Podcast
Questions and Answers
What is the function of Tyrosine Kinase Receptors (RTK) in a dimeric fashion?
What is the function of Tyrosine Kinase Receptors (RTK) in a dimeric fashion?
- The receptors function separately, with no interaction between them
- They require three receptors to initiate a signal when binding to the ligand
- They function in pairs, with a signal binding to one receptor and bringing the other receptor to form a complex (correct)
- They function independently, each receptor initiating its own signal when bound to a ligand
What is the characteristic of receptors with intrinsic tyrosine kinase activity?
What is the characteristic of receptors with intrinsic tyrosine kinase activity?
- They have their own intrinsic kinase activity when bound to a ligand (correct)
- They lack the ability to recruit a tyrosine kinase when bound to a ligand
- Their activity does not change when bound to a ligand
- They require multiple receptors to activate tyrosine kinase activity
What is the structure of the insulin receptor, which is the most studied receptor with intrinsic tyrosine kinase activity?
What is the structure of the insulin receptor, which is the most studied receptor with intrinsic tyrosine kinase activity?
- Monomeric structure with only one α and one β chain
- Dimeric structure with 2 α and 2 β chains held together by hydrogen bonds
- Homo-tetrameric structure with 2 α and 2 β chains held together by S-S bonds
- Hetero-tetrameric structure with 2 α and 2 β chains held together by disulfide bonds (correct)
What is the length of the β subunit of the insulin receptor, which consists of ectodomain, transmembrane domain, and cytoplasmic domain?
What is the length of the β subunit of the insulin receptor, which consists of ectodomain, transmembrane domain, and cytoplasmic domain?
Which enzyme is responsible for the conversion of GTP to GDP in the RAS signaling pathway?
Which enzyme is responsible for the conversion of GTP to GDP in the RAS signaling pathway?
In the MAPK pathway, which protein is most studied among the family of proteins?
In the MAPK pathway, which protein is most studied among the family of proteins?
Which receptor substrate participates in signaling pathways other than insulin?
Which receptor substrate participates in signaling pathways other than insulin?
Which protein can bind to DNA and inhibit other transcription factors from binding in the nucleus?
Which protein can bind to DNA and inhibit other transcription factors from binding in the nucleus?
Which enzyme is responsible for lipid mobilization in the context of insulin change and TG degradation into FA?
Which enzyme is responsible for lipid mobilization in the context of insulin change and TG degradation into FA?
What is the main function of MAPK kinase in cellular response?
What is the main function of MAPK kinase in cellular response?
What is the product of signaling through PIP3?
What is the product of signaling through PIP3?
Which receptors are best known for their recruited tyrosine kinase activity?
Which receptors are best known for their recruited tyrosine kinase activity?
What is the first step in recruiting JAK-2 in the JAK-STAT pathway?
What is the first step in recruiting JAK-2 in the JAK-STAT pathway?
Which class of ligands need intracellular receptors called nuclear receptor?
Which class of ligands need intracellular receptors called nuclear receptor?
What is required for the nuclear receptor to regulate transcription of a target gene?
What is required for the nuclear receptor to regulate transcription of a target gene?
Which process results from activation of PIP3 pathway?
Which process results from activation of PIP3 pathway?
"Serine and threonine phosphorylation cascade" typically involve the dimerization of which type of receptor?
"Serine and threonine phosphorylation cascade" typically involve the dimerization of which type of receptor?
"The receptors function as transcription factors" in which type of receptor?
"The receptors function as transcription factors" in which type of receptor?
Which enzyme plays a role similar to IRS1 in the JAK-STAT pathway?
Which enzyme plays a role similar to IRS1 in the JAK-STAT pathway?
What is the main function of PIP2 in GPCR signaling?
What is the main function of PIP2 in GPCR signaling?
