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Questions and Answers
What is the significance of HLA-B*5701 testing?
What is the significance of HLA-B*5701 testing?
- It indicates an increased risk of hypersensitivity reaction to certain drugs (correct)
- It is only relevant for patients with Korean ancestry
- It is associated with a decreased risk of Stevens-Johnson syndrome (SJS)
- It is important for patients with renal impairment or with Han Chinese or Thai ancestry
What action should be taken if a patient tests positive for HLA-B*5801?
What action should be taken if a patient tests positive for HLA-B*5801?
- No action is necessary
- Continue the drug but monitor closely for any allergic reactions
- Switch to a higher dose of the drug
- Discontinue the drug at the first sign of allergic reaction (correct)
Who should be tested for HLA-B*5701?
Who should be tested for HLA-B*5701?
- Only patients with a family history of drug allergies
- Patients of European descent
- All patients prior to starting certain drugs (correct)
- Patients with a history of autoimmune diseases
What is the significance of HLA-B*1502 testing?
What is the significance of HLA-B*1502 testing?
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What is the population consideration for HLA-B*5801 testing?
What is the population consideration for HLA-B*5801 testing?
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What action should be taken if a patient tests positive for HLA-B*5701?
What action should be taken if a patient tests positive for HLA-B*5701?
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What is the implication of a positive KRAS mutation for drug response?
What is the implication of a positive KRAS mutation for drug response?
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What action is recommended if a pharmacogenomic test for HER2 is negative?
What action is recommended if a pharmacogenomic test for HER2 is negative?
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Which drug strongly requires pharmacogenomic testing according to the text?
Which drug strongly requires pharmacogenomic testing according to the text?
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What is the implication of a positive CYP2C19 test for clopidogrel (Plavix) use?
What is the implication of a positive CYP2C19 test for clopidogrel (Plavix) use?
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