Hgb SC Disease and Double Heterozygous Condition Quiz
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Questions and Answers

What is the function of erythrocytes?

  • Transporting oxygen and removing metabolic waste (correct)
  • Synthesizing hemoglobin
  • Producing erythropoietin
  • Maintaining immunological memory

    • Which type of cells influence colony-forming unit-erythrocytes to differentiate into erythroblasts?

  • Neutrophils
  • Basophils
  • Monocytes
  • Myeloid progenitor cells (correct)

    • What is the characteristic size of an erythrocyte?

  • 10 um
  • 5 um
  • 20 um
  • 8 um (correct)

    • Which type of normoblast has a centrally located nucleus with 0-1 nucleoli?

    <p>Prorubricyte</p> Signup and view all the answers

    Which disease involves RBCs coated with IgM and complement at 37 degrees Celsius?

    <p>Cold autoimmune hemolytic anemia</p> Signup and view all the answers

    What can cause immediate intravascular hemolysis in a hemolytic transfusion reaction?

    <p>ABO incompatibility</p> Signup and view all the answers

    What is a characteristic of paroxysmal cold hemoglobinuria?

    <p>Presence of IgG biphasic Donath-Landsteiner antibody</p> Signup and view all the answers

    Which condition can trigger disseminated intravascular coagulation (DIC) due to the release of tissue factor?

    <p>Hemolytic transfusion reaction</p> Signup and view all the answers

    What is the hallmark feature of thalassemias?

    <p>Target cells</p> Signup and view all the answers

    Which population is most commonly affected by beta-thalassemia?

    <p>Mediterranean</p> Signup and view all the answers

    What is a common symptom of beta-thalassemia major in infants?

    <p>Delayed growth</p> Signup and view all the answers

    Which laboratory finding is characteristic of beta-thalassemia?

    <p>Howell-Jolly bodies</p> Signup and view all the answers

    What is the genetic basis of Hgb SC disease?

    <p>Inheriting the sickle gene from one parent and the abnormal C gene from the other parent</p> Signup and view all the answers

    Which populations are commonly affected by Hemoglobin E disorder?

    <p>Southeast Asian, African, and African American</p> Signup and view all the answers

    What characterizes Hemoglobin D disorder?

    <p>Glycine replacing glutamic acid at position 121 on the beta chain</p> Signup and view all the answers

    What is the laboratory characteristic of Hgb SC disease?

    <p>Moderate to severe normocytic/normochromic anemia with target cells</p> Signup and view all the answers

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