Hemostasis and Coagulation Altering Medications Quiz
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Questions and Answers

What is the mechanism of action of VKA Warfarin?

  • Inhibit active vitamin K and dependent clotting factors II, VII, IX, and X and proteins C&S (correct)
  • Inhibit platelet aggregation
  • Inhibit P2Y12 receptors on platelets to prevent aggregation
  • Activate fibrin to reinforce clot formation

    • What is the primary indication for the use of IIB/IIIA Inhibitors (eptifibatide; tirofiban)?

  • Prophylaxis for ischemic stroke
  • Treatment of deep vein thrombosis
  • PCI in the setting of acute coronary syndrome (correct)
  • Prevention of myocardial infarction

    • What is the main side effect of P2Y12 Inhibitors (clopidogrel, prasugrel, ticagrelor)?

  • Thrombocytopenia
  • Gastrointestinal bleeding (correct)
  • Increased risk of ischemic stroke
  • Rash and dyspnea

    • What is the reason for holding ASA for 7 days before a procedure?

    <p>To allow time for platelet function to return to normal (C)</p> Signup and view all the answers

    Which class of medications manipulates fibrin activation in the hemostasis process?

    <p>Anticoagulants (C)</p> Signup and view all the answers

    What is the primary monitoring parameter for VKA Warfarin therapy?

    <p>International normalized ratio (INR) (B)</p> Signup and view all the answers

    What is the main mechanism of action of Fibrinolytics?

    <p>Break down existing clots (A)</p> Signup and view all the answers

    Which medication is a direct Xa Inhibitor?

    <p>Rivaroxaban (D)</p> Signup and view all the answers

    What is the reversal agent for Dabigatran?

    <p>Idarucizumab (D)</p> Signup and view all the answers

    What is the primary indication for the use of tPA (alteplase)?

    <p>Severe thrombotic disease (A)</p> Signup and view all the answers

    What is the main mechanism of action of Heparin/LMWH (enoxaparin)?

    <p>Suppress coagulation by activating antithrombin (B)</p> Signup and view all the answers

    What is the primary monitoring parameter for LMWH therapy?

    <p>PTT or anti-Xa (B)</p> Signup and view all the answers

    Which medication is usually given if someone has Heparin Induced Thrombocytopenia (HIT) or is allergic to heparin?

    <p>Argatroban (A)</p> Signup and view all the answers

    What is the Black Box Warning associated with Direct Xa Inhibitors?

    <p>Abruptly stopping leads to hypercoagulable state (A)</p> Signup and view all the answers

    What is the reversal agent for tPA (alteplase)?

    <p>Aminocaproic acid (C)</p> Signup and view all the answers

    Which medication irreversibly binds to platelets, necessitating a 7-day hold before a procedure?

    <p>Clopidogrel (B)</p> Signup and view all the answers

    What is the primary mechanism of action of IIB/IIIA Inhibitors (eptifibatide; tirofiban)?

    <p>Inhibit binding of factor 8 &amp; fibrinogen to platelets (B)</p> Signup and view all the answers

    What is the main indication for the use of Fibrinolytics?

    <p>Break down clots (A)</p> Signup and view all the answers

    Which medication class manipulates fibrin activation in the hemostasis process?

    <p>Anticoagulants (D)</p> Signup and view all the answers

    What is the primary side effect of P2Y12 Inhibitors (clopidogrel, prasugrel, ticagrelor)?

    <p>Increase risk of bleeding (C)</p> Signup and view all the answers

    What is the main mechanism of action of VKA Warfarin?

    <p>Inhibit active vitamin K and dependent clotting factors (C)</p> Signup and view all the answers

    What is the primary monitoring parameter for VKA Warfarin therapy?

    <p>PT/PTT/INR (C)</p> Signup and view all the answers

    What is the reversal agent for Heparin?

    <p>Protamine sulfate (D)</p> Signup and view all the answers

    Which medication is a Direct Thrombin Inhibitor?

    <p>Dabigatran (D)</p> Signup and view all the answers

    What is the primary contraindication for Fibrinolytic Therapy?

    <p>Intracranial hemorrhage (B)</p> Signup and view all the answers

    What is the primary monitoring parameter for Direct Xa Inhibitors therapy?

    <p>CBC; renal; liver (C)</p> Signup and view all the answers

    Which medication is given prior to PCI (percutaneous coronary intervention)?

    <p>Heparin (D)</p> Signup and view all the answers

    What is the Black Box Warning associated with tPA (alteplase)?

    <p>Bleeding (A)</p> Signup and view all the answers

    What is the primary indication for the use of Direct Xa Inhibitors?

    <p>DOACS (less bleeding risk than warfarin) (B)</p> Signup and view all the answers

    What is the reversal agent for tPA (alteplase)?

    <p>Aminocaproic acid (A)</p> Signup and view all the answers

    Which of the following is a contraindication for the use of LMWH?

    <p>Hemophilia (C)</p> Signup and view all the answers

    What is the reversal agent for heparin?

    <p>Protamine sulfate (A)</p> Signup and view all the answers

    Which of the following is a contraindication for the use of Direct Xa Inhibitors?

    <p>Pregnancy (C)</p> Signup and view all the answers

    What is the mechanism of action of Fibrinolytic Therapy (tPA)?

    <p>Lysis of existing thrombus (B)</p> Signup and view all the answers

    Which monitoring parameter is specifically associated with LMWH?

    <p>PTT or anti-Xa (C)</p> Signup and view all the answers

    What is the reversal agent for dabigatran?

    <p>Idarucizumab (A)</p> Signup and view all the answers

    Which of the following is an indication for the use of Direct Thrombin Inhibitors?

    <p>Atrial fibrillation (A)</p> Signup and view all the answers

    What is the Black Box Warning associated with Direct Xa Inhibitors?

    <p>Abruptly stopping leads to hypercoagulable state (D)</p> Signup and view all the answers

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