Podcast
Questions and Answers
Which of the following is NOT a feature of a herpesvirus?
Which of the following is NOT a feature of a herpesvirus?
What is the primary location of replication for herpesviruses?
What is the primary location of replication for herpesviruses?
Which of these is a key feature that distinguishes herpesviruses from poxviruses?
Which of these is a key feature that distinguishes herpesviruses from poxviruses?
What is the significance of the 'tegument' within the structure of a herpesvirus?
What is the significance of the 'tegument' within the structure of a herpesvirus?
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Which of the following characteristics is unique to the Herpes simplex-1 virus?
Which of the following characteristics is unique to the Herpes simplex-1 virus?
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Which of the following statements regarding herpesviruses is correct?
Which of the following statements regarding herpesviruses is correct?
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What is the significance of the formation of multinucleated giant cells in Herpesvirus infections?
What is the significance of the formation of multinucleated giant cells in Herpesvirus infections?
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Which of the following statements is TRUE about herpesviruses?
Which of the following statements is TRUE about herpesviruses?
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What distinguishes HSV-1 from HSV-2 regarding their typical lesion locations?
What distinguishes HSV-1 from HSV-2 regarding their typical lesion locations?
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Which enzyme encoded in the HSV viral genome is essential for replication?
Which enzyme encoded in the HSV viral genome is essential for replication?
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What is the role of latency-associated transcripts (LATs) in HSV-infected cells?
What is the role of latency-associated transcripts (LATs) in HSV-infected cells?
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How can HSV-1 and HSV-2 be differentiated at the genomic level?
How can HSV-1 and HSV-2 be differentiated at the genomic level?
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In latently infected cells, how is HSV DNA maintained?
In latently infected cells, how is HSV DNA maintained?
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Which of the following statements about monoclonal antibodies against the F protein is true?
Which of the following statements about monoclonal antibodies against the F protein is true?
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What is the approved age group for the Arexvy vaccine?
What is the approved age group for the Arexvy vaccine?
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Which feature is characteristic of coronaviruses?
Which feature is characteristic of coronaviruses?
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What is the primary consequence of SARS infection?
What is the primary consequence of SARS infection?
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What treatment is currently established for SARS infection?
What treatment is currently established for SARS infection?
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What characteristic distinguishes rhinovirus in terms of its genome?
What characteristic distinguishes rhinovirus in terms of its genome?
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Which method of transmission is primarily associated with adenovirus?
Which method of transmission is primarily associated with adenovirus?
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What is a significant feature of adenovirus that aids in its infection process?
What is a significant feature of adenovirus that aids in its infection process?
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Which statement is true regarding the treatment options available for rhinovirus infections?
Which statement is true regarding the treatment options available for rhinovirus infections?
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What is the immunity characteristic associated with rhinovirus infections?
What is the immunity characteristic associated with rhinovirus infections?
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What is the primary treatment for encephalitis caused by HSV-1?
What is the primary treatment for encephalitis caused by HSV-1?
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Which medication is indicated for patients resistant to acyclovir?
Which medication is indicated for patients resistant to acyclovir?
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What is true regarding the transmission of varicella-zoster virus?
What is true regarding the transmission of varicella-zoster virus?
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What does the term 'latent stage' refer to in the context of herpes simplex virus?
What does the term 'latent stage' refer to in the context of herpes simplex virus?
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How many serotypes of varicella-zoster virus are there?
How many serotypes of varicella-zoster virus are there?
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Which of the following is an effective preventative measure against recurrent HSV-2 lesions?
Which of the following is an effective preventative measure against recurrent HSV-2 lesions?
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Which statement is true about the presence of antibodies to varicella-zoster virus in the US population?
Which statement is true about the presence of antibodies to varicella-zoster virus in the US population?
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What characterizes zoster (shingles) lesions?
What characterizes zoster (shingles) lesions?
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What distinguishes Cytomegalovirus (CMV) from other herpesviruses in its latency mechanism?
What distinguishes Cytomegalovirus (CMV) from other herpesviruses in its latency mechanism?
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Which of the following treatments is recommended for CMV infections in AIDS patients?
Which of the following treatments is recommended for CMV infections in AIDS patients?
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What is the main reason that smallpox was successfully eradicated?
What is the main reason that smallpox was successfully eradicated?
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What is unique about the structure of poxviruses compared to other viruses?
What is unique about the structure of poxviruses compared to other viruses?
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Which of the following statements is true regarding Cytomegalovirus (CMV) infections?
Which of the following statements is true regarding Cytomegalovirus (CMV) infections?
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Why is Acyclovir avoided in the treatment of CMV infections?
Why is Acyclovir avoided in the treatment of CMV infections?
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Human papillomavirus (HPV) primarily causes what type of growth?
Human papillomavirus (HPV) primarily causes what type of growth?
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What role do chemokine receptors play in the immune evasion of CMV?
What role do chemokine receptors play in the immune evasion of CMV?
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Flashcards
Major Viral Pathogens
Major Viral Pathogens
Viruses categorized by infection site, transmission, lesions, and diseases.
Herpesviruses
Herpesviruses
Group of viruses that replicate in the nucleus with double-stranded DNA.
Poxviruses
Poxviruses
Viruses with a circular double-stranded DNA genome, causing diseases like smallpox.
Human Papillomavirus (HPV)
Human Papillomavirus (HPV)
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Virions
Virions
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Tegument
Tegument
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Multinucleated Giant Cells
Multinucleated Giant Cells
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Characteristics of Herpesviruses
Characteristics of Herpesviruses
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Herpes Simplex Virus 1 (HSV-1)
Herpes Simplex Virus 1 (HSV-1)
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Herpes Simplex Virus 2 (HSV-2)
Herpes Simplex Virus 2 (HSV-2)
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Glycoprotein G
Glycoprotein G
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Latency-Associated Transcripts (LATs)
Latency-Associated Transcripts (LATs)
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HSV DNA Replication
HSV DNA Replication
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Cytoplasm
Cytoplasm
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Acyclovir
Acyclovir
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HSV-1
HSV-1
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HSV-2
HSV-2
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Foscarnet
Foscarnet
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Varicella-zoster virus
Varicella-zoster virus
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Chickenpox
Chickenpox
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Shingles
Shingles
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Cytomegalovirus (CMV)
Cytomegalovirus (CMV)
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CMV Latency
CMV Latency
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CMV Immune Evasion
CMV Immune Evasion
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Treatment for CMV in AIDS
Treatment for CMV in AIDS
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Poxviruses Characteristics
Poxviruses Characteristics
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Smallpox Eradication
Smallpox Eradication
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CMV Transmission
CMV Transmission
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Palivizumab
Palivizumab
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Arexvy
Arexvy
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Abrysvo
Abrysvo
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Coronaviruses
Coronaviruses
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SARS Mortality Rate
SARS Mortality Rate
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Rhinovirus
Rhinovirus
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Rhinovirus Replication
Rhinovirus Replication
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Adenovirus Features
Adenovirus Features
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Adenovirus Transmission
Adenovirus Transmission
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Adenovirus Consequences
Adenovirus Consequences
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Study Notes
Herpesviruses
- Herpesviruses are a group of DNA enveloped viruses.
- Herpes simplex virus types 1 and 2, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus, and human herpesvirus 8 are examples of herpesviruses.
- Herpes simplex virus type 1 (HSV-1) typically causes lesions above the waist, while HSV-2 typically causes lesions below the waist.
- HSV-1 and HSV-2 are indistinguishable morphologically and structurally.
- Genomes can be differentiated using restriction digestion analysis and glycoprotein G antisera analysis.
- HSV-1 binds to heparin sulfate on the host cell surface.
- Replication needs DNA polymerase and thymidine kinase.
- In latently infected cells, circular HSV DNA is not integrated into the cellular DNA.
- Transcription of HSV DNA produces latency-associated transcripts (LATS).
- LATs are non-coding regulatory RNAs that suppress viral replication.
- Reactivation of viral replication can occur when genes encoding LATs are excised.
- Treatment for encephalitis and systemic diseases from HSV-1 is acyclovir.
- Primary and recurrent HSV-2 can be treated with acyclovir, which shortens lesion duration and reduces shedding.
- Foscarnet is used when acyclovir is resistant.
- No vaccine exists for HSV.
Poxviruses
- Poxviruses are large, complex viruses classified as a linear, double-stranded DNA.
- Vaccinia virus, molluscum contagiosum virus, and smallpox virus are examples of poxviruses.
- Smallpox is the only poxvirus that has been eradicated.
- The virus typically replicates in the cytoplasm and cannot access the host RNA polymerase in the nucleus.
- Smallpox virus has a single, stable serotype.
- Humans are the only host for smallpox.
- Vaccination can protect people exposed to smallpox.
Human Papillomavirus (HPV)
- HPV is a common, sexually transmitted infection. It leads to benign tumors of squamous cells causing warts.
- HPV is non-enveloped and has double-stranded circular DNA.
- Over 100 HPV types exist.
- HPV types 1 to 4 usually cause skin warts. Types 6 and 11 can cause genital warts.
- HPV types 16 and 18 are frequently associated with intraepithelial neoplasia, which can progress to carcinomas.
- Skin warts can be treated with liquid nitrogen.
- Genital warts can be treated with topical imiquimod, podophyllin, or other treatments.
- Gardasil 9 vaccine protects against several HPV types that cause warts and cancer.
Respiratory Viruses
- Respiratory viruses cause predominantly upper and lower respiratory tract symptoms.
Influenza Viruses
- Influenza is a segmented, single-stranded RNA virus.
- Hemagglutinin and neuraminidase are protein spikes on the influenza envelope.
- Influenza A and B both cause worldwide epidemics and major outbreaks, respectively.
- The H and N proteins vary antigenically resulting in wide diversity within each strain, causing annual epidemics and pandemics, potentially resulting in reassortment of gene segments
- Oseltamivir and zanamivir are examples of treatments that inhibit neuraminidase.
- There are inactivated and attenuated vaccines for Influenza.
Parainfluenza Virus
- Parainfluenza is an RNA virus causing croup, laryngitis, bronchiolitis, and pneumonia, especially in children.
- It has an RNA genome, similar nucleocapsid to other paramyxoviruses.
- Surface spikes are formed from H, N, and F proteins.
Respiratory Syncytial Virus (RSV)
- RSV is an RNA virus that is the primary cause of pneumonia and bronchiolitis, especially in infants.
- RSV can cause otitis media and pneumonia in the elderly.
- The virus has an RNA genome, a similar nucleocapsid to paramyxoviruses, and only a fusion F protein.
- Treatment with ribavirin is used for severely ill infants and is not guaranteed to be effective.
- Monoclonal antibodies (e.g., palivizumab and nirsevimab) to target the F protein can be used for passive immunity.
Coronavirus
- Coronaviruses are enveloped RNA viruses, causing common colds, SARS, MERS, and COVID-19.
- They have nonsegmented RNA genomes, a helical nucleocapsid, and do not have virion polymerase.
- Coronavirus replication occurs in the cytoplasm.
- Treatment options include ribavirin and steroids, but with uncertain efficacy.
Rhinovirus
- Rhinovirus is a non-enveloped virus causing the common cold.
- The RNA genome is single-stranded and nonsegmented.
- It has multiple serotypes.
- The virus is inactivated by stomach acid upon ingestion. Replication is optimal at 30°C, and poor at 37°C
- No antiviral therapy currently approved.
Adenovirus
- Adenovirus is a non-enveloped virus causing pharyngitis, conjunctivitis, common colds and pneumonia.
- It has a double-stranded linear DNA genome.
- The icosahedral capsid includes a fiber that facilitates attachment.
- No antiviral therapy currently available.
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Description
Test your knowledge on herpesviruses and their unique features. This quiz covers topics including replication sites, distinguishing characteristics, and genetic aspects of HSV-1 and HSV-2. Challenge yourself with questions about structure, function, and differentiation of herpesviruses.