Hemostasis and Platelet Transfusion

What is the total platelet count in platelet-rich plasma (PRP)?

2.1 x 10^10 Plts
7.1 x 10^10 Plts (correct)
5.8 x 10^10 Plts
3.1 x 10^10 Plts

What is the percentage yield of platelet concentrate?

82%
90%
72%
78% (correct)

What is the purpose of cryoprecipitate in transfusion medicine?

Replacement of platelets in thrombocytopenia
Replacement of red blood cells
Replacement of fibrinogen, fibronectin, and coagulation factors FVIII and FXIII (correct)
Treatment of bleeding disorders

What is the recommended storage condition for cryoprecipitate?

Frozen at -18°C for 1 year (B) Signup and view all the answers

What is the role of platelets in hemostasis?

Formation of blood clots (D) Signup and view all the answers

What is the primary purpose of platelets in the body?

To facilitate the formation of blood clots (D) Signup and view all the answers

What is the minimum number of platelets that a random donor platelet (RDP) unit must contain?

5.5 x 10^10 platelets (C) Signup and view all the answers

What is the correct formula to calculate the corrected count increment (CCI) after platelet transfusion?

(Post-transfusion PC - Pre-transfusion PC) x BSA / # of RDP transfused (B) Signup and view all the answers

What is the primary indication for platelet transfusion in thrombocytopenia?

All of the above (D) Signup and view all the answers

How should single donor platelets (SDP) be stored and handled?

At room temperature with constant agitation for 3-5 days (C) Signup and view all the answers

What is the total platelet count in platelet-rich plasma (PRP) in the given formula?

71,500,000/mL (C) Signup and view all the answers

What is the Corrected Count Increment (CCI) in the given scenario?

20,250/μL (A) Signup and view all the answers

What is the percentage yield of platelets in the given case?

53.6% (C) Signup and view all the answers

What is the primary function of platelets in hemostasis?

Aggregation (B) Signup and view all the answers

What is the recommended storage temperature for platelet concentrates?

20-24°C (A) Signup and view all the answers

What is the formula to calculate the corrected count increment for a single donor platelet transfusion?

CCI = (Post-transfusion PC - Pre-transfusion PC) x BSA x 0.55 (A) Signup and view all the answers

What is the temperature range for storing random donor platelets?

20-24°C (C) Signup and view all the answers

What is the approximate volume of a platelet concentrate?

50-70 mL (D) Signup and view all the answers

What is the minimum platelet count required to indicate bleeding risks in patients with dengue hemorrhagic fever?

10,000/μL (A) Signup and view all the answers

What is the effect of 4-6 pools of random donor platelets (RDP) equivalent to?

20,000 - 60,000/μL of platelet count (D) Signup and view all the answers

What is the estimated blood volume of a 65 kg individual?

4, 550 mL (B) Signup and view all the answers

What is the estimated plasma volume of a 65 kg individual with a hematocrit of 0.28?

3, 276 mL (C) Signup and view all the answers

What is the required amount of fibrinogen to be transfused to reach the desired level of 100 mg/dL in a 65 kg individual?

2, 228 mg (B) Signup and view all the answers

How many units of cryoprecipitate are required to be transfused to reach the desired fibrinogen level of 100 mg/dL in a 65 kg individual?

9 units (C) Signup and view all the answers

What is the factor for blood volume estimation used in the calculation of estimated blood volume?

70 mL/kg body weight (C) Signup and view all the answers

What is the indication for transfusing fresh frozen plasma to a patient with acute blood loss?

Clotting factor deficiency (A) Signup and view all the answers

If a patient's serum has no antibodies against the antigens present on the donor's red cells, what can be transfused?

Whole blood and packed red cells (D) Signup and view all the answers

What is the consequence of transfusing donor red cells to a patient with antibodies against the antigens present on the donor's red cells?

Hemolytic transfusion reaction (D) Signup and view all the answers

What is the minimum requirement for proceeding with transfusion in major crossmatching?

No agglutination reaction (B) Signup and view all the answers

What is the primary consideration for transfusing whole blood or packed red cells to a patient?

Need of the patient (C) Signup and view all the answers

What is the primary function of enzymes in the context of blood group antigens?

To enhance or destroy certain blood group antigens (B) Signup and view all the answers

Which antigens are destroyed by enzymes in the RBC membrane?

M, N, S, and s (B) Signup and view all the answers

What is the key difference between the one-step and two-step enzyme treatment processes?

The application of the enzyme (C) Signup and view all the answers

What is the outcome of the one-step enzyme treatment process?

Washed red blood cells are then tested with specific antibodies (C) Signup and view all the answers

What is the purpose of the two-step enzyme treatment process?

To enhance antigen detection (C) Signup and view all the answers

Which antigens are enhanced by the enzyme treatment process?

Rh, Kidd, and Lewis (B) Signup and view all the answers

What is the role of ficin, bromelin, and papain in the enzyme treatment process?

To remove sialic acid from the RBC membrane (B) Signup and view all the answers

What is the difference between the one-step and two-step enzyme treatment processes in terms of specificity?

One-step potentially weakens all antibodies (C) Signup and view all the answers

What is the purpose of using enzymes in the context of blood group antigens?

To enhance or destroy certain blood group antigens (A) Signup and view all the answers

What is the result of the enzyme treatment process on the RBC membrane?

The sialic acid is removed from the RBC membrane (D) Signup and view all the answers