Hgb SC Disease and Double Heterozygous Condition Quiz

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Questions and Answers

What is the function of erythrocytes?

  • Transporting oxygen and removing metabolic waste (correct)
  • Synthesizing hemoglobin
  • Producing erythropoietin
  • Maintaining immunological memory

Which type of cells influence colony-forming unit-erythrocytes to differentiate into erythroblasts?

  • Neutrophils
  • Basophils
  • Monocytes
  • Myeloid progenitor cells (correct)

What is the characteristic size of an erythrocyte?

  • 10 um
  • 5 um
  • 20 um
  • 8 um (correct)

Which type of normoblast has a centrally located nucleus with 0-1 nucleoli?

<p>Prorubricyte (A)</p> Signup and view all the answers

Which disease involves RBCs coated with IgM and complement at 37 degrees Celsius?

<p>Cold autoimmune hemolytic anemia (A)</p> Signup and view all the answers

What can cause immediate intravascular hemolysis in a hemolytic transfusion reaction?

<p>ABO incompatibility (B)</p> Signup and view all the answers

What is a characteristic of paroxysmal cold hemoglobinuria?

<p>Presence of IgG biphasic Donath-Landsteiner antibody (B)</p> Signup and view all the answers

Which condition can trigger disseminated intravascular coagulation (DIC) due to the release of tissue factor?

<p>Hemolytic transfusion reaction (B)</p> Signup and view all the answers

What is the hallmark feature of thalassemias?

<p>Target cells (D)</p> Signup and view all the answers

Which population is most commonly affected by beta-thalassemia?

<p>Mediterranean (A)</p> Signup and view all the answers

What is a common symptom of beta-thalassemia major in infants?

<p>Delayed growth (D)</p> Signup and view all the answers

Which laboratory finding is characteristic of beta-thalassemia?

<p>Howell-Jolly bodies (A)</p> Signup and view all the answers

What is the genetic basis of Hgb SC disease?

<p>Inheriting the sickle gene from one parent and the abnormal C gene from the other parent (C)</p> Signup and view all the answers

Which populations are commonly affected by Hemoglobin E disorder?

<p>Southeast Asian, African, and African American (C)</p> Signup and view all the answers

What characterizes Hemoglobin D disorder?

<p>Glycine replacing glutamic acid at position 121 on the beta chain (D)</p> Signup and view all the answers

What is the laboratory characteristic of Hgb SC disease?

<p>Moderate to severe normocytic/normochromic anemia with target cells (A)</p> Signup and view all the answers

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