30 Questions
What is the primary difference between arterial thrombus and venous thrombus?
Arterial thrombus has more platelets and fibrin, while venous thrombus has fewer RBCs.
Where does a venous thrombus commonly cause an embolism?
Lungs
Which part of Virchow's triad refers to the blood's tendency to clot excessively?
Hypercoagulability
Which coagulation pathway does PT measure?
Extrinsic pathway
How does coumadin exert its anticoagulant effect?
Inhibits vitamin K
What does INR measure in relation to anticoagulation therapy?
Clot formation time
What is the primary function of heparin in the context of coagulation?
Increases antithrombin III activity
Why is it important to measure PT and PTT in patients with suspected clotting disorders?
To identify abnormalities in the coagulation cascade pathways
'Hypercoagulability' in Virchow's triad refers to:
Increased tendency for blood clotting
'Endothelial dysfunction' in Virchow's triad relates to:
Decreased nitric oxide production
What is the role of plasmin in fibrinolysis?
Break down fibrin units after clot formation
Which of the following is a cause of hypercoagulation?
Predisposition for clots
What can cause inappropriate thrombosis according to the text?
Venous thrombus with more fibrin and RBCs
What is the primary function of tissue plasminogen activator (TPA)?
Break down clots
What is the cause of hypocoagulation according to the provided text?
Poor platelet function
What is the main difference between extrinsic and intrinsic coagulation pathways?
Extrinsic pathway involves factors released by damaged tissues, while intrinsic pathway involves factors released when exposed to collagen and damaged endothelium
What is the role of vitamin K in the coagulation pathways?
Vitamin K activates factors 2, 7, 9, and 10 in the coagulation cascade
Where are most of the coagulation factors produced?
Liver
Describe the role of proteins C in the coagulation cascade.
Proteins C inactivate factors Xa and thrombin
Which molecule is activated by thrombin in the context of clot dissolution?
Plasminogen
What is the main role of erythropoietin in the regulation of erythropoiesis?
Stimulating red bone marrow production of RBCs
Which of the following correctly describes the distribution of bone marrow as we age?
Red bone marrow is replaced by yellow bone marrow as we age
What can tumors cause in relation to erythrocyte production?
Increased bone marrow leading to high reticulocytes
What is the primary function of RhoGAM in preventing HDN?
Inhibiting the mother's immune system from attacking fetal RBCs
Which blood type is considered the universal donor?
Type O
What is the primary role of thromboxane A2 (TxA2) and serotonin (5HT) in hemostasis?
Promote vasoconstriction
What determines the presence of antigens on the surface of red blood cells?
Agglutinogens present on the RBC surface
Which component binds collagen in plasma and glycoprotein 1b to bridge platelets and damaged vessels during platelet plug formation?
Von Willebrand factor (vWF)
What is the main function of the platelet phospholipid membrane in the coagulation mechanism?
Serve as a site for enzymatic reactions
What is the role of procoagulants (clotting factors) in hemostasis?
Participate in the coagulation process
Test your knowledge on Hemolytic Disease of the Newborn (HDN) prevention with RhoGAM and the stages of hemostasis including thrombocytes. Learn about the components of clot formation and the characteristics of thrombocytes.
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