Podcast
Questions and Answers
What is African trypanosomiasis commonly known as?
What is African trypanosomiasis commonly known as?
- Malaria
- Sleeping sickness (correct)
- Dengue fever
- Yellow fever
What is the most effective way to prevent tsetse fly bites?
What is the most effective way to prevent tsetse fly bites?
- Applying pentamidine or suramin chemoprophylaxis
- Wearing long-sleeved, bright (but not blue) clothing (correct)
- Avoiding infested strips of land
- Using insect repellents
What is the primary adverse effect of melarsoprol treatment?
What is the primary adverse effect of melarsoprol treatment?
- Nausea and vomiting
- Acute encephalopathy (correct)
- Skin rash
- Muscle weakness
What is the main advantage of using pentamidine over other drugs to treat HAT?
What is the main advantage of using pentamidine over other drugs to treat HAT?
Which drug is the preferred first-line treatment for stage II T. b. gambiense HAT?
Which drug is the preferred first-line treatment for stage II T. b. gambiense HAT?
Which adverse effects are most pronounced in patients taking nifurtimox?
Which adverse effects are most pronounced in patients taking nifurtimox?
Which type of trypanosomiasis is most resistant to eflornithine treatment?
Which type of trypanosomiasis is most resistant to eflornithine treatment?
Which subgenus of Trypanosoma has three morphologically indistinguishable species, including T. brucei?
Which subgenus of Trypanosoma has three morphologically indistinguishable species, including T. brucei?
How is Human African trypanosomiasis transmitted?
How is Human African trypanosomiasis transmitted?
What is the main strategy for controlling sleeping sickness in endemic areas?
What is the main strategy for controlling sleeping sickness in endemic areas?
What is the drug of choice for stage I HAT caused by T. b. gambiense?
What is the drug of choice for stage I HAT caused by T. b. gambiense?
What is the current status of sleeping sickness as a public health problem?
What is the current status of sleeping sickness as a public health problem?
What are the two stages of Human African trypanosomiasis?
What are the two stages of Human African trypanosomiasis?
Which subspecies of T. brucei infects humans, domestic livestock, and some wild antelopes?
Which subspecies of T. brucei infects humans, domestic livestock, and some wild antelopes?
What can happen if African trypanosomiasis is not treated in time?
What can happen if African trypanosomiasis is not treated in time?
Which drug is used for melarsoprol-refractory cases of T. b. gambiense sleeping sickness?
Which drug is used for melarsoprol-refractory cases of T. b. gambiense sleeping sickness?
What are the adverse effects of suramin?
What are the adverse effects of suramin?
What is the most widely used stage II anti-trypanosomal drug?
What is the most widely used stage II anti-trypanosomal drug?
Which drug combination is the preferred first-line treatment for stage II T. b. gambiense HAT?
Which drug combination is the preferred first-line treatment for stage II T. b. gambiense HAT?
Which drug has a high rate of serious adverse effects?
Which drug has a high rate of serious adverse effects?
Which stage of Human African trypanosomiasis is associated with progressive disease and death if left untreated?
Which stage of Human African trypanosomiasis is associated with progressive disease and death if left untreated?
Which subspecies of T. brucei can infect pigs and sheep, and only occasionally other orders?
Which subspecies of T. brucei can infect pigs and sheep, and only occasionally other orders?
What are the different methods used for diagnosis of African trypanosomiasis?
What are the different methods used for diagnosis of African trypanosomiasis?
What is the trypanolytic factor found in normal human plasma?
What is the trypanolytic factor found in normal human plasma?
What is the drug of choice for stage I HAT caused by T. b. rhodesiense?
What is the drug of choice for stage I HAT caused by T. b. rhodesiense?
What are the clinical features of African trypanosomiasis?
What are the clinical features of African trypanosomiasis?
What is the estimated number of people in sub-Saharan Africa who are at risk of Human African trypanosomiasis?
What is the estimated number of people in sub-Saharan Africa who are at risk of Human African trypanosomiasis?
Which subspecies of T. brucei can infect all domestic animals, camels, some antelopes, and carnivores, but not humans?
Which subspecies of T. brucei can infect all domestic animals, camels, some antelopes, and carnivores, but not humans?
What are the new rapid diagnostic tests for African trypanosomiasis like?
What are the new rapid diagnostic tests for African trypanosomiasis like?
Which drug is widely used for stage II anti-trypanosomal treatment of both T. b. gambiense and T. b. rhodesiense infections?
Which drug is widely used for stage II anti-trypanosomal treatment of both T. b. gambiense and T. b. rhodesiense infections?
What is the surface coat of glycoprotein that Trypanosoma has evolved?
What is the surface coat of glycoprotein that Trypanosoma has evolved?
Which of the following is not a method used for diagnosis of African trypanosomiasis?
Which of the following is not a method used for diagnosis of African trypanosomiasis?
What is the second-line treatment in melarsoprol-refractory cases?
What is the second-line treatment in melarsoprol-refractory cases?
Which protozoal parasite causes a more acute form of Human African trypanosomiasis?
Which protozoal parasite causes a more acute form of Human African trypanosomiasis?
Which drug is a new oral treatment for all stages of T. b. gambiense HAT?
Which drug is a new oral treatment for all stages of T. b. gambiense HAT?
Which protozoal parasite causes a more chronic infection of Human African trypanosomiasis?
Which protozoal parasite causes a more chronic infection of Human African trypanosomiasis?
What is the trypanosome subspecies that is an animal pathogen?
What is the trypanosome subspecies that is an animal pathogen?
What is the trypanosome subspecies that infects humans in West and Central Africa?
What is the trypanosome subspecies that infects humans in West and Central Africa?
What is the preferred first-line treatment for stage II T. b. rhodesiense HAT?
What is the preferred first-line treatment for stage II T. b. rhodesiense HAT?
Which of the following is a clinical feature of African trypanosomiasis in the late stage?
Which of the following is a clinical feature of African trypanosomiasis in the late stage?
What is the outcome of Human African trypanosomiasis if left untreated?
What is the outcome of Human African trypanosomiasis if left untreated?
Which drug is mostly used for melarsoprol-refractory cases of T. b. rhodesiense sleeping sickness?
Which drug is mostly used for melarsoprol-refractory cases of T. b. rhodesiense sleeping sickness?
What is the trypanosome subspecies that infects humans in East and Southern Africa?
What is the trypanosome subspecies that infects humans in East and Southern Africa?
What is the trypanosome subspecies that can infect a wide range of mammalian hosts except primates?
What is the trypanosome subspecies that can infect a wide range of mammalian hosts except primates?
What is a significant concern associated with the treatment of Human African trypanosomiasis?
What is a significant concern associated with the treatment of Human African trypanosomiasis?
How is HAT prevention achieved in endemic areas?
How is HAT prevention achieved in endemic areas?
What are the new rapid diagnostic tests for African trypanosomiasis (the HAT Sero-K-SeT and the SD Bioline HAT 1.0) characterized by?
What are the new rapid diagnostic tests for African trypanosomiasis (the HAT Sero-K-SeT and the SD Bioline HAT 1.0) characterized by?
Study Notes
Human African trypanosomiasis, also known as HAT or sleeping sickness, is a disease caused by the protozoa genus Trypanosoma and transmitted by tsetse flies. It has two stages: the hematologic stage (I) which is associated with systemic illness, and the neurologic stage (II) which is associated with progressive disease, disability, and death if left untreated. It may be difficult to diagnose and treatments are associated with significant toxicity. Although case numbers have been reduced in the last decade, HAT remains a threat to 65 million people in sub-Saharan Africa. HAT is caused by two morphologically indistinguishable protozoal parasites: T. b. rhodesiense, which is responsible for a more acute form of the disease, and T. b. gambiense, which causes a more chronic infection. Both invariably progress to a fatal outcome unless treated.
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Description
Test your knowledge on Human African Trypanosomiasis, also known as sleeping sickness, with this informative quiz. Learn about the two stages of the disease, its causes, transmission, and potential treatments. Discover the impact of HAT on millions of people in sub-Saharan Africa and the challenges associated with diagnosis and treatment. Keywords: HAT, sleeping sickness, Trypanosoma, tsetse flies, hematologic stage, neurologic stage, T. b. rhodesiense,
