10 Questions
What is the significance of HLA-B*5701 testing?
It indicates an increased risk of hypersensitivity reaction to certain drugs
What action should be taken if a patient tests positive for HLA-B*5801?
Discontinue the drug at the first sign of allergic reaction
Who should be tested for HLA-B*5701?
All patients prior to starting certain drugs
What is the significance of HLA-B*1502 testing?
It indicates an increased risk of Stevens-Johnson syndrome (SJS)
What is the population consideration for HLA-B*5801 testing?
High-risk individuals with Korean ancestry, renal impairment, or Han Chinese or Thai ancestry
What action should be taken if a patient tests positive for HLA-B*5701?
Avoid the drug associated with hypersensitivity risk
What is the implication of a positive KRAS mutation for drug response?
Predicts poor response to cetuximab
What action is recommended if a pharmacogenomic test for HER2 is negative?
Avoid HER2 inhibitors as they would not be effective
Which drug strongly requires pharmacogenomic testing according to the text?
Abacavir (Ziagen)
What is the implication of a positive CYP2C19 test for clopidogrel (Plavix) use?
Decreased effectiveness of clopidogrel
Test your knowledge on the significance of human leukocyte antigen (HLA) testing and its impact on drug reactions. Explore the population results and recommended actions for drugs like Abacavir, Allopurinol, Carbamazepine, Oxcarbazepine, and Phenytoin.
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