Histocompatibility Antigens in Transplantation
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Questions and Answers

What is the primary biological function of the HLA system?

  • To induce autoimmune diseases
  • To facilitate organ transplantation
  • To cause drug hypersensitivity reactions
  • To protect the body from pathogens and malignancy (correct)

Which of the following is NOT a potential detrimental effect of the HLA system at the individual level?

  • Protection from infectious diseases (correct)
  • Drug hypersensitivity reactions
  • Multiple autoimmune diseases
  • Transplant rejection

Which of the following HLA-associated diseases is NOT mentioned in the text?

  • Celiac disease
  • Parkinson's disease (correct)
  • Narcolepsy
  • Ankylosing spondylitis (AS)

What is the primary purpose of crossmatching against donor cells in the transplantation process?

<p>To detect sensitization to HLA antigens in the recipient (A)</p> Signup and view all the answers

Which of the following is NOT a method of HLA typing mentioned in the text?

<p>Genetic sequencing (A)</p> Signup and view all the answers

What is the primary purpose of identifying donor-specific antibodies in the recipient during the transplantation process?

<p>To determine the level of sensitization in the recipient (D)</p> Signup and view all the answers

Which of the following statements about the HLA system is NOT true?

<p>It is not associated with any autoimmune diseases (A)</p> Signup and view all the answers

What is the primary purpose of donor searches in the transplantation process?

<p>To identify suitable HSCT donors (C)</p> Signup and view all the answers

Which of the following is NOT a potential application of an HLA laboratory in 2024?

<p>Development of new HLA typing technologies (C)</p> Signup and view all the answers

Which of the following HLA-associated conditions is NOT mentioned in the text?

<p>Multiple sclerosis (D)</p> Signup and view all the answers

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