Human Anatomy: Digestive System Overview
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Questions and Answers

What role do Kupffer cells play within the liver's sinusoids?

  • They secrete bile for digestion.
  • They produce hormones for endocrine function.
  • They facilitate the regeneration of liver tissue.
  • They act as phagocytes, removing waste and pathogens. (correct)
  • If two-thirds of a rodent's liver is surgically removed, what is the liver's main response?

  • The liver will not regenerate.
  • The remaining tissue regenerates, restoring its original mass in about one week. (correct)
  • The remaining tissue will regenerate to approximately half its original mass.
  • The remaining tissue slowly decays over several weeks.
  • Which structure directly transports bile from the gallbladder to the common bile duct?

  • The right hepatic duct
  • The cystic duct (correct)
  • The left hepatic duct
  • The hepatic vein
  • Where does the output from the liver's endocrine function go?

    <p>It is routed back towards the heart via the hepatic vein. (C)</p> Signup and view all the answers

    What is the correct pathway of bile from the liver to the small intestine?

    <p>Liver → hepatic ducts → gallbladder → common bile duct → intestines. (B)</p> Signup and view all the answers

    What is the primary function of the ileum?

    <p>Absorbing bile salts, water, and electrolytes. (C)</p> Signup and view all the answers

    Which of the following is responsible for activating pepsinogen to pepsin?

    <p>Hydrochloric acid (HCL) (A)</p> Signup and view all the answers

    What is the approximate length of the jejunum?

    <p>1 meter (B)</p> Signup and view all the answers

    What structure is found within the ileum that is an aggregate of lymph nodes?

    <p>Peyer's Patches (A)</p> Signup and view all the answers

    What is the role of the cardiac sphincter?

    <p>Preventing the backflow of stomach contents into the esophagus. (A)</p> Signup and view all the answers

    Which of the following describes the primary function of the villi and microvilli?

    <p>To provide increased surface area for absorption of nutrients. (C)</p> Signup and view all the answers

    Which region of the small intestine receives secretions from the pancreas and liver?

    <p>Duodenum (A)</p> Signup and view all the answers

    What is the primary role of bile in digestion?

    <p>To neutralize hydrochloric acid (A)</p> Signup and view all the answers

    What is the primary function of Paneth cells located in the intestinal crypts?

    <p>To release antibacterial molecules like lysozyme. (C)</p> Signup and view all the answers

    Where do new epithelial cells originate that replace those at the tips of the villi?

    <p>From the intestinal crypts. (B)</p> Signup and view all the answers

    Which of the following best describes the relationship between villi and microvilli?

    <p>Microvilli are cellular extensions, while villi are larger structures (C)</p> Signup and view all the answers

    What type of cells secrete mucus in the small intestine?

    <p>Goblet cells (A)</p> Signup and view all the answers

    What are the brush border enzymes associated with?

    <p>The cell membrane of microvilli. (B)</p> Signup and view all the answers

    What is the primary role of columnar epithelial cells in the small intestine?

    <p>Forming the surface of the villi. (B)</p> Signup and view all the answers

    If a healthy individual has a decreased number of Paneth cells, what would be the most likely consequence?

    <p>Heightened susceptibility to intestinal inflammation. (D)</p> Signup and view all the answers

    What is the role of lysozyme in the small intestine?

    <p>To act as an antibacterial agent. (D)</p> Signup and view all the answers

    What is the primary function of bile salts in lipid digestion?

    <p>To emulsify lipids, increasing the surface area for enzyme action. (C)</p> Signup and view all the answers

    Where does the majority of lipid digestion take place?

    <p>In the small intestine, with the aid of pancreatic lipases and bile salts. (D)</p> Signup and view all the answers

    What is the main reason why enzymes in solution have limited access to insoluble lipid molecules?

    <p>Lipid molecules clump together and are not well mixed in the aqueous environment. (B)</p> Signup and view all the answers

    Which of the following best describes the role of lingual lipase in the digestive process?

    <p>It initiates fat digestion but accounts for a small percentage of total fat breakdown. (C)</p> Signup and view all the answers

    Which of these is TRUE regarding pancreatic lipases?

    <p>They are crucial for lipid digestion in the small intestine after emulsification. (B)</p> Signup and view all the answers

    Which enzyme is NOT involved in the digestion of carbohydrates in the small intestine?

    <p>Salivary amylase (B)</p> Signup and view all the answers

    What are the final products of carbohydrate digestion after hydrolysis in the small intestine?

    <p>Monosaccharides (C)</p> Signup and view all the answers

    Compared to salivary amylase, pancreatic amylase is considered:

    <p>More potent (A)</p> Signup and view all the answers

    Which disaccharide is broken down into galactose and glucose?

    <p>Lactose (B)</p> Signup and view all the answers

    What is the primary location where most carbohydrates are hydrolyzed to maltose and other small glucose polymers?

    <p>Duodenum and jejunum (B)</p> Signup and view all the answers

    Which enzyme is specifically responsible for breaking down maltose?

    <p>Maltase (B)</p> Signup and view all the answers

    What happens to monosaccharides after they are produced in the small intestine?

    <p>They are absorbed directly into the bloodstream (A)</p> Signup and view all the answers

    Which of the following enzymes is a brush border enzyme that digests disaccharides

    <p>Lactase (D)</p> Signup and view all the answers

    Which enzyme type is responsible for breaking down internal peptide bonds?

    <p>Endopeptidases (A)</p> Signup and view all the answers

    What is the primary final product of protein digestion that is absorbed into the bloodstream?

    <p>Single amino acids (A)</p> Signup and view all the answers

    By what mechanism are amino acids transported into absorptive cells?

    <p>Active transport via transport proteins (D)</p> Signup and view all the answers

    Where does the digestion of small peptides into amino acids primarily occur prior to absorption?

    <p>At the brush border of absorptive cells (D)</p> Signup and view all the answers

    What happens to amino acids that are in excess of the body's immediate needs?

    <p>They are stored as components of cell protein. (A)</p> Signup and view all the answers

    Which of the following is NOT a type of peptidase mentioned in the context?

    <p>Microvilli peptidases (A)</p> Signup and view all the answers

    What is the role of transport proteins in the absorption of amino acids?

    <p>To actively transport amino acids into absorptive cells and then out to the capillaries (D)</p> Signup and view all the answers

    Which hormone plays a key role in the active absorption of calcium ions?

    <p>Parathyroid hormone (B)</p> Signup and view all the answers

    Flashcards

    Villi

    Finger-like projections that extend into the lumen of the small intestine, increasing surface area for absorption.

    Microvilli

    Microscopic projections on the surface of intestinal epithelial cells, further increasing surface area for absorption.

    Paneth Cells

    Specialized cells within intestinal crypts that produce antibacterial substances like lysozyme and antimicrobial peptides.

    Brush Border Enzymes

    Enzymes attached to the cell membrane of microvilli, aiding in the digestion of carbohydrates, proteins, and fats.

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    Time Restricted Eating (TRE)

    A dietary pattern that restricts eating to a specific time window, typically 8-12 hours per day.

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    Intermittent Fasting

    A type of intermittent fasting that involves alternating periods of eating and fasting.

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    Feeding Window

    The time window during which a person eats, as opposed to fasting.

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    Fasting Window

    The time window during which a person fasts, as opposed to eating.

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    Duodenum

    The first 25 centimeters of the small intestine. It receives acidic chyme from the stomach, pancreatic secretions, and bile from the liver to begin the digestive process.

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    Jejunum

    The middle section of the small intestine, measuring about 1 meter in length. It's characterized by numerous folds and villi, maximizing surface area for nutrient absorption.

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    Ileum

    The last 2 meters of the small intestine. While it has fewer folds than the jejunum, it still absorbs nutrients, particularly bile salts, water, and electrolytes.

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    Pyloric Sphincter

    A ring of muscle that controls the flow of food from the stomach into the small intestine.

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    Ileocecal Valve

    A flap of tissue that prevents food from flowing back from the large intestine into the small intestine.

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    Digestion

    The process of breaking down food into smaller molecules that can be absorbed by the body.

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    Kupffer Cells

    Specialized cells in the liver that act as phagocytes, engulfing and breaking down foreign particles and debris.

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    Regenerative Capabilities of the Liver

    The liver's remarkable ability to repair and restore itself after damage or removal.

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    Bile Production

    The liver produces bile, a fluid that helps break down fats in the small intestine.

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    Hepatic Vein

    The main output of the liver's endocrine function, carried by the hepatic vein to the heart.

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    Gallbladder

    A small sac that stores bile produced by the liver.

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    Triglyceride digestion

    Triglycerides are broken down with the help of enzymes called lipases.

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    Lipases

    Enzymes that digest triglycerides are called lipases.

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    Bile emulsification

    Bile salts break down fat into smaller droplets which makes it more accessible to lipases

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    Emulsification

    The process where large fat droplets are broken down into smaller droplets. It increases the surface area for lipases to act upon.

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    Lingual Lipase

    Lingual lipase is an enzyme in saliva that starts the digestion of triglycerides.

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    Pancreatic Amylase

    An enzyme secreted by the pancreas that breaks down carbohydrates into smaller sugars like maltose.

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    Salivary Amylase Role

    The initial stage of carbohydrate digestion occurs in the mouth, where salivary amylase breaks down starch into smaller polysaccharides.

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    Pancreatic Amylase vs. Salivary Amylase

    Pancreatic amylase is more effective than salivary amylase at breaking down carbohydrates in the small intestine.

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    Small Intestine: Carbohydrate Digestion Site

    The small intestine, specifically the duodenum and jejunum, is where the majority of carbohydrate digestion takes place.

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    Carbohydrate Digestion Time

    Within 30 minutes, pancreatic amylase breaks down almost all carbohydrates into smaller sugar molecules, especially maltose.

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    Disaccharide Breakdown by Brush Border Enzymes

    Lactase breaks down lactose into galactose and glucose, sucrase breaks down sucrose into glucose and fructose, and maltase breaks down maltose into two glucose molecules.

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    Final Products of Carbohydrate Digestion

    The final products of carbohydrate digestion are simple sugars (monosaccharides) like glucose, fructose, and galactose, which are absorbed into the bloodstream.

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    Endopeptidases

    Enzymes that break down proteins into smaller peptides by cleaving internal peptide bonds.

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    Exopeptidases

    Enzymes that break down proteins by removing single amino acids from the ends of peptide chains.

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    Protein Digestion: Final Product

    The final products of protein digestion are almost entirely single amino acids that enter the bloodstream.

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    Amino Acid Transport

    Amino acids are transported across the intestinal lining using carrier proteins.

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    Calcium Absorption

    The primary mechanism for absorbing calcium ions into the bloodstream.

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    Parathyroid Hormone

    A hormone that regulates calcium levels, activating vitamin D, which is crucial for calcium absorption.

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    Amino Acid Absorption

    The process by which amino acids are taken up from the digestive system and enter the body's circulation.

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    Amino Acid Storage

    Amino acids can only be stored as components of cell proteins; excess amino acids cannot be stored directly.

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    Study Notes

    Digestive System and Metabolism

    • Readings: All of Chapter 18, with the exception of 18.6.
    • Learning Outcomes:
      • Functional Anatomy of the Digestive System (mouth, esophagus, stomach, small intestine, large intestine, colon, liver, gall bladder, pancreas)
      • Accessory Organs
      • Critical thinking (time restricted feeding, microbiota)
    • Gastrointestinal Gas:
      • Approximately 0.5 liters per day, spread across 14-25 incidents.
    • Digestion time:
      • Different digestion times depending on food.

    Digestion

    • Breakdown of ingested food
    • Absorption of nutrients into the blood
    • Excretion of waste.
    • Production of cellular energy (ATP)
    • Regulation of cellular activities

    Structures of the Alimentary Canal

    • Mouth, pharynx, esophagus, stomach, small intestine, large intestine, anus

    Structure of the Digestive System

    • Two Main Functional Groups of Organs:
      • Alimentary Canal
      • Accessory Digestive Organs

    Functions of the Salivary Glands

    • Lubrication/binding
    • Solubilization of dry food
    • Oral hygiene by debris flushing
    • Begins starch digestion (salivary amylases)
    • Alkaline buffering
    • Evaporative cooling (important in dogs)

    From Mouth to Stomach

    • Mastication (chewing food)
    • Teeth (incisors, canines, premolars, and molars)
    • Deglutition (swallowing)
    • 25 muscles in the mouth, pharynx, larynx, upper esophagus
    • Somatic motor neurons (mouth, pharynx, upper esophagus)
    • Autonomic neurons (middle and lower esophagus)
    • Esophagus connects pharynx and stomach (25cm long)
    • Peristalsis moves food via muscular contractions.

    The Stomach

    • Smooth muscle layers mix and mechanically break down food.
    • Oblique direction for mixing and breakdown.
    • Circular, longitudinal, and oblique muscles.
    • Mucosal region contains gastric pits and gastric glands.

    Secretory Components of the Stomach

    • Gastric pits are the openings of the gastric glands.
    • Gastric glands contain mucous cells, chief cells, and parietal cells that each produce specific secretions.
    • Secretions include: -Mucous cells: secrete mucus -Parietal cells: secrete hydrochloric acid (HCl), intrinsic factor for vitamin B12 -Chief (zymogenic) cells: secrete pepsinogen

    Secretory Components of the Stomach- questions

    • Why doesn't the stomach digest itself?
    • Effects of Helicobacter pylori on the stomach

    Small Intestine

    • Regions:
      • Duodenum (first 25 cm)
      • Jejunum (1 meter)
      • Ileum (2 meters)
    • Numerous folds and villi for absorption
    • Absorbs primarily bile salts and water, electrolytes.
    • Ileocecal valve empties into the large intestine.

    Small Intestine: Villi

    • Covered with columnar epithelial cells.
    • Goblet cells secrete mucous.
    • Epithelial cells at the tip of villi are continuously sloughed and replaced from intestinal crypts.
    • Paneth cells secrete antibacterial molecules for protection.

    Small Intestine: Microvilli

    • Enzymes are attached here for digestion: (sucrase, maltase, lactase, peptidase, aminopeptidase, enterokinase, phosphatase, Ca2+, Mg2+2+-ATPase, alkaline phosphatase)

    Large Intestine

    • The colon.
    • Bacterial colony plays an essential role in digestive processes.
    • "Good" bacteria compete with pathogenic bacteria.
    • Elimination of colon content through diarrhea.
    • Intestinal microbiota are about 10x more than the number of human cells in the body, and they are important for immune system development.

    The Colon (Large Intestine)

    • The appendix does not function in digestion, but has lymph vessels.
    • Ruptured appendix can cause inflammation (Peritonitis) in the peritoneal cavity.
    • Intestinal microbiota about 10x more than human cells.
    • "Commensal", "mutualism".
    • Intestinal Microbiota originates at birth.

    Time Restricted Eating/Feeding/Intermittent Fasting

    • Can changing your meal schedule effectively fight body fat?
    • Eating only during a smaller window of time than typical may help with weight loss.
    • Mice consuming food every 24 hours or 8 hours.

    Accessory Digestive Organs: Liver

    • Hepatic cells that line large capillaries known as sinusoids.
    • Sinusoids also lined by endothelial cells.
    • Sinusoids contain Kupffer cells (phagocytes).
    • Amazing regenerative capabilities: can regenerate to original state in a week if 2/3rds of liver surgically removed.

    Accessory Digestive Organs: Pancreas

    • Pancreatic juice contains ~20 digestive enzymes (amylase, trypsin, lipase).
    • Endocrine portion makes hormones, exocrine portion makes enzymes to digest fat, protein, and carbs.

    Accessory Digestive Organs: Gallbladder

    • Sac-like, attached to the liver, stores and concentrates bile from liver.
    • Stores and concentrates bile.
    • Common complication: gallstones (mineral deposits).
    • Treatment: surgery, oral ingestion of bile acids, or fragmentation by high-energy shock waves.

    Learning Outcomes

    • Carbohydrate, Cholesterol, Lipid, and Protein metabolism.
    • Absorption of Ions and Vitamins.
    • Digestion: the need for processing, foods used by the body.
    • Comparative Physiology of Digestive Systems.
    • Main functions of the digestive system.

    Classification of Animals Based on Food Habits (Herbivores, Carnivores, Omnivores)

    • Herbivores eat plants
    • Carnivores eat meat
    • Omnivores eat both plants and meat

    Types of Digestion in Animals

    • Enzymatic
    • Microbial Digestion (Fermentation)

    Classes of Carbohydrates

    • Polysaccharides (starches, complex carbohydrates)
    • Disaccharides (sucrose, maltose, lactose)
    • Monosaccharides (glucose, fructose, galactose)

    Chemical digestion of Carbohydrates

    • Starch (Polysaccharides): Amylase breaks it down
    • Disaccharides: Brush border enzymes (dextrinase, glucoamylase, lactase, maltase, sucrase) break it down
    • Monosaccharides (Simple sugars): absorbed

    Digestion of Carbs in the Mouth & Stomach

    • Ptyalin (a-amylase) hydrolyzes ingested starch into maltose.
    • Initial starch digestion.

    Digestion of Carbs in the Small Intestine

    • Pancreatic amylase hydrolyzes remaining carbohydrates into maltose and other small glucose polymers.

    Absorbing the products of carbohydrate digestion

    • Disaccharidases (lactase, sucrase, maltase) break down disaccharides to monosaccharides (glucose, galactose, fructose).
    • Monosaccharides absorbed.

    Post-absorptive events, cholesterol

    • Cholesterol absorbed from food without being digested.
    • Liver produces most cholesterol.
    • Cholesterol transported (in the blood) with lipoproteins

    Lipids - Fats

    • Triglycerides
    • Phospholipids
    • Sterols (eg., cholesterol)

    Digestion of Fats in the Stomach

    • Small amount of fat digestion.
    • Triglycerides are digested by lingual lipase and swallowed with saliva.
    • Accounts for <10% of fat digestion.

    Chemical digestion of lipids

    • Lipids are not water-soluble; enzymes have limited access.
    • Bile salts emulsify lipids into small droplets, increasing enzyme access.

    Digestion of Triglycerides by Pancreatic Enzymes

    • Pancreatic lipase digests triglycerides to free fatty acids and monoglycerides (important enzyme).
    • Pancreatic juice has substantial lipase enzyme concentration; sufficient to digest Triglycerides rapidly.

    Absorbing Lipid Digestion Products

    • Monoglycerides and fatty acids absorbed by absorptive cells.
    • Triglycerides re-synthesized; enter lacteals (lymph vessels).
    • Chylomicrons enter the blood.

    Proteins

    • Polymers of amino acids
    • Protein digestion produces large polypeptides, then smaller peptides, then amino acids.
    • Peptides digested by proteases and peptidases.

    Chemical Digestion of Proteins

    • Proteins are broken down into smaller peptide fragments by proteases, eventually to amino acids.
    • Pepsin in the stomach is a crucial protease.
    • Pancreatic proteases and small intestine brush border peptidases further break down the peptides.

    Digestion of Proteins by Pancreatic Secretions

    • Pancreatic enzymes (trypsin, chymotrypsin, carboxypeptidase, proelastase) further break down proteins to peptides.

    Digestion of Proteins in Small Intestinal Villi

    • Exopeptidases and endopeptidases further break down peptides to individual amino acids.

    Absorbing the products of protein digestion

    • Amino acids are absorbed into absorptive cells using transport proteins.
    • Peptides are further digested into individual amino acids using peptidases.

    Post-absorptive events, amino acids

    • Amino acids absorbed into cells, cannot be stored, but used in many processes.
    • Excess amino acids are metabolized by the liver.
    • The nitrogen portion is removed forming urea, which is excreted in urine.

    Vitamin Absorption

    • Water-soluble vitamins diffuse into the bloodstream and are absorbed in the jejunum and ileum;
    • Fat-soluble vitamins absorbed with dietary lipids.

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    Description

    This quiz covers essential topics related to the digestive system, focusing on liver functions, bile transportation, and the specific roles of various intestinal structures. Test your knowledge about Kupffer cells, the pathway of bile, and the functions of different segments of the small intestine.

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