Pharmacology of Reproductive Hormones and HPG Axis

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What is the function of GnRH produced by the Hypothalamus?

To stimulate the gonads directly
To stimulate the Anterior Pituitary (correct)
To produce testosterone and estrogen
To inhibite the HPG Axis

Which of the following is a GnRH Antagonist drug?

Menotropin
Degarelix (correct)
Testosterone
Leuprolide

What is the effect of estrogen on endometrium?

It drives the growth of endometrium (correct)
It inhibits the growth of endometrium
It has no effect on endometrium
It causes cancer in endometrium

Which of the following is a SERM?

Raloxifene (A) Signup and view all the answers

What is the use of HPG Axis drugs in Hormone Replacement Therapy?

To prevent osteoporosis post menopause (C) Signup and view all the answers

Which of the following is a Progestin?

Levonorgestrel (C) Signup and view all the answers

What is the result of disruption of HPG Axis in females?

All of the above (D) Signup and view all the answers

What is the use of HPG Axis drugs in treatment of Benign Prostatic Hyperplasia (BPH)?

To inhibit testosterone production (B) Signup and view all the answers

Which of the following is a Testosterone Agonist?

Methyltestosterone (D) Signup and view all the answers

What is the initial effect of GnRH on LH and FSH levels?

Increase (D) Signup and view all the answers

What is the long-term effect of continuous GnRH administration on LH and FSH levels?

Decrease (D) Signup and view all the answers

What is the role of testosterone in its own production?

Negative feedback (A) Signup and view all the answers

What is the effect of estrogen on its own production?

Either negative or positive feedback (A) Signup and view all the answers

What is the effect of progesterone on its own production?

Negative feedback (B) Signup and view all the answers

What is the purpose of GnRH analogs in prostate carcinoma treatment?

To decrease testosterone levels (A) Signup and view all the answers

What is the purpose of GnRH antagonists in ovulation induction?

To inhibit FSH and LH release (D) Signup and view all the answers

What is a common side effect of long-term GnRH analog use?

Osteoporosis (C) Signup and view all the answers

What is the purpose of GnRH antagonists in endometriosis treatment?

To inhibit estrogen release (C) Signup and view all the answers

What is the type of hormones that LH, FSH, and hCG belong to?

Glycopeptide hormones (A) Signup and view all the answers

Which of the following is NOT a site of synthesis for gonadotropins?

Posterior pituitary (A) Signup and view all the answers

What is the function of hCG in infertility treatment?

To trigger ovulation (C) Signup and view all the answers

What is the goal of controlled ovarian stimulation?

To harvest multiple oocytes (A) Signup and view all the answers

What is menotropin derived from?

Urine of menopausal women (D) Signup and view all the answers

What is the side effect of ovarian hyperstimulation syndrome (OHSS)?

Excessive stimulation of the ovaries (B) Signup and view all the answers

What is the function of GnRH agonist and antagonist in fertility treatment?

To suppress endogenous cycle (C) Signup and view all the answers

What is the function of follitropin in fertility treatment?

To stimulate follicular development (B) Signup and view all the answers

What is the purpose of hormone replacement therapy in fertility treatment?

To stimulate growth and development of ovarian follicles (D) Signup and view all the answers

What is lutropin?

Recombinant LH (C) Signup and view all the answers