27 Questions
What is the primary function of the hypothalamus in the HPG axis?
Production of GnRH
Which of the following is a GnRH antagonist?
Degarelix
What is the effect of estrogen on endometrial tissue?
Drives growth
What is the primary use of aromatase inhibitors in HPG axis therapy?
Treatment of hormone-dependent cancers
What is the mechanism of action of spironolactone?
Antagonism of testosterone
What is the primary use of GnRH agonists in HPG axis therapy?
Suppression of puberty in precocious puberty
What is the effect of HPG axis disruption on ovulation?
Irregular ovulation
What is the primary use of progestins in HPG axis therapy?
Contraception
What is the effect of testosterone on spermatogenesis?
Stimulates spermatogenesis
What is the effect of continuous use of GnRH on LH and FSH?
It decreases LH and FSH
What is the primary mechanism of GnRH agonists in suppressing LH and FSH?
They inhibit the release of GnRH from the hypothalamus
What is the purpose of using GnRH antagonists in IVF treatment?
To induce ovulation and control its timing
What is the effect of GnRH on testosterone production?
It decreases testosterone production through negative feedback
What is the primary indication for using GnRH agonists in prostate cancer treatment?
To reduce the growth of prostate cancer cells
What is the common side effect of GnRH agonists and antagonists?
All of the above
What is the purpose of using GnRH agonists in gender-affirming hormone therapy?
To delay puberty in gender dysphoric children
What is the effect of estrogen on its own production?
It has a mixed feedback effect on its own production
What is the primary difference between GnRH agonists and antagonists?
GnRH agonists have a initial flare-up, while antagonists do not
What type of hormones are gonadotropins?
Glycopeptide hormones
Which cell type produces LH and FSH?
Gonadotrophs
What is the function of hCG in infertility treatment?
To stimulate ovulation
What is the goal of controlled ovarian stimulation?
To harvest multiple oocytes
What is the role of GnRH agonist in infertility treatment?
To suppress endogenous cycle
What is the purpose of Menotropin in fertility treatment?
To stimulate follicle development
What is the common side effect of ovarian stimulation?
Ovarian hyperstimulation syndrome
What causes ovarian hyperstimulation syndrome?
Excessive stimulation of ovaries
What is the consequence of ovarian hyperstimulation syndrome?
Bloating and weight gain
Test your knowledge on the Hypothalamic Pituitary-Gonadal (HPG) Axis, including hormone agonists and antagonists and their effects on the body. Learn about GnRH, FSH, LH, testosterone, estrogen, and more!
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