Herpesvirus Biology Quiz
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Questions and Answers

Which of the following is NOT a feature of a herpesvirus?

  • Lipoprotein envelope
  • Linear, double-stranded DNA
  • Icosahedral core
  • Circular, double-stranded DNA (correct)
  • What is the primary location of replication for herpesviruses?

  • Mitochondria
  • Nucleus (correct)
  • Golgi apparatus
  • Cytoplasm
  • Which of these is a key feature that distinguishes herpesviruses from poxviruses?

  • Type of genetic material
  • Presence of a capsid
  • Presence of a tegument
  • Presence of a lipoprotein envelope
  • Size (correct)
  • What is the significance of the 'tegument' within the structure of a herpesvirus?

    <p>It contains regulatory proteins that play a role in viral gene expression (C)</p> Signup and view all the answers

    Which of the following characteristics is unique to the Herpes simplex-1 virus?

    <p>It can induce formation of multinucleated giant cells (D)</p> Signup and view all the answers

    Which of the following statements regarding herpesviruses is correct?

    <p>Herpesviruses can remain latent within the host’s cells. (B)</p> Signup and view all the answers

    What is the significance of the formation of multinucleated giant cells in Herpesvirus infections?

    <p>It is a process that helps the virus to spread to new cells (D)</p> Signup and view all the answers

    Which of the following statements is TRUE about herpesviruses?

    <p>Herpesviruses are prevalent globally and infect various human populations. (E)</p> Signup and view all the answers

    What distinguishes HSV-1 from HSV-2 regarding their typical lesion locations?

    <p>HSV-1 typically causes lesions above the waist. (D)</p> Signup and view all the answers

    Which enzyme encoded in the HSV viral genome is essential for replication?

    <p>Thymidine kinase (D)</p> Signup and view all the answers

    What is the role of latency-associated transcripts (LATs) in HSV-infected cells?

    <p>They suppress viral replication. (D)</p> Signup and view all the answers

    How can HSV-1 and HSV-2 be differentiated at the genomic level?

    <p>Through restriction digestion analysis. (C)</p> Signup and view all the answers

    In latently infected cells, how is HSV DNA maintained?

    <p>As circularized DNA without integration. (B)</p> Signup and view all the answers

    Which of the following statements about monoclonal antibodies against the F protein is true?

    <p>They provide passive immunity. (B)</p> Signup and view all the answers

    What is the approved age group for the Arexvy vaccine?

    <p>Adults 60 years and older. (A)</p> Signup and view all the answers

    Which feature is characteristic of coronaviruses?

    <p>No virion polymerase. (B)</p> Signup and view all the answers

    What is the primary consequence of SARS infection?

    <p>Severe acute respiratory syndrome. (A)</p> Signup and view all the answers

    What treatment is currently established for SARS infection?

    <p>No antiviral therapy is available. (A)</p> Signup and view all the answers

    What characteristic distinguishes rhinovirus in terms of its genome?

    <p>Nonsegmented, single-stranded RNA (D)</p> Signup and view all the answers

    Which method of transmission is primarily associated with adenovirus?

    <p>Fecal-oral route (C)</p> Signup and view all the answers

    What is a significant feature of adenovirus that aids in its infection process?

    <p>A fiber that facilitates attachment (A)</p> Signup and view all the answers

    Which statement is true regarding the treatment options available for rhinovirus infections?

    <p>No antiviral therapy is approved for rhinovirus infections. (A)</p> Signup and view all the answers

    What is the immunity characteristic associated with rhinovirus infections?

    <p>Serotype-specific immunity (C)</p> Signup and view all the answers

    What is the primary treatment for encephalitis caused by HSV-1?

    <p>Acyclovir (D)</p> Signup and view all the answers

    Which medication is indicated for patients resistant to acyclovir?

    <p>Foscarnet (B)</p> Signup and view all the answers

    What is true regarding the transmission of varicella-zoster virus?

    <p>It is transmitted by respiratory droplets. (B)</p> Signup and view all the answers

    What does the term 'latent stage' refer to in the context of herpes simplex virus?

    <p>A dormant infection without symptoms. (A)</p> Signup and view all the answers

    How many serotypes of varicella-zoster virus are there?

    <p>One (B)</p> Signup and view all the answers

    Which of the following is an effective preventative measure against recurrent HSV-2 lesions?

    <p>Acyclovir (B)</p> Signup and view all the answers

    Which statement is true about the presence of antibodies to varicella-zoster virus in the US population?

    <p>Over 90% of people have antibodies by age 10. (A)</p> Signup and view all the answers

    What characterizes zoster (shingles) lesions?

    <p>Vesicles along the dermatome of a thoracic nerve. (C)</p> Signup and view all the answers

    What distinguishes Cytomegalovirus (CMV) from other herpesviruses in its latency mechanism?

    <p>It produces microRNAs that inhibit MHC protein translation. (A)</p> Signup and view all the answers

    Which of the following treatments is recommended for CMV infections in AIDS patients?

    <p>Foscarnet (A), Ganciclovir (D)</p> Signup and view all the answers

    What is the main reason that smallpox was successfully eradicated?

    <p>The rapid antibody response following vaccination. (D)</p> Signup and view all the answers

    What is unique about the structure of poxviruses compared to other viruses?

    <p>They have a double membrane and a disc-shaped core. (C)</p> Signup and view all the answers

    Which of the following statements is true regarding Cytomegalovirus (CMV) infections?

    <p>It can evade the immune system through several mechanisms. (B), Only one serotype of CMV exists. (D)</p> Signup and view all the answers

    Why is Acyclovir avoided in the treatment of CMV infections?

    <p>Resistance to Acyclovir has developed in CMV. (C)</p> Signup and view all the answers

    Human papillomavirus (HPV) primarily causes what type of growth?

    <p>Benign tumors of squamous cells. (B)</p> Signup and view all the answers

    What role do chemokine receptors play in the immune evasion of CMV?

    <p>They prevent migration of immunocompetent cells to the site of infection. (C)</p> Signup and view all the answers

    Flashcards

    Major Viral Pathogens

    Viruses categorized by infection site, transmission, lesions, and diseases.

    Herpesviruses

    Group of viruses that replicate in the nucleus with double-stranded DNA.

    Poxviruses

    Viruses with a circular double-stranded DNA genome, causing diseases like smallpox.

    Human Papillomavirus (HPV)

    A virus that is part of the major viral pathogens affecting human skin.

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    Virions

    Complete viral particles that include nucleocapsid and envelope for herpesviruses.

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    Tegument

    Structure in herpesviruses that associates nucleocapsid and envelope with regulatory proteins.

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    Multinucleated Giant Cells

    Cells formed due to the presence of certain herpesviruses, visible in Tzanck smear.

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    Characteristics of Herpesviruses

    Icosaheral structure, large size, lipoprotein envelope, and ability to cause latency.

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    Herpes Simplex Virus 1 (HSV-1)

    Causes lesions primarily above the waist.

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    Herpes Simplex Virus 2 (HSV-2)

    Causes lesions primarily below the waist.

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    Glycoprotein G

    Used in differentiating HSV-1 and HSV-2 via analysis.

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    Latency-Associated Transcripts (LATs)

    Regulatory RNA that suppresses viral replication in latency.

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    HSV DNA Replication

    Requires DNA polymerase and thymidine kinase encoded in viral genome.

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    Cytoplasm

    The jelly-like substance within a cell that contains organelles and is the site for many cellular processes.

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    Acyclovir

    An antiviral medication used to treat infections caused by certain viruses, especially HSV-1 and HSV-2.

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    HSV-1

    Herpes simplex virus type 1, primarily causing oral herpes and encephalitis.

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    HSV-2

    Herpes simplex virus type 2, primarily causing genital herpes.

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    Foscarnet

    An antiviral medication used when herpes viruses are resistant to acyclovir.

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    Varicella-zoster virus

    The virus that causes chickenpox (varicella) and shingles (zoster).

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    Chickenpox

    An infectious disease caused by the varicella-zoster virus, characterized by an itchy rash and flu-like symptoms.

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    Shingles

    A reactivation of the varicella-zoster virus, causing a painful rash typically along a dermatome.

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    Cytomegalovirus (CMV)

    A common congenital virus that can cause serious disease in immunocompromised patients.

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    CMV Latency

    CMV can remain dormant and reactivate during weakened immune response.

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    CMV Immune Evasion

    CMV prevents T-cell response by disrupting MHC presentation and using decoys.

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    Treatment for CMV in AIDS

    Ganciclovir is commonly used to treat CMV retinitis and pneumonia in AIDS patients.

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    Poxviruses Characteristics

    Largest, complex viruses with linear double-stranded DNA and replicate in the cytoplasm.

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    Smallpox Eradication

    Achieved through vaccination; only disease eradicated completely from Earth.

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    CMV Transmission

    CMV is transmitted through bodily fluids and affects humans as natural hosts.

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    Palivizumab

    A monoclonal antibody used for passive immunity against RSV.

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    Arexvy

    An FDA-approved RSV vaccine for adults aged 60 and older.

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    Abrysvo

    An FDA-approved RSV vaccine for pregnant women at 32-36 weeks gestation.

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    Coronaviruses

    Family of viruses causing diseases from common colds to severe pneumonia (e.g., COVID-19).

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    SARS Mortality Rate

    SARS has a mortality rate of about 9% with horseshoe bats as a reservoir.

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    Rhinovirus

    Most common cause of the common cold; nonsegmented, single-stranded RNA virus.

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    Rhinovirus Replication

    RNA acts as mRNA after uncoating; replication optimal at 30˚C.

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    Adenovirus Features

    Nonenveloped, double-stranded DNA virus; has an icosahedral shape.

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    Adenovirus Transmission

    Spread via fecal-oral route, aerosol droplets, and direct contact.

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    Adenovirus Consequences

    Can cause pharyngitis, conjunctivitis, common cold, and pneumonia.

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    Study Notes

    Herpesviruses

    • Herpesviruses are a group of DNA enveloped viruses.
    • Herpes simplex virus types 1 and 2, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus, and human herpesvirus 8 are examples of herpesviruses.
    • Herpes simplex virus type 1 (HSV-1) typically causes lesions above the waist, while HSV-2 typically causes lesions below the waist.
    • HSV-1 and HSV-2 are indistinguishable morphologically and structurally.
    • Genomes can be differentiated using restriction digestion analysis and glycoprotein G antisera analysis.
    • HSV-1 binds to heparin sulfate on the host cell surface.
    • Replication needs DNA polymerase and thymidine kinase.
    • In latently infected cells, circular HSV DNA is not integrated into the cellular DNA.
    • Transcription of HSV DNA produces latency-associated transcripts (LATS).
    • LATs are non-coding regulatory RNAs that suppress viral replication.
    • Reactivation of viral replication can occur when genes encoding LATs are excised.
    • Treatment for encephalitis and systemic diseases from HSV-1 is acyclovir.
    • Primary and recurrent HSV-2 can be treated with acyclovir, which shortens lesion duration and reduces shedding.
    • Foscarnet is used when acyclovir is resistant.
    • No vaccine exists for HSV.

    Poxviruses

    • Poxviruses are large, complex viruses classified as a linear, double-stranded DNA.
    • Vaccinia virus, molluscum contagiosum virus, and smallpox virus are examples of poxviruses.
    • Smallpox is the only poxvirus that has been eradicated.
    • The virus typically replicates in the cytoplasm and cannot access the host RNA polymerase in the nucleus.
    • Smallpox virus has a single, stable serotype.
    • Humans are the only host for smallpox.
    • Vaccination can protect people exposed to smallpox.

    Human Papillomavirus (HPV)

    • HPV is a common, sexually transmitted infection. It leads to benign tumors of squamous cells causing warts.
    • HPV is non-enveloped and has double-stranded circular DNA.
    • Over 100 HPV types exist.
    • HPV types 1 to 4 usually cause skin warts. Types 6 and 11 can cause genital warts.
    • HPV types 16 and 18 are frequently associated with intraepithelial neoplasia, which can progress to carcinomas.
    • Skin warts can be treated with liquid nitrogen.
    • Genital warts can be treated with topical imiquimod, podophyllin, or other treatments.
    • Gardasil 9 vaccine protects against several HPV types that cause warts and cancer.

    Respiratory Viruses

    • Respiratory viruses cause predominantly upper and lower respiratory tract symptoms.

    Influenza Viruses

    • Influenza is a segmented, single-stranded RNA virus.
    • Hemagglutinin and neuraminidase are protein spikes on the influenza envelope.
    • Influenza A and B both cause worldwide epidemics and major outbreaks, respectively.
    • The H and N proteins vary antigenically resulting in wide diversity within each strain, causing annual epidemics and pandemics, potentially resulting in reassortment of gene segments
    • Oseltamivir and zanamivir are examples of treatments that inhibit neuraminidase.
    • There are inactivated and attenuated vaccines for Influenza.

    Parainfluenza Virus

    • Parainfluenza is an RNA virus causing croup, laryngitis, bronchiolitis, and pneumonia, especially in children.
    • It has an RNA genome, similar nucleocapsid to other paramyxoviruses.
    • Surface spikes are formed from H, N, and F proteins.

    Respiratory Syncytial Virus (RSV)

    • RSV is an RNA virus that is the primary cause of pneumonia and bronchiolitis, especially in infants.
    • RSV can cause otitis media and pneumonia in the elderly.
    • The virus has an RNA genome, a similar nucleocapsid to paramyxoviruses, and only a fusion F protein.
    • Treatment with ribavirin is used for severely ill infants and is not guaranteed to be effective.
    • Monoclonal antibodies (e.g., palivizumab and nirsevimab) to target the F protein can be used for passive immunity.

    Coronavirus

    • Coronaviruses are enveloped RNA viruses, causing common colds, SARS, MERS, and COVID-19.
    • They have nonsegmented RNA genomes, a helical nucleocapsid, and do not have virion polymerase.
    • Coronavirus replication occurs in the cytoplasm.
    • Treatment options include ribavirin and steroids, but with uncertain efficacy.

    Rhinovirus

    • Rhinovirus is a non-enveloped virus causing the common cold.
    • The RNA genome is single-stranded and nonsegmented.
    • It has multiple serotypes.
    • The virus is inactivated by stomach acid upon ingestion. Replication is optimal at 30°C, and poor at 37°C
    • No antiviral therapy currently approved.

    Adenovirus

    • Adenovirus is a non-enveloped virus causing pharyngitis, conjunctivitis, common colds and pneumonia.
    • It has a double-stranded linear DNA genome.
    • The icosahedral capsid includes a fiber that facilitates attachment.
    • No antiviral therapy currently available.

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    Test your knowledge on herpesviruses and their unique features. This quiz covers topics including replication sites, distinguishing characteristics, and genetic aspects of HSV-1 and HSV-2. Challenge yourself with questions about structure, function, and differentiation of herpesviruses.

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