HPG Axis and Hormone Regulation
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Questions and Answers

What is the effect of continuous administration of GnRH on LH and FSH?

  • Initially increases then decreases LH and FSH
  • Increases LH and FSH
  • Decreases LH and FSH (correct)
  • Has no effect on LH and FSH

    • What is the purpose of GnRH agonists in the treatment of precocious puberty?

  • To treat polycystic ovarian syndrome
  • To suppress puberty (correct)
  • To stimulate ovulation
  • To treat endometriosis

    • Which of the following is NOT a use of HPG axis drugs?

  • Gender-affirming hormone therapy
  • Treatment of asthma (correct)
  • Cancer treatment
  • Hormone replacement therapy

    • What is the effect of testosterone on its own production?

    <p>Negative feedback</p> Signup and view all the answers

    What is the effect of estrogen on its own production?

    <p>Either negative or positive feedback</p> Signup and view all the answers

    What is the purpose of GnRH agonists in the treatment of endometriosis?

    <p>To suppress hormone production</p> Signup and view all the answers

    What is the initial effect of short-acting GnRH agonists on FSH and LH?

    <p>Increase in FSH and LH</p> Signup and view all the answers

    What is a potential adverse effect of testosterone replacement therapy?

    <p>Erythrocytosis</p> Signup and view all the answers

    Why does excess testosterone decrease sperm production?

    <p>Due to the negative feedback on the HPG axis</p> Signup and view all the answers

    What is the primary use of 5-alpha reductase inhibitors in the context of androgens?

    <p>Treatment of male pattern baldness</p> Signup and view all the answers

    What is the effect of testosterone on the integument?

    <p>Sebum production and male hair pattern</p> Signup and view all the answers

    What is the clinical use of testosterone agonists in females?

    <p>Treatment of female-to-male gender affirmation</p> Signup and view all the answers

    What is the effect of testosterone on metabolism?

    <p>Improved glucose metabolism and insulin sensitivity</p> Signup and view all the answers

    What is the potential consequence of physical contact with someone using transdermal testosterone gel?

    <p>Transdermal absorption of testosterone</p> Signup and view all the answers

    What is the goal of using LH and FSH agonists in ovulation induction?

    <p>To harvest multiple oocytes</p> Signup and view all the answers

    What is the purpose of using GnRH agonist and antagonist in ovulation induction?

    <p>To suppress endogenous cycle</p> Signup and view all the answers

    What is Menotropin used for?

    <p>Fertility treatments</p> Signup and view all the answers

    What is a possible adverse effect of ovarian stimulation?

    <p>Ovarian hyperstimulation syndrome</p> Signup and view all the answers

    What is Lutropin?

    <p>Recombinant LH</p> Signup and view all the answers

    What is Follitropin?

    <p>Purified from the urine of menopausal women with high FSH</p> Signup and view all the answers

    What is the cause of ovarian hyperstimulation syndrome?

    <p>Excessive stimulation of the ovaries</p> Signup and view all the answers

    What is the primary indication for the use of clomiphene?

    <p>Infertility due to anovulation</p> Signup and view all the answers

    Which of the following is a side effect of tamoxifen?

    <p>Hot flashes</p> Signup and view all the answers

    What is the mechanism of action of clomiphene?

    <p>Antagonist at estrogen receptors in the hypothalamus</p> Signup and view all the answers

    What is the effect of tamoxifen on the uterus?

    <p>Partial agonist</p> Signup and view all the answers

    What is the primary indication for the use of tamoxifen?

    <p>Prevention and treatment of ER/PR ⊕ breast cancer</p> Signup and view all the answers

    What is the mechanism of action of aromatase inhibitors?

    <p>Inhibitor of peripheral conversion of androgens to estrogen</p> Signup and view all the answers

    Which of the following is a side effect of clomiphene?

    <p>Thickening of cervical mucus</p> Signup and view all the answers

    What is the primary function of progesterone in the menstrual cycle?

    <p>To prepare the uterine lining for implantation of a fertilized egg</p> Signup and view all the answers

    What is the effect of progesterone on breast tissue?

    <p>It promotes lactation during pregnancy and breastfeeding</p> Signup and view all the answers

    What is the clinical use of progesterone agonists in HPG axis?

    <p>Contraception and prevention of uterine cancer in women with uterus</p> Signup and view all the answers

    What is the effect of progesterone on HDL levels?

    <p>It decreases HDL levels</p> Signup and view all the answers

    What is the adverse effect of progesterone on sodium and water retention?

    <p>It increases hypertension</p> Signup and view all the answers

    What is the use of 17-OH progesterone in pregnancy?

    <p>To support pregnancy at high risk of loss</p> Signup and view all the answers

    What is the function of mifepristone?

    <p>It is a progesterone antagonist used in abortion and emergency contraception</p> Signup and view all the answers

    What is the effect of progesterone on androgenic symptoms?

    <p>It increases androgenic symptoms depending on the individual synthetic drug</p> Signup and view all the answers

    What is the former category of synthetic progestins in pregnancy?

    <p>Category X</p> Signup and view all the answers

    What is the mechanism of action of antiprogestins?

    <p>They are competitive inhibitors of progestins at progesterone receptors</p> Signup and view all the answers

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