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History of Hemolytic Disease of the Newborn (HDN)

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History of Hemolytic Disease of the Newborn (HDN)

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Questions and Answers

In erythroblastosis fetalis cases, what was the Rh factor of the majority of mothers?

Rh-negative (correct)

Rh-neutral

Rh-positive

Rh-ambiguous

Which antigen was inherited from the father and caused the maternal antibody response in erythroblastosis fetalis?

C antigen

e antigen

E antigen

D antigen (correct)

What was the main factor identified as causing erythroblastosis fetalis according to the text?

Maternal gene

Maternal antibody (correct)

Fetal gene

Fetal antibody

What did Sir Ronald Aylmer Fisher and Dr. Robert Russell Race name the agglutinins causing the HTR?

Anti-Rh antibodies Signup and view all the answers

What is the significance of placing parentheses around (D), (C), and (e) in the Fisher-Race terminology?

To indicate weakened antigen expression Signup and view all the answers

What does the presence of 'r' indicate in the haplotype described by Dr. Alexander Weiner?

'r' indicates absence of D antigen Signup and view all the answers

What was the key finding that led to the discovery of the Rh factor?

The mother's serum reacted with the father's RBCs, suggesting a common antigen they shared Signup and view all the answers

What was the significance of the discovery of the Rh factor?

It explained the mortality and morbidity problems seen in some blood transfusions despite correct ABO matching Signup and view all the answers

What was the initial approach used to identify the Rh factor?

Researchers injected Rhesus monkey RBCs into guinea pigs and rabbits and identified the resulting antibody Signup and view all the answers

What was the connection between the discovery of the Rh factor and the development of treatments for hemolytic disease of the newborn (HDN)?

The discovery of the Rh factor led to the understanding that HDN was caused by maternal-fetal blood group incompatibility Signup and view all the answers

What was the significance of the initial report of a hemolytic transfusion reaction (HTR) in an obstetrical patient?

It provided the first evidence that the Rh factor was a distinct blood group antigen Signup and view all the answers

What was the key limitation in understanding blood types prior to the discovery of the Rh factor?

Researchers were only concerned with ABO blood types Signup and view all the answers