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HLA Testing and Drug Reactions Quiz

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Questions and Answers

What is the significance of HLA-B*5701 testing?

It indicates an increased risk of hypersensitivity reaction to certain drugs (correct)

It is only relevant for patients with Korean ancestry

It is associated with a decreased risk of Stevens-Johnson syndrome (SJS)

It is important for patients with renal impairment or with Han Chinese or Thai ancestry

What action should be taken if a patient tests positive for HLA-B*5801?

No action is necessary

Continue the drug but monitor closely for any allergic reactions

Switch to a higher dose of the drug

Discontinue the drug at the first sign of allergic reaction (correct)

Who should be tested for HLA-B*5701?

Only patients with a family history of drug allergies

Patients of European descent

All patients prior to starting certain drugs (correct)

Patients with a history of autoimmune diseases

What is the significance of HLA-B*1502 testing?

It indicates an increased risk of Stevens-Johnson syndrome (SJS) Signup and view all the answers

What is the population consideration for HLA-B*5801 testing?

High-risk individuals with Korean ancestry, renal impairment, or Han Chinese or Thai ancestry Signup and view all the answers

What action should be taken if a patient tests positive for HLA-B*5701?

Avoid the drug associated with hypersensitivity risk Signup and view all the answers

What is the implication of a positive KRAS mutation for drug response?

Predicts poor response to cetuximab Signup and view all the answers

What action is recommended if a pharmacogenomic test for HER2 is negative?

Avoid HER2 inhibitors as they would not be effective Signup and view all the answers

Which drug strongly requires pharmacogenomic testing according to the text?

Abacavir (Ziagen) Signup and view all the answers

What is the implication of a positive CYP2C19 test for clopidogrel (Plavix) use?

Decreased effectiveness of clopidogrel Signup and view all the answers