Hormone Regulation and Receptor Affinity

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Questions and Answers

What is the serum concentration of a hormone primarily dependent on?

The rate of hormone release and reabsorption

The rate of hormone degradation and excretion

The rate of hormone production and metabolic clearance (correct)

The rate of hormone synthesis and storage

What happens to the serum concentration of a hormone if its production rate increases while its metabolic clearance rate remains constant?

It remains constant

It increases (correct)

It decreases

It fluctuates randomly

What is the primary function of metabolic clearance rate?

To store hormones

To regulate hormone release

To synthesize hormones

To remove excess hormones from the bloodstream (correct)

Which of the following best describes the relationship between hormone production and metabolic clearance rate?

They are inversely proportional Signup and view all the answers

What would be the result of an increase in both hormone production and metabolic clearance rates?

The serum concentration would remain constant Signup and view all the answers

What happens to the number and affinity of receptors when the hormone level is high?

They decrease in number and affinity Signup and view all the answers

What is the effect of low hormone levels on the number and affinity of receptors?

They increase in number and affinity Signup and view all the answers

What is the purpose of down regulation?

To decrease the response to the hormone Signup and view all the answers

What is the relationship between hormonal levels and receptor affinity?

Inversely proportional Signup and view all the answers

What is the effect of up regulation on the response to the hormone?

It increases the response to the hormone Signup and view all the answers

What is the primary mechanism that controls hormone secretion?

Feedback regulation Signup and view all the answers

What occurs when the serum level of one hormone stimulates the release of another hormone?

Positive feedback regulation Signup and view all the answers

What is the result of elevated serum levels of one hormone?

Stimulation of another hormone's release Signup and view all the answers

What is the purpose of feedback regulation in hormone secretion?

To maintain homeostasis Signup and view all the answers

What type of regulation is characteristic of a self-reinforcing cycle?

Positive feedback regulation Signup and view all the answers

What is the primary function of feedback loops in the context of hormone production?

To regulate hormone secretion Signup and view all the answers

In which system are feedback loops used extensively to regulate hormone secretion?

Hypothalamic-pituitary axis Signup and view all the answers

What is the role of the hypothalamic-pituitary axis in hormone production?

To regulate hormone secretion through feedback loops Signup and view all the answers

What is the purpose of feedback control in hormone production?

To maintain homeostasis Signup and view all the answers

What is the result of feedback loops in hormone production?

Regulated hormone production Signup and view all the answers

How do hormones act?

Through multiple mechanisms Signup and view all the answers

What determines the effect of a hormone on its target cells?

The concentration of hormone in the serum Signup and view all the answers

What is the role of metabolic clearance rate in hormone action?

Removing excess hormone from the serum Signup and view all the answers

What happens when the production rate of a hormone increases?

The serum concentration of the hormone increases Signup and view all the answers

How do changes in hormone production and metabolic clearance rate affect the serum concentration of a hormone?

Both changes in hormone production and metabolic clearance rate affect serum concentration Signup and view all the answers

Study Notes

Control of Hormone Secretion

The serum concentration of a hormone is determined by its production rate and metabolic clearance rate.
Hormone secretion is primarily controlled by feedback regulation.

Feedback Regulation

Elevated serum levels of one hormone can stimulate the release of another hormone, known as positive feedback regulation.
Feedback loops are extensively used to regulate hormone secretion in the hypothalamic-pituitary axis.

Regulation of Hormone Receptors

The number and affinity of hormone receptors can change depending on the hormonal level.
Down regulation occurs when the hormone level is high, resulting in a decrease in receptor number and affinity.
Up regulation occurs when the hormone level is low, resulting in an increase in receptor number and affinity.

Mechanism of Action of Hormones

Hormones act through various mechanisms.

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Description

Learn how hormone levels affect the number and affinity of receptors, including down regulation and up regulation. Understand the concept with the help of figure 3B.