Histology of the Renal and Urinary Systems Practical Session Objectives

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Questions and Answers

What is the sequence of flow of glomerular filtrate through the renal tubules before it is excreted as urine?

PCT → Loop of Henle → DCT → Collecting tubule → Collecting duct

What is the equation for urinary excretion?

Urinary excretion = Glomerular filtrate – Tubular reabsorption + Tubular secretion

What plays a more important role in determining the final urinary excretion rate for many substances: reabsorption or secretion?

Reabsorption

What are some common disease processes that can be better understood by studying tubular functions?

<p>CKD (Chronic Kidney Disease)</p> Signup and view all the answers

What are some substances that are significantly secreted in the tubules?

<p>H+, K+, etc</p> Signup and view all the answers

Name a class of diuretics used in managing fluid overload.

<p>Loop diuretics, thiazides</p> Signup and view all the answers

What is the mechanism by which water and solutes are transported through the cell membranes in tubular reabsorption?

<p>Transcellular and paracellular routes</p> Signup and view all the answers

What type of transport is directly coupled to an energy source and moves solutes against an electrochemical gradient?

<p>Primary active transport</p> Signup and view all the answers

What are the two types of sodium glucose transporters present on the brush border of the proximal convoluted tubule?

<p>SGLT-2 and SGLT-1</p> Signup and view all the answers

What type of transport is indirectly coupled to an energy source and involves the interaction of two or more solutes with a specific membrane protein?

<p>Secondary active transport</p> Signup and view all the answers

What is the mechanism by which some solutes are secreted into the tubules, often involving counter transport of the solute with the Na+ ions?

<p>Secondary active secretion</p> Signup and view all the answers

What type of transport reabsorbs large molecules via a type of endocytosis in the proximal convoluted tubule?

<p>Pinocytosis</p> Signup and view all the answers

In tubular reabsorption, which type of transport is always passive?

<p>Osmosis</p> Signup and view all the answers

What is the term for the maximum rate at which a solute can be transported due to saturation of the specific transport system?

<p>Transport maximum</p> Signup and view all the answers

What are the substances actively reabsorbed or secreted in the proximal tubule?

<p>H+, K+, glucose, amino acids</p> Signup and view all the answers

What is the term for the type of endocytosis utilized by the proximal convoluted tubule to reabsorb large molecules such as proteins?

<p>Pinocytosis</p> Signup and view all the answers

What are the components of the urinary system?

<p>Two kidneys, two ureters, a bladder, and a urethra</p> Signup and view all the answers

Identify the major components of a nephron.

<p>Renal corpuscle and renal tubule</p> Signup and view all the answers

What is the function of the renal cortex?

<p>It is the outer part of the kidney</p> Signup and view all the answers

What is the inner portion of the kidney called?

<p>Medulla</p> Signup and view all the answers

What is the functional unit of the kidney?

<p>Nephron</p> Signup and view all the answers

What are the two main components of a nephron?

<p>Renal corpuscle and renal tubule</p> Signup and view all the answers

What is the structure that surrounds the glomerulus?

<p>Bowman's capsule</p> Signup and view all the answers

What specialized layer of epithelial cells invests the capillary loops of the glomerulus?

<p>Visceral layer of Bowman’s capsule</p> Signup and view all the answers

What is the term for the small foot-like processes of the podocytes' cytoplasm?

<p>Pedicles</p> Signup and view all the answers

What forms the glomerular filtration barrier?

<p>Basal lamina and slit membranes</p> Signup and view all the answers

What is the first segment of a renal tubule called?

<p>Proximal convoluted tubule</p> Signup and view all the answers

What are the three segments of the loop of Henle?

<p>Descending limb, loop, ascending limb</p> Signup and view all the answers

What is the lining epithelium of the proximal convoluted tubule characterized by?

<p>Tall cuboidal epithelium with wide brush border</p> Signup and view all the answers

What is the permeability of the thin descending segment of the loop of Henle to water and solutes?

<p>Permeable to water but not solutes</p> Signup and view all the answers

What is the last part of a renal tubule where distal tubules of several nephrons join to form a single tubule?

<p>Collecting tubule</p> Signup and view all the answers

What type of cells fill the spaces between the capillary loops in the glomerular lobule?

<p>Mesangial cells</p> Signup and view all the answers

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