Hodgkin Lymphoma Overview

Epstein-Barr virus infection

Childhood (0-14 years), young adult (15-34 years), and older adult (55+ years)

Localized painless lymphadenopathy, fever, night sweats, weight loss

<p>Nodular sclerosing, mixed cellularity, lymphocyte depleted, lymphocyte rich, nodular lymphocyte predominant</p> Signup and view all the answers

<p>Large with abundant basophilic/amphophilic cytoplasm, binucleate or bilobed nucleus, express CD15 and CD30</p> Signup and view all the answers

<p>Characteristic for nodular Lymphocyte predominant subtype</p> Signup and view all the answers

<p>Nodular growth pattern with broad fibroblast poor birefringent collagen bands surrounding at least one nodule</p> Signup and view all the answers

<p>Typical Hodgkin Reed-Sternberg cells in a variable inflammatory background (eosinophils, histiocytes, neutrophils, plasma cells)</p> Signup and view all the answers

<p>Total replacement of nodal architecture by expansive vague nodules of small lymphocytes with sparse, relatively large tumor cells with multilobulated or round nucleus, thin nuclear membrane, finely granular chromatin and variable small nucleoli (popcorn cells)</p> Signup and view all the answers

<p>2 or more lymph node areas on the same side of the diaphragm</p> Signup and view all the answers

<p>Mixed Cellularity type</p> Signup and view all the answers

<p>Relatively large tumor cells with multilobulated or round nucleus, thin nuclear membrane, finely granular chromatin and variable small nucleoli</p> Signup and view all the answers