16 Questions
What is the function of erythrocytes?
Transporting oxygen and removing metabolic waste
Which type of cells influence colony-forming unit-erythrocytes to differentiate into erythroblasts?
Myeloid progenitor cells
What is the characteristic size of an erythrocyte?
8 um
Which type of normoblast has a centrally located nucleus with 0-1 nucleoli?
Prorubricyte
Which disease involves RBCs coated with IgM and complement at 37 degrees Celsius?
Cold autoimmune hemolytic anemia
What can cause immediate intravascular hemolysis in a hemolytic transfusion reaction?
ABO incompatibility
What is a characteristic of paroxysmal cold hemoglobinuria?
Presence of IgG biphasic Donath-Landsteiner antibody
Which condition can trigger disseminated intravascular coagulation (DIC) due to the release of tissue factor?
Hemolytic transfusion reaction
What is the hallmark feature of thalassemias?
Target cells
Which population is most commonly affected by beta-thalassemia?
Mediterranean
What is a common symptom of beta-thalassemia major in infants?
Delayed growth
Which laboratory finding is characteristic of beta-thalassemia?
Howell-Jolly bodies
What is the genetic basis of Hgb SC disease?
Inheriting the sickle gene from one parent and the abnormal C gene from the other parent
Which populations are commonly affected by Hemoglobin E disorder?
Southeast Asian, African, and African American
What characterizes Hemoglobin D disorder?
Glycine replacing glutamic acid at position 121 on the beta chain
What is the laboratory characteristic of Hgb SC disease?
Moderate to severe normocytic/normochromic anemia with target cells
Test your knowledge on Hgb SC Disease, a double heterozygous condition where a sickle gene from one parent combines with an abnormal C gene from the other parent. Learn about its prevalence in African, Mediterranean, and Middle Eastern populations and its characteristics.
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