11 Questions
What factors influence Glomerular Filtration Rate (GFR)?
Net filtration pressure and filtration coefficient
What are the three levels of control for GFR?
Autoregulation, autonomic regulation, and hormonal regulation
How does autoregulation maintain GFR?
By changing diameters of arterioles and capillaries
What triggers dilation of afferent arterioles and capillaries?
Reduced blood flow
What happens when renal blood pressure rises?
Afferent arterioles constrict and glomerular blood flow decreases
What is the tubuloglomerular feedback mechanism?
A mechanism involving macula densa cells detecting changes in salt level of fluid
What do macula densa cells secrete in response to increased salt level?
ATP and adenosine
What is the effect of constricting the afferent arteriole?
It reduces blood flow into the glomerulus and GFR
Which level of control for GFR occurs at the local level?
Autoregulation
What initiates autonomic and hormonal regulation of GFR?
The kidneys
What determines the filtration coefficient?
Surface area of glomerular capillaries available for filtration and permeability of interface between capillary and Bowman's capsule
Study Notes
- Glomerular Filtration Rate (GFR) is influenced by net filtration pressure and filtration coefficient.
- Three levels of control for GFR: autoregulation, autonomic regulation, and hormonal regulation.
- Autoregulation maintains GFR by changing diameters of arterioles and capillaries.
- Reduced blood flow triggers dilation of afferent arterioles and capillaries, and constriction of efferent arterioles.
- Rise in renal blood pressure causes constriction of afferent arterioles and decreases glomerular blood flow.
- Tubuloglomerular feedback mechanism involves macula densa cells detecting changes in salt level of fluid.
- Increased salt causes macula densa to secrete ATP and adenosine, which constricts smooth muscles of adjacent afferent arteriole.
- Constriction of afferent arteriole reduces blood flow into the glomerulus and GFR.
- Autoregulation occurs at the local level, while autonomic and hormonal regulation are initiated by the kidneys.
- Filtration coefficient is determined by surface area of glomerular capillaries available for filtration and permeability of interface between capillary and Bowman's capsule.
Test your knowledge on the intricate workings of the renal system with this quiz on Glomerular Filtration Rate (GFR). From the factors that influence GFR, to the three levels of GFR control and the tubuloglomerular feedback mechanism, this quiz covers it all. Learn about autoregulation, autonomic and hormonal regulation, and how filtration coefficient is determined. Put your understanding to the test and see how well you know the complex mechanisms that govern GFR.
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