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Questions and Answers
What role do Kupffer cells play within the liver's sinusoids?
What role do Kupffer cells play within the liver's sinusoids?
If two-thirds of a rodent's liver is surgically removed, what is the liver's main response?
If two-thirds of a rodent's liver is surgically removed, what is the liver's main response?
Which structure directly transports bile from the gallbladder to the common bile duct?
Which structure directly transports bile from the gallbladder to the common bile duct?
Where does the output from the liver's endocrine function go?
Where does the output from the liver's endocrine function go?
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What is the correct pathway of bile from the liver to the small intestine?
What is the correct pathway of bile from the liver to the small intestine?
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What is the primary function of the ileum?
What is the primary function of the ileum?
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Which of the following is responsible for activating pepsinogen to pepsin?
Which of the following is responsible for activating pepsinogen to pepsin?
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What is the approximate length of the jejunum?
What is the approximate length of the jejunum?
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What structure is found within the ileum that is an aggregate of lymph nodes?
What structure is found within the ileum that is an aggregate of lymph nodes?
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What is the role of the cardiac sphincter?
What is the role of the cardiac sphincter?
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Which of the following describes the primary function of the villi and microvilli?
Which of the following describes the primary function of the villi and microvilli?
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Which region of the small intestine receives secretions from the pancreas and liver?
Which region of the small intestine receives secretions from the pancreas and liver?
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What is the primary role of bile in digestion?
What is the primary role of bile in digestion?
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What is the primary function of Paneth cells located in the intestinal crypts?
What is the primary function of Paneth cells located in the intestinal crypts?
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Where do new epithelial cells originate that replace those at the tips of the villi?
Where do new epithelial cells originate that replace those at the tips of the villi?
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Which of the following best describes the relationship between villi and microvilli?
Which of the following best describes the relationship between villi and microvilli?
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What type of cells secrete mucus in the small intestine?
What type of cells secrete mucus in the small intestine?
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What are the brush border enzymes associated with?
What are the brush border enzymes associated with?
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What is the primary role of columnar epithelial cells in the small intestine?
What is the primary role of columnar epithelial cells in the small intestine?
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If a healthy individual has a decreased number of Paneth cells, what would be the most likely consequence?
If a healthy individual has a decreased number of Paneth cells, what would be the most likely consequence?
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What is the role of lysozyme in the small intestine?
What is the role of lysozyme in the small intestine?
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What is the primary function of bile salts in lipid digestion?
What is the primary function of bile salts in lipid digestion?
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Where does the majority of lipid digestion take place?
Where does the majority of lipid digestion take place?
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What is the main reason why enzymes in solution have limited access to insoluble lipid molecules?
What is the main reason why enzymes in solution have limited access to insoluble lipid molecules?
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Which of the following best describes the role of lingual lipase in the digestive process?
Which of the following best describes the role of lingual lipase in the digestive process?
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Which of these is TRUE regarding pancreatic lipases?
Which of these is TRUE regarding pancreatic lipases?
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Which enzyme is NOT involved in the digestion of carbohydrates in the small intestine?
Which enzyme is NOT involved in the digestion of carbohydrates in the small intestine?
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What are the final products of carbohydrate digestion after hydrolysis in the small intestine?
What are the final products of carbohydrate digestion after hydrolysis in the small intestine?
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Compared to salivary amylase, pancreatic amylase is considered:
Compared to salivary amylase, pancreatic amylase is considered:
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Which disaccharide is broken down into galactose and glucose?
Which disaccharide is broken down into galactose and glucose?
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What is the primary location where most carbohydrates are hydrolyzed to maltose and other small glucose polymers?
What is the primary location where most carbohydrates are hydrolyzed to maltose and other small glucose polymers?
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Which enzyme is specifically responsible for breaking down maltose?
Which enzyme is specifically responsible for breaking down maltose?
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What happens to monosaccharides after they are produced in the small intestine?
What happens to monosaccharides after they are produced in the small intestine?
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Which of the following enzymes is a brush border enzyme that digests disaccharides
Which of the following enzymes is a brush border enzyme that digests disaccharides
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Which enzyme type is responsible for breaking down internal peptide bonds?
Which enzyme type is responsible for breaking down internal peptide bonds?
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What is the primary final product of protein digestion that is absorbed into the bloodstream?
What is the primary final product of protein digestion that is absorbed into the bloodstream?
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By what mechanism are amino acids transported into absorptive cells?
By what mechanism are amino acids transported into absorptive cells?
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Where does the digestion of small peptides into amino acids primarily occur prior to absorption?
Where does the digestion of small peptides into amino acids primarily occur prior to absorption?
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What happens to amino acids that are in excess of the body's immediate needs?
What happens to amino acids that are in excess of the body's immediate needs?
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Which of the following is NOT a type of peptidase mentioned in the context?
Which of the following is NOT a type of peptidase mentioned in the context?
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What is the role of transport proteins in the absorption of amino acids?
What is the role of transport proteins in the absorption of amino acids?
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Which hormone plays a key role in the active absorption of calcium ions?
Which hormone plays a key role in the active absorption of calcium ions?
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Flashcards
Villi
Villi
Finger-like projections that extend into the lumen of the small intestine, increasing surface area for absorption.
Microvilli
Microvilli
Microscopic projections on the surface of intestinal epithelial cells, further increasing surface area for absorption.
Paneth Cells
Paneth Cells
Specialized cells within intestinal crypts that produce antibacterial substances like lysozyme and antimicrobial peptides.
Brush Border Enzymes
Brush Border Enzymes
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Time Restricted Eating (TRE)
Time Restricted Eating (TRE)
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Intermittent Fasting
Intermittent Fasting
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Feeding Window
Feeding Window
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Fasting Window
Fasting Window
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Duodenum
Duodenum
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Jejunum
Jejunum
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Ileum
Ileum
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Pyloric Sphincter
Pyloric Sphincter
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Ileocecal Valve
Ileocecal Valve
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Digestion
Digestion
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Kupffer Cells
Kupffer Cells
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Regenerative Capabilities of the Liver
Regenerative Capabilities of the Liver
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Bile Production
Bile Production
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Hepatic Vein
Hepatic Vein
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Gallbladder
Gallbladder
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Triglyceride digestion
Triglyceride digestion
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Lipases
Lipases
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Bile emulsification
Bile emulsification
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Emulsification
Emulsification
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Lingual Lipase
Lingual Lipase
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Pancreatic Amylase
Pancreatic Amylase
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Salivary Amylase Role
Salivary Amylase Role
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Pancreatic Amylase vs. Salivary Amylase
Pancreatic Amylase vs. Salivary Amylase
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Small Intestine: Carbohydrate Digestion Site
Small Intestine: Carbohydrate Digestion Site
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Carbohydrate Digestion Time
Carbohydrate Digestion Time
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Disaccharide Breakdown by Brush Border Enzymes
Disaccharide Breakdown by Brush Border Enzymes
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Final Products of Carbohydrate Digestion
Final Products of Carbohydrate Digestion
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Endopeptidases
Endopeptidases
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Exopeptidases
Exopeptidases
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Protein Digestion: Final Product
Protein Digestion: Final Product
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Amino Acid Transport
Amino Acid Transport
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Calcium Absorption
Calcium Absorption
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Parathyroid Hormone
Parathyroid Hormone
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Amino Acid Absorption
Amino Acid Absorption
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Amino Acid Storage
Amino Acid Storage
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Study Notes
Digestive System and Metabolism
- Readings: All of Chapter 18, with the exception of 18.6.
- Learning Outcomes:
- Functional Anatomy of the Digestive System (mouth, esophagus, stomach, small intestine, large intestine, colon, liver, gall bladder, pancreas)
- Accessory Organs
- Critical thinking (time restricted feeding, microbiota)
- Gastrointestinal Gas:
- Approximately 0.5 liters per day, spread across 14-25 incidents.
- Digestion time:
- Different digestion times depending on food.
Digestion
- Breakdown of ingested food
- Absorption of nutrients into the blood
- Excretion of waste.
- Production of cellular energy (ATP)
- Regulation of cellular activities
Structures of the Alimentary Canal
- Mouth, pharynx, esophagus, stomach, small intestine, large intestine, anus
Structure of the Digestive System
- Two Main Functional Groups of Organs:
- Alimentary Canal
- Accessory Digestive Organs
Functions of the Salivary Glands
- Lubrication/binding
- Solubilization of dry food
- Oral hygiene by debris flushing
- Begins starch digestion (salivary amylases)
- Alkaline buffering
- Evaporative cooling (important in dogs)
From Mouth to Stomach
- Mastication (chewing food)
- Teeth (incisors, canines, premolars, and molars)
- Deglutition (swallowing)
- 25 muscles in the mouth, pharynx, larynx, upper esophagus
- Somatic motor neurons (mouth, pharynx, upper esophagus)
- Autonomic neurons (middle and lower esophagus)
- Esophagus connects pharynx and stomach (25cm long)
- Peristalsis moves food via muscular contractions.
The Stomach
- Smooth muscle layers mix and mechanically break down food.
- Oblique direction for mixing and breakdown.
- Circular, longitudinal, and oblique muscles.
- Mucosal region contains gastric pits and gastric glands.
Secretory Components of the Stomach
- Gastric pits are the openings of the gastric glands.
- Gastric glands contain mucous cells, chief cells, and parietal cells that each produce specific secretions.
- Secretions include: -Mucous cells: secrete mucus -Parietal cells: secrete hydrochloric acid (HCl), intrinsic factor for vitamin B12 -Chief (zymogenic) cells: secrete pepsinogen
Secretory Components of the Stomach- questions
- Why doesn't the stomach digest itself?
- Effects of Helicobacter pylori on the stomach
Small Intestine
- Regions:
- Duodenum (first 25 cm)
- Jejunum (1 meter)
- Ileum (2 meters)
- Numerous folds and villi for absorption
- Absorbs primarily bile salts and water, electrolytes.
- Ileocecal valve empties into the large intestine.
Small Intestine: Villi
- Covered with columnar epithelial cells.
- Goblet cells secrete mucous.
- Epithelial cells at the tip of villi are continuously sloughed and replaced from intestinal crypts.
- Paneth cells secrete antibacterial molecules for protection.
Small Intestine: Microvilli
- Enzymes are attached here for digestion: (sucrase, maltase, lactase, peptidase, aminopeptidase, enterokinase, phosphatase, Ca2+, Mg2+2+-ATPase, alkaline phosphatase)
Large Intestine
- The colon.
- Bacterial colony plays an essential role in digestive processes.
- "Good" bacteria compete with pathogenic bacteria.
- Elimination of colon content through diarrhea.
- Intestinal microbiota are about 10x more than the number of human cells in the body, and they are important for immune system development.
The Colon (Large Intestine)
- The appendix does not function in digestion, but has lymph vessels.
- Ruptured appendix can cause inflammation (Peritonitis) in the peritoneal cavity.
- Intestinal microbiota about 10x more than human cells.
- "Commensal", "mutualism".
- Intestinal Microbiota originates at birth.
Time Restricted Eating/Feeding/Intermittent Fasting
- Can changing your meal schedule effectively fight body fat?
- Eating only during a smaller window of time than typical may help with weight loss.
- Mice consuming food every 24 hours or 8 hours.
Accessory Digestive Organs: Liver
- Hepatic cells that line large capillaries known as sinusoids.
- Sinusoids also lined by endothelial cells.
- Sinusoids contain Kupffer cells (phagocytes).
- Amazing regenerative capabilities: can regenerate to original state in a week if 2/3rds of liver surgically removed.
Accessory Digestive Organs: Pancreas
- Pancreatic juice contains ~20 digestive enzymes (amylase, trypsin, lipase).
- Endocrine portion makes hormones, exocrine portion makes enzymes to digest fat, protein, and carbs.
Accessory Digestive Organs: Gallbladder
- Sac-like, attached to the liver, stores and concentrates bile from liver.
- Stores and concentrates bile.
- Common complication: gallstones (mineral deposits).
- Treatment: surgery, oral ingestion of bile acids, or fragmentation by high-energy shock waves.
Learning Outcomes
- Carbohydrate, Cholesterol, Lipid, and Protein metabolism.
- Absorption of Ions and Vitamins.
- Digestion: the need for processing, foods used by the body.
- Comparative Physiology of Digestive Systems.
- Main functions of the digestive system.
Classification of Animals Based on Food Habits (Herbivores, Carnivores, Omnivores)
- Herbivores eat plants
- Carnivores eat meat
- Omnivores eat both plants and meat
Types of Digestion in Animals
- Enzymatic
- Microbial Digestion (Fermentation)
Classes of Carbohydrates
- Polysaccharides (starches, complex carbohydrates)
- Disaccharides (sucrose, maltose, lactose)
- Monosaccharides (glucose, fructose, galactose)
Chemical digestion of Carbohydrates
- Starch (Polysaccharides): Amylase breaks it down
- Disaccharides: Brush border enzymes (dextrinase, glucoamylase, lactase, maltase, sucrase) break it down
- Monosaccharides (Simple sugars): absorbed
Digestion of Carbs in the Mouth & Stomach
- Ptyalin (a-amylase) hydrolyzes ingested starch into maltose.
- Initial starch digestion.
Digestion of Carbs in the Small Intestine
- Pancreatic amylase hydrolyzes remaining carbohydrates into maltose and other small glucose polymers.
Absorbing the products of carbohydrate digestion
- Disaccharidases (lactase, sucrase, maltase) break down disaccharides to monosaccharides (glucose, galactose, fructose).
- Monosaccharides absorbed.
Post-absorptive events, cholesterol
- Cholesterol absorbed from food without being digested.
- Liver produces most cholesterol.
- Cholesterol transported (in the blood) with lipoproteins
Lipids - Fats
- Triglycerides
- Phospholipids
- Sterols (eg., cholesterol)
Digestion of Fats in the Stomach
- Small amount of fat digestion.
- Triglycerides are digested by lingual lipase and swallowed with saliva.
- Accounts for <10% of fat digestion.
Chemical digestion of lipids
- Lipids are not water-soluble; enzymes have limited access.
- Bile salts emulsify lipids into small droplets, increasing enzyme access.
Digestion of Triglycerides by Pancreatic Enzymes
- Pancreatic lipase digests triglycerides to free fatty acids and monoglycerides (important enzyme).
- Pancreatic juice has substantial lipase enzyme concentration; sufficient to digest Triglycerides rapidly.
Absorbing Lipid Digestion Products
- Monoglycerides and fatty acids absorbed by absorptive cells.
- Triglycerides re-synthesized; enter lacteals (lymph vessels).
- Chylomicrons enter the blood.
Proteins
- Polymers of amino acids
- Protein digestion produces large polypeptides, then smaller peptides, then amino acids.
- Peptides digested by proteases and peptidases.
Chemical Digestion of Proteins
- Proteins are broken down into smaller peptide fragments by proteases, eventually to amino acids.
- Pepsin in the stomach is a crucial protease.
- Pancreatic proteases and small intestine brush border peptidases further break down the peptides.
Digestion of Proteins by Pancreatic Secretions
- Pancreatic enzymes (trypsin, chymotrypsin, carboxypeptidase, proelastase) further break down proteins to peptides.
Digestion of Proteins in Small Intestinal Villi
- Exopeptidases and endopeptidases further break down peptides to individual amino acids.
Absorbing the products of protein digestion
- Amino acids are absorbed into absorptive cells using transport proteins.
- Peptides are further digested into individual amino acids using peptidases.
Post-absorptive events, amino acids
- Amino acids absorbed into cells, cannot be stored, but used in many processes.
- Excess amino acids are metabolized by the liver.
- The nitrogen portion is removed forming urea, which is excreted in urine.
Vitamin Absorption
- Water-soluble vitamins diffuse into the bloodstream and are absorbed in the jejunum and ileum;
- Fat-soluble vitamins absorbed with dietary lipids.
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Description
This quiz covers essential topics related to the digestive system, focusing on liver functions, bile transportation, and the specific roles of various intestinal structures. Test your knowledge about Kupffer cells, the pathway of bile, and the functions of different segments of the small intestine.