damaged tissues- histamine and heparin (blood clotting).
    • Monocytes: 2-8%; Aggressive phagocytes that engulf large pathogens, release chemicals to attract other phagocytic cells to injured areas.
    • Lymphocytes: 20-40% (Continuously migrate in and out of bloodstream, reside in lymphatic system). (T cells, B cells, and Natural killer cells (NK cells))

    WBC disorders

    • Leukopenia: low WBC count.
    • Leukocytosis: high WBC count.
    • Leukemia: cancer of WBCs, indicated by extreme leukocytosis.

    Platelets

    • Cell fragments involved in the clotting system.

    • Circulate for 9-12 days; removed by phagocytes mainly in the spleen

    • 150,000-500,000 per microliter.

    • One-third of platelets are stored in vascular organs like the spleen.

    • Mobilized during a circulatory crisis.

    Platelet functions

    • Release important clotting chemicals and temporarily patch damaged vessel walls, reducing the size of breaks.
    • Thrombocytopoiesis: platelet production occurs in the red bone marrow via megakaryocytes.

    Hemostasis

    • The cessation of bleeding (has 3 phases)
    • Vascular phase, platelet phase and coagulation phase, and clot retraction.
      1. Vascular phase (about 30 minutes): A cut triggers vascular spasm (contraction of smooth muscle fibers of vessel wall- lasts about 30-minutes). Endothelial cells contract and expose basement membrane to bloodstream.
      1. Platelet phase (within 15 seconds of injury): Platelet adhesion (platelets attach to exposed surfaces) and platelets aggregation (platelets stick to each other) forming a platelet plug. Chemicals released that promote aggregation, vascular spasm, clotting, and vessel repair (ADP, PDGF, Ca2+, and clotting factors).
      1. Coagulation phase (blood clotting): Begins 30 seconds or more after injury; highly regulated. Dependent on clotting factors (Ca2+ and 11 proteins) and highly regulated mechanisms (proenzymes, which converts to active enzymes that direct reactions in the clotting response). The extrinsic and intrinsic pathways, leading to the common pathway, all converging to produce a stable fibrin clot.
      1. Clot retraction: Pulling torn edges of vessel closer together, reducing residual bleeding, stabilizing the injury site, making it easier for fibroblasts, smooth muscle cells, and endothelial cells to complete repairs. (Fibrin meshwork forms, platelets and red blood cells stick to the fibrin strands and contract).
    • Fibrinolysis: Gradual process of dissolving clot. Plasmin digests fibrin strands; thrombin and tissue plasminogen activator activate plasminogen, producing plasmin.

    Compatibility testing

    • Performed in advance to avoid transfusion reactions when donor's RBCs and recipient's plasma are not compatible
    • Type O- is the universal donor.
    • AB+ is the universal recipient

    Rh factors

    • Surface antigen on RBCs, used to determine blood types and compatibility. Involved in Hemolytic disease of the newborn.

    Hemolytic Disease of the Newborn

    • Problems seldom develop during a first pregnancy with an Rh+ fetus.
    • Exposure to fetal red blood cell antigens during delivery causes the mother's immune system to develop anti-Rh antibodies leading sensitization.
    • Subsequent pregnancies with an Rh+ fetus can result in destruction/lysis of fetal RBCs as the maternal anti-Rh antibodies enter the fetal bloodstream.
    • Prevents maternal sensitization to Rh factor: Administering RhoGAM to Rh- mothers during and after pregnancy (crucial for avoiding hemolytic disease).

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