Histology of the Nervous System

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson
Download our mobile app to listen on the go
Get App

Questions and Answers

The nervous tissue is derived from the ______ germ layer.

ectoderm

The outer region of the brain is primarily composed of ______ matter, while the inner region of the spinal cord consists of ______ matter.

gray, gray

[Blank] are the phagocytes of the nervous tissue, migrating through the CNS to engulf infectious agents and cellular debris.

Microglia

The ______ is the functional unit of nervous tissue, responsible for transmitting electrical and chemical signals.

<p>neuron</p> Signup and view all the answers

[Blank] are equivalent to the rough endoplasmic reticulum in other cells and are responsible for protein synthesis in neurons.

<p>Nissl bodies</p> Signup and view all the answers

A ______ neuron has a single axon and multiple dendrites, making it a common type of neuron in the central nervous system.

<p>multipolar</p> Signup and view all the answers

The ______ substance, formed by glial cells, insulates nerve fibers in the CNS and PNS, facilitating faster signal transmission.

<p>myelin</p> Signup and view all the answers

The distinguishing microscopic features of different types of neurons are the number of processes, the positioning of the soma, and the arrangement of ______.

<p>dendrites</p> Signup and view all the answers

A key histological difference between gray matter in the cerebrum and the cerebellum is the arrangement of cells into cortical layers in the ______ and the presence of Purkinje cells in the ______.

<p>cerebrum, cerebellum</p> Signup and view all the answers

[Blank] are glial cells responsible for myelinating axons within the central nervous system.

<p>Oligodendrocytes</p> Signup and view all the answers

The meningeal layer directly attached to the surface of the brain and spinal cord is the ______.

<p>pia mater</p> Signup and view all the answers

The ______ mater is the middle meningeal layer and is characterized by a web-like appearance due to its trabeculae.

<p>arachnoid</p> Signup and view all the answers

The outermost meningeal layer, notable for its thickness and attachment to the periosteum of the skull, is the ______ mater.

<p>dura</p> Signup and view all the answers

The ______ cells, line the ventricles of the brain and the central canal of the spinal cord aiding in the production and circulation of cerebrospinal fluid.

<p>ependymal</p> Signup and view all the answers

[Blank] form part of the blood-brain barrier, regulate interstitial fluid composition, and provide structural support to the CNS.

<p>Astrocytes</p> Signup and view all the answers

In the spinal cord, the ______ horns contain interneurons and receive sensory fibers, whereas the ______ horns contain multipolar motor neurons.

<p>dorsal, ventral</p> Signup and view all the answers

A ______ is a bundle of axons in the peripheral nervous system, while a ______ refers to a bundle of axons in the central nervous system.

<p>nerve, tract</p> Signup and view all the answers

A key difference between a spinal ganglion and an autonomic ganglion is the presence of ______ cell bodies in the spinal ganglion and ______ neuronal cell bodies in the autonomic ganglion.

<p>sensory, postganglionic</p> Signup and view all the answers

The three layers of connective tissue in the PNS are the ______, ______, and ______.

<p>epineurium, perineurium, endoneurium</p> Signup and view all the answers

[Blank] cells surround and insulate PNS axons and myelinate those with large diameters, allowing for faster action potential propagation.

<p>Schwann</p> Signup and view all the answers

In myelinated nerve fibers, the myelin sheath prevents ion flow except at the ______, enhancing the speed of conduction.

<p>Nodes of Ranvier</p> Signup and view all the answers

The ______ is the outer connective tissue coat of a nerve

<p>epineurium</p> Signup and view all the answers

The middle layer of connective tissue in a nerve, that surrounds each bundle of nerve fibers is the ______.

<p>perineurium</p> Signup and view all the answers

The connective tissue layer that surrounds individual nerve fibers is the ______.

<p>endoneurium</p> Signup and view all the answers

Unlike oligodendrocytes, ______ cells only myelinate one axon segment.

<p>Schwann</p> Signup and view all the answers

[Blank] glial cells regulate the exchange of nutrients and waste for cell bodies in PNS ganglia.

<p>Satellite</p> Signup and view all the answers

The cerebral cortex layers include the Molecular layer, External granular layer, External pyramidal layer, Internal granular layer, Internal pyramidal layer and the ______ layer.

<p>Multiform</p> Signup and view all the answers

In the spinal cord, the ______ matter is peripherally located

<p>white</p> Signup and view all the answers

In the spinal cord, the ______ horns contain interneurons and receives sensory fibers.

<p>dorsal</p> Signup and view all the answers

In regards to Central Nervous System, ______ myelinates and insulates CNS axons.

<p>Oligodendrocyte</p> Signup and view all the answers

[Blank] are the cells that form part of the blood-brain barrier.

<p>Astrocytes</p> Signup and view all the answers

The ______ mater is consists of flattened mesenchymal derived cells.

<p>pia</p> Signup and view all the answers

The ______ cell is classified as phagocytic and moves throughout the Central Nervous System.

<p>microglial</p> Signup and view all the answers

In the PNS the ______ cells surround and insulate axons and myelinate those having large diameters

<p>Schwann</p> Signup and view all the answers

A major function of ______ cells is to electrically insulate PNS cell bodies

<p>satellite</p> Signup and view all the answers

In unmyelinated nerve fibers there is no multiple wrapping, smaller diameter axons and the ______ are still present.

<p>schwann cells</p> Signup and view all the answers

In myelinated nerve fibers, the myelin sheath is responsible for preventing the loss of nerve ______.

<p>impulse</p> Signup and view all the answers

The three components of Peripheral Nervous System include Nerve, ______ and Nerve Endings

<p>Ganglia</p> Signup and view all the answers

The two types of Central Neuroglia are Protoplasmic and ______

<p>Fibrous</p> Signup and view all the answers

The Cerebrum is divided between a ______ and White Matter

<p>Grey</p> Signup and view all the answers

The ability of oligodendrocytes to speed up action potential propagation along axons is due to their capacity to ______ axons in the CNS.

<p>myelinate</p> Signup and view all the answers

Unlike neurons, ______ in the CNS can replicate to occupy spaces left by dying neurons, playing a role in tissue repair and maintenance.

<p>astrocytes</p> Signup and view all the answers

Central nervous system support and organization are mainly provided by ______ because they regulate the interstitial fluid.

<p>astrocytes</p> Signup and view all the answers

The brain's ventricles and the spinal cord's central canal are lined with ______, which aids in producing and circulating cerebrospinal fluid.

<p>ependymal cells</p> Signup and view all the answers

While both myelinated and unmyelinated nerve fibers rely on Schwann cells, only myelinated fibers benefit from multiple wrapping that forms a ______, increasing the speed of signal transmission.

<p>myelin sheath</p> Signup and view all the answers

Damage to the cerebellum can be assessed by analyzing the cells in the ______ layer because the layer is the output neurons integrating cerebellar cortical computation.

<p>Purkinje cell</p> Signup and view all the answers

In the cerebral cortex, the multiform layer, also known as the polymorphic layer, is characterized by diverse cell types and is located next to the ______.

<p>white matter</p> Signup and view all the answers

Unlike the cerebrum which has a less defined organization, the ______ contains granule cells for processing information.

<p>cerebellum</p> Signup and view all the answers

The irregular connective tissue that is continuous with the periosteum of the skull is the ______ which provides critical protection for the brain.

<p>dura mater</p> Signup and view all the answers

The ______ is responsible for engulfing infectious agents and harmful substances to protect the CNS.

<p>microglia</p> Signup and view all the answers

A key distinction between the white and gray matter in the central nervous system is that white matter primarily consists of myelinated nerve fibers, while gray matter is characterized by ______.

<p>neuronal cell bodies</p> Signup and view all the answers

The dorsal horns of the spinal cord gray matter contain interneurons which are responsible for receiving inputs from sensory fibers, while the ventral horns contain ______ motor neurons.

<p>multipolar</p> Signup and view all the answers

Satellite cells in the peripheral nervous system perform similar support functions to astrocytes in the central nervous system, primarily by regulating the microenvironment and electrically ______ PNS cell bodies.

<p>insulating</p> Signup and view all the answers

Because Schwann cells insulate and myelinate axons, they permit faster action potential propagation along axons in the ______.

<p>PNS</p> Signup and view all the answers

In the peripheral nervous system, individual nerve fibers are surrounded by the ______, a layer of connective tissue that supports and insulates the axon.

<p>endoneurium</p> Signup and view all the answers

While myelinated nerve fibers are insulated by a myelin sheath to prevent signal loss and are characterized by nodes of Ranvier, unmyelinated fibers lack such sheaths and have ______ axons.

<p>naked</p> Signup and view all the answers

A neuron characterized by a single axon and multiple dendrites is classified as a ______ neuron.

<p>multipolar</p> Signup and view all the answers

Structures such as Nissl bodies which are similar to rough endoplasmic reticulum are equivalent to rough endoplasmic reticulum in neurons, and are involved in ______ synthesis.

<p>protein</p> Signup and view all the answers

Unlike a nucleus, which is a cluster of neuron cell bodies within the central nervous system, a ______ is a cluster of neuron cell bodies in the peripheral nervous system.

<p>ganglion</p> Signup and view all the answers

Three layers of meninges protecting the CNS by limiting infection include the dura mater, the arachnoid mater, and the ______.

<p>pia mater</p> Signup and view all the answers

In contrast to the outer region of the spinal cord, the outer region of the brain primarily consists of blank matter which allows for protection.

<p>grey</p> Signup and view all the answers

Nervous tissue is derived from the ectoderm, which is the primary ______ layer of the embryo.

<p>germ</p> Signup and view all the answers

While peripheral nerves rely on epineurium, perineurium, and endoneurium for structural integrity, central nervous system tracts lack these distinct connective tissue layers and instead rely on ______.

<p>glial cells</p> Signup and view all the answers

In contrast to spinal ganglia, autonomic ganglia are characterized by processes that dictate specific responses in smooth muscle, cardiac muscle, of glands involving ______ neurons.

<p>multipolar</p> Signup and view all the answers

The functional unit of nervous tissue, responsible for transmitting electrical and chemical signals, is the ______.

<p>neuron</p> Signup and view all the answers

Flashcards

What is a Neuron?

A nerve cell that transmits electrical signals.

What is the Cell Body (Soma)?

The main part of a neuron, containing the nucleus.

What are Dendrites?

Branch-like extensions of a neuron that receive signals.

What is an Axon?

A long, slender projection of a neuron that conducts electrical impulses.

Signup and view all the flashcards

What is the Axon Hillock?

The region where the axon connects to the cell body.

Signup and view all the flashcards

What is Nissl Substance?

Clusters of ribosomes and endoplasmic reticulum in neurons.

Signup and view all the flashcards

What is a Synapse?

A junction between two neurons where signals are transmitted.

Signup and view all the flashcards

What are Multipolar Neurons?

Neurons with multiple dendrites and one axon.

Signup and view all the flashcards

What are Bipolar Neurons?

Neurons with one dendrite and one axon.

Signup and view all the flashcards

What are Unipolar Neurons?

Neurons with a single process extending from the cell body.

Signup and view all the flashcards

What are Anaxonic Neurons?

Neurons lacking a distinguishable axon.

Signup and view all the flashcards

What are Glial Cells?

Cells supporting and protecting neurons in the nervous system.

Signup and view all the flashcards

What are Astrocytes?

Glial cells that form the blood-brain barrier and regulate the environment.

Signup and view all the flashcards

What are Oligodendrocytes?

Glial cells that myelinate axons in the central nervous system.

Signup and view all the flashcards

What are Microglia?

Glial cells acting as phagocytes in the central nervous system.

Signup and view all the flashcards

What are Ependymal Cells?

Glial cells lining the ventricles of the brain and producing cerebrospinal fluid.

Signup and view all the flashcards

What are Meninges?

Protective layers covering the brain and spinal cord.

Signup and view all the flashcards

What is the Dura Mater?

The outermost layer of the meninges, thick connective tissue.

Signup and view all the flashcards

What is the Arachnoid Mater?

The middle layer of the meninges, with web-like trabeculae.

Signup and view all the flashcards

What is the Pia Mater?

The innermost layer of the meninges, closely adhering to the brain.

Signup and view all the flashcards

What is White Matter?

Region of the central nervous system mainly composed of myelinated axons.

Signup and view all the flashcards

What is Gray Matter?

Region of the central nervous system mainly composed of neuronal cell bodies.

Signup and view all the flashcards

What is the Cerebrum?

The largest part of the brain, responsible for higher functions.

Signup and view all the flashcards

What is the Cerebral Cortex?

Outer layer of the cerebrum, responsible for complex processing.

Signup and view all the flashcards

What is the Cerebral Cortex Layers?

Brain region with six distinct layers of neurons.

Signup and view all the flashcards

What is the Cerebellum?

Brain region responsible for coordination and motor control.

Signup and view all the flashcards

What is the Cerebellar Cortex?

A three-layered structure of the cerrebellum.

Signup and view all the flashcards

What are Dorsal & Ventral Horns?

The main types of the spinal cord regions.

Signup and view all the flashcards

What are Dorsal Horns?

Contain interneurons that receive sensory fibers.

Signup and view all the flashcards

What are Ventral Horns?

Contain multipolar motor neurons.

Signup and view all the flashcards

What is the Perineurium?

Connective tissue surrounding each bundle of nerve fibers in the PNS.

Signup and view all the flashcards

What is the Endoneurium?

Connective tissue surrounding individual nerve fibers in the PNS.

Signup and view all the flashcards

What is the Epineurium?

The external covering of a nerve in the PNS.

Signup and view all the flashcards

What are Schwann Cells?

A cell in the peripheral nervous system that wraps around a nerve fiber, forming the myelin sheath.

Signup and view all the flashcards

What are Satellite Cells?

Small glial cells that surround neurons in sensory, sympathetic, and parasympathetic ganglia.

Signup and view all the flashcards

What are Myelinated Nerve Fibers?

Nerve fibers enclosed by myelin sheath.

Signup and view all the flashcards

What are Unmyelinated Nerve Fibers?

Nerve fibers without a myelin sheath.

Signup and view all the flashcards

Study Notes

  • Histology of the nervous system covers nervous tissue of the central and peripheral nervous systems.

Prayer

  • The provided is a prayer for illumination, wisdom, understanding, memory, and clarity in study.
  • It asks for guidance in work from start to completion, through Christ.

Topic Outline

  • Nervous tissue overview
  • Central nervous system focus
  • Peripheral nervous system focus
  • Laboratory activities/review

Learning Outcomes

  • Differentiate neuron types by structure.
  • Identify neuroglial cells in CNS and PNS.
  • Distinguish regions of the brain/spinal cord by location and structure.
  • Identify cerebellar histologic layers.
  • Differentiate myelinated/unmyelinated nerve fibers microscopically.

Neuron Morphology

  • Neurons come in a variety of forms
  • Important aspects include cell body, axon, and dendrites,

Cells of the Nervous Tissue: Neurons

  • Neurons can be classified into structural classes
  • Multipolar neurons have multiple dendrites and one axon
  • Bipolar neurons have a single dendrite and an axon
  • Unipolar neurons have a peripheral and central process and one axon
  • Anaxonic neurons have no axon

Neuron Classification

  • Neurons are classified as
  • Pseudounipolar
  • Unipolar
  • Bipolar
  • Multipolar

Synapse

  • Synapses are where neurons communicate

Central Nervous System

Glial Cells of the CNS

  • Includes astrocytes, oligodendrocytes, microglia, and ependymal cells
  • Astrocytes form the blood-brain barrier, regulate fluid, and support the CNS
  • Oligodendrocytes myelinate CNS axons for faster action potential propagation
  • Microglia are phagocytic cells protecting the CNS by engulfing harmful substances
  • Ependymal cells line brain ventricles/spinal cord, aiding CSF production/circulation

Connective Tissue of the CNS

  • The CNS has meningeal layers
  • Dura mater is the outermost layer
    • It has thick, dense connective tissue
    • It is continuous with the periosteum of the skull
  • Arachnoid mater is the middle layer
    • It has two components, a sheet of connective tissue and trabeculae
    • The trabeculae are loosely arranged and continuous with the pia mater
  • Pia mater is the innermost layer comprised of flattened mesenchymal-derived cells

CNS Structures

  • White matter consists mainly of myelinated nerve fibers, with some unmyelinated fibers and glial cells
  • Gray matter is mainly neuronal cell bodies, unmyelinated fibers, and neuroglial cells.

Cerebrum

  • Study of the cerebrum

Cerebral Cortex

  • Examination of the cerebral cortex

Layers of the Cerebral Cortex

  • Mnemonic to remember the layers = "Many Exes who Got Poisoned Inside GIT Promised to Move on"
  • The layers are:
    • Molecular layer
    • External granular layer
    • External pyramidal layer
    • Internal granular layer
    • Internal pyramidal layer
    • Multiform layer

Cerebellum

  • Study of the cerebellum

Spinal Cord

  • Gray matter is H-shaped and contains dorsal and ventral horns
    • Dorsal horns contain interneurons, receiving sensory fibers from spinal cord neurons
    • Ventral horns contain multipolar motor neurons.
  • White matter is peripherally located
    • It is made up of ascending and descending, mostly myelinated, fibers

Review Activities

  • Germ layer for nervous tissue origin

  • Brain's outer region vs. spinal cord's inner region

  • Nervous tissue phagocyte

  • Functional unit of nervous tissue

  • Rough endoplasmic reticulum equivalents

  • Neuron with single axon, multiple dendrites

  • Lipoidal substance covering nerve fibers in CNS and PNS

Microscopic Features

  • Study the distinguishing features of neurons

Histologic Differences

  • Review histologic differences between gray matter in the cerebrum and cerebellum

Peripheral Nervous System

  • Focus on the peripheral nervous system

Components of the PNS

  • Nerves
  • Ganglia
  • Nerve endings

Glial Cells

  • Astrocytes
  • Oligodendrocytes
  • Microglia
  • Ependymal cells
  • Schwann cells
  • Satellite cells

PNS Neuroglia

  • Schwann cells
  • Satellite cells

Connective Tissue of the Peripheral Nervous System

  • Epineurium: This is the external coat of a nerve.
  • Perineurium: This surrounds each bundle of nerve fibers.
  • Endoneurium: This surrounds individual nerve fibers.

Peripheral Nervous System

  • Focus on the peripheral nervous system

Ganglion

  • Focus on the ganglion structure

Myelinated Nerve Fibers

  • Have a myelin sheath
    • This feature prevents loss of nerve impulse
    • Nodes of ranvier
    • Internodal segments or schwann segments

Peripheral Nerve

  • Focus on the peripheral nerve

Unmyelinated Nerve Fibers

  • Naked axons
  • There is no multiple wrapping to form a myelin sheath
  • Smaller diameter axons
  • Still has schwann cells
  • Nodes of Ranvier are not seen

Lab Activities / Review

  • Study to differentiate a nerve from a tract and a nucleus from a ganglion
  • Study how to differentiate spinal and autonomic ganglia

Preparation for next session:

  • Connective tissue and blood smear prep for labs

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

Related Documents

More Like This

Histology of the Nervous System
34 questions
Human Histology: Nervous Tissue Lab
65 questions
Use Quizgecko on...
Browser
Browser