30 Questions
Which enzyme is present in biliary epithelium?
Alkaline phosphatase
What is a test of hepatocyte function that can be affected by increased ammonia levels?
Prothrombin time
What is a complication associated with cholestasis?
Jaundice
Which histologic feature is characteristic of liver cirrhosis?
Bridging fibrous septa
What occurs in cholestasis as a result of hepatocyte swelling?
Foamy degeneration
Which liver condition results from irreversible end-stage chronic liver disease?
Liver cirrhosis
What is the main cause of hepatocytes swelling?
Defects in membrane and/or mitochondrial function
Which type of necrosis is characterized by poorly staining mummified hepatocytes with shadows of cells?
Coagulative necrosis
What causes yellowish discoloration of skin & sclera in jaundice?
Systemic retention of bilirubin
What happens in Kernicterus?
Accumulation of bilirubin in the brain
How is unconjugated bilirubin different from conjugated bilirubin?
Unconjugated bilirubin is tightly bound to serum albumin, whereas conjugated bilirubin is loosely bound.
Which lab test can evaluate conjugated bilirubin specifically?
Direct bilirubin test
What is a major etiologic association for the development of Hepatocellular Carcinoma (HCC)?
Continuous bouts of inflammation caused by HBV
In what percentage of cases does Hepatocellular Carcinoma (HCC) occur without cirrhosis?
50%
Which toxin, produced by certain fungi, is mentioned as a cause for mutation in p53 leading to Hepatocellular Carcinoma?
Aflatoxin
What is the male-to-female ratio for Hepatocellular Carcinoma (HCC) between 20 - 40 years?
8:1
Which condition is mentioned as a cause for accumulation of iron inside hepatocytes, contributing to Hepatocellular Carcinoma?
Hemochromatosis
In which setting does Hepatocellular Carcinoma (HCC) almost exclusively occur in patients with HCV according to the text?
In the setting of cirrhosis
Which of the following is a characteristic of focal nodular hyperplasia (FNH)?
It is a solitary focus of hyperplastic hepatocyte nodules with a central fibrous scar.
What is the most common site of origin for metastatic carcinomas in the liver?
Colon
Which of the following is a characteristic of liver cell dysplasia?
It is a precursor lesion to liver cell carcinoma.
Which of the following is a benign epithelial neoplasm of the liver?
Liver cell adenoma
Which of the following is a characteristic of nodular regenerative hyperplasia?
It is a benign condition.
Which of the following is a malignant non-epithelial neoplasm of the liver?
Angiosarcoma
Which of the following is NOT a characteristic of hepatocellular carcinoma (HCC)?
Presence of bile pigment or hyaline inclusions
What is the median survival for patients with hepatocellular carcinoma (HCC)?
7 months
Which of the following factors is associated with a better prognosis for hepatocellular carcinoma (HCC)?
Single tumor < 2 cm in diameter
What is the most effective treatment for hepatocellular carcinoma (HCC) mentioned in the text?
Surgical resection of smaller tumors
What is the length of the pancreas mentioned in the text?
20 cm
Where does the pancreatic duct empty into, according to the text?
Duodenum or the common bile duct
Test your knowledge on hepatocytes swelling and necrosis in the liver. Learn about the causes and characteristics of swelling, hydropic change, and different types of necrosis like coagulative and lytic necrosis.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
