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Questions and Answers
The term homeostasis refers to the maintenance of a relatively constant internal environment within the body.
The term homeostasis refers to the maintenance of a relatively constant internal environment within the body.
True
Which of the following is NOT a component of the extracellular fluid compartment?
Which of the following is NOT a component of the extracellular fluid compartment?
What is the primary mechanism by which homeostasis is generally regulated?
What is the primary mechanism by which homeostasis is generally regulated?
Which of the following accurately illustrates the role of negative feedback in regulating body temperature?
Which of the following accurately illustrates the role of negative feedback in regulating body temperature?
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Define the term gland in the context of the endocrine system.
Define the term gland in the context of the endocrine system.
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How do endocrine glands differ from exocrine glands?
How do endocrine glands differ from exocrine glands?
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Match the following glands with their corresponding secretions:
Match the following glands with their corresponding secretions:
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What is the connection between the hypothalamus and the pituitary gland in the endocrine system?
What is the connection between the hypothalamus and the pituitary gland in the endocrine system?
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What is the primary function of the anterior pituitary gland?
What is the primary function of the anterior pituitary gland?
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Which of the following hormones is NOT produced by the anterior pituitary gland?
Which of the following hormones is NOT produced by the anterior pituitary gland?
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The hormone ______ is crucial for regulating blood calcium levels.
The hormone ______ is crucial for regulating blood calcium levels.
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What is the main function of calcitonin?
What is the main function of calcitonin?
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Describe the location and function of the pancreas in the endocrine system.
Describe the location and function of the pancreas in the endocrine system.
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Insulin and glucagon have opposing effects on blood glucose levels, with insulin decreasing glucose levels and glucagon increasing glucose levels.
Insulin and glucagon have opposing effects on blood glucose levels, with insulin decreasing glucose levels and glucagon increasing glucose levels.
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Which of the following hormones does NOT directly influence blood glucose levels?
Which of the following hormones does NOT directly influence blood glucose levels?
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What are the two main regions of the adrenal glands and what types of hormones are produced in each region?
What are the two main regions of the adrenal glands and what types of hormones are produced in each region?
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Cortisol is a steroid hormone that plays a significant role in regulating blood glucose levels and is involved in stress response.
Cortisol is a steroid hormone that plays a significant role in regulating blood glucose levels and is involved in stress response.
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What is the primary function of aldosterone?
What is the primary function of aldosterone?
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What are the main effects of epinephrine and norepinephrine on the body?
What are the main effects of epinephrine and norepinephrine on the body?
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Which of the following is NOT considered a type of stress?
Which of the following is NOT considered a type of stress?
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Match the following phases of the General Adaptation Syndrome (GAS) with their corresponding characteristics:
Match the following phases of the General Adaptation Syndrome (GAS) with their corresponding characteristics:
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Which of the following hormones is primarily involved in the resistance phase of stress response?
Which of the following hormones is primarily involved in the resistance phase of stress response?
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The ovaries are the primary female reproductive organs responsible for producing estrogen and progesterone.
The ovaries are the primary female reproductive organs responsible for producing estrogen and progesterone.
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What are the roles of estrogen and progesterone in the female body?
What are the roles of estrogen and progesterone in the female body?
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Testosterone is the primary male sex hormone produced by the testes.
Testosterone is the primary male sex hormone produced by the testes.
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What are the roles of testosterone in the male body?
What are the roles of testosterone in the male body?
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Which of the following hormones is primarily associated with the regulation of the menstrual cycle?
Which of the following hormones is primarily associated with the regulation of the menstrual cycle?
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What are some of the functions of prostaglandins in the body?
What are some of the functions of prostaglandins in the body?
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Which hormone is released by the pituitary gland and plays a significant role in water retention in the kidneys?
Which hormone is released by the pituitary gland and plays a significant role in water retention in the kidneys?
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Which of the following hormones is responsible for increasing blood glucose levels during fasting?
Which of the following hormones is responsible for increasing blood glucose levels during fasting?
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What is the primary function of growth hormone in the body?
What is the primary function of growth hormone in the body?
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Which hormone is primarily responsible for regulating menstrual cycle and preparing the uterus for pregnancy?
Which hormone is primarily responsible for regulating menstrual cycle and preparing the uterus for pregnancy?
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Which of the following hormones is released by the pancreas and helps to lower blood glucose levels?
Which of the following hormones is released by the pancreas and helps to lower blood glucose levels?
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What is the role of hormones in the endocrine system?
What is the role of hormones in the endocrine system?
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Which type of hormones require transport proteins in the bloodstream?
Which type of hormones require transport proteins in the bloodstream?
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What is one function of the anterior pituitary hormones?
What is one function of the anterior pituitary hormones?
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How do intracellular receptors differ from cell membrane receptors in hormone signaling?
How do intracellular receptors differ from cell membrane receptors in hormone signaling?
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What regulates the release of hormones in the endocrine system?
What regulates the release of hormones in the endocrine system?
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Which glands are responsible for producing hormones that control other endocrine glands?
Which glands are responsible for producing hormones that control other endocrine glands?
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What is a characteristic of negative feedback loops in the endocrine system?
What is a characteristic of negative feedback loops in the endocrine system?
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Which of the following hormonal functions is associated with the adrenal medulla?
Which of the following hormonal functions is associated with the adrenal medulla?
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What role do glucagon and insulin play in blood glucose regulation?
What role do glucagon and insulin play in blood glucose regulation?
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Which hormone is produced by the pineal gland and is primarily involved in regulating sleep cycles?
Which hormone is produced by the pineal gland and is primarily involved in regulating sleep cycles?
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Which gland is embedded in the thyroid gland and helps regulate calcium levels in the blood?
Which gland is embedded in the thyroid gland and helps regulate calcium levels in the blood?
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Which gland produces hormones critical for proper immune system development?
Which gland produces hormones critical for proper immune system development?
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What hormone is primarily produced by the adrenal glands and is essential for stress response?
What hormone is primarily produced by the adrenal glands and is essential for stress response?
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What are the main hormones produced by the testes, and what is their primary function?
What are the main hormones produced by the testes, and what is their primary function?
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Which gland is considered the control center of the endocrine system?
Which gland is considered the control center of the endocrine system?
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What is the primary function of prostaglandins in the body?
What is the primary function of prostaglandins in the body?
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What type of hormones are primarily associated with the anterior pituitary gland?
What type of hormones are primarily associated with the anterior pituitary gland?
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Which of the following glands requires iodine to produce its hormones?
Which of the following glands requires iodine to produce its hormones?
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Which of the following glands is responsible for the production of testosterone?
Which of the following glands is responsible for the production of testosterone?
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Which hormones are primarily produced by the ovaries?
Which hormones are primarily produced by the ovaries?
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Which of the following hormones regulates ovulation and female sex characteristics?
Which of the following hormones regulates ovulation and female sex characteristics?
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What is the primary function of the hormone secreted by the thymus?
What is the primary function of the hormone secreted by the thymus?
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Which gland is located at the base of the brain and controls many other glands in the body?
Which gland is located at the base of the brain and controls many other glands in the body?
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Which of the following is NOT a function of the parathyroid glands?
Which of the following is NOT a function of the parathyroid glands?
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Study Notes
Hormone Regulation and the Endocrine System
- The endocrine system is a group of glands that regulate bodily functions through the release of hormones.
- Hormones are chemical messengers that travel through the bloodstream and act on target organs to control diverse bodily functions.
- Homeostasis is the physiological control of the body under stressful circumstances.
- The internal environment, outside of cells, is maintained relatively stable by the constant dynamic state of the extracellular fluids.
- Factors include the optimal concentration of gases, nutrients, ions, and water as well as optimal temperature and pressure.
- The endocrine system and the nervous system work together to coordinate body functions.
Fluid Compartments of the Body
- Total body mass varies slightly between males and females.
- 40-45% of total body mass in males/females is solids
- 60-55% of total body mass in males/females is fluids.
- 2/3 of total body fluid is intracellular fluid (inside cells)
- 1/3 of total body fluid is extracellular fluid (outside cells)
- Extracellular fluid is partitioned between plasma (20% of ECF) and interstitial fluid (80% of ECF).
- Interstitial fluid surrounds tissue cells and is connected to other extracellular fluids like cerebrospinal fluid and eye fluid.
- The distribution of fluid among these compartments is important for maintaining homeostasis.
Definitions
- Internal environment is the extracellular fluid compartment.
- Homeostasis is the relatively stable condition of the internal environment within the extracellular fluid.
- Homeostasis is a dynamic state of the extracellular fluid.
- Crucial for optimal concentration of gases, nutrients, ions, and water along with optimal temperatures and pressures.
How Homeostatic Mechanisms Maintain Body Health
- Homeostasis is maintained or restored through negative feedback.
- Negative feedback processes are important for normal body functioning and survival.
- Negative feedback processes are usually involved in self-regulation.
- Example: Increase in blood CO2 levels leads to an increase in breathing rate, which causes carbon dioxide concentration in the blood to return to homeostasis levels.
Homeostasis: Negative Feedback Loop
- Receptors detect imbalances (e.g. heat, cold).
- Afferent pathways carry information to the control center.
- The control center (thermoregulatory center in brain) processes the information.
- Efferent pathways deliver commands to effectors (sweat glands, muscles).
- Effectors produce responses (sweating, shivering) to restore balance.
What is a Gland?
- A gland is an organ that produces secretions.
- Secretions can include enzymes, hormones, etc.
- They are produced and secreted by specialized cells within the gland.
- Secretions can be secreted onto body surfaces (skin), into lumens of digestive organs, or into body tissues (including blood).
- Glands are either endocrine or exocrine.
Gland Types
- Exocrine glands discharge secretions into ducts leading to a specific target.
- Examples include sudoriferous glands (sweat), mammary glands (milk), salivary glands (enzymes), sebaceous glands (oil), and pancreatic enzymes.
- Endocrine glands release secretions (hormones) into interstitial fluid, which then enters the bloodstream and acts on distant target cells.
- Examples include pituitary gland, thyroid, adrenal glands, pancreatic islets, ovaries, testes, and placenta.
Hormones
- Hormones are chemical messengers produced by endocrine glands that travel through blood or lymph.
- Hormones regulate activity in one part of the body, in another.
- Each hormone has a specific receptor in the target organs.
- Hormones have variable structures (lipid or amino acid based)
Binding of Hormones
- Lipid-soluble hormones diffuse easily through the plasma membrane of target cells and bind to receptors inside the cytoplasm or nucleus.
- Water-soluble hormones bind to receptors on the plasma membrane, initiating intracellular signaling cascades.
- The speed of hormone action can be fast or slow, depending on whether it is water or lipid soluble.
Functions of Hormones
- Stimulate exocrine glands
- Stimulate other endocrine glands
- Affect growth and development
- Regulate metabolic processes
- Regulate muscle contraction, nervous stimulation
- Control reproductive processes
Endocrine and Nervous System
- The endocrine and nervous systems coordinate and integrate body cell activity.
- The endocrine system generates slower, longer-lasting responses as compared to the nervous system.
- Both are directed by the hypothalamus.
Endocrine Glands
- A list of glands and organs found in the endocrine system. Includes: pineal gland, hypothalamus, pituitary gland, thyroid gland, parathyroid glands, adrenal glands, pancreas, ovaries/testes (gonads), thymus, stomach, duodenum, and placenta(and other less understood ones).
Hypothalamus and Pituitary Gland
- The hypothalamus is a crucial link between the nervous and endocrine systems.
- It controls the release of hormones from the pituitary gland.
- The pituitary gland hangs down from the hypothalamus by a stalk called the infundibulum.
- The pituitary gland has two lobes: anterior and posterior, which have different functions and hormonal control pathways.
Hypothalamus and Anterior Pituitary
- Hypothalamic hormones travel through portal veins to the anterior pituitary to stimulate/inhibit hormone release.
- The anterior pituitary releases hormones into the secondary capillary plexus, then the general circulation.
Anterior Pituitary Hormones
- Six hormones are produced by the anterior pituitary: Growth Hormone, Thyroid Stimulating Hormone, Adrenocorticotropic Hormone, Follicle-Stimulating Hormone, Luteinizing Hormone, and Prolactin..
Anterior Pituitary Hormones details
- Table that describes Hypothalamus Hormones, Hormone released from the Anterior Pituitary, and Major function/target for each hormone
- Includes Gonadotropin releasing hormone, Prolactin releasing hormone and inhibiting hormone
The Hypothalamus and the Posterior Pituitary
- The hypothalamus produces two hormones: oxytocin and antidiuretic hormone (ADH).
- The posterior pituitary stores and releases these hormones.
- When stimulated, neurons in the hypothalamus release oxytocin and ADH into the posterior pituitary.
Hypothalamus and Posterior Pituitary details
- Table describing Hypothalamic neurons synthesizing oxytocin and ADH
- Oxytocin and ADH are transported down the axons to the posterior pituitary
- When stimulated, action potentials cause oxytocin or ADH to be released. Oxytocin and ADH effects are on target tissues.
Oxytocin
- Oxytocin targets smooth muscle in the uterus and breasts.
- In the uterus it stimulates uterine contractions, aiding in labor and delivery.
- After delivery, oxytocin is responsible for milk letdown in response to suckling from an infant.
- Involved in social bonding and maternal behavior
ADH = Antidiuretic Hormone
- ADH targets the collecting ducts in the kidneys to retain water.
- ADH targets sweat glands to minimize water loss.
- ADH causes arterioles to constrict, increasing blood pressure.
Thyroid Gland
- The butterfly-shaped thyroid gland is located inferior to the larynx and anterior to the trachea.
- It has two laterally placed lobes separated by a bridge-like isthmus.
Hormones of the Thyroid Gland
- Thyroid hormone (T3 and T4) is stimulated by thyroid-stimulating hormone (TSH), produced in the anterior pituitary.
- It is the major metabolic hormone of the body.
- It raises metabolic rate and affects tissue and development, and it impacts heart rate and blood pressure.
- Thyroid hormones are crucial for growth, development, and metabolism.
Disorders of Thyroid Hormone Secretion
- Hypersecretion causes Graves' disease, goiter, and increased metabolic rate.
- Hyposecretion can cause hypothyroidism.
Goiter and Low Iodine in Diet
- Goiter is an enlarged thyroid gland, often caused by low iodine levels in the diet or due to disorders in thyroid hormone production.
- The thyroid gland enlarges in an effort to produce more thyroid hormones.
Hormones of the Thyroid Gland (Calcitonin Details)
- Calcitonin lowers blood calcium levels by inhibiting osteoclasts (cells that break down bone) and stimulating osteoblasts (cells that form bone).
- It decreases calcium absorption in the intestines and increases the loss of calcium in urine.
Stop and Think Questions (Thyroid Gland)
- Various questions about the roles of various hormones (e.g. TSH)
Parathyroid Glands
- The parathyroid glands are small, round masses of tissue attached to the posterior surface of the lateral lobes of the thyroid gland; Usually two per lobe.
Parathyroid Hormones
- Parathyroid hormone (PTH) raises blood calcium levels, a crucial component of bone health, nerve, and muscle functions.
- It stimulates osteoclast activity, releases calcium from bone into the bloodstream, inhibits osteoblast activity.
- It enhances calcium reabsorption by the kidneys and promotes activation of Vitamin D, increasing calcium absorption in the intestine.
Regulation of Blood Calcium
- Low blood calcium levels trigger parathyroid hormone (PTH) release; PTH raises blood calcium by affecting bone, kidneys and intestines.
- High blood calcium levels trigger calcitonin release, which lowers blood calcium.
What if there is too much/too little parathyroid hormone
- Hyperparathyroidism: high blood calcium (hypercalcemia), impacts various bodily functions(bone issues).
- Hypoparathyroidism: Insufficient calcium that impacts the health of neurons and cells (spasms, convulsions).
The Pancreas
- The pancreas is both an endocrine and exocrine gland.
- Located posterior and inferior to the stomach.
- Most of the exocrine cells form clusters called acini and produce digestive enzymes.
- Endocrine tissue in the pancreas are in clusters called islets of Langerhans.
- Each pancreatic islet has four types of hormone-secreting cells: alpha, beta, delta, and F cells. Involved in the regulation of blood sugar.
Hormones of the Pancreas
- Alpha cells produce glucagon, increasing blood glucose levels. Crucial for maintaining glucose levels.
- Beta cells produce insulin, decreasing blood glucose levels. Crucial for maintaining glucose levels.
- These hormones work together in a delicate feedback system.
Carbohydrate Metabolism
- Glycogenesis is the formation of glycogen from glucose
- Glycogenolysis is the breakdown of glycogen to glucose
- Gluconeogenesis is the formation of glucose from noncarbohydrate sources (e.g., amino acids, glycerol)
Hormones of the Pancreas Details
- Hormonal control of blood glucose is complex, involving epinephrine, growth hormone, and cortisol, in addition to insulin and glucagon.
- Insulin and glucagon are counter-regulatory hormones that balance each other's effects on blood glucose.
- Detailed descriptions of the actions of these hormones on the body and how they regulate metabolism.
Glucose Homeostasis
- Blood glucose regulation through insulin and glucagon, and other hormones.
- Roles of the beta cells in insulin release, and alpha cells in glucagon release.
- Effects of the hormones on various body cells detailed.
When Things Go Wrong (Diabetes Mellitus)
- Diabetes mellitus occurs due to a loss of insulin or to cells that do not respond to insulin.
- Causes hyperglycemia and ketoacidosis.
- Two main types: Type 1 (juvenile) and Type 2 (mature onset)
- Symptoms and treatments are important.
Hormonal Control of Blood Glucose
- Table describing different endocrine glands, their stimulated action and the effects on blood glucose.
Thyroid Gland relationship to Blood Glucose
- Hypothyroidism leads to hypoglycemia, slowing down the metabolic process.
- Hyperthyroidism leads to hyperglycemia, increasing the metabolic process.
Stop and Think (Glucose metabolism)
- Question about which hormone isn't involved in glucose metabolism.
The Adrenal Glands
- Two adrenal glands, one superior to each kidney.
- Two distinct regions: cortex and medulla.
- Cortex secretes steroid hormones, including cortisol and aldosterone; also related to regulating sodium, potassium and water balance.
- Medulla secretes catecholamines, including epinephrine and norepinephrine. Involved with the fast-acting stress response.
The Adrenal Cortex
- The adrenal cortex is divided into three zones, each producing different steroid hormones:
- Mineralocorticoids (aldosterone), regulates electrolytes in the blood.
- Glucocorticoids (cortisol), regulates metabolism and stress response.
- Cortical sex hormones (androgens and estrogens), support development and maintenance of secondary sex characteristics.
Mineralocorticoids: Aldosterone
- Aldosterone regulates Na+ and K+ concentrations in urine, sweat, and saliva.
- It regulates fluid and electrolyte balance by influencing reabsorption of sodium, which affects water reabsorption and impacts blood volume/pressure.
Glucocorticoids: Cortisol
- Cortisol regulates metabolism by promoting protein and fat breakdown to form glucose (gluconeogenesis)
- Raising blood glucose levels
- Helps the body cope with stress.
Cushing's Syndrome
- High levels of circulating cortisol (often caused by drug use or tumors).
- Manifests as hyperglycemia, poor wound healing, osteoporosis, dermatitis, moon face (facial features), buffalo hump (fat accumulation at the base of the neck), etc.
Addison's Disease
- Hyposecretion of glucocorticoids and aldosterone (often due to an autoimmune disorder).
- Symptoms include hypoglycemia, low blood pressure, dehydration, muscle weakness, weight loss, and electrolyte imbalances.
Testosterone and Estrogen
- Testosterone and estrogen are produced by glands and impact various aspects of growth and development.
Adrenal Medulla Hormones: Epinephrine and Norepinephrine
- Epinephrine and norepinephrine are produced in the adrenal medulla.
- They increase blood pressure, heart rate, breathing, blood glucose, and divert blood flow.
Stop and Think (Adrenal Gland)
- Question about the source of norepinephrine and epinephrine.
What is Stress?
- Stress is any stimulus that leads to an imbalance from homeostasis.
- Includes environmental physical stimuli and internal factors like pain, emotions, and psychological factors.
How Does the Body Deal with Stress?
- General Adaptation Syndrome (GAS) has three stages: Alarm phase, Resistance phase, and Exhaustion phase; response to stress.
Alarm Phase
- Hypothalamus activates autonomic nervous system to release epinephrine and norepinephrine from the adrenal medulla.
- Body responds with increased metabolic rate, respiratory and cardiovascular effects (increased heart rate, breathing, blood pressure).
Resistance Phase
- Hormones from the hypothalamus stimulate the anterior pituitary to release hormones (e.g., ACTH).
- These hormones stimulate the release of other hormones; body adapts and prepares to combat the stressor long-term; maintaining blood glucose levels and blood pressure.
Exhaustion Phase
- If the resistance phase fails, the body resources are depleted.
- Health problems may occur including low carbohydrate and fat stores, muscle loss, suppression of the immune system, ulcers, anxiety and depression.
Stop and Think (Stress response)
- Question about the what doesn't occur in the alarm phase while responding to a stressor
Ovaries: Estrogens and Progesterone
- Paired oval bodies in the female pelvic cavity.
- Stimulated by follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
- Produce estrogens and progesterone. Impacts development of female reproductive system and sex characteristics.
- Estrogens and progesterone have crucial roles in menstrual cycle, reproduction, and overall development.
Testes: Testosterone
- The male gonads (testes) are oval glands in the scrotum.
- Also stimulated by follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
- Produce testosterone, influencing primary and secondary sex characteristics and contributing to bone and muscle development.
Undercover Endocrine Organs
- Placenta regulates during reproduction.
- Stomach secretes gastrin to aid in digestion.
- Duodenum secretes secretin and cholecystokinin to regulate digestion.
Less Understood Endocrine Organs
- Thymus regulates immune system (development of T Cells), size decreases with age.
- Pineal gland secretes melatonin, affecting daily rhythms, and responding to light. (Important for regulating circadian rhythm and sleep.)
Prostaglandins
- Hormones found in most body cells. Made of lipids in the plasma membrane.
- Have various functions, such as influencing blood pressure, stomach secretions, immune responses , nerve impulses, and uterine contractions.
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Description
Explore the crucial role of the endocrine system in hormone regulation and the significance of body fluid compartments. This quiz covers key concepts such as homeostasis, the distribution of body fluids, and the physiological responses under varying conditions. Test your understanding of how these systems work together to maintain bodily functions.