25 Questions
What is the serum concentration of a hormone primarily dependent on?
The rate of hormone production and metabolic clearance
What happens to the serum concentration of a hormone if its production rate increases while its metabolic clearance rate remains constant?
It increases
What is the primary function of metabolic clearance rate?
To remove excess hormones from the bloodstream
Which of the following best describes the relationship between hormone production and metabolic clearance rate?
They are inversely proportional
What would be the result of an increase in both hormone production and metabolic clearance rates?
The serum concentration would remain constant
What happens to the number and affinity of receptors when the hormone level is high?
They decrease in number and affinity
What is the effect of low hormone levels on the number and affinity of receptors?
They increase in number and affinity
What is the purpose of down regulation?
To decrease the response to the hormone
What is the relationship between hormonal levels and receptor affinity?
Inversely proportional
What is the effect of up regulation on the response to the hormone?
It increases the response to the hormone
What is the primary mechanism that controls hormone secretion?
Feedback regulation
What occurs when the serum level of one hormone stimulates the release of another hormone?
Positive feedback regulation
What is the result of elevated serum levels of one hormone?
Stimulation of another hormone's release
What is the purpose of feedback regulation in hormone secretion?
To maintain homeostasis
What type of regulation is characteristic of a self-reinforcing cycle?
Positive feedback regulation
What is the primary function of feedback loops in the context of hormone production?
To regulate hormone secretion
In which system are feedback loops used extensively to regulate hormone secretion?
Hypothalamic-pituitary axis
What is the role of the hypothalamic-pituitary axis in hormone production?
To regulate hormone secretion through feedback loops
What is the purpose of feedback control in hormone production?
To maintain homeostasis
What is the result of feedback loops in hormone production?
Regulated hormone production
How do hormones act?
Through multiple mechanisms
What determines the effect of a hormone on its target cells?
The concentration of hormone in the serum
What is the role of metabolic clearance rate in hormone action?
Removing excess hormone from the serum
What happens when the production rate of a hormone increases?
The serum concentration of the hormone increases
How do changes in hormone production and metabolic clearance rate affect the serum concentration of a hormone?
Both changes in hormone production and metabolic clearance rate affect serum concentration
Study Notes
Control of Hormone Secretion
- The serum concentration of a hormone is determined by its production rate and metabolic clearance rate.
- Hormone secretion is primarily controlled by feedback regulation.
Feedback Regulation
- Elevated serum levels of one hormone can stimulate the release of another hormone, known as positive feedback regulation.
- Feedback loops are extensively used to regulate hormone secretion in the hypothalamic-pituitary axis.
Regulation of Hormone Receptors
- The number and affinity of hormone receptors can change depending on the hormonal level.
- Down regulation occurs when the hormone level is high, resulting in a decrease in receptor number and affinity.
- Up regulation occurs when the hormone level is low, resulting in an increase in receptor number and affinity.
Mechanism of Action of Hormones
- Hormones act through various mechanisms.
Learn how hormone levels affect the number and affinity of receptors, including down regulation and up regulation. Understand the concept with the help of figure 3B.
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