40 Questions
What is the total platelet count in platelet-rich plasma (PRP)?
7.1 x 10^10 Plts
What is the percentage yield of platelet concentrate?
78%
What is the purpose of cryoprecipitate in transfusion medicine?
Replacement of fibrinogen, fibronectin, and coagulation factors FVIII and FXIII
What is the recommended storage condition for cryoprecipitate?
Frozen at -18°C for 1 year
What is the role of platelets in hemostasis?
Formation of blood clots
What is the primary purpose of platelets in the body?
To facilitate the formation of blood clots
What is the minimum number of platelets that a random donor platelet (RDP) unit must contain?
5.5 x 10^10 platelets
What is the correct formula to calculate the corrected count increment (CCI) after platelet transfusion?
(Post-transfusion PC - Pre-transfusion PC) x BSA / # of RDP transfused
What is the primary indication for platelet transfusion in thrombocytopenia?
All of the above
How should single donor platelets (SDP) be stored and handled?
At room temperature with constant agitation for 3-5 days
What is the total platelet count in platelet-rich plasma (PRP) in the given formula?
71,500,000/mL
What is the Corrected Count Increment (CCI) in the given scenario?
20,250/μL
What is the percentage yield of platelets in the given case?
53.6%
What is the primary function of platelets in hemostasis?
Aggregation
What is the recommended storage temperature for platelet concentrates?
20-24°C
What is the formula to calculate the corrected count increment for a single donor platelet transfusion?
CCI = (Post-transfusion PC - Pre-transfusion PC) x BSA x 0.55
What is the temperature range for storing random donor platelets?
20-24°C
What is the approximate volume of a platelet concentrate?
50-70 mL
What is the minimum platelet count required to indicate bleeding risks in patients with dengue hemorrhagic fever?
10,000/μL
What is the effect of 4-6 pools of random donor platelets (RDP) equivalent to?
20,000 - 60,000/μL of platelet count
What is the estimated blood volume of a 65 kg individual?
4, 550 mL
What is the estimated plasma volume of a 65 kg individual with a hematocrit of 0.28?
3, 276 mL
What is the required amount of fibrinogen to be transfused to reach the desired level of 100 mg/dL in a 65 kg individual?
2, 228 mg
How many units of cryoprecipitate are required to be transfused to reach the desired fibrinogen level of 100 mg/dL in a 65 kg individual?
9 units
What is the factor for blood volume estimation used in the calculation of estimated blood volume?
70 mL/kg body weight
What is the indication for transfusing fresh frozen plasma to a patient with acute blood loss?
Clotting factor deficiency
If a patient's serum has no antibodies against the antigens present on the donor's red cells, what can be transfused?
Whole blood and packed red cells
What is the consequence of transfusing donor red cells to a patient with antibodies against the antigens present on the donor's red cells?
Hemolytic transfusion reaction
What is the minimum requirement for proceeding with transfusion in major crossmatching?
No agglutination reaction
What is the primary consideration for transfusing whole blood or packed red cells to a patient?
Need of the patient
What is the primary function of enzymes in the context of blood group antigens?
To enhance or destroy certain blood group antigens
Which antigens are destroyed by enzymes in the RBC membrane?
M, N, S, and s
What is the key difference between the one-step and two-step enzyme treatment processes?
The application of the enzyme
What is the outcome of the one-step enzyme treatment process?
Washed red blood cells are then tested with specific antibodies
What is the purpose of the two-step enzyme treatment process?
To enhance antigen detection
Which antigens are enhanced by the enzyme treatment process?
Rh, Kidd, and Lewis
What is the role of ficin, bromelin, and papain in the enzyme treatment process?
To remove sialic acid from the RBC membrane
What is the difference between the one-step and two-step enzyme treatment processes in terms of specificity?
One-step potentially weakens all antibodies
What is the purpose of using enzymes in the context of blood group antigens?
To enhance or destroy certain blood group antigens
What is the result of the enzyme treatment process on the RBC membrane?
The sialic acid is removed from the RBC membrane
This quiz covers the role of platelets in primary hemostasis, preparation and quality control of platelet concentrates, and indications for platelet transfusion. It also involves calculation of platelet count before and after transfusion.
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