Coccidioidomycosis

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Questions and Answers

What is the drug of choice for less severely ill patients with coccidioidomycosis?

  • Voriconazole
  • Posaconazole
  • Amphotericin B
  • Fluconazole (correct)

What is the genus of fungi that causes coccidioidomycosis?

  • Candida
  • Aspergillus
  • Coccidioides (correct)
  • Cryptococcus

What is the characteristic size range of the spherules produced by Coccidioides?

  • 30-40 µm diameter
  • 50-60 µm diameter
  • 8-24 µm diameter (correct)
  • 2-6 µm diameter

What are the typical symptoms of a pulmonary coccidioidomycosis infection?

<p>Fever, dry cough, and pleuritic chest pain (B)</p> Signup and view all the answers

What is the reported incidence of hospitalizations among children in endemic regions?

<p>8 to 12/100,000 (C)</p> Signup and view all the answers

What percentage of coccidioides isolates have elevated MIC values to fluconazole?

<p>37% (D)</p> Signup and view all the answers

What percentage of hospitalized children had pulmonary disease according to one series?

<p>56% (B)</p> Signup and view all the answers

What is the most common site for coccidioidomycosis to disseminate to?

<p>Central nervous system (D)</p> Signup and view all the answers

What percentage of patients with primary pneumonia experience chronic pulmonary infiltrates, cough, and pleuritic chest pain?

<p>5% to 19% (D)</p> Signup and view all the answers

What is the primary method of transmission of Coccidioides?

<p>Airborne inhalation of conidia (A)</p> Signup and view all the answers

What is the recommended treatment for life-threatening coccidioidomycosis?

<p>Amphotericin B (D)</p> Signup and view all the answers

What type of immune response is necessary for protective immunity against Coccidioides?

<p>Both Th1 and Th2 (A)</p> Signup and view all the answers

What is the endemic area for coccidioidomycosis?

<p>Deserts (B)</p> Signup and view all the answers

What is the most common extrapulmonary manifestation of coccidioidomycosis?

<p>Skin lesions (A)</p> Signup and view all the answers

What is the gold-standard technique for the diagnosis of coccidioidomycosis?

<p>Culture of the organism (D)</p> Signup and view all the answers

What is the primary reason for the increase in coccidioidomycosis cases in Arizona?

<p>Soil disturbance from construction (C)</p> Signup and view all the answers

What is the cerebrospinal fluid (CSF) like in patients with coccidioidal meningitis?

<p>Shows lymphocytosis and hypoglycorrhachia (B)</p> Signup and view all the answers

What is the recommended approach for handling culture plates with suspected mycelia?

<p>Seal them and open them carefully (D)</p> Signup and view all the answers

What is the response to therapy considered when the cumulative score is reduced to less than what percentage of baseline?

<p>50% (B)</p> Signup and view all the answers

What is the prognosis for untreated coccidioidal meningitis?

<p>Fatal within 2 years (C)</p> Signup and view all the answers

Which ethnic/racial group has the highest rate of coccidioidomycosis in Arizona?

<p>African American (C)</p> Signup and view all the answers

What is the sensitivity of the urinary antigen test in moderate to severe disease?

<p>71% (A)</p> Signup and view all the answers

Which antifungal agents are recommended as salvage therapy for azole failures?

<p>Voriconazole and posaconazole (C)</p> Signup and view all the answers

What is the preferred treatment during the first trimester of pregnancy?

<p>Amphotericin B (B)</p> Signup and view all the answers

What is an important adjunct to antifungal therapy in the management of coccidioidomycosis?

<p>Immunosuppression (B)</p> Signup and view all the answers

What may be required for vertebral osteomyelitis?

<p>Surgery (C)</p> Signup and view all the answers

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