Hodgkin Lymphoma Overview

Classic Hodgkin Reed-Sternberg ______ type

Nodular growth pattern with broad fibroblast poor birefringent collagen bands surrounding at least one ______

Highly variable numbers of HRS cells, small lymphocytes and other inflammatory cells; often numerous eosinophils, histiocytes and ______; occasional foamy macrophages

Effaced lymph node architecture; interfollicular pattern also possible. May have interstitial fibrosis but no broad bands of sclerosis or capsular thickening. Typical Hodgkin Reed-Sternberg cells in a variable inflammatory background (eosinophils, histiocytes, neutrophils, plasma ______)

May have prominent epithelioid histiocytes that may form ______ (especially in EBV+ cases)

Usually total replacement of nodal architecture by expansive vague nodules of small lymphocytes with sparse, relatively large tumor cells with multilobulated or round nucleus, thin nuclear membrane, finely granular chromatin and variable small nucleoli (popcorn cells) which is negative for CD 15 and CD30 while B cell marker (CD ______)

Hodgkin lymphoma is a type of cancer of the ______ system

Etiology of some subtypes of CHL involves Epstein-Barr virus infection, especially in pediatric patients from tropical or developing countries. CHL stands for Classical Hodgkin ______

The clinical features of Hodgkin lymphoma include localized painless ______, fever, night sweats, and weight loss

The World Health Organization classifies Hodgkin lymphoma into different types, including Nodular sclerosing, Mixed cellularity, Lymphocyte depleted, Lymphocyte rich, and Nodular lymphocyte ______

Classic Hodgkin Lymphoma is characterized by neoplastic cells called Hodgkin and Reed-Sternberg (HRS) cells, which usually express CD15 and CD30. HRS cells are large with abundant basophilic / amphophilic cytoplasm and may have single / multiple multilobate nucleoli or large, inclusion-like, owl-eyed eosinophilic nucleoli surrounded by clear ______

Popcorn cells are found in which subtype of Hodgkin lymphoma?