Hormones and Receptor Regulation Quiz
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Questions and Answers

What is the process by which excess hormone leads to a reduction in receptor density?

  • Upregulation
  • Internalization
  • Downregulation (correct)
  • Desensitization
  • Which of the following mechanisms is NOT associated with receptor downregulation?

  • Increased receptor synthesis (correct)
  • Decreased receptor synthesis
  • Uncoupling from effector system protein
  • Enhanced receptor degradation
  • What is the result of hormone absence with respect to receptors?

  • Receptor internalization
  • Enhanced receptor degradation
  • Upregulation (correct)
  • Downregulation
  • Which hormone is known to act as a positive regulator of its own receptors?

    <p>Prolactin (A)</p> Signup and view all the answers

    Which receptors are primarily associated with fat-soluble hormones?

    <p>Both cytoplasmic and nuclear receptors (B)</p> Signup and view all the answers

    Which of the following hormones activates the cAMP signaling system?

    <p>Adrenocorticotropic hormone (ACTH) (A)</p> Signup and view all the answers

    What role do heat shock proteins (Hsp) play in the function of steroid hormone receptors?

    <p>Stabilizing receptors in the absence of hormones (B)</p> Signup and view all the answers

    Which of the following hormones activates the calcium–phosphoinositol system?

    <p>Antidiuretic hormone (ADH) on V1 receptors (D)</p> Signup and view all the answers

    What primary role do hormones play in the body?

    <p>They regulate fundamental biochemical reactions. (A)</p> Signup and view all the answers

    Which of the following is an example of how hormonal action is classified?

    <p>All of the above. (D)</p> Signup and view all the answers

    Which substance is released from the heart and plays a role in endocrine secretion?

    <p>Atrial natriuretic peptide (ANP) (D)</p> Signup and view all the answers

    Which statement about hormones is true?

    <p>They can have multiple functions in different locations. (A)</p> Signup and view all the answers

    What term describes the secretion of a substance that regulates neighboring cells?

    <p>Paracrine (C)</p> Signup and view all the answers

    What is an example of a substance that can act both as a hormone in the digestive system and a neurotransmitter in the CNS?

    <p>CCK (Cholecystokinin) (A)</p> Signup and view all the answers

    What distinguishes autocrine signaling from other types of hormonal signaling?

    <p>It regulates the releasing cell itself. (C)</p> Signup and view all the answers

    Which of the following hormones is synthesized in the liver?

    <p>Somatomedines (A)</p> Signup and view all the answers

    What term is used to describe an episode of endocrine release that occurs every hour?

    <p>Circhoral (B)</p> Signup and view all the answers

    Which hormone is secreted by the pineal gland to help synchronize diurnal rhythms?

    <p>Melatonin (A)</p> Signup and view all the answers

    What is the effect of ablating the suprachiasmatic nucleus (SCN)?

    <p>Loss of rest-activity rhythm (C)</p> Signup and view all the answers

    Which pattern of pulsatile secretion is critical for maintaining gonadal function when administered for fertility treatment?

    <p>Once hourly (A)</p> Signup and view all the answers

    What type of rhythm describes periodicity that is approximately 24 hours?

    <p>Circadian (A)</p> Signup and view all the answers

    Which element assists in the control of the cortisol/ACTH axis concerning daily biorhythms?

    <p>Suprachiasmatic Nucleus (D)</p> Signup and view all the answers

    Which stimuli primarily influence the hypothalamic hormones produced by magno- and parvocellular cell groups?

    <p>Stimuli from various brain parts (A)</p> Signup and view all the answers

    What is the primary consequence of slower-than-hourly frequency GnRH administration?

    <p>Inhibition of gonadotropin secretion (A)</p> Signup and view all the answers

    What role do biogenic amines play in the neuroendocrine control mechanism?

    <p>They control the secretion of hormones from parvicellular neurons. (A)</p> Signup and view all the answers

    What is the primary function of negative feedback in an endocrine feedback system?

    <p>To ensure hormone secretion remains constant within limits. (D)</p> Signup and view all the answers

    How does an increase in hormone plasma concentration affect receptor exposure on target cells?

    <p>Receptor numbers decrease, a process known as down regulation. (B)</p> Signup and view all the answers

    Which of the following hormones is involved in a positive feedback mechanism during ovulation?

    <p>Luteinizing Hormone (LH) (B)</p> Signup and view all the answers

    What mechanism primarily regulates hormone release from magnocellular neurosecretory neurons?

    <p>Acetylcholine stimulates while norepinephrine inhibits. (A)</p> Signup and view all the answers

    Which statement best describes positive feedback in the endocrine system?

    <p>It is a rare mechanism that amplifies hormone concentration. (D)</p> Signup and view all the answers

    What phenomenon occurs when hormone concentration reaches a peak in the case of positive feedback?

    <p>A biological event is triggered. (C)</p> Signup and view all the answers

    What type of feedback mechanism is typically involved in regulatory processes for maintaining stable hormone levels?

    <p>Negative feedback (A)</p> Signup and view all the answers

    What is the significance of down-regulating insulin receptors in target cells?

    <p>It maintains the constant amount of hormone action on cells. (C), It reduces the amplitude of the hormonal response. (D)</p> Signup and view all the answers

    Which factor does NOT directly affect the magnitude of a hormone's effect on a cell?

    <p>Extracellular temperature. (A)</p> Signup and view all the answers

    Which method is NOT a functional test in endocrinology?

    <p>X-ray imaging. (B)</p> Signup and view all the answers

    What is the role of recombinant DNA technology in hormone production?

    <p>It allows the production of hormones in large quantities. (B)</p> Signup and view all the answers

    What are the new techniques developed for the detection of low concentration molecules?

    <p>Immunometric assays and chromatography/mass spectroscopy. (A)</p> Signup and view all the answers

    Which hormone is NOT mentioned as being produced through recombinant DNA technology?

    <p>Adrenaline. (C)</p> Signup and view all the answers

    In the context of hormonal response, what does up-regulation refer to?

    <p>Exposing more receptors when hormone levels decrease. (A)</p> Signup and view all the answers

    Which of the following conditions is associated with hyperfunction syndromes in endocrinology?

    <p>Cushing's syndrome. (B)</p> Signup and view all the answers

    What year did Brown-Séquard report enhancing his physical strength with animal testes extracts?

    <p>1889 (B)</p> Signup and view all the answers

    Who discovered the term 'hormone' to describe chemical messengers?

    <p>Starling (B)</p> Signup and view all the answers

    Which hormone was discovered in 1922 that significantly impacted diabetes treatment?

    <p>Insulin (B)</p> Signup and view all the answers

    What medical condition was treated with posterior pituitary extracts by Farmi and von den Velden in 1918?

    <p>Diabetes insipidus (A)</p> Signup and view all the answers

    Which discovery in 1915 linked parathyroid glands to calcium metabolism?

    <p>MacCallum and Voetlin (C)</p> Signup and view all the answers

    Which of the following is NOT mentioned as an important therapeutic advance in medical practice?

    <p>Antibiotic therapy (B)</p> Signup and view all the answers

    In which year was the role of Leydig cells in male phenotype development deduced?

    <p>1910 (B)</p> Signup and view all the answers

    What field contributed significantly to the advances in hormonal therapies mentioned?

    <p>Cybernetics (D)</p> Signup and view all the answers

    Flashcards

    Hormone

    A chemical messenger produced by specialized cells, often in glands, and released in small quantities. Hormones act on target cells to influence their function, affecting physiological processes, metabolism, behavior, and morphology.

    Endocrine System

    The system of glands that produce and secrete hormones into the bloodstream to regulate various bodily functions. It works closely with the nervous system and immune system.

    Autocrine

    A type of hormone action where the hormone is released by a cell and acts on that same cell. Self-regulation.

    Paracrine

    A type of hormone action where the hormone is released by a cell and acts on nearby cells. Local communication.

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    Endocrine

    The most common type of hormone action where the hormone is released by a cell, travels through the bloodstream, and acts on a distance target cell. Long-distance communication.

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    Hormonal Regulation

    Hormones do not create new processes or mechanisms. They act as regulators of existing biochemical reactions.

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    Hormonal Function

    Hormones do not provide the building blocks or energy for the processes they regulate. Their role is strictly to influence the rate and direction of existing biochemical reactions.

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    Neurosecretion

    The secretion of hormones by neurons, often organized in networks, which acts on target cells or other neurons. This is a key communication mechanism in the nervous system.

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    Downregulation

    Decrease in the number of hormone receptors on the cell surface, reducing the cell's sensitivity to the hormone.

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    Upregulation

    Increase in the number of hormone receptors on the cell surface, making the cell more sensitive to the hormone.

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    Membrane receptors

    A type of hormone receptor located on the cell membrane, specifically for protein, peptide, and catecholamine hormones.

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    Cytoplasmic receptors

    A type of hormone receptor found inside the cell, specifically for steroid hormones, acting as an intracellular transporter.

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    Nuclear receptors

    A type of hormone receptor located in the nucleus, responsible for interactions with thyroid and steroid hormones.

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    Second messenger

    A signaling molecule that relays signals from a hormone receptor to intracellular targets.

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    cAMP system

    A second messenger system activated by hormones such as ACTH, FSH, LH, TSH, MSH, Ang II, and ADH (acting on V2 receptors).

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    Calcium-phosphoinositol system (Ca-PIP)

    A second messenger system activated by hormones such as ADH (acting on V1 receptors), angiotensin II, catecholamines (alpha-receptors), GnRH, GHRH, oxytocin, and TRH.

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    Cichoral rhythm

    Hormone release patterns that occur with a period of approximately one hour.

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    Ultradian rhythm

    Hormone release patterns that have a periodicity longer than an hour but less than 24 hours.

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    Circadian rhythm

    Hormone release patterns with a periodicity of approximately 24 hours. Often associated with daily light-dark cycles.

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    Suprachiasmatic nucleus (SCN)

    The brain region acting as a biological clock, responsible for regulating circadian rhythms.

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    Melatonin

    A hormone secreted by the pineal gland, involved in the synchronization of circadian rhythms with the 24-hour day/night cycle.

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    Pulsatile secretion

    The specific pattern of hormone release where secretion occurs in bursts or pulses.

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    Pulsatile secretion importance

    The importance of specific hormone release patterns for proper function. GnRH, for example, must be released hourly for normal gonadotropin secretion.

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    Extrahypothalamic areas

    Different brain areas, including the amygdala, hippocampus, and various brainstem regions, that send signals to the hypothalamus to modulate hormone release.

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    Endocrine Feedback System

    A type of hormone regulation where the first hormone controls the secretion of the second, which then feeds back to modulate the secretion of the first.

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    Negative Feedback

    The most common type of feedback, where the second hormone inhibits the secretion of the first, maintaining a stable balance.

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    Positive Feedback

    A rare type of feedback, where the second hormone amplifies the secretion of the first, leading to a rapid increase in its concentration.

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    Neuroendocrine Control

    The control mechanism of the hypothalamus, where neurons release factors that stimulate or inhibit the production of pituitary hormones.

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    Parvicellular and Magnocellular Neurosecretory Cells

    These neurons in the hypothalamus are responsible for producing and releasing hormones that regulate the pituitary gland.

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    Monoaminergic Neuron Regulation

    Monoaminergic neurons, with cell bodies in the brainstem, regulate hormone secretion from the hypothalamus using biogenic amines like norepinephrine, dopamine, and serotonin.

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    Endocrinology

    The study of hormones and their effects on the body, including their production, regulation, and functions.

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    Pancreas

    The gland responsible for producing insulin, a hormone that regulates blood sugar levels. It is located near the stomach.

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    George Murray

    The first discovery of a hormone, this scientist studied the effects of thyroid extract in treating myxoedema.

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    Insulin

    The key hormone produced by the pancreas responsible for regulating blood sugar, also known as 'blood sugar' hormone.

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    Oral Contraceptives

    Oral contraceptives are a form of birth control that use hormones to prevent pregnancy.

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    Insulin Treatment

    The treatment of diabetes using insulin injections to regulate blood sugar levels.

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    Hormone receptor population

    The ability of a cell to respond to a hormone depends on the number of hormone receptors it possesses.

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    Hormone Receptor

    A specific type of protein on the surface of a cell that recognizes and binds hormones. This interaction triggers a chain of events within the cell, leading to a specific response.

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    Biochemical responsiveness

    The biochemical responsiveness of a cell to a hormone is determined by the number of receptors occupied by the hormone.

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    Factors influencing hormonal effect

    The magnitude of a hormone's effect is influenced by multiple factors like receptor number, hormone concentration, receptor affinity, exposure duration, intracellular conditions, and the presence of synergistic or antagonistic modulators.

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    Radioimmunoassay (RIA)

    A technique used to analyze hormone levels in blood or other bodily fluids. Antibodies are used to identify and quantify specific hormones.

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    Recombinant DNA technology for hormone production

    Cloning genes that express peptide hormones allows for the production of hormones through recombinant DNA technology, providing a source of hormones for therapeutic purposes.

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    Study Notes

    Endocrine System Introduction

    • Endocrine system works with nervous and immune systems to maintain homeostasis
    • Endocrine glands are also called glands with internal secretion
    • Claude Bernard introduced the concept of internal secretion
    • Hormones are stimulatory substances released into the internal environment (blood, lymph)
    • Hormones are chemical messengers, secreted by specialized cells, not necessarily in glands
    • Hormones act on target cells, regulating physiological, metabolic, behavioral, and morphological effects
    • Hormones don't create new processes, but regulate existing biochemical reactions
    • Many organs have endocrine secretions (e.g., brain, heart, kidney, liver, skin, digestive tube)
    • Endocrine secretion includes endocrine glands, APUD cells, paracrine secretions, autocrine secretions, and neurosecretion
    • Hormones can have multiple roles (e.g., CCK is both a hormone and a neurotransmitter)

    Hormone Classification

    • Hormones are classified based on their structure:
    • Proteic hormones: also called glycoproteic or peptidic hormones
    • Amino acid-derived hormones: phenol or indol ring derived
    • Lipid hormones: steroidal hormones
    • Hormones can also be classified based on their target organs (e.g., thyroid stimulating hormone - TSH, growth hormone - GH, insulin)

    Hormone Receptors

    • Hormones interact with specific receptors
    • Receptors are represented by a protein which has high affinity for the hormon
    • The number of receptors can vary based on factors including hormone concentration
    • Downregulation of receptors occurs with excess hormone, decreasing binding and response
    • Downregulation mechanisms include internalization, compartmentalization, and degradation of receptors
    • Upregulation of receptors occurs with lack of hormone
    • Upregulation mechanisms include increasing receptor density and activation of protein kinases
    • Hormones can act as positive regulators for other hormone receptors (e.g., thyroid hormones upregulate cathecolamines receptors)
    • Receptors are categorized by location: membrane receptors, cytoplasmic receptors, and nuclear receptors
    • Steroid hormones pass through cell membranes and bind cytoplasmic receptors
    • Hormone-receptor complexes then move to the nucleus, acting on nuclear receptors to trigger gene transcription and protein synthesis

    Second Messengers

    • After binding with a receptor, a secondary messenger system becomes activated
    • This system can activate other proteins or enzymes
    • The cAMP system involves hormones that activate adenylate cyclase
    • The Ca++, phospho-inositol system involves hormones that activate calcium channels and phospholipase C
    • Hormones can be directly enzymes, or linked to an enzyme
    • Hormone interaction with receptors can lead to activation or inhibition in a secondary messenger system

    Transport of Hormones

    • Hormones are transported mainly through blood, with some in lymph
    • Most hormones are bound to transport proteins (e.g., Albumin, TBG, CBG)
    • The free form of a hormone is less abundant but plays an active role
    • Free hormones are more accessible to target tissues

    Hormone Metabolism and Elimination

    • Peptide hormones are inactivated via intracellular hydrolysis
    • Catecholamines are inactivated via oxidation
    • Steroid hormones undergo metabolic processes like dehydrogenation and conjugation
    • Hormones are excreted in urine or bile after being conjugated with glucuronic acid or sulfate
    • Enterohepatic circulation assists in reaccumulating these hormones

    Hormone Secretion Regulation

    • Secretion is regulated through chronic, nervous, feedback and regulatory mechanisms
    • Biorhythms are endogenous or exogenous; examples include circadians rhythms (growth hormones and cortisol), diurnal rhythms, sleep-wake cycles, and seasonal cycles
    • The suprachiasmatic nucleus (SCN) acts as a biological clock, influencing daily biorhythms
    • Nervous control involves input from the hypothalamus, brainstem, and other areas of the brain to the hypothalamic nuclei
    • Feedback control is a common regulatory mechanism, where the hormone itself can regulate its own secretion, maintaining the hormone concetration within physiological limits

    Hormonal Receptor Regulation

    • Downregulation: occurs when the plasma concentration of a hormone rises
    • Reduced receptor number on target cells leads to a decreased effect from the hormone
    • Upregulation occurs when the plasma concentration of the hormone falls
    • Increased receptor number on target cells to maintain the level of the hormone interaction on the cell

    Hormone Methods of Investigation

    • Imaging techniques (X-rays, CT scans, MRI)
    • Functional tests (measuring hormone levels at rest and during stimulation/inhibition)
    • Radioimmunoassay (RIA), a technique used to measure hormones in blood samples
    • Immunometric assays and chromatography/mass spectrometry, provide more sensitive methods in detecting molecules with very low concentrations

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    Test your knowledge on hormonal functions and receptor regulation mechanisms. This quiz covers various aspects of hormones, including their effects on receptor density, signaling systems, and classification of hormonal actions. Explore the intricate relationship between hormones and their receptors in the endocrine system.

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