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Questions and Answers
What does pyrrole form in dilute acids?
What does pyrrole form in dilute acids?
Which type of aromatic character do these five-membered heterocycles belong to?
Which type of aromatic character do these five-membered heterocycles belong to?
Which atom in furan and thiophene is sp2 hybridized?
Which atom in furan and thiophene is sp2 hybridized?
What property of pyrrole makes it undergo electrophilic substitution more favorably at the 𝛼- (2- ) position?
What property of pyrrole makes it undergo electrophilic substitution more favorably at the 𝛼- (2- ) position?
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What type of substitution do furan, thiophene, and pyrrole undergo at the 𝛼- (2- ) position?
What type of substitution do furan, thiophene, and pyrrole undergo at the 𝛼- (2- ) position?
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Study Notes
Heterocycles
- In dilute acids, pyrrole forms a cation.
Aromatic Character
- Five-membered heterocycles, such as pyrrole, furan, and thiophene, belong to non-benzenoid aromatic compounds.
Hybridization in Furan and Thiophene
- In furan and thiophene, the oxygen and sulfur atoms, respectively, are sp2 hybridized.
Electrophilic Substitution in Pyrrole
- The high electron density at the 𝛂- (2-) position in pyrrole makes it undergo electrophilic substitution more favorably at this position.
Substitution in Furan, Thiophene, and Pyrrole
- Furan, thiophene, and pyrrole undergo electrophilic substitution at the 𝛂- (2-) position.
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Description
Test your knowledge on the topic of heterocyclic chemistry, specifically focusing on five-membered heterocycles and their aromatic character. This quiz is based on lecture #7 of the Pharmaceutical Organic Chemistry-3 course for Clinical PharmD students at National Mansoura University.
