Pharmacology of Reproductive Hormones and HPG Axis
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Questions and Answers

What is the function of GnRH produced by the Hypothalamus?

  • To stimulate the gonads directly
  • To stimulate the Anterior Pituitary (correct)
  • To produce testosterone and estrogen
  • To inhibite the HPG Axis
  • Which of the following is a GnRH Antagonist drug?

  • Menotropin
  • Degarelix (correct)
  • Testosterone
  • Leuprolide
  • What is the effect of estrogen on endometrium?

  • It drives the growth of endometrium (correct)
  • It inhibits the growth of endometrium
  • It has no effect on endometrium
  • It causes cancer in endometrium
  • Which of the following is a SERM?

    <p>Raloxifene</p> Signup and view all the answers

    What is the use of HPG Axis drugs in Hormone Replacement Therapy?

    <p>To prevent osteoporosis post menopause</p> Signup and view all the answers

    Which of the following is a Progestin?

    <p>Levonorgestrel</p> Signup and view all the answers

    What is the result of disruption of HPG Axis in females?

    <p>All of the above</p> Signup and view all the answers

    What is the use of HPG Axis drugs in treatment of Benign Prostatic Hyperplasia (BPH)?

    <p>To inhibit testosterone production</p> Signup and view all the answers

    Which of the following is a Testosterone Agonist?

    <p>Methyltestosterone</p> Signup and view all the answers

    What is the initial effect of GnRH on LH and FSH levels?

    <p>Increase</p> Signup and view all the answers

    What is the long-term effect of continuous GnRH administration on LH and FSH levels?

    <p>Decrease</p> Signup and view all the answers

    What is the role of testosterone in its own production?

    <p>Negative feedback</p> Signup and view all the answers

    What is the effect of estrogen on its own production?

    <p>Either negative or positive feedback</p> Signup and view all the answers

    What is the effect of progesterone on its own production?

    <p>Negative feedback</p> Signup and view all the answers

    What is the purpose of GnRH analogs in prostate carcinoma treatment?

    <p>To decrease testosterone levels</p> Signup and view all the answers

    What is the purpose of GnRH antagonists in ovulation induction?

    <p>To inhibit FSH and LH release</p> Signup and view all the answers

    What is a common side effect of long-term GnRH analog use?

    <p>Osteoporosis</p> Signup and view all the answers

    What is the purpose of GnRH antagonists in endometriosis treatment?

    <p>To inhibit estrogen release</p> Signup and view all the answers

    What is the type of hormones that LH, FSH, and hCG belong to?

    <p>Glycopeptide hormones</p> Signup and view all the answers

    Which of the following is NOT a site of synthesis for gonadotropins?

    <p>Posterior pituitary</p> Signup and view all the answers

    What is the function of hCG in infertility treatment?

    <p>To trigger ovulation</p> Signup and view all the answers

    What is the goal of controlled ovarian stimulation?

    <p>To harvest multiple oocytes</p> Signup and view all the answers

    What is menotropin derived from?

    <p>Urine of menopausal women</p> Signup and view all the answers

    What is the side effect of ovarian hyperstimulation syndrome (OHSS)?

    <p>Excessive stimulation of the ovaries</p> Signup and view all the answers

    What is the function of GnRH agonist and antagonist in fertility treatment?

    <p>To suppress endogenous cycle</p> Signup and view all the answers

    What is the function of follitropin in fertility treatment?

    <p>To stimulate follicular development</p> Signup and view all the answers

    What is the purpose of hormone replacement therapy in fertility treatment?

    <p>To stimulate growth and development of ovarian follicles</p> Signup and view all the answers

    What is lutropin?

    <p>Recombinant LH</p> Signup and view all the answers

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