12 Questions
Which G-protein is primarily associated with H2 receptor activation?
Gs protein
What is the main pharmacological action of H3 receptor activation?
Decreased histamine release from neurons
Which receptor stimulation is primarily responsible for the Triple Response to histamine?
H1 receptor
What is necessary for an allergic reaction to occur according to the text?
Prior exposure to an allergen
What is the initial immune system response to an allergen?
Production of IgE antibodies
What is the role of mast cells and basophils in allergic reactions?
They carry receptors for IgE antibodies and release histamine upon subsequent exposure to allergens
Which antihistamine group can cross the blood-brain barrier, causing sedation?
Sedating antihistamines
What is the mechanism of non-sedating antihistamines?
Block/inhibit H1 receptors, limited crossing of the blood-brain barrier
What are the therapeutic uses of sedating antihistamines?
Allergy symptoms, insomnia, motion sickness
What are the therapeutic uses of non-sedating antihistamines?
Allergy treatment (rhinitis, hives), with longer half-lives
What is the characteristic of sensitization in allergic individuals?
Production of IgE antibodies specific to encountered allergens
What triggers the release of histamine and other mediators in allergic reactions?
Allergen binding to IgE antibodies on mast cells and basophils
Test your knowledge of histamine receptors, G-proteins, and pharmacological actions in this quiz. Identify the relevant G-proteins for each histamine receptor and understand the main pharmacological effects of histamine activation.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
