Hormones Receptors and Rhythms Part 3: Tyrosine Kinase Receptors

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What is the function of Tyrosine Kinase Receptors (RTK) in a dimeric fashion?

The receptors function separately, with no interaction between them

They require three receptors to initiate a signal when binding to the ligand

They function in pairs, with a signal binding to one receptor and bringing the other receptor to form a complex (correct)

They function independently, each receptor initiating its own signal when bound to a ligand

What is the characteristic of receptors with intrinsic tyrosine kinase activity?

They have their own intrinsic kinase activity when bound to a ligand (correct)

They lack the ability to recruit a tyrosine kinase when bound to a ligand

Their activity does not change when bound to a ligand

They require multiple receptors to activate tyrosine kinase activity

What is the structure of the insulin receptor, which is the most studied receptor with intrinsic tyrosine kinase activity?

Monomeric structure with only one α and one β chain

Dimeric structure with 2 α and 2 β chains held together by hydrogen bonds

Homo-tetrameric structure with 2 α and 2 β chains held together by S-S bonds

Hetero-tetrameric structure with 2 α and 2 β chains held together by disulfide bonds (correct)

What is the length of the β subunit of the insulin receptor, which consists of ectodomain, transmembrane domain, and cytoplasmic domain?

618 amino acids Signup and view all the answers

Which enzyme is responsible for the conversion of GTP to GDP in the RAS signaling pathway?

RAS GTPase Signup and view all the answers

In the MAPK pathway, which protein is most studied among the family of proteins?

MEK1/2 Signup and view all the answers

Which receptor substrate participates in signaling pathways other than insulin?

IRS-1 Signup and view all the answers

Which protein can bind to DNA and inhibit other transcription factors from binding in the nucleus?

ERK2 Signup and view all the answers

Which enzyme is responsible for lipid mobilization in the context of insulin change and TG degradation into FA?

MAPK kinase Signup and view all the answers

What is the main function of MAPK kinase in cellular response?

Gene expression Signup and view all the answers

What is the product of signaling through PIP3?

Phosphatidylinositol (3,4,5)-trisphosphate Signup and view all the answers

Which receptors are best known for their recruited tyrosine kinase activity?

Receptors for growth hormone (GH) Signup and view all the answers

What is the first step in recruiting JAK-2 in the JAK-STAT pathway?

Dimerization of the cytoplasmic regions Signup and view all the answers

Which class of ligands need intracellular receptors called nuclear receptor?

Thyroid hormone Signup and view all the answers

What is required for the nuclear receptor to regulate transcription of a target gene?

Binding to a specific sequence element on DNA Signup and view all the answers

Which process results from activation of PIP3 pathway?

Proliferation Signup and view all the answers

"Serine and threonine phosphorylation cascade" typically involve the dimerization of which type of receptor?

"Serine-Threonine kinase receptor (RSTK)" Signup and view all the answers

Hormones Receptors and Rhythms Part 3: Tyrosine Kinase Receptors

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Questions and Answers

What is the function of Tyrosine Kinase Receptors (RTK) in a dimeric fashion?

What is the characteristic of receptors with intrinsic tyrosine kinase activity?

What is the structure of the insulin receptor, which is the most studied receptor with intrinsic tyrosine kinase activity?

What is the length of the β subunit of the insulin receptor, which consists of ectodomain, transmembrane domain, and cytoplasmic domain?

Which enzyme is responsible for the conversion of GTP to GDP in the RAS signaling pathway?

In the MAPK pathway, which protein is most studied among the family of proteins?

Which receptor substrate participates in signaling pathways other than insulin?

Which protein can bind to DNA and inhibit other transcription factors from binding in the nucleus?

Which enzyme is responsible for lipid mobilization in the context of insulin change and TG degradation into FA?

What is the main function of MAPK kinase in cellular response?

What is the product of signaling through PIP3?

Which receptors are best known for their recruited tyrosine kinase activity?

What is the first step in recruiting JAK-2 in the JAK-STAT pathway?

Which class of ligands need intracellular receptors called nuclear receptor?

What is required for the nuclear receptor to regulate transcription of a target gene?

Which process results from activation of PIP3 pathway?

"Serine and threonine phosphorylation cascade" typically involve the dimerization of which type of receptor?

"The receptors function as transcription factors" in which type of receptor?

Which enzyme plays a role similar to IRS1 in the JAK-STAT pathway?

What is the main function of PIP2 in GPCR signaling?

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